CS186391A3 - Pharmaceuticals - Google Patents

Pharmaceuticals Download PDF

Info

Publication number
CS186391A3
CS186391A3 CS911863A CS186391A CS186391A3 CS 186391 A3 CS186391 A3 CS 186391A3 CS 911863 A CS911863 A CS 911863A CS 186391 A CS186391 A CS 186391A CS 186391 A3 CS186391 A3 CS 186391A3
Authority
CS
Czechoslovakia
Prior art keywords
methyl
group
amino
quinazolin
compound
Prior art date
Application number
CS911863A
Other languages
Czech (cs)
English (en)
Inventor
William Pendergast
Scott Howard Dickerson
Julius Vass Johnson
Robert Ferone
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of CS186391A3 publication Critical patent/CS186391A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
CS911863A 1990-06-19 1991-06-18 Pharmaceuticals CS186391A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909013615A GB9013615D0 (en) 1990-06-19 1990-06-19 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
CS186391A3 true CS186391A3 (en) 1992-04-15

Family

ID=10677828

Family Applications (1)

Application Number Title Priority Date Filing Date
CS911863A CS186391A3 (en) 1990-06-19 1991-06-18 Pharmaceuticals

Country Status (26)

Country Link
US (4) US6090941A (ja)
EP (2) EP0535034B1 (ja)
JP (1) JP2966929B2 (ja)
KR (1) KR0183042B1 (ja)
CN (1) CN1049215C (ja)
AP (1) AP218A (ja)
AT (2) ATE260262T1 (ja)
AU (1) AU639815B2 (ja)
CA (1) CA2085589C (ja)
CS (1) CS186391A3 (ja)
DE (2) DE69133371T2 (ja)
DK (2) DK1199307T3 (ja)
ES (2) ES2178632T3 (ja)
FI (1) FI925778A (ja)
GB (1) GB9013615D0 (ja)
HU (2) HUT62273A (ja)
IE (1) IE912073A1 (ja)
IL (1) IL98542A (ja)
MC (1) MC2290A1 (ja)
MY (1) MY107001A (ja)
NO (1) NO924929L (ja)
NZ (1) NZ238582A (ja)
PL (1) PL169927B1 (ja)
PT (1) PT98021B (ja)
WO (1) WO1991019700A1 (ja)
ZA (1) ZA914676B (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
GB9226842D0 (en) * 1992-12-23 1993-02-17 Wellcome Found Pharmaceutical compounds
GB9408936D0 (en) * 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
WO2000055166A1 (en) 1999-03-16 2000-09-21 Regents Of The University Of California Glycosylated polyamines
KR100851957B1 (ko) * 2000-06-09 2008-08-12 오에스아이 파마슈티컬스, 인코포레이티드 벤조퀴나졸린 티미딜레이트 신타제 억제제의 리포솜 제형
EP1432710A1 (en) * 2001-09-26 2004-06-30 Bayer Pharmaceuticals Corporation 1, 8-naphthyridine derivatives as antidiabetics
CN100434425C (zh) * 2005-03-09 2008-11-19 首都师范大学 4-喹唑啉酮衍生物及其在抗肿瘤药物中的应用
EP1754484A1 (en) 2005-08-17 2007-02-21 Dan Stoicescu Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes
DK1969031T3 (da) 2005-12-05 2009-09-14 Nitto Denko Corp Polyglutamat-aminosyre-konjugater og fremgangsmåder
GB0525069D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
KR101129868B1 (ko) 2006-10-04 2012-04-12 화이자 프로덕츠 인코포레이티드 칼슘 수용체 길항제로서의 피리도［4,3-ｄ］피리미딘-4(3Ｈ)-온 유도체
EP1958632A1 (en) 2007-02-14 2008-08-20 Dan Stoicescu Use of condensed pyrimidine derivatives for the treatment of autoimmune and inflammatory diseases
EP2155255B1 (en) * 2007-05-09 2013-08-14 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
WO2008141110A2 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
EP2155254B1 (en) * 2007-05-09 2012-11-28 Nitto Denko Corporation Polymers conjugated with platinum drugs
US8517760B2 (en) 2007-08-20 2013-08-27 Ford Global Technologies, Llc Cord wrap and power plug receptacle arrangement for inflator
US8146622B2 (en) 2007-08-20 2012-04-03 Ford Global Technologies, Llc Switch and hose-valve connection arrangement for vehicle temporary mobility kit
US8501242B2 (en) 2009-05-29 2013-08-06 University Of Florida Research Foundation Methods and compositions for treating neoplasia
CN101580501B (zh) * 2009-06-01 2011-03-09 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体
WO2011078226A1 (ja) * 2009-12-22 2011-06-30 協和発酵キリン株式会社 三環系化合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UST862021I4 (en) * 1969-01-27 1969-05-27 Defensive publication
ZA72442B (en) * 1971-02-05 1972-10-25 Apaw Sa Automatic ice-cream machine
DE3069468D1 (en) * 1979-12-19 1984-11-22 Nat Res Dev Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
US4603186A (en) 1985-10-21 1986-07-29 The Standard Oil Company Tetrapolymers containing indene
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
US4902624A (en) * 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US5405851A (en) * 1990-06-19 1995-04-11 Burroughs Wellcome Co. Pharmaceutical compounds
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds

Also Published As

Publication number Publication date
DK1199307T3 (da) 2004-06-14
NO924929D0 (no) 1992-12-18
ATE222243T1 (de) 2002-08-15
HU211265A9 (en) 1995-11-28
US6090941A (en) 2000-07-18
PT98021A (pt) 1992-04-30
MC2290A1 (fr) 1993-07-14
NZ238582A (en) 1993-12-23
US5661155A (en) 1997-08-26
EP0535034A1 (en) 1993-04-07
ES2178632T3 (es) 2003-01-01
EP1199307B1 (en) 2004-02-25
GB9013615D0 (en) 1990-08-08
PL169927B1 (pl) 1996-09-30
KR0183042B1 (ko) 1999-05-01
ZA914676B (en) 1993-02-24
DE69133371T2 (de) 2005-01-27
HUT62273A (en) 1993-04-28
US5663337A (en) 1997-09-02
WO1991019700A1 (en) 1991-12-26
EP1199307A1 (en) 2002-04-24
FI925778A0 (fi) 1992-12-18
PT98021B (pt) 1998-11-30
AP9100283A0 (en) 1991-07-31
ATE260262T1 (de) 2004-03-15
DE69133088T2 (de) 2003-03-20
HU9204011D0 (en) 1993-03-29
DE69133088D1 (de) 2002-09-19
ES2211851T3 (es) 2004-07-16
CA2085589C (en) 2001-12-18
NO924929L (no) 1992-12-18
DE69133371D1 (de) 2004-04-01
EP0535034B1 (en) 2002-08-14
CN1049215C (zh) 2000-02-09
AP218A (en) 1992-09-27
JPH05507704A (ja) 1993-11-04
JP2966929B2 (ja) 1999-10-25
US6306865B1 (en) 2001-10-23
MY107001A (en) 1995-08-30
KR930701415A (ko) 1993-06-11
CN1058208A (zh) 1992-01-29
AU8094391A (en) 1992-01-07
DK0535034T3 (da) 2002-12-09
AU639815B2 (en) 1993-08-05
IE912073A1 (en) 1992-01-01
IL98542A0 (en) 1992-07-15
FI925778A (fi) 1992-12-18
IL98542A (en) 1995-05-26
CA2085589A1 (en) 1991-12-20

Similar Documents

Publication Publication Date Title
CS186391A3 (en) Pharmaceuticals
US20050171101A1 (en) Phenanthridinones as parp inhibitors
EP0831829B1 (en) Heterocyclic ring-fused pyrimidine derivatives
FI113765B (fi) Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi
ES2262087T3 (es) Compuestos heteroaromiticos biciclicos como inhibidores de proteina tirosina cinasa.
JP7157764B2 (ja) 新規なピペリジン－２，６－ジオン誘導体及びその用途
AU2006271297B2 (en) Novel heterocyclidene acetamide derivative
JP2000508657A (ja) チロシンキナーゼの不可逆的阻害剤
US6407116B1 (en) Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs
BR112013004750B1 (pt) Derivados de quinolina e quinoxalina como inibidores da cinase
CN107614503A (zh) 稠环或三环芳基嘧啶化合物用作激酶抑制剂
WO2016022460A1 (en) Potent dual brd4-kinase inhibitors as cancer therapeutics
CN104936963B (zh) 作为蛋白激酶抑制剂的硫醚衍生物
SK283952B6 (sk) Pyrido [2,3-D]pyrimidíny a farmaceutické kompozície na ich báze
US5405851A (en) Pharmaceutical compounds
US6762188B1 (en) Pharmaceutically active benzoquinazoline compounds
CA3093323A1 (en) Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof
AU680431B2 (en) 2,5-disubstituted isoquindazole-6-(2H)-ones
KR870000279B1 (ko) 피리도 [1,4] 벤조디아제핀 및 [2-[(니트로피리디닐) 아미노]페닐] 아릴메타논의 제조방법
WO1994003439A1 (en) Antiproliferative tricyclic compounds
CN117285527A (zh) 一种噌啉类par4拮抗剂及其医药应用