DK248384D0 - Piperazinderivater - Google Patents

Piperazinderivater

Info

Publication number
DK248384D0
DK248384D0 DK2483/84A DK248384A DK248384D0 DK 248384 D0 DK248384 D0 DK 248384D0 DK 2483/84 A DK2483/84 A DK 2483/84A DK 248384 A DK248384 A DK 248384A DK 248384 D0 DK248384 D0 DK 248384D0
Authority
DK
Denmark
Prior art keywords
lower alkyl
independently hydrogen
together form
och2o
halo
Prior art date
Application number
DK2483/84A
Other languages
English (en)
Other versions
DK248384A (da
DK168535B1 (da
Inventor
Arthur Frederick Kluge
Robin Douglas Clark
Arthur Martin Strosberg
Jean Claude Pascal
Roger Lewis Whiting
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK248384D0 publication Critical patent/DK248384D0/da
Publication of DK248384A publication Critical patent/DK248384A/da
Application granted granted Critical
Publication of DK168535B1 publication Critical patent/DK168535B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
DK248384A 1983-05-18 1984-05-17 2,6-Dialkylphenylaminocarbonylmethyl-piperazinderivater, fremgangsmåde til fremstilling deraf, samt farmaceutisk præparat indeholdende disse derivater DK168535B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49590483 1983-05-18
US06/495,904 US4567264A (en) 1983-05-18 1983-05-18 Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry

Publications (3)

Publication Number Publication Date
DK248384D0 true DK248384D0 (da) 1984-05-17
DK248384A DK248384A (da) 1984-11-19
DK168535B1 DK168535B1 (da) 1994-04-18

Family

ID=23970461

Family Applications (1)

Application Number Title Priority Date Filing Date
DK248384A DK168535B1 (da) 1983-05-18 1984-05-17 2,6-Dialkylphenylaminocarbonylmethyl-piperazinderivater, fremgangsmåde til fremstilling deraf, samt farmaceutisk præparat indeholdende disse derivater

Country Status (26)

Country Link
US (1) US4567264A (da)
EP (1) EP0126449B1 (da)
JP (1) JPS59219271A (da)
KR (1) KR890000020B1 (da)
AT (1) ATE31533T1 (da)
AU (1) AU566489B2 (da)
BR (1) BR1100474A (da)
CA (1) CA1256874A (da)
CS (1) CS246080B2 (da)
DE (1) DE3468215D1 (da)
DK (1) DK168535B1 (da)
ES (1) ES532565A0 (da)
FI (1) FI78479C (da)
HK (1) HK91989A (da)
HU (1) HU192404B (da)
IE (1) IE57487B1 (da)
IL (1) IL71863A (da)
MX (1) MX9203001A (da)
NO (1) NO163618C (da)
NZ (1) NZ208188A (da)
PH (1) PH20016A (da)
PL (2) PL143558B1 (da)
PT (1) PT78604B (da)
RU (2) RU2071471C1 (da)
SG (1) SG25086G (da)
ZA (1) ZA843746B (da)

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Also Published As

Publication number Publication date
FI78479B (fi) 1989-04-28
IL71863A (en) 1987-10-30
HU192404B (en) 1987-06-29
FI841989A0 (fi) 1984-05-17
JPS59219271A (ja) 1984-12-10
JPH0469151B2 (da) 1992-11-05
ES8601947A1 (es) 1985-12-01
ATE31533T1 (de) 1988-01-15
PT78604B (en) 1986-07-15
KR890000020B1 (ko) 1989-03-06
NO841968L (no) 1984-11-19
PL247722A1 (en) 1985-08-13
IE57487B1 (en) 1993-02-10
FI78479C (fi) 1989-08-10
FI841989A (fi) 1984-11-19
PL142760B1 (en) 1987-11-30
RU2083570C1 (ru) 1997-07-10
EP0126449B1 (en) 1987-12-23
AU566489B2 (en) 1987-10-22
CA1256874A (en) 1989-07-04
DE3468215D1 (en) 1988-02-04
SG25086G (en) 1989-12-29
PL252856A1 (en) 1985-11-19
ZA843746B (en) 1986-01-29
RU2071471C1 (ru) 1997-01-10
ES532565A0 (es) 1985-12-01
HK91989A (en) 1989-11-24
IE841224L (en) 1984-11-18
NO163618C (no) 1990-06-27
BR1100474A (pt) 2000-03-14
MX9203001A (es) 1992-07-01
PT78604A (en) 1984-06-01
US4567264A (en) 1986-01-28
PH20016A (en) 1986-09-01
CS246080B2 (en) 1986-10-16
NZ208188A (en) 1987-10-30
AU2834684A (en) 1984-11-22
DK248384A (da) 1984-11-19
HUT34177A (en) 1985-02-28
NO163618B (no) 1990-03-19
PL143558B1 (en) 1988-02-29
EP0126449A1 (en) 1984-11-28
DK168535B1 (da) 1994-04-18
IL71863A0 (en) 1984-09-30
KR850002475A (ko) 1985-05-13

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