CS207773B2 - Method of making the new substituted 2-phenyl-iminoimidazolines - Google Patents
Method of making the new substituted 2-phenyl-iminoimidazolines Download PDFInfo
- Publication number
- CS207773B2 CS207773B2 CS791092A CS109279A CS207773B2 CS 207773 B2 CS207773 B2 CS 207773B2 CS 791092 A CS791092 A CS 791092A CS 109279 A CS109279 A CS 109279A CS 207773 B2 CS207773 B2 CS 207773B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- acid
- formula
- dihydroxyphenyl
- acid addition
- bromo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782806775 DE2806775A1 (de) | 1978-02-17 | 1978-02-17 | Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
Publications (1)
Publication Number | Publication Date |
---|---|
CS207773B2 true CS207773B2 (en) | 1981-08-31 |
Family
ID=6032231
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS791092A CS207773B2 (en) | 1978-02-17 | 1979-02-19 | Method of making the new substituted 2-phenyl-iminoimidazolines |
CS798500A CS207774B2 (en) | 1978-02-17 | 1979-02-19 | Method of making the new substituted 2-phenyliminoimidazolines |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS798500A CS207774B2 (en) | 1978-02-17 | 1979-02-19 | Method of making the new substituted 2-phenyliminoimidazolines |
Country Status (32)
Country | Link |
---|---|
US (2) | US4250186A (fr) |
JP (1) | JPS54122273A (fr) |
AT (1) | AT370093B (fr) |
AU (1) | AU519356B2 (fr) |
BE (1) | BE874252A (fr) |
CA (1) | CA1115717A (fr) |
CH (1) | CH640230A5 (fr) |
CS (2) | CS207773B2 (fr) |
DD (1) | DD142048A5 (fr) |
DE (1) | DE2806775A1 (fr) |
DK (1) | DK69479A (fr) |
ES (2) | ES477784A1 (fr) |
FI (1) | FI69301C (fr) |
FR (1) | FR2417502A1 (fr) |
GB (1) | GB2014575B (fr) |
GR (2) | GR67626B (fr) |
HU (1) | HU180430B (fr) |
IE (1) | IE48073B1 (fr) |
IL (1) | IL56678A (fr) |
IT (1) | IT1113469B (fr) |
LU (1) | LU80924A1 (fr) |
NL (1) | NL7901241A (fr) |
NO (1) | NO151239C (fr) |
NZ (1) | NZ189684A (fr) |
PH (1) | PH16188A (fr) |
PL (2) | PL116527B1 (fr) |
PT (1) | PT69239A (fr) |
RO (2) | RO81504B (fr) |
SE (1) | SE7901405L (fr) |
SU (2) | SU812175A3 (fr) |
YU (1) | YU36779A (fr) |
ZA (1) | ZA79709B (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2854659A1 (de) * | 1978-12-18 | 1980-07-10 | Boehringer Sohn Ingelheim | Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
DE3168754D1 (en) * | 1980-07-09 | 1985-03-21 | Beecham Group Plc | Clonidine derivatives useful in the treatment of diarrhoea |
EP0070084A3 (fr) * | 1981-04-24 | 1983-02-16 | Beecham Group Plc | Dérivés d'imidazoline |
US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
CA1201066A (fr) * | 1981-11-20 | 1986-02-25 | Alcon Laboratories, Inc. | Solutions de n-¬3,5-dichloro-4-(2- imidazolidinylidene-amino)-phenyl|-acetamide pour diminuer la pression intra-oculaire |
US4644007A (en) * | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
FR2521140A1 (fr) * | 1982-02-05 | 1983-08-12 | Synthelabo | Derives d'imidazolidine, leur preparation et leur application en therapeutique |
GB2137191A (en) * | 1983-02-28 | 1984-10-03 | Sumitomo Chemical Co | Fungicidal N-phenylimidates |
DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
JP2003166617A (ja) | 2001-11-28 | 2003-06-13 | Honda Motor Co Ltd | トルクコンバータ付き内燃機関 |
JP2007308392A (ja) * | 2006-05-16 | 2007-11-29 | Bayer Cropscience Ag | 殺虫性ベンズアミジン類 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2938038A (en) * | 1960-05-24 | X-dihydroxyphenylamino | ||
US2899426A (en) * | 1959-08-11 | Synthesis of l | ||
FR1211341A (fr) * | 1955-12-19 | 1960-03-15 | A Wander Dr | Procédé pour la préparation de 2-amino-imidazolines |
US3595961A (en) * | 1965-10-01 | 1971-07-27 | Boehringer Sohn Ingelheim | Hypotensive compositions containing 2-(2' - halo-anilino) - 1,3 -diazacyclopentenes-(2) and methods of using the same |
DE1670274A1 (de) * | 1966-10-31 | 1970-07-16 | Boehringer Sohn Ingelheim | Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2) |
AT285599B (de) * | 1968-06-21 | 1970-11-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen |
DE2446758C3 (de) * | 1974-10-01 | 1979-01-04 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-(2-Fluor-6-trifluormethylphenylimino)-imidazolidin, dessen Säureadditionssalze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung der Hypertonie |
DE2523103C3 (de) * | 1975-05-24 | 1979-11-29 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung |
DE2630060C2 (de) * | 1976-07-03 | 1984-04-19 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung |
-
1978
- 1978-02-17 DE DE19782806775 patent/DE2806775A1/de not_active Withdrawn
-
1979
- 1979-02-09 SU SU792721602A patent/SU812175A3/ru active
- 1979-02-12 AT AT0101579A patent/AT370093B/de not_active IP Right Cessation
- 1979-02-12 GR GR58340A patent/GR67626B/el unknown
- 1979-02-13 RO RO103172A patent/RO81504B/ro unknown
- 1979-02-14 CH CH142879A patent/CH640230A5/de not_active IP Right Cessation
- 1979-02-15 DD DD79211044A patent/DD142048A5/de unknown
- 1979-02-15 HU HU79BO1764A patent/HU180430B/hu unknown
- 1979-02-15 IT IT48010/79A patent/IT1113469B/it active
- 1979-02-15 FI FI790510A patent/FI69301C/fi not_active IP Right Cessation
- 1979-02-15 LU LU80924A patent/LU80924A1/de unknown
- 1979-02-15 YU YU00367/79A patent/YU36779A/xx unknown
- 1979-02-15 IL IL56678A patent/IL56678A/xx unknown
- 1979-02-15 PT PT7969239A patent/PT69239A/pt unknown
- 1979-02-16 GB GB7905506A patent/GB2014575B/en not_active Expired
- 1979-02-16 DK DK69479A patent/DK69479A/da not_active Application Discontinuation
- 1979-02-16 NO NO790523A patent/NO151239C/no unknown
- 1979-02-16 ES ES477784A patent/ES477784A1/es not_active Expired
- 1979-02-16 JP JP1715679A patent/JPS54122273A/ja active Pending
- 1979-02-16 NL NL7901241A patent/NL7901241A/xx not_active Application Discontinuation
- 1979-02-16 ZA ZA79709A patent/ZA79709B/xx unknown
- 1979-02-16 SE SE7901405A patent/SE7901405L/xx not_active Application Discontinuation
- 1979-02-16 IE IE311/79A patent/IE48073B1/en unknown
- 1979-02-16 PL PL1979221508A patent/PL116527B1/pl unknown
- 1979-02-16 FR FR7904052A patent/FR2417502A1/fr active Granted
- 1979-02-16 NZ NZ189684A patent/NZ189684A/xx unknown
- 1979-02-16 US US06/012,650 patent/US4250186A/en not_active Expired - Lifetime
- 1979-02-16 PL PL1979213475A patent/PL115759B1/pl unknown
- 1979-02-16 AU AU44325/79A patent/AU519356B2/en not_active Ceased
- 1979-02-16 CA CA321,805A patent/CA1115717A/fr not_active Expired
- 1979-02-16 BE BE0/193531A patent/BE874252A/fr not_active IP Right Cessation
- 1979-02-17 RO RO7996602A patent/RO76799A/fr unknown
- 1979-02-19 CS CS791092A patent/CS207773B2/cs unknown
- 1979-02-19 CS CS798500A patent/CS207774B2/cs unknown
- 1979-06-18 GR GR59371A patent/GR69232B/el unknown
- 1979-10-16 ES ES485043A patent/ES485043A1/es not_active Expired
-
1980
- 1980-01-30 SU SU802874805A patent/SU828964A3/ru active
- 1980-08-20 US US06/179,839 patent/US4293564A/en not_active Expired - Lifetime
- 1980-09-08 PH PH24546A patent/PH16188A/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1079733A (fr) | OBTENTION DE BENZILATES QUATERNAIRES DE N-ALKYL-NORTROPINE SUBSTITUEE EN N-.beta. | |
CS207773B2 (en) | Method of making the new substituted 2-phenyl-iminoimidazolines | |
US3708485A (en) | 2-(n-allyl-phenylamino)-imidazolines-(2)and salts thereof | |
JPH01131156A (ja) | ピペリジン誘導体 | |
US4166859A (en) | 2-Bromo-6-fluoro-N-(2-imidazolidinylidene)-benzamine and salts thereof and the use to treat hypertension | |
US4213995A (en) | 2-Phenylimino-imidazolidines and salts thereof | |
JPS6026112B2 (ja) | 2−フエニルアミノ−イミダゾリン−(2)化合物 | |
US3740401A (en) | 2-(n-cycloalkyl-phenylamino)-2-imidazolines-(2) and salts thereof | |
US4361575A (en) | Substituted 2-phenylamino-2-imidazolines and salts thereof | |
US4215133A (en) | 2-[N-(2'-Chloro-4'-methyl-thienyl-3')-N-(cyclopropyl-methyl)-amino]-2-imidazoline and salts thereof | |
US4277487A (en) | Substituted 2-phenylamino-2-imidazolines as bradycardiacs | |
SK94793A3 (en) | N-[[4,5-dihydroxy-and 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo- -2-anthracene-yl] carbonyl] amino acids useful in the therapy of osteorticular affections | |
US4263300A (en) | Substituted 2-phenylamino-1,3-tetrahydro-2-pyrimidines and salts thereof | |
US4612324A (en) | Imidazole derivatives for treating joint diseases and Wilson's disease | |
CS226449B2 (en) | Method of preparing new imidazo(1,2-a)-pyrimidines | |
US4327106A (en) | 2-(Phenyl-amino)-2-imidazolines and salts | |
KR820001715B1 (ko) | 치환된 2-페닐이미노-이미다졸리딘의 제조방법 | |
KR830001441B1 (ko) | 치환된 2-페닐아미노-이미다졸린-(2)의 제조방법 | |
KR820001714B1 (ko) | 치환된 2-페닐이미노-이미다졸리딘의 제조방법 | |
JPH0127073B2 (fr) | ||
US4239764A (en) | Substituted 2-phenylamino-2-imidazolines and salts thereof | |
KR810000631B1 (ko) | 치환된 2-페닐아미노-이미다졸린-(2)유도체의 제조방법 | |
US4409235A (en) | Substituted 7-(2,6-dibromo-4-methyl-phenyl)-2,3-dihydro-imidazo[1,2-a]imidazoles, compositions and use | |
AU2001100436A4 (en) | Amlodipine hemimaleate | |
CS212724B2 (en) | Process for the production of 2-(chlor-4-cyclopropylphenylimono)-imidazolidine |