DE60328545D1 - Substituierte Piperazinderivate und ihre Verwendung als Inhibitoren der Fettsäureoxidation - Google Patents
Substituierte Piperazinderivate und ihre Verwendung als Inhibitoren der FettsäureoxidationInfo
- Publication number
- DE60328545D1 DE60328545D1 DE60328545T DE60328545T DE60328545D1 DE 60328545 D1 DE60328545 D1 DE 60328545D1 DE 60328545 T DE60328545 T DE 60328545T DE 60328545 T DE60328545 T DE 60328545T DE 60328545 D1 DE60328545 D1 DE 60328545D1
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- fatty acid
- acid oxidation
- piperazine derivatives
- substituted piperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 235000014113 dietary fatty acids Nutrition 0.000 title 1
- 229930195729 fatty acid Natural products 0.000 title 1
- 239000000194 fatty acid Substances 0.000 title 1
- 150000004665 fatty acids Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000003647 oxidation Effects 0.000 title 1
- 238000007254 oxidation reaction Methods 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 2
- 206010002388 Angina unstable Diseases 0.000 abstract 1
- 206010003130 Arrhythmia supraventricular Diseases 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010022562 Intermittent claudication Diseases 0.000 abstract 1
- 208000007718 Stable Angina Diseases 0.000 abstract 1
- 208000007814 Unstable Angina Diseases 0.000 abstract 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 abstract 1
- 230000001746 atrial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 abstract 1
- 208000021156 intermittent vascular claudication Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Lubricants (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43150602P | 2002-12-05 | 2002-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60328545D1 true DE60328545D1 (de) | 2009-09-03 |
Family
ID=32507739
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60314662T Expired - Lifetime DE60314662T2 (de) | 2002-12-05 | 2003-12-05 | Substituierte piperazinverbindungen und deren verwendung als fettsäureoxidationsinhibitoren |
| DE60328545T Expired - Lifetime DE60328545D1 (de) | 2002-12-05 | 2003-12-05 | Substituierte Piperazinderivate und ihre Verwendung als Inhibitoren der Fettsäureoxidation |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60314662T Expired - Lifetime DE60314662T2 (de) | 2002-12-05 | 2003-12-05 | Substituierte piperazinverbindungen und deren verwendung als fettsäureoxidationsinhibitoren |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7125876B2 (de) |
| EP (1) | EP1567525B1 (de) |
| JP (1) | JP2006510670A (de) |
| KR (1) | KR20050084182A (de) |
| AT (1) | ATE365737T1 (de) |
| AU (1) | AU2003300827B2 (de) |
| CA (1) | CA2508608A1 (de) |
| DE (2) | DE60314662T2 (de) |
| ES (2) | ES2327873T3 (de) |
| HK (2) | HK1083492A1 (de) |
| NZ (1) | NZ540548A (de) |
| WO (1) | WO2004052887A2 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004063180A1 (en) * | 2003-01-03 | 2004-07-29 | Cv Therapeutics, Inc. | Substituted heterocyclic compounds |
| AU2005282492A1 (en) * | 2004-09-08 | 2006-03-16 | Gilead Palo Alto, Inc. | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
| TW200745025A (en) * | 2005-12-29 | 2007-12-16 | Schering Ag | Amide inhibitors of leukotriene A4 hydrolase |
| KR101476379B1 (ko) * | 2011-11-30 | 2014-12-29 | 한국과학기술연구원 | 페녹시프로판올 유도체 및 이를 함유하는 약학적 조성물 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2267104A1 (en) * | 1974-04-12 | 1975-11-07 | Ferlux Labo Sa | Hypotensive and antiarrhythmic piperazines - 1-(3-phenoxy-2-hydroxy propyl)-4-substd. piperazines |
| US4766125A (en) | 1981-06-23 | 1988-08-23 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia |
| US4567264A (en) * | 1983-05-18 | 1986-01-28 | Syntex (U.S.A.) Inc. | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry |
| US4558129A (en) | 1983-05-18 | 1985-12-10 | Syntex (U.S.A.) Inc. | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade |
| US4588129A (en) * | 1983-09-06 | 1986-05-13 | Hudson Oxygen Therapy Sales Company | Nebulizer |
| US4788306A (en) * | 1987-04-03 | 1988-11-29 | American Home Products Corporation | Fluorooxirane carboxylates as hypoglycemic agents |
| JPH0730456Y2 (ja) | 1989-05-11 | 1995-07-12 | 株式会社神戸製鋼所 | ホイールクレーンのステアリング制御装置 |
| EP0714660B1 (de) | 1989-06-23 | 2002-09-04 | Syntex (U.S.A.) LLC | Ranolazin und verwandte Piperazine zum Schutz der Skelettmuskulatur |
| JPH03141258A (ja) | 1989-10-25 | 1991-06-17 | Kowa Co | 新規なピペラジン誘導体 |
| US5455045A (en) | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
| EP0987254B1 (de) * | 1997-05-26 | 2004-12-22 | Kowa Co., Ltd. | Neue zyklische diaminverbindungen und heilmittel das diese enthält |
| MXPA02007639A (es) * | 2000-02-18 | 2004-08-23 | Cv Therapeutics Inc | Inhibidores de la oxidacion parcial de los acidos grasos en el tratamiento de la falla cardiaca congestiva. |
| AU3862301A (en) | 2000-02-22 | 2001-09-03 | Cv Therapeutics Inc | Substituted piperazine compounds |
| US6677336B2 (en) | 2000-02-22 | 2004-01-13 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| AU2001238590A1 (en) | 2000-02-22 | 2001-09-03 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| US6552023B2 (en) | 2000-02-22 | 2003-04-22 | Cv Therapeutics, Inc. | Aralkyl substituted piperazine compounds |
| US6451798B2 (en) | 2000-02-22 | 2002-09-17 | Cv Therapeutics, Inc. | Substituted alkyl piperazine derivatives |
| WO2001062711A2 (en) | 2000-02-22 | 2001-08-30 | Cv Therapeutics, Inc. | Substituted alkylene diamine compounds |
| US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| SE0003795D0 (sv) * | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
| US6573264B1 (en) * | 2000-10-23 | 2003-06-03 | Cv Therapeutics, Inc. | Heteroaryl alkyl piperazine derivatives |
| DE60203623T2 (de) | 2001-07-19 | 2006-01-19 | CV Therapeutics, Inc., Palo Alto | Substituierte piperazinderivate und ihre verwendung als fettsaüre-oxidationsinhibitoren |
-
2003
- 2003-12-05 AU AU2003300827A patent/AU2003300827B2/en not_active Ceased
- 2003-12-05 DE DE60314662T patent/DE60314662T2/de not_active Expired - Lifetime
- 2003-12-05 AT AT03812835T patent/ATE365737T1/de not_active IP Right Cessation
- 2003-12-05 EP EP03812835A patent/EP1567525B1/de not_active Expired - Lifetime
- 2003-12-05 CA CA002508608A patent/CA2508608A1/en not_active Abandoned
- 2003-12-05 NZ NZ540548A patent/NZ540548A/en unknown
- 2003-12-05 JP JP2004559388A patent/JP2006510670A/ja active Pending
- 2003-12-05 ES ES07008429T patent/ES2327873T3/es not_active Expired - Lifetime
- 2003-12-05 US US10/729,499 patent/US7125876B2/en not_active Expired - Fee Related
- 2003-12-05 WO PCT/US2003/038867 patent/WO2004052887A2/en active IP Right Grant
- 2003-12-05 KR KR1020057010236A patent/KR20050084182A/ko not_active Application Discontinuation
- 2003-12-05 ES ES03812835T patent/ES2287574T3/es not_active Expired - Lifetime
- 2003-12-05 DE DE60328545T patent/DE60328545D1/de not_active Expired - Lifetime
-
2006
- 2006-02-17 HK HK06102183A patent/HK1083492A1/xx not_active IP Right Cessation
- 2006-09-07 US US11/518,085 patent/US7407960B2/en not_active Expired - Fee Related
-
2008
- 2008-01-10 HK HK08100361.3A patent/HK1111683A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ540548A (en) | 2008-03-28 |
| WO2004052887A3 (en) | 2004-07-15 |
| ATE365737T1 (de) | 2007-07-15 |
| DE60314662T2 (de) | 2008-03-13 |
| US20040152890A1 (en) | 2004-08-05 |
| HK1083492A1 (en) | 2006-07-07 |
| ES2327873T3 (es) | 2009-11-04 |
| CA2508608A1 (en) | 2004-06-24 |
| ES2287574T3 (es) | 2007-12-16 |
| US7125876B2 (en) | 2006-10-24 |
| AU2003300827A1 (en) | 2004-06-30 |
| WO2004052887A2 (en) | 2004-06-24 |
| JP2006510670A (ja) | 2006-03-30 |
| EP1567525A2 (de) | 2005-08-31 |
| EP1567525B1 (de) | 2007-06-27 |
| US20070004751A1 (en) | 2007-01-04 |
| AU2003300827B2 (en) | 2009-08-13 |
| US7407960B2 (en) | 2008-08-05 |
| HK1111683A1 (en) | 2008-08-15 |
| DE60314662D1 (de) | 2007-08-09 |
| KR20050084182A (ko) | 2005-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |