CS197300B2 - Method of producing new 1-/isoquinoline-1-one-2-yl and 1,2,3,4-tetrahydrobenzazepine-1-one-2-ylalkyl/ phenyl-et - Google Patents
Method of producing new 1-/isoquinoline-1-one-2-yl and 1,2,3,4-tetrahydrobenzazepine-1-one-2-ylalkyl/ phenyl-et Download PDFInfo
- Publication number
- CS197300B2 CS197300B2 CS775664A CS566477A CS197300B2 CS 197300 B2 CS197300 B2 CS 197300B2 CS 775664 A CS775664 A CS 775664A CS 566477 A CS566477 A CS 566477A CS 197300 B2 CS197300 B2 CS 197300B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- group
- formula
- isoquinolin
- dimethoxy
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762639718 DE2639718A1 (de) | 1976-09-03 | 1976-09-03 | Neue phenylaethylamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS197300B2 true CS197300B2 (en) | 1980-04-30 |
Family
ID=5987076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS775664A CS197300B2 (en) | 1976-09-03 | 1977-08-30 | Method of producing new 1-/isoquinoline-1-one-2-yl and 1,2,3,4-tetrahydrobenzazepine-1-one-2-ylalkyl/ phenyl-et |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US4137318A (ja) |
| JP (1) | JPS6026107B2 (ja) |
| AT (1) | AT357536B (ja) |
| AU (1) | AU513325B2 (ja) |
| BE (1) | BE858383A (ja) |
| BG (1) | BG31377A3 (ja) |
| CA (1) | CA1086726A (ja) |
| CS (1) | CS197300B2 (ja) |
| DD (1) | DD132585A5 (ja) |
| DE (1) | DE2639718A1 (ja) |
| DK (1) | DK392877A (ja) |
| ES (8) | ES462006A1 (ja) |
| FI (1) | FI63225C (ja) |
| FR (1) | FR2363556A1 (ja) |
| GB (1) | GB1548844A (ja) |
| GR (1) | GR63605B (ja) |
| HK (1) | HK54082A (ja) |
| IE (1) | IE45674B1 (ja) |
| IL (1) | IL52867A (ja) |
| LU (1) | LU78066A1 (ja) |
| MY (1) | MY8300244A (ja) |
| NL (1) | NL7709678A (ja) |
| NO (1) | NO147986C (ja) |
| NZ (1) | NZ185081A (ja) |
| PH (1) | PH16512A (ja) |
| PL (3) | PL109757B1 (ja) |
| PT (1) | PT66987B (ja) |
| RO (1) | RO71931A (ja) |
| SE (1) | SE437515B (ja) |
| SG (1) | SG45082G (ja) |
| SU (3) | SU659081A3 (ja) |
| ZA (1) | ZA775311B (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4393210A (en) * | 1980-08-28 | 1983-07-12 | Seiyaku Co., Ltd. | 1(2H)-Isoquinolone compounds and acid addition salts thereof |
| US4473501A (en) * | 1981-05-04 | 1984-09-25 | G. D. Searle & Co. | Dihydro azino isoquinolines |
| DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
| DE3242599A1 (de) * | 1982-11-18 | 1984-05-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| US4490369A (en) * | 1981-05-19 | 1984-12-25 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Benzazepine derivatives, their pharmaceutical compositions and method of use |
| DE3242345A1 (de) * | 1982-11-16 | 1984-05-17 | Dr. Karl Thomae Gmbh, 7950 Biberach | Verfahren zur herstellung von benzazepinderivaten |
| DE3343801A1 (de) * | 1983-12-03 | 1985-06-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| JPS61158603A (ja) * | 1984-12-29 | 1986-07-18 | 株式会社小糸製作所 | 自動車用ランプの反射鏡 |
| JPS6220402U (ja) * | 1985-07-22 | 1987-02-06 | ||
| US5175157A (en) * | 1985-11-27 | 1992-12-29 | Boehringer Ingelheim Gmbh | Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them |
| DE3717561A1 (de) * | 1987-05-25 | 1988-12-08 | Thomae Gmbh Dr K | Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3541811A1 (de) * | 1985-11-27 | 1987-06-04 | Thomae Gmbh Dr K | Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| GB8609331D0 (en) * | 1986-04-16 | 1986-05-21 | Pfizer Ltd | Anti-arrythmia agents |
| DE3631013A1 (de) * | 1986-09-12 | 1988-03-24 | Thomae Gmbh Dr K | Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3640641A1 (de) * | 1986-11-28 | 1988-07-14 | Thomae Gmbh Dr K | Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3736866A1 (de) * | 1987-10-30 | 1989-05-11 | Thomae Gmbh Dr K | Mittel zur behandlung des bluthochdrucks und der herzinsuffizienz |
| JP2807577B2 (ja) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
| CN101250157B (zh) * | 2008-03-07 | 2012-03-28 | 西安交通大学 | 2-取代-3,4-二氢-1-异喹啉酮类合成方法及其制备心血管药物的用途 |
| FR2988720B1 (fr) * | 2012-03-27 | 2014-03-14 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3600394A (en) * | 1968-05-17 | 1971-08-17 | Searle & Co | 2-aminoalkyl-3-arylisocarbostyrils |
| SE368009B (ja) * | 1971-09-16 | 1974-06-17 | Kabi Ab | |
| US4021558A (en) * | 1973-09-08 | 1977-05-03 | Boehringer Ingelheim Gmbh | 1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines and salts thereof useful as hypotensive agents |
| AT330777B (de) * | 1973-09-08 | 1976-07-26 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen |
| CH605914A5 (ja) * | 1974-07-31 | 1978-10-13 | Ciba Geigy Ag |
-
1976
- 1976-09-03 DE DE19762639718 patent/DE2639718A1/de active Granted
-
1977
- 1977-03-29 PH PH20177A patent/PH16512A/en unknown
- 1977-07-22 FI FI772262A patent/FI63225C/fi not_active IP Right Cessation
- 1977-08-19 AT AT600477A patent/AT357536B/de not_active IP Right Cessation
- 1977-08-22 US US05/826,853 patent/US4137318A/en not_active Expired - Lifetime
- 1977-08-29 BG BG7737254A patent/BG31377A3/xx unknown
- 1977-08-30 CS CS775664A patent/CS197300B2/cs unknown
- 1977-08-31 ES ES462006A patent/ES462006A1/es not_active Expired
- 1977-08-31 RO RO7791507A patent/RO71931A/ro unknown
- 1977-08-31 DD DD7700200828A patent/DD132585A5/xx unknown
- 1977-09-01 PT PT66987A patent/PT66987B/pt unknown
- 1977-09-01 LU LU78066A patent/LU78066A1/xx unknown
- 1977-09-01 FR FR7726566A patent/FR2363556A1/fr active Granted
- 1977-09-01 SE SE7709865A patent/SE437515B/xx not_active IP Right Cessation
- 1977-09-01 IL IL52867A patent/IL52867A/xx unknown
- 1977-09-02 NZ NZ185081A patent/NZ185081A/xx unknown
- 1977-09-02 SU SU772517658A patent/SU659081A3/ru active
- 1977-09-02 PL PL1977200630A patent/PL109757B1/pl unknown
- 1977-09-02 DK DK392877A patent/DK392877A/da not_active Application Discontinuation
- 1977-09-02 NO NO773038A patent/NO147986C/no unknown
- 1977-09-02 CA CA286,009A patent/CA1086726A/en not_active Expired
- 1977-09-02 AU AU28516/77A patent/AU513325B2/en not_active Expired
- 1977-09-02 JP JP52105032A patent/JPS6026107B2/ja not_active Expired
- 1977-09-02 GB GB36812/77A patent/GB1548844A/en not_active Expired
- 1977-09-02 BE BE180664A patent/BE858383A/xx not_active IP Right Cessation
- 1977-09-02 ZA ZA00775311A patent/ZA775311B/xx unknown
- 1977-09-02 PL PL1977212691A patent/PL112814B1/pl unknown
- 1977-09-02 GR GR54280A patent/GR63605B/el unknown
- 1977-09-02 NL NL7709678A patent/NL7709678A/xx not_active Application Discontinuation
- 1977-09-02 PL PL1977212692A patent/PL110397B1/pl unknown
- 1977-09-21 IE IE1831/77A patent/IE45674B1/en unknown
- 1977-12-28 ES ES465526A patent/ES465526A1/es not_active Expired
- 1977-12-28 ES ES465524A patent/ES465524A1/es not_active Expired
- 1977-12-28 ES ES465523A patent/ES465523A1/es not_active Expired
- 1977-12-28 ES ES465527A patent/ES465527A1/es not_active Expired
- 1977-12-28 ES ES465529A patent/ES465529A1/es not_active Expired
- 1977-12-28 ES ES465525A patent/ES465525A1/es not_active Expired
- 1977-12-28 ES ES465528A patent/ES465528A1/es not_active Expired
-
1978
- 1978-05-05 SU SU782611302A patent/SU688127A3/ru active
- 1978-05-05 SU SU782611303A patent/SU700061A3/ru active
-
1982
- 1982-09-13 SG SG450/82A patent/SG45082G/en unknown
- 1982-12-22 HK HK540/82A patent/HK54082A/xx unknown
-
1983
- 1983-12-30 MY MY244/83A patent/MY8300244A/xx unknown
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