CS215142B2 - Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers - Google Patents

Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers Download PDF

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Publication number
CS215142B2
CS215142B2 CS806756A CS675680A CS215142B2 CS 215142 B2 CS215142 B2 CS 215142B2 CS 806756 A CS806756 A CS 806756A CS 675680 A CS675680 A CS 675680A CS 215142 B2 CS215142 B2 CS 215142B2
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CS
Czechoslovakia
Prior art keywords
compound
acid
mol
mixture
solvate
Prior art date
Application number
CS806756A
Other languages
Czech (cs)
English (en)
Inventor
Billy G Jackson
Donna Gardner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS215142B2 publication Critical patent/CS215142B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
CS806756A 1979-10-09 1980-10-07 Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers CS215142B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/082,822 US4252951A (en) 1979-10-09 1979-10-09 Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid

Publications (1)

Publication Number Publication Date
CS215142B2 true CS215142B2 (en) 1982-07-30

Family

ID=22173679

Family Applications (1)

Application Number Title Priority Date Filing Date
CS806756A CS215142B2 (en) 1979-10-09 1980-10-07 Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers

Country Status (27)

Country Link
US (1) US4252951A (de)
EP (1) EP0027050B1 (de)
JP (1) JPS5661388A (de)
KR (1) KR840000866B1 (de)
AT (1) AT369008B (de)
AU (1) AU6306180A (de)
BE (1) BE885569A (de)
CA (1) CA1146539A (de)
CH (1) CH647523A5 (de)
CS (1) CS215142B2 (de)
DD (1) DD153375A5 (de)
DE (1) DE3065181D1 (de)
DK (1) DK424680A (de)
ES (1) ES495753A0 (de)
FI (1) FI803200L (de)
FR (1) FR2467211A1 (de)
GB (1) GB2059966B (de)
GR (1) GR70219B (de)
HU (1) HU183230B (de)
IE (1) IE50390B1 (de)
IL (1) IL61227A (de)
IT (1) IT1132926B (de)
PH (1) PH15023A (de)
PT (1) PT71886B (de)
RO (1) RO80664B (de)
YU (1) YU256480A (de)
ZA (1) ZA806192B (de)

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CA2498944C (en) * 2002-09-19 2011-05-17 Yasushi Kohno Amino alcohol derivatives, salts thereof and immunosuppressive agents
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
JP2006521355A (ja) * 2003-03-17 2006-09-21 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア・センター・フオー・テクノロジー・トランスフアー 表面的に両親媒性のポリマー及びオリゴマーならびにそれらの使用
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
US20050203184A1 (en) 2003-09-10 2005-09-15 Petasis Nicos A. Benzo lipoxin analogues
CN1922133A (zh) * 2004-01-23 2007-02-28 宾夕法尼亚州大学理事会 表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途
US7825278B2 (en) * 2004-05-06 2010-11-02 The Regents Of The University Of California Substituted enaminones, their derivatives and uses thereof
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
US7220742B2 (en) * 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
JP2008531585A (ja) * 2005-02-25 2008-08-14 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 表面が両親媒性のポリマーおよびオリゴマー、それらの組成物そして癌治療方法におけるそれらの使用
CN101166706B (zh) * 2005-02-28 2011-08-24 明治乳业株式会社 氢醌长链衍生物和/或苯氧基长链衍生物及含有它们的药品
AU2006279943B2 (en) * 2005-08-10 2012-02-16 The Johns Hopkins University Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
JP5270343B2 (ja) * 2005-08-15 2013-08-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベータミメティックスの製造方法
US8592433B2 (en) * 2005-10-28 2013-11-26 Advait Nagle Compounds and compositions as protein kinase inhibitors
EP1954259A2 (de) * 2005-11-29 2008-08-13 Hammersmith Imanet, Ltd Amidin-derivate zur darstellung in vivo
ES2288107B1 (es) * 2006-01-27 2008-11-01 Fundacion Imabis Instituto Mediterraneo Para El Avance De La Biotecnologia Y La Investigacion Sanita Derivados aciclicos saturados e insaturados de cadena larga de sulfamidas como activadores especificos de receptores ppar-alfa.
FR2903004B1 (fr) * 2006-07-03 2009-07-10 Oreal Utilisation en cosmetique d'un derive c-glycoside en association avec de l'acide ascorbique
FR2902996B1 (fr) * 2006-07-03 2008-09-26 Oreal Compositions cosmetiques associant un derive c-glycoside et un derive n-acylaminoamide
US20090075935A1 (en) * 2006-07-03 2009-03-19 L'oreal Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use
FR2902999B1 (fr) * 2006-07-03 2012-09-28 Oreal Utilisation de derives c-glycoside a titre d'actif prodesquamant
ES2375761T3 (es) * 2006-12-14 2012-03-06 Teva Pharmaceutical Industries Ltd. Base de rasagilina cristalina sólida.
CN101730706B (zh) * 2007-05-11 2015-04-15 生物科技研究有限公司 具有神经保护和增强记忆活性的受体拮抗剂
US7696383B2 (en) * 2007-06-26 2010-04-13 Solvay Pharmaceuticals B.V. N-oxides of venlafaxine and o-desmethylvenlafaxine as prodrugs
FR2920000B1 (fr) * 2007-08-13 2010-01-29 Oreal Composition cosmetique ou pharmaceutique contenant de l'acide hyaluronique, et procede cosmetique pour diminuer les signes du vieilissement
US8252935B2 (en) * 2007-10-19 2012-08-28 Janssen Pharmaceutica N.V. Piperidinyl and piperazinyl modulators of γ-secretase
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Also Published As

Publication number Publication date
JPS5661388A (en) 1981-05-26
KR840000866B1 (ko) 1984-06-20
RO80664A (ro) 1983-02-15
IL61227A (en) 1983-07-31
PT71886B (en) 1981-08-13
ES8201166A1 (es) 1981-12-01
EP0027050A1 (de) 1981-04-15
EP0027050B1 (de) 1983-10-05
IE50390B1 (en) 1986-04-16
DK424680A (da) 1981-04-10
PH15023A (en) 1982-05-13
IT8025200A0 (it) 1980-10-08
DE3065181D1 (en) 1983-11-10
GB2059966A (en) 1981-04-29
KR830004314A (ko) 1983-07-09
ATA498080A (de) 1982-04-15
HU183230B (en) 1984-04-28
AT369008B (de) 1982-11-25
ES495753A0 (es) 1981-12-01
FI803200L (fi) 1981-04-10
FR2467211B1 (de) 1983-06-10
BE885569A (fr) 1981-04-08
CA1146539A (en) 1983-05-17
IL61227A0 (en) 1980-12-31
GR70219B (de) 1982-08-31
IE802086L (en) 1981-04-09
GB2059966B (en) 1983-09-01
DD153375A5 (de) 1982-01-06
AU6306180A (en) 1981-04-16
IT1132926B (it) 1986-07-09
CH647523A5 (fr) 1985-01-31
YU256480A (en) 1983-02-28
PT71886A (en) 1980-11-01
RO80664B (ro) 1983-02-28
FR2467211A1 (fr) 1981-04-17
US4252951A (en) 1981-02-24
ZA806192B (en) 1982-05-26

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