EA201890150A1 - 3-тетразолил-бензол-1,2-дисульфонамидные производные в качестве ингибиторов металло-бета-лактамазы - Google Patents

3-тетразолил-бензол-1,2-дисульфонамидные производные в качестве ингибиторов металло-бета-лактамазы

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Publication number
EA201890150A1
EA201890150A1 EA201890150A EA201890150A EA201890150A1 EA 201890150 A1 EA201890150 A1 EA 201890150A1 EA 201890150 A EA201890150 A EA 201890150A EA 201890150 A EA201890150 A EA 201890150A EA 201890150 A1 EA201890150 A1 EA 201890150A1
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EA
Eurasian Patent Office
Prior art keywords
beta
lactamase
compounds
methogal
disulphonamide
Prior art date
Application number
EA201890150A
Other languages
English (en)
Other versions
EA032698B1 (ru
Inventor
Франк Беннетт
Цзиньлун Цзян
Александер Пастернак
Шучжи Дун
Синь Гу
Джек Д. Скотт
Хайцюнь Тан
Чжицян Чжао
Юхуа Хуанг
Дэси Ян
Кэтрин Янг
Ли Сяо
Чжибо Чжан
Цзяньминь Фу
Original Assignee
Мерк Шарп И Доум Корп.
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Publication date
Application filed by Мерк Шарп И Доум Корп. filed Critical Мерк Шарп И Доум Корп.
Publication of EA201890150A1 publication Critical patent/EA201890150A1/ru
Publication of EA032698B1 publication Critical patent/EA032698B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/4245—Oxadiazoles
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    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

Настоящее изобретение относится к соединениям формулы I, являющимся ингибиторами металло-β-лактамазы,и их фармацевтически приемлемым солям, где Z, R, X, Xи Rимеют значения, определенные выше. Настоящее изобретение также относится к композициям, которые включают соединение по настоящему изобретению, являющееся ингибитором металло-β-лактамазы, или его фармацевтически приемлемую соль и фармацевтически приемлемый носитель необязательно в комбинации с бета-лактамовым антибиотиком и/или ингибитором бета-лактамазы. Изобретение также относится к способам лечения бактериальной инфекции, включающим введение пациенту терапевтически эффективного количества соединения по изобретению в комбинации с терапевтически эффективным количеством одного или нескольких β-лактамовых антибиотиков и необязательно в комбинации с одним или несколькими соединениями, являющимися ингибиторами бета-лактамазы. Соединения по изобретению являются полезными в способах, описанных в настоящей заявке, для преодоления резистентности к антибиотикам.
EA201890150A 2015-06-26 2016-06-24 3-ТЕТРАЗОЛИЛ-БЕНЗОЛ-1,2-ДИСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ МЕТАЛЛО-β-ЛАКТАМАЗЫ EA032698B1 (ru)

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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016206101A1 (en) 2015-06-26 2016-12-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
CN106892845B (zh) * 2017-02-28 2018-10-30 四川同晟生物医药有限公司 一种2,4-二氨基丁酸衍生物及其制备方法
US11207312B2 (en) * 2017-07-17 2021-12-28 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors and methods of use thereof
US11447488B2 (en) 2017-10-06 2022-09-20 Takeda Pharmaceutical Company Limited Heterocyclic compounds
US20200375987A1 (en) * 2018-01-03 2020-12-03 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors and methods of use thereof
US11497731B2 (en) 2018-05-14 2022-11-15 National University Corporation Tokai National Higher Education And Research System β-lactamase inhibitor
UY38540A (es) 2019-01-14 2020-08-31 Pi Industries Ltd Compuestos de fenilamidina 3-sustituida, preparación y uso
WO2021023813A1 (en) * 2019-08-06 2021-02-11 Domain Therapeutics 5-heteroaryl-pyridin-2-amine confounds as neuropeptide ff receptor antagonists
US20220306648A1 (en) * 2019-08-15 2022-09-29 Fujian Akeylink Biotechnology Co., Ltd. Preparation Method for Oxazepine Compound
CN114531850B (zh) * 2019-10-04 2024-08-06 富士胶片株式会社 以含有新的青霉素衍生物或其盐以及选自β-内酰胺酶抑制化合物及抗菌性化合物或其盐中的1种以上的化合物为特征的医药组合物及试剂盒
CN110840897B (zh) * 2019-11-28 2023-08-08 河北旺发生物科技有限公司 金属β-内酰胺酶抑制剂
AU2021256876A1 (en) 2020-04-14 2022-11-03 Basf Se Tricyclic pesticidal compounds
CN111484506A (zh) * 2020-04-16 2020-08-04 天津大学 添加表面活性剂改进美罗培南侧链中间体硫醇内酯的制备方法
WO2021237111A1 (en) * 2020-05-21 2021-11-25 Stemsynergy Therapeutics, Inc. Notch inhibitors and uses thereof
AR124167A1 (es) 2020-11-30 2023-02-22 Pi Industries Ltd Una nueva composición agroquímica que comprende compuestos de fenilamidina 3-sustituidos
CN114349711B (zh) * 2022-02-28 2023-08-15 四川依维欣医药科技有限公司 一种（R）-1-Boc-3-羟甲基哌嗪的合成方法
WO2023250467A2 (en) * 2022-06-24 2023-12-28 Baylor College Of Medicine Inhibitors of antimicrobial resistance and methods using same
CN117342983B (zh) * 2023-12-05 2024-02-06 康羽生命科学技术(苏州)有限公司 过乙酰化GalNAc-L96合成方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071843A (en) 1978-07-24 1991-12-10 Merck & Co., Inc. Combination of 2-substituted carbapenems with dipeptidase inhibitors
US4616038A (en) 1978-07-24 1986-10-07 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4880793A (en) 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4539208A (en) 1980-09-17 1985-09-03 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4786311A (en) 1985-05-30 1988-11-22 E. I. Du Pont De Nemours And Company Herbicidal sulfonamides
CA1231336A (en) 1985-05-30 1988-01-12 George Levitt Herbicidal sulfonamides
JPS62242679A (ja) 1986-04-11 1987-10-23 イ−・アイ・デユポン・デ・ニモアス・アンド・カンパニ− スルホニル尿素化合物
CA1273336A (en) 1986-04-25 1990-08-28 Chi-Ping Tseng Herbicidal heterocyclic carbonyl sulfonamides
US4838925A (en) 1986-04-25 1989-06-13 E. I. Du Pont De Nemours And Company Heterocyclic acyl sulfonamides
US4927453A (en) 1986-10-17 1990-05-22 E. I. Du Pont De Nemours And Company Herbicidal sulfonamides
CN1095549A (zh) 1986-11-24 1994-11-30 纳幕尔杜邦公司 除草磺酰胺组合物及其制法和应用
ES2090393T3 (es) 1991-04-11 1996-10-16 Hoffmann La Roche Beta-lactamas.
JP4226818B2 (ja) 1999-07-06 2009-02-18 メチルジーン・インコーポレーテッド ベータ−ラクタマーゼのスルフォンアミドメチルホスホン酸阻害剤
FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
US7439253B2 (en) 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
AU2007300531A1 (en) 2006-09-27 2008-04-03 Merck Sharp & Dohme Corp. Novel inhibitors of beta-lactamase
CN103130686B (zh) 2011-12-02 2016-09-14 天津市国际生物医药联合研究院 N，n′-不对称二芳基取代脲类化合物及其制备方法和用途
CN103191091B (zh) 2012-01-04 2016-12-14 天津市国际生物医药联合研究院 磺酰胺类化合物在抑制ndm-1活性中的应用
WO2013103760A1 (en) * 2012-01-06 2013-07-11 University Of South Florida Compositions, methods of use, and methods of treatment
GB201310542D0 (en) 2013-06-13 2013-07-31 Antabio Sas Compounds
US20160257668A1 (en) 2013-10-07 2016-09-08 Merck Sharp & Dohme Corp. Factor XIa Inhibitors
US9708336B2 (en) 2014-01-22 2017-07-18 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
WO2015171474A1 (en) 2014-05-09 2015-11-12 Merck Sharp & Dohme Corp. Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
WO2016206101A1 (en) * 2015-06-26 2016-12-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
US10323027B2 (en) 2015-06-26 2019-06-18 Takeda Pharmaceutical Company Limited 2,3-dihydro-4H-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic M1 receptor
US11207312B2 (en) 2017-07-17 2021-12-28 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors and methods of use thereof

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US10544130B2 (en) 2020-01-28
IL256265B (en) 2021-08-31
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SI3313832T1 (sl) 2021-05-31
ES2865284T3 (es) 2021-10-15
JO3588B1 (ar) 2020-07-05
CA2990234A1 (en) 2016-12-29
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HUE054410T2 (hu) 2021-09-28
CO2017013360A2 (es) 2018-03-20
CY1124086T1 (el) 2022-05-27
BR112017027719B1 (pt) 2024-02-06
CR20170605A (es) 2018-05-15
IL256265A (en) 2018-02-28
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BR112017027719A2 (pt) 2018-09-11
JP6670333B2 (ja) 2020-03-18
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ECSP18005828A (es) 2018-04-30
BR112017027719A8 (pt) 2023-04-11
TW201713633A (en) 2017-04-16
DOP2017000310A (es) 2018-04-30
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LT3313832T (lt) 2021-05-10
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CA2990234C (en) 2020-07-21
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EP3313828B1 (en) 2023-07-12
RS61696B1 (sr) 2021-05-31
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PT3313832T (pt) 2021-04-21
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