CR20150193A - Moduladores de quinolinilo unidos a metileno de ror-gamma-t - Google Patents
Moduladores de quinolinilo unidos a metileno de ror-gamma-tInfo
- Publication number
- CR20150193A CR20150193A CR20150193A CR20150193A CR20150193A CR 20150193 A CR20150193 A CR 20150193A CR 20150193 A CR20150193 A CR 20150193A CR 20150193 A CR20150193 A CR 20150193A CR 20150193 A CR20150193 A CR 20150193A
- Authority
- CR
- Costa Rica
- Prior art keywords
- ror
- gamma
- methylene
- united
- quinolinyl modulators
- Prior art date
Links
- -1 QUINOLINYL Chemical class 0.000 title 1
- 125000001570 methylene group Chemical class [H]C([H])([*:1])[*:2] 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000011580 syndromic disease Diseases 0.000 abstract 2
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261714419P | 2012-10-16 | 2012-10-16 | |
| US201261725528P | 2012-11-13 | 2012-11-13 | |
| US201361782257P | 2013-03-14 | 2013-03-14 | |
| PCT/US2013/065013 WO2014062658A1 (en) | 2012-10-16 | 2013-10-15 | Methylene linked quinolinyl modulators of ror-gamma-t |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20150193A true CR20150193A (es) | 2015-05-18 |
Family
ID=49546611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20150193A CR20150193A (es) | 2012-10-16 | 2015-04-13 | Moduladores de quinolinilo unidos a metileno de ror-gamma-t |
Country Status (38)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2814814B1 (en) * | 2012-02-13 | 2019-05-08 | F.Hoffmann-La Roche Ag | Imidazolylketone derivatives asd aldosterone synthase inhibitors |
| AU2013403335B2 (en) * | 2012-10-16 | 2018-11-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of ROR-gamma-t |
| TWI644671B (zh) | 2013-03-14 | 2018-12-21 | 比利時商健生藥品公司 | Ｐ２ｘ７調節劑 |
| MX363936B (es) | 2013-03-14 | 2019-04-09 | Boehringer Ingelheim Int | (bencil-ciano-metil)-amidas del acido 2-aza-biciclo[2.2.1]heptano- 3-carboxilico sustituidas como inhibidores de catepsina c. |
| ES2689526T3 (es) | 2013-03-14 | 2018-11-14 | Janssen Pharmaceutica Nv | Moduladores de P2X7 |
| JO3509B1 (ar) | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | معدلات p2x7 |
| EP3321266A1 (en) | 2013-03-14 | 2018-05-16 | Janssen Pharmaceutica NV | P2x7 modulators |
| WO2015035278A1 (en) * | 2013-09-09 | 2015-03-12 | Bristol-Myers Squibb Company | RORγ MODULATORS |
| US10555941B2 (en) * | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9346782B2 (en) | 2013-10-15 | 2016-05-24 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| CN105636952A (zh) * | 2013-10-15 | 2016-06-01 | 詹森药业有限公司 | Rorγt的仲醇喹啉基调节剂 |
| AU2014334616A1 (en) | 2013-10-15 | 2016-04-28 | Janssen Pharmaceutica Nv | Quinolinyl modulators of RORyt |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US9284308B2 (en) * | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| EA032272B1 (ru) * | 2014-05-28 | 2019-05-31 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Новые соединения |
| CN107074841B (zh) | 2014-08-11 | 2021-03-26 | 安吉恩生物医药公司 | 细胞色素p450抑制剂及其用途 |
| US20180118749A1 (en) | 2014-09-12 | 2018-05-03 | Janssen Pharmaceutica Nv | P2x7 modulators |
| RS59444B1 (sr) | 2014-09-12 | 2019-11-29 | Boehringer Ingelheim Int | Spirociklični inhibitori katepsina c |
| AU2015315687B2 (en) | 2014-09-12 | 2019-07-11 | Janssen Pharmaceutica Nv | P2X7 modulators |
| JP2018501279A (ja) | 2014-12-31 | 2018-01-18 | アンギオン バイオメディカ コーポレイション | 疾患を治療するための方法及び薬剤 |
| EP3856179A1 (en) | 2018-09-28 | 2021-08-04 | Janssen Pharmaceutica N.V. | Monoacylglycerol lipase modulators |
| PE20211773A1 (es) | 2018-09-28 | 2021-09-08 | Janssen Pharmaceutica Nv | Moduladores de monoacilglicerol lipasa |
| US10947253B2 (en) | 2019-08-05 | 2021-03-16 | Ankh Life Sciences Limited | Fused polycyclic dimers |
| KR20220075386A (ko) | 2019-09-30 | 2022-06-08 | 얀센 파마슈티카 엔.브이. | 방사성 표지된 mgl pet 리간드 |
| MX2022005260A (es) * | 2019-10-31 | 2022-06-09 | Jiangsu Hengrui Medicine Co | Sal de adicion acida de regulador rorgamma. |
| EP4126860A1 (en) | 2020-03-26 | 2023-02-08 | Janssen Pharmaceutica NV | Monoacylglycerol lipase modulators |
| BR112022021976A2 (pt) | 2020-04-30 | 2022-12-13 | Idorsia Pharmaceuticals Ltd | Composto, e, composição farmacêutica compreendendo um composto |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
| CN112939974B (zh) * | 2021-03-11 | 2023-10-20 | 中山大学 | 一种氮杂苯并薁衍生物的制备方法 |
| WO2023057548A1 (en) | 2021-10-07 | 2023-04-13 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| JP2024539987A (ja) | 2021-10-26 | 2024-10-31 | イドルシア・ファーマシューティカルズ・リミテッド | Ｃｃｒ６受容体調節剤 |
| AR127486A1 (es) | 2021-10-28 | 2024-01-31 | Idorsia Pharmaceuticals Ltd | Moduladores del receptor ccr6 |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3472859A (en) | 1966-11-01 | 1969-10-14 | Sterling Drug Inc | 1-alkyl-1,4-dihydro-4-oxo-3 quinoline-carboxylic acids and esters |
| JPS4826772Y1 (enExample) | 1969-04-04 | 1973-08-06 | ||
| DE3276432D1 (en) | 1981-03-24 | 1987-07-02 | Ciba Geigy Ag | Acyl quinolinone derivatives, processes for their preparation, pharmaceutical compositions containing them and their use |
| US4656283A (en) | 1982-05-25 | 1987-04-07 | American Cyanamid Company | Alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid |
| US4910327A (en) | 1982-05-25 | 1990-03-20 | American Cyanamid Company | Alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid: dialkyl 3-(substituted)phenylaminobut-2-ene-dioates and methods for the preparation thereof |
| PT79699B (en) | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| FR2634483B2 (fr) | 1987-12-29 | 1994-03-04 | Esteve Labor Dr | Derives des acides 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoleine-3-carboxyliques, leur preparation et leur application en tant que medicaments |
| CA2002864C (en) | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
| ATE159009T1 (de) | 1991-05-10 | 1997-10-15 | Rhone Poulenc Rorer Int | Bis mono- und bicyclische aryl- und heteroarylderivate mit inhibierender wirkung auf die egf und/oder pdgf-rezeptor tyrosinkinase |
| US5478832A (en) | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
| JPH0826772A (ja) | 1994-07-22 | 1996-01-30 | Sony Corp | 融着用ガラス、その製造方法及び製造装置、並びに磁気ヘッドの製造方法 |
| ES2136782T3 (es) | 1994-10-27 | 1999-12-01 | Asahi Glass Co Ltd | Procedimiento para producir compuestos de acido quinolin-2-il-benzoico. |
| GB9523267D0 (en) | 1995-11-14 | 1996-01-17 | Sandoz Ltd | Organic compounds |
| ES2260156T3 (es) | 1995-12-08 | 2006-11-01 | Janssen Pharmaceutica N.V. | Derivados de (imidazol-5-il)metil-2-quinolinona como inhibidores de la proteina farnesil-transferasa. |
| WO1997044339A1 (en) | 1996-05-20 | 1997-11-27 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| BR9810423A (pt) | 1997-06-02 | 2000-10-03 | Janssen Pharmaceutica Nv | Derivados de (imidazol-5-il)metil-2-quinolinona como inibidores da proliferação das células do músculo liso |
| DE69831506T2 (de) | 1997-12-22 | 2006-06-29 | Pharmacia & Upjohn Co. Llc, Kalamazoo | 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe |
| FR2776388B1 (fr) | 1998-03-20 | 2006-04-28 | Lipha | Utilisation de recepteurs de la famille ror pour le criblage de substances utiles pour le traitement de l'atherosclerose |
| US6399629B1 (en) | 1998-06-01 | 2002-06-04 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
| CA2336624C (en) | 1998-07-06 | 2008-10-21 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties |
| HRP20000904A2 (en) * | 1998-07-06 | 2001-12-31 | Janssen Pharmaceutica Nv | Farnesyl protein transferase inhibitors for treating arthropathies |
| JP2000169451A (ja) | 1998-09-30 | 2000-06-20 | Kyorin Pharmaceut Co Ltd | ６，７―ジ置換キノリンカルボン酸誘導体とその付加塩及びそれらの製造方法 |
| ES2200591T3 (es) | 1998-12-23 | 2004-03-01 | Janssen Pharmaceutica N.V. | Derivados de 1,2-quinolina anelados. |
| US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| US6248736B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents |
| AU2124800A (en) | 1999-02-11 | 2000-08-29 | Pfizer Products Inc. | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents |
| ATE259365T1 (de) | 1999-11-30 | 2004-02-15 | Pfizer Prod Inc | Chinolinderivate verwendbar zur hemmung der farnesyl-protein transferase |
| CA2396865C (en) | 2000-02-04 | 2009-04-14 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitors for treating breast cancer |
| US6838467B2 (en) | 2000-02-24 | 2005-01-04 | Janssen Pharmaceutica N. V. | Dosing regimen |
| WO2001064195A2 (en) | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with anti-tumor nucleoside derivatives |
| EP1261374A2 (en) | 2000-02-29 | 2002-12-04 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with further anti-cancer agents |
| EP1267929A2 (en) | 2000-02-29 | 2003-01-02 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with an her2 antibody |
| AU2001246477A1 (en) | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with platinum compounds |
| AU2001240658A1 (en) | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with camptothecin compounds |
| EP1267871A2 (en) | 2000-02-29 | 2003-01-02 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives |
| US20030078281A1 (en) | 2000-02-29 | 2003-04-24 | Rybak Mary Ellen Margaret | Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents |
| CA2397694A1 (en) | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica Inc. | Farnesyl protein transferase inhibitor combinations |
| WO2001064196A2 (en) | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with vinca alkaloids |
| EP1265611A2 (en) | 2000-02-29 | 2002-12-18 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with taxane compounds |
| JP2003525237A (ja) | 2000-02-29 | 2003-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗腫瘍性アントラサイクリン誘導体とのファルネシルタンパク質トランスフェラーゼ阻害剤組み合わせ剤 |
| US6844357B2 (en) | 2000-05-01 | 2005-01-18 | Pfizer Inc. | Substituted quinolin-2-one derivatives useful as antiproliferative agents |
| US6525049B2 (en) | 2000-07-05 | 2003-02-25 | Pharmacia & Upjohn Company | Pyrroloquinolones as antiviral agents |
| AU2001269704A1 (en) | 2000-07-12 | 2002-01-21 | Pharmacia And Upjohn Company | Oxazinoquinolones useful for the treatment of viral infections |
| US6624159B2 (en) | 2000-07-12 | 2003-09-23 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| US7196094B2 (en) | 2000-09-25 | 2007-03-27 | Janssen Pharmaceutica, N.V. | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives |
| US7067531B2 (en) | 2000-09-25 | 2006-06-27 | Angibaud Patrick Rene | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives |
| JP4911866B2 (ja) | 2000-09-25 | 2012-04-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ファルネシルトランスフェラーゼ阻害剤としてのファルネシルトランスフェラーゼを阻害するキノリンおよびキナゾリン誘導体 |
| BR0114253A (pt) | 2000-10-02 | 2003-07-01 | Janssen Pharmaceutica Nv | Antagonistas de receptor de glutamato metabotrópico |
| DE60118953T2 (de) | 2000-11-28 | 2007-01-11 | Janssen Pharmaceutica N.V. | Farnesyl-protein-transferasehemmer zur behandlung der entzündlichen darmerkrankung |
| ATE319704T1 (de) | 2000-12-27 | 2006-03-15 | Janssen Pharmaceutica Nv | Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate |
| ES2318000T3 (es) | 2001-02-15 | 2009-05-01 | Janssen Pharmaceutica Nv | Combinaciones de inhibidores de la farnesil-protein-transferasa con agentes antiestrogenos. |
| CA2433467A1 (en) | 2001-03-01 | 2002-09-12 | Joseph W. Strohbach | Substituted quinolinecarboxamides as antiviral agents |
| EP1390033A1 (en) | 2001-04-25 | 2004-02-25 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitors for treating cachexia |
| WO2003000705A1 (en) | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Novel quinolines and uses thereof |
| US20030207877A1 (en) | 2001-12-20 | 2003-11-06 | Strohbach Joseph Walter | Pyridoquinoxaline antivirals |
| WO2003053972A1 (en) | 2001-12-20 | 2003-07-03 | Pharmacia & Upjohn Company | Pyridoquinoxaline antivirals |
| CN1642580B (zh) | 2002-03-29 | 2010-05-26 | 詹森药业有限公司 | 放射性标记的喹啉和喹啉酮衍生物及其作为代谢性谷氨酸受体配体的制造用途 |
| JP3908248B2 (ja) | 2002-08-13 | 2007-04-25 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有するヘテロ環化合物 |
| US20040186131A1 (en) | 2002-08-30 | 2004-09-23 | Wathen Michael W | Method of preventing or treating atherosclerosis or restenosis |
| GB0222516D0 (en) | 2002-09-27 | 2002-11-06 | Karobio Ab | Novel compounds |
| AU2004257267B2 (en) | 2003-07-14 | 2009-12-03 | Arena Pharmaceuticals,Inc | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
| AU2004295058B9 (en) | 2003-11-20 | 2011-06-30 | Janssen Pharmaceutica N.V. | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
| KR101159118B1 (ko) | 2003-12-05 | 2012-06-22 | 얀센 파마슈티카 엔.브이. | 폴리(ａｄｐ-리보스)폴리머라제 저해제로서의 6-치환된2-퀴놀리논 및 2-퀴녹살리논 |
| CN1890225A (zh) | 2003-12-10 | 2007-01-03 | 詹森药业有限公司 | 作为多聚(adp－核糖)聚合酶抑制剂的被取代的6－环己基烷基取代的2－喹啉酮和2－喹喔啉酮 |
| KR20070001922A (ko) | 2003-12-12 | 2007-01-04 | 와이어쓰 | 심장혈관질환 치료에 유용한 퀴놀린 |
| WO2005070430A1 (en) | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Quinoline derivatives and use thereof as mycobacterial inhibitors |
| BRPI0507312A (pt) | 2004-01-29 | 2007-06-26 | Janssen Pharmaceutica Nv | derivados de quinolina para uso como inibidores micobacterianos |
| JP2005225250A (ja) | 2004-02-10 | 2005-08-25 | Murakami Corp | 車載用監視装置 |
| US7875621B2 (en) | 2004-06-30 | 2011-01-25 | Janssen Pharmaceutica Nv | Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors |
| IL180887A (en) | 2004-08-04 | 2014-04-30 | Nippon Kayaku Kk | Quinoline derivatives and insecticides containing them as active substance |
| KR100686531B1 (ko) | 2004-08-31 | 2007-02-23 | 한국화학연구원 | 히스톤 디아세틸라제 저해활성을 갖는 아릴아미노메틸프로페닐 벤즈하이드록시아마이드 유도체 및 그의 제조방법 |
| EP2362218B1 (en) | 2004-11-05 | 2014-08-27 | Janssen Pharmaceutica N.V. | Methods of monitoring the efficacy of farnesyltransferase inhibitors |
| JO2855B1 (en) | 2005-08-03 | 2015-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2952B1 (en) | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| WO2007088978A1 (ja) | 2006-02-03 | 2007-08-09 | Meiji Seika Kaisha, Ltd. | 新規キノリン誘導体およびこれを有効成分として含有する農園芸用殺菌剤 |
| US8389739B1 (en) | 2006-10-05 | 2013-03-05 | Orphagen Pharmaceuticals | Modulators of retinoid-related orphan receptor gamma |
| CA2667453A1 (en) | 2006-10-23 | 2008-05-02 | Sgx Pharmaceuticals, Inc. | Triazolo-pyridazine protein kinase modulators |
| JO3271B1 (ar) | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| AR065093A1 (es) | 2007-02-05 | 2009-05-13 | Merck Frosst Canada Ltd | Compuestos farmacéuticos inhibidores de la biosintesis de leucotrienos |
| UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| US20100184803A1 (en) | 2007-03-09 | 2010-07-22 | Link Medicine Corporation | Treatment of Lysosomal Storage Diseases |
| EA200971077A1 (ru) | 2007-05-21 | 2010-04-30 | ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. | Гетероциклические модуляторы киназы |
| CN101143845B (zh) | 2007-10-15 | 2010-08-25 | 中国药科大学 | 取代喹啉甲酰胍衍生物、其制备方法及其医药用途 |
| EP2250153B1 (en) | 2008-01-18 | 2013-06-19 | Allergan, Inc. | Substituted-aryl-(imidazole)-methyl)-phenyl compounds as subtype selective modulators of alpha 2b and/or alpha 2c adrenergic receptors |
| JP2011511056A (ja) | 2008-02-05 | 2011-04-07 | ファイザー・インク | Ｃｎｓ障害および代謝障害治療のためのピリジニルアミド |
| EP2296655A1 (en) | 2008-05-13 | 2011-03-23 | Allergan, Inc. | Quinolynylmethylimidizoles as therapeutic agents |
| WO2010068296A1 (en) | 2008-12-11 | 2010-06-17 | Stiefel Laboratories, Inc. | Piperazine carboxamidines as antimicrobial agents |
| WO2010127208A1 (en) | 2009-04-30 | 2010-11-04 | Forest Laboratories Holdings Limited | Inhibitors of acetyl-coa carboxylase |
| CN101899011B (zh) | 2009-05-26 | 2013-01-16 | 北京大学 | 氨基二硫代甲酸酯类化合物、其制备方法和应用 |
| AR077004A1 (es) | 2009-06-09 | 2011-07-27 | Hoffmann La Roche | Compuestos heterociclicos antivirales |
| CA2781865A1 (en) | 2009-06-25 | 2010-12-29 | Amgen Inc. | Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases |
| KR20120089463A (ko) | 2009-08-20 | 2012-08-10 | 노파르티스 아게 | 헤테로시클릭 옥심 화합물 |
| EP2368886A1 (en) | 2010-03-01 | 2011-09-28 | Phenex Pharmaceuticals AG | Novel compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (ROR gamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune desease |
| US9101600B2 (en) | 2010-03-11 | 2015-08-11 | New York University | Compounds as RORγt modulators and uses thereof |
| MX2012011996A (es) | 2010-04-15 | 2013-11-27 | Chromocell Corp | Compuestos , composiciones y metodos para reducir o eliminar el sabor amargo. |
| JP6063870B2 (ja) * | 2010-11-08 | 2017-01-18 | ライセラ・コーポレイション | ＲＯＲγ活性の阻害用のＮ−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療 |
| EP2678052B1 (en) | 2011-02-24 | 2018-09-26 | Emory University | Jab1 blocking compositions for ossification and methods related thereto |
| TWI532728B (zh) | 2011-04-28 | 2016-05-11 | 日本煙草產業股份有限公司 | 醯胺化合物及其醫藥用途 |
| US9586928B2 (en) | 2011-05-16 | 2017-03-07 | The Scripps Research Institute | Modulators of the nuclear hormone receptor ROR |
| GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| WO2013064231A1 (en) | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
| EP2800745B1 (en) | 2011-12-02 | 2020-02-12 | Phenex Pharmaceuticals AG | Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rory, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
-
2013
- 2013-10-15 AU AU2013331496A patent/AU2013331496B2/en not_active Ceased
- 2013-10-15 JP JP2015537769A patent/JP6466335B2/ja not_active Expired - Fee Related
- 2013-10-15 WO PCT/US2013/065013 patent/WO2014062658A1/en not_active Ceased
- 2013-10-15 CA CA2888210A patent/CA2888210C/en not_active Expired - Fee Related
- 2013-10-15 SM SM20170347T patent/SMT201700347T1/it unknown
- 2013-10-15 LT LTEP13786564.8T patent/LT2909192T/lt unknown
- 2013-10-15 DK DK13786564.8T patent/DK2909192T3/en active
- 2013-10-15 EA EA201590736A patent/EA026415B1/ru unknown
- 2013-10-15 UY UY0001035084A patent/UY35084A/es unknown
- 2013-10-15 EP EP13786564.8A patent/EP2909192B1/en active Active
- 2013-10-15 MX MX2015004783A patent/MX358508B/es active IP Right Grant
- 2013-10-15 CN CN201380065903.1A patent/CN105209453B/zh not_active Expired - Fee Related
- 2013-10-15 PE PE2015000491A patent/PE20150778A1/es active IP Right Grant
- 2013-10-15 NZ NZ706775A patent/NZ706775A/en not_active IP Right Cessation
- 2013-10-15 ES ES13786564.8T patent/ES2632269T3/es active Active
- 2013-10-15 HR HRP20171082TT patent/HRP20171082T1/hr unknown
- 2013-10-15 ME MEP-2017-151A patent/ME02794B/me unknown
- 2013-10-15 PL PL13786564T patent/PL2909192T3/pl unknown
- 2013-10-15 HU HUE13786564A patent/HUE035335T2/en unknown
- 2013-10-15 SI SI201330702T patent/SI2909192T1/sl unknown
- 2013-10-15 SG SG11201502369XA patent/SG11201502369XA/en unknown
- 2013-10-15 AR ARP130103735A patent/AR093017A1/es unknown
- 2013-10-15 KR KR1020157012838A patent/KR20150070347A/ko not_active Abandoned
- 2013-10-15 BR BR112015008308A patent/BR112015008308A2/pt not_active Application Discontinuation
- 2013-10-15 RS RS20170741A patent/RS56283B1/sr unknown
- 2013-10-15 PT PT137865648T patent/PT2909192T/pt unknown
- 2013-10-15 TW TW102137062A patent/TWI606045B/zh not_active IP Right Cessation
- 2013-10-15 MY MYPI2015701186A patent/MY189505A/en unknown
- 2013-10-15 US US14/053,653 patent/US9290476B2/en not_active Expired - Fee Related
-
2015
- 2015-03-22 IL IL237866A patent/IL237866B/en active IP Right Grant
- 2015-04-13 CR CR20150193A patent/CR20150193A/es unknown
- 2015-04-14 PH PH12015500817A patent/PH12015500817B1/en unknown
- 2015-04-15 CL CL2015000945A patent/CL2015000945A1/es unknown
- 2015-04-15 GT GT201500093A patent/GT201500093A/es unknown
- 2015-04-15 NI NI201500053A patent/NI201500053A/es unknown
- 2015-04-15 EC ECIEPI201515022A patent/ECSP15015022A/es unknown
- 2015-05-15 ZA ZA2015/03418A patent/ZA201503418B/en unknown
-
2017
- 2017-07-25 CY CY20171100793T patent/CY1119234T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CR20150193A (es) | Moduladores de quinolinilo unidos a metileno de ror-gamma-t | |
| CR20150192A (es) | Moduladores de quinolinilo unidos a fenilo de ror-gamma-t | |
| CY1124022T1 (el) | Σχημα χορηγησης για νιτροκατεχολες | |
| ECSP18094790A (es) | Piridinas sustituidas con heteroarilo y métodos de uso referencia cruzada a solicitudes relacionadas | |
| UY35908A (es) | Moduladores de tetrahidropiridopirazinas de gpr6 | |
| CL2015001392A1 (es) | Compuestos y sus métodos de empleo | |
| EA201790317A1 (ru) | Ингибиторы smyd | |
| NI201400107A (es) | Compuestos de heterociclilo como inhibidores de mek | |
| CR20210079A (es) | Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b | |
| DOP2017000278A (es) | Piridinas sustituidas y método de uso | |
| EA201992183A3 (ru) | Синтез полициклических карбамоилпиридоновых соединений | |
| BR112014019909A8 (pt) | Processo para produção de compostos úteis como antagonistas do receptor de orexina-2 | |
| DK2854769T3 (da) | Fremgangsmåder til behandling af artritis | |
| UY34661A (es) | Inhibidores de benzodioxano de la producción de leucotrieno para terapia de combinación | |
| CO2017008600A2 (es) | Análogos de desacetoxitubulisina h, composiciones y método de producción de los mismos | |
| DOP2015000059A (es) | Amino-quinolinas como inhibidores de cinasa | |
| CL2014003130A1 (es) | Compuestos derivados de n-piridinil amidas ciclicas,inhibidores de quinasas pim; composicion farmaceutica que los comprende; combinacion farmaceutica; metodo para tratar enfermedades tales como canceres o un trastorno autoinmune. | |
| MX385914B (es) | Método para tratar un tumor cerebral | |
| CR20170166A (es) | ALCOHOLES TRIFLUOROMETÍLICOS COMO MODULADORES DE RORyT | |
| ECSP17010238A (es) | Compuestos novedosos de pirimidina sustituidos | |
| CU20160003A7 (es) | Pirazololpiridinaminas sustituidas | |
| MX2015012579A (es) | Compuestos de azetidiniloxifenilpirrolidina. | |
| PE20160855A1 (es) | Quinazolin-thf-aminas como inhibidores de pde1 | |
| UY34504A (es) | Prevención de los efectos adversos causados por los anticuerpos biespecíficos EpCAMxCD3 | |
| CO6630197A2 (es) | Nuevos procesos |