CS226037B2 - Method of preparing 2-amino-3-carbethoxyamino(6-p-fluorobenzylamino)pyridine-maleate - Google Patents
Method of preparing 2-amino-3-carbethoxyamino(6-p-fluorobenzylamino)pyridine-maleate Download PDFInfo
- Publication number
- CS226037B2 CS226037B2 CS816725A CS672581A CS226037B2 CS 226037 B2 CS226037 B2 CS 226037B2 CS 816725 A CS816725 A CS 816725A CS 672581 A CS672581 A CS 672581A CS 226037 B2 CS226037 B2 CS 226037B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- amino
- pyridine
- fluorobenzylamino
- temperature
- modification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3034638 | 1980-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS226037B2 true CS226037B2 (en) | 1984-03-19 |
Family
ID=6111900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS816725A CS226037B2 (en) | 1980-09-13 | 1981-09-11 | Method of preparing 2-amino-3-carbethoxyamino(6-p-fluorobenzylamino)pyridine-maleate |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4481205A (el) |
| JP (1) | JPS5781465A (el) |
| KR (1) | KR860000585B1 (el) |
| AR (1) | AR229101A1 (el) |
| AT (1) | AT375924B (el) |
| AU (1) | AU541020B2 (el) |
| BE (1) | BE890331A (el) |
| CA (1) | CA1147736A (el) |
| CH (1) | CH646952A5 (el) |
| CS (1) | CS226037B2 (el) |
| DD (1) | DD201786A5 (el) |
| DK (1) | DK159878C (el) |
| EG (1) | EG15446A (el) |
| ES (1) | ES505423A0 (el) |
| FI (1) | FI79531C (el) |
| FR (1) | FR2490225B1 (el) |
| GB (1) | GB2084138B (el) |
| GR (1) | GR75777B (el) |
| HU (1) | HU182720B (el) |
| IE (1) | IE51547B1 (el) |
| IL (1) | IL63801A (el) |
| IN (1) | IN155674B (el) |
| IT (1) | IT1171520B (el) |
| LU (1) | LU83633A1 (el) |
| NL (1) | NL189856C (el) |
| NO (1) | NO160919C (el) |
| PL (1) | PL130030B1 (el) |
| SE (1) | SE454693B (el) |
| SU (1) | SU1091855A3 (el) |
| YU (1) | YU43037B (el) |
| ZA (1) | ZA816336B (el) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3416609A1 (de) * | 1984-05-05 | 1985-11-07 | Degussa Ag, 6000 Frankfurt | 2-amino-3-ethoxycarbonylamino-6-(p-fluor-benzylamino)- pyridin-gluconat und pharmazeutische zubereitungen, die diese substanz enthalten |
| NO860825L (no) * | 1985-03-23 | 1986-09-24 | Degussa | Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin. |
| JPH0568848U (ja) * | 1991-11-18 | 1993-09-17 | 京都機械工具株式会社 | チューブ絞り器 |
| DE4327516A1 (de) * | 1993-08-17 | 1995-02-23 | Asta Medica Ag | Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin |
| DE19625582A1 (de) * | 1996-06-27 | 1998-01-02 | Asta Medica Ag | Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen die mit einer unphysiologisch hohen Zellsterberate einhergehen |
| DE19716984A1 (de) * | 1997-04-23 | 1998-10-29 | Asta Medica Ag | Verfahren zur Herstellung von reinem Flupirtin-Maleat und dessen Modifikation A |
| US6187324B1 (en) * | 1998-08-11 | 2001-02-13 | Kabushiki Kaisha Ogi Kogei | Cosmetic composition comprising at least one of Kumazasa extract and medicinal carbon |
| US6821995B1 (en) | 1999-12-01 | 2004-11-23 | Duke University | Method of treating batten disease |
| DE10327674A1 (de) * | 2003-06-20 | 2005-01-05 | Awd.Pharma Gmbh & Co. Kg | Injizierbare Darreichungsform von Flupirtin |
| US7741358B2 (en) * | 2005-04-14 | 2010-06-22 | N.V. Organon | Crystal form of asenapine maleate |
| US20080279930A1 (en) * | 2007-05-07 | 2008-11-13 | Bernd Terhaag | Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof |
| WO2009152647A1 (zh) | 2008-06-20 | 2009-12-23 | 江苏恩华药业股份有限公司 | 芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用 |
| EP2361247A4 (en) * | 2008-08-06 | 2012-08-08 | Bionevia Pharmaceuticals Inc | FLUPIRTINHYDROCHLORID-maleic acid co-crystal |
| DE102009023162B4 (de) * | 2009-05-29 | 2011-07-07 | Corden PharmaChem GmbH, 68305 | Verfahren zur Herstellung von Flupirtin |
| CN102140077A (zh) * | 2010-01-28 | 2011-08-03 | 范扶民 | 氟吡汀a晶型及其制备方法 |
| WO2012004391A1 (en) | 2010-07-09 | 2012-01-12 | K.H.S. Pharma Holding Gmbh | Process for the preparation of flupirtine maleate |
| CN102241626B (zh) * | 2011-05-03 | 2013-07-03 | 北京华睿鼎信科技有限公司 | 一种马来酸氟吡汀的合成工艺 |
| WO2013080215A1 (en) | 2011-11-30 | 2013-06-06 | Arch Pharmalabs Limited | An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof |
| CN103086963A (zh) * | 2013-01-29 | 2013-05-08 | 吉林修正药业新药开发有限公司 | 一种马来酸氟吡汀a晶型化合物及中间体的合成方法 |
| CN104086481B (zh) * | 2014-07-18 | 2016-05-11 | 四川新斯顿制药股份有限公司 | 一种马来酸氟吡汀的合成方法 |
| CN111100010A (zh) * | 2019-12-30 | 2020-05-05 | 山东省越兴化工有限公司 | 一种对氟苄胺的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1795858C2 (de) * | 1968-07-19 | 1979-01-11 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Benzylaminopyridine |
| US3969361A (en) * | 1972-05-10 | 1976-07-13 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler | 2-Benzoyl-3-amino-pyridines |
-
1981
- 1981-09-02 US US06/298,886 patent/US4481205A/en not_active Expired - Lifetime
- 1981-09-04 GB GB8126788A patent/GB2084138B/en not_active Expired
- 1981-09-04 IE IE2055/81A patent/IE51547B1/en not_active IP Right Cessation
- 1981-09-08 AR AR286685A patent/AR229101A1/es active
- 1981-09-09 YU YU2157/81A patent/YU43037B/xx unknown
- 1981-09-10 SU SU813332400A patent/SU1091855A3/ru active
- 1981-09-10 NO NO813082A patent/NO160919C/no unknown
- 1981-09-10 IN IN1018/CAL/81A patent/IN155674B/en unknown
- 1981-09-11 PL PL1981232999A patent/PL130030B1/pl unknown
- 1981-09-11 DD DD81233226A patent/DD201786A5/de unknown
- 1981-09-11 NL NLAANVRAGE8104211,A patent/NL189856C/xx not_active IP Right Cessation
- 1981-09-11 FI FI812836A patent/FI79531C/fi not_active IP Right Cessation
- 1981-09-11 LU LU83633A patent/LU83633A1/de unknown
- 1981-09-11 CS CS816725A patent/CS226037B2/cs unknown
- 1981-09-11 HU HU812635A patent/HU182720B/hu not_active IP Right Cessation
- 1981-09-11 GR GR66021A patent/GR75777B/el unknown
- 1981-09-11 AU AU75163/81A patent/AU541020B2/en not_active Expired
- 1981-09-11 IT IT49272/81A patent/IT1171520B/it active
- 1981-09-11 SE SE8105425A patent/SE454693B/sv not_active IP Right Cessation
- 1981-09-11 IL IL63801A patent/IL63801A/xx unknown
- 1981-09-11 AT AT0393481A patent/AT375924B/de not_active IP Right Cessation
- 1981-09-11 ZA ZA816336A patent/ZA816336B/xx unknown
- 1981-09-11 JP JP56143721A patent/JPS5781465A/ja active Granted
- 1981-09-11 ES ES505423A patent/ES505423A0/es active Granted
- 1981-09-11 CA CA000385703A patent/CA1147736A/en not_active Expired
- 1981-09-11 KR KR1019810003406A patent/KR860000585B1/ko active
- 1981-09-11 CH CH591081A patent/CH646952A5/de not_active IP Right Cessation
- 1981-09-11 DK DK404681A patent/DK159878C/da active
- 1981-09-11 BE BE6/47521A patent/BE890331A/fr not_active IP Right Cessation
- 1981-09-13 EG EG81515A patent/EG15446A/xx active
- 1981-09-14 FR FR8117328A patent/FR2490225B1/fr not_active Expired
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