CR20170605A - DERIVADOS DE 3-TETRAZOLIL-BENCENO-1,2-DISULFONAMIDA COMO INHIBIDORES DE METALO -ß-LACTAMASA - Google Patents
DERIVADOS DE 3-TETRAZOLIL-BENCENO-1,2-DISULFONAMIDA COMO INHIBIDORES DE METALO -ß-LACTAMASAInfo
- Publication number
- CR20170605A CR20170605A CR20170605A CR20170605A CR20170605A CR 20170605 A CR20170605 A CR 20170605A CR 20170605 A CR20170605 A CR 20170605A CR 20170605 A CR20170605 A CR 20170605A CR 20170605 A CR20170605 A CR 20170605A
- Authority
- CR
- Costa Rica
- Prior art keywords
- beta
- compounds
- pharmaceutically acceptable
- relates
- lactamasa
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 3
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 3
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 abstract 3
- 239000003782 beta lactam antibiotic agent Substances 0.000 abstract 2
- 102000020235 metallo-beta-lactamase Human genes 0.000 abstract 2
- 108060004734 metallo-beta-lactamase Proteins 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002132 β-lactam antibiotic Substances 0.000 abstract 2
- 229940124586 β-lactam antibiotics Drugs 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- -1 compounds compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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WO2016206101A1 (en) | 2015-06-26 | 2016-12-29 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors |
CN106892845B (zh) * | 2017-02-28 | 2018-10-30 | 四川同晟生物医药有限公司 | 一种2,4-二氨基丁酸衍生物及其制备方法 |
US11207312B2 (en) * | 2017-07-17 | 2021-12-28 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors and methods of use thereof |
JP7250687B2 (ja) | 2017-10-06 | 2023-04-03 | 武田薬品工業株式会社 | 複素環化合物 |
US20200375987A1 (en) * | 2018-01-03 | 2020-12-03 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors and methods of use thereof |
WO2019221122A1 (ja) * | 2018-05-14 | 2019-11-21 | 国立大学法人名古屋大学 | β-ラクタマーゼ阻害剤 |
AR117788A1 (es) | 2019-01-14 | 2021-08-25 | Pi Industries Ltd | Compuestos de fenilamidina 3-sustituida, preparación y uso |
WO2021023813A1 (en) * | 2019-08-06 | 2021-02-11 | Domain Therapeutics | 5-heteroaryl-pyridin-2-amine confounds as neuropeptide ff receptor antagonists |
US20220306648A1 (en) * | 2019-08-15 | 2022-09-29 | Fujian Akeylink Biotechnology Co., Ltd. | Preparation Method for Oxazepine Compound |
CN114531850A (zh) * | 2019-10-04 | 2022-05-24 | 富士胶片株式会社 | 以含有新的青霉素衍生物或其盐以及选自β-内酰胺酶抑制化合物及抗菌性化合物或其盐中的1种以上的化合物为特征的医药组合物及试剂盒 |
CN110840897B (zh) * | 2019-11-28 | 2023-08-08 | 河北旺发生物科技有限公司 | 金属β-内酰胺酶抑制剂 |
BR112022020641A2 (pt) | 2020-04-14 | 2022-11-29 | Basf Se | Compostos, uso de compostos, mistura pesticida, composições agroquímicas ou veterinárias, métodos para controlar pragas invertebradas, proteger plantas em crescimento e tratar ou proteger animais contra infestação ou infecção por parasitas e semente |
CN111484506A (zh) * | 2020-04-16 | 2020-08-04 | 天津大学 | 添加表面活性剂改进美罗培南侧链中间体硫醇内酯的制备方法 |
MX2023006347A (es) | 2020-11-30 | 2023-06-12 | Pi Industries Ltd | Una nueva composicion agroquimica que comprende compuestos de fenilamidina 3-sustituidos. |
CN114349711B (zh) * | 2022-02-28 | 2023-08-15 | 四川依维欣医药科技有限公司 | 一种(R)-1-Boc-3-羟甲基哌嗪的合成方法 |
WO2023250467A2 (en) * | 2022-06-24 | 2023-12-28 | Baylor College Of Medicine | Inhibitors of antimicrobial resistance and methods using same |
CN117342983B (zh) * | 2023-12-05 | 2024-02-06 | 康羽生命科学技术(苏州)有限公司 | 过乙酰化GalNAc-L96合成方法 |
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JP6745824B2 (ja) | 2015-06-26 | 2020-08-26 | 武田薬品工業株式会社 | 複素環化合物 |
US11207312B2 (en) * | 2017-07-17 | 2021-12-28 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors and methods of use thereof |
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2018
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2019
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