PE20160855A1 - Quinazolin-thf-aminas como inhibidores de pde1 - Google Patents
Quinazolin-thf-aminas como inhibidores de pde1Info
- Publication number
- PE20160855A1 PE20160855A1 PE2016000825A PE2016000825A PE20160855A1 PE 20160855 A1 PE20160855 A1 PE 20160855A1 PE 2016000825 A PE2016000825 A PE 2016000825A PE 2016000825 A PE2016000825 A PE 2016000825A PE 20160855 A1 PE20160855 A1 PE 20160855A1
- Authority
- PE
- Peru
- Prior art keywords
- quinazolin
- ethyl
- methyl
- amine
- thf
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Referida a un compuesto derivado de quinazolin-amina de formula (I), donde R1 es H o alquilo C1-C3; R2 es H o alquilo C1-C3; R3 es H, metilo o etilo; R4 es H, OH, metoxi o etoxi; R5, R6 y R7 son H; R8 es H, metilo, etilo, ciclopropilo; R9 es es H, metilo o etilo. Son compuestos preferidos: 7,8-dimetoxi-N-(tetrahidrofuran-3il)quinazolin-4-amina, trans-N-(-2-ciclopropiltetrahidrofuran-3-il)-7,8-dimetoxiquinazolin-4-amina, entre otros. Dichos compuestos actuan como inhibidores de enzimas PDE1, siendo utiles para el tratamiento del trastorno por deficit de atencion con hiperactividad (TDAH), esquizofrenia o deterioro cognitivo asociado con la esquizofrenia, entre otros
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201300707 | 2013-12-19 | ||
DKPA201400249 | 2014-05-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20160855A1 true PE20160855A1 (es) | 2016-09-23 |
Family
ID=52350066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016000825A PE20160855A1 (es) | 2013-12-19 | 2014-12-18 | Quinazolin-thf-aminas como inhibidores de pde1 |
Country Status (26)
Country | Link |
---|---|
US (3) | US9701665B2 (es) |
EP (1) | EP3083607B1 (es) |
JP (1) | JP6419832B2 (es) |
KR (1) | KR20160098269A (es) |
CN (1) | CN105829300B (es) |
AP (1) | AP2016009293A0 (es) |
AU (1) | AU2014368601B2 (es) |
BR (1) | BR112016013946A8 (es) |
CA (1) | CA2933299A1 (es) |
CL (1) | CL2016001488A1 (es) |
CR (1) | CR20160282A (es) |
DO (1) | DOP2016000152A (es) |
EA (1) | EA201691108A1 (es) |
EC (1) | ECSP16061208A (es) |
ES (1) | ES2728079T3 (es) |
GE (1) | GEP201706764B (es) |
IL (1) | IL246230A0 (es) |
MX (1) | MX2016007945A (es) |
PE (1) | PE20160855A1 (es) |
PH (1) | PH12016501173A1 (es) |
RU (1) | RU2016125315A (es) |
SG (1) | SG11201604936TA (es) |
SV (1) | SV2016005220A (es) |
TN (1) | TN2016000239A1 (es) |
TW (1) | TW201609713A (es) |
WO (1) | WO2015091805A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201609713A (zh) | 2013-12-19 | 2016-03-16 | H 朗德貝克公司 | 作爲pde1抑制劑之喹唑啉-thf-胺 |
ES2776359T3 (es) * | 2014-04-04 | 2020-07-30 | H Lundbeck As | Quinazolin-thf-aminas halogenadas como inhibidores de PDE1 |
TWI729109B (zh) * | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
CN110337437B (zh) | 2016-12-28 | 2023-02-03 | 达特神经科学有限公司 | 作为pde2抑制剂的取代的吡唑并嘧啶酮化合物 |
KR20200108419A (ko) | 2017-11-27 | 2020-09-18 | 다트 뉴로사이언스, 엘엘씨 | Pde1 억제제로서의 치환된 푸라노피리미딘 화합물 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030211040A1 (en) * | 2001-08-31 | 2003-11-13 | Paul Greengard | Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain |
CN1802177A (zh) * | 2003-04-01 | 2006-07-12 | 应用研究系统Ars股份公司 | 用于不育症中的磷酸二酯酶抑制剂 |
US7517888B2 (en) * | 2004-04-28 | 2009-04-14 | Cv Therapeutics, Inc. | A1 adenosine receptor antagonists |
CA2619462A1 (en) * | 2005-08-16 | 2007-02-22 | Amgen, Inc. | Phosphodiesterase 10 inhibitors |
US20090023756A1 (en) * | 2006-02-23 | 2009-01-22 | Pfizer Inc | Substituted quinazolines as pde10 inhibitors |
EP2279009A4 (en) * | 2008-05-05 | 2011-09-21 | Univ Rochester | METHOD AND COMPOSITIONS FOR TREATING OR PREVENTING PATHOLOGICAL CARDIAL REMODELING AND HEART FAILURE |
JP2012526810A (ja) * | 2009-05-13 | 2012-11-01 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
JP2013505909A (ja) * | 2009-09-24 | 2013-02-21 | ビーエーエスエフ ソシエタス・ヨーロピア | 無脊椎動物害虫を駆除するためのアミノキナゾリン化合物 |
TW201609713A (zh) | 2013-12-19 | 2016-03-16 | H 朗德貝克公司 | 作爲pde1抑制劑之喹唑啉-thf-胺 |
-
2014
- 2014-12-01 TW TW103141539A patent/TW201609713A/zh unknown
- 2014-12-18 EP EP14827431.9A patent/EP3083607B1/en active Active
- 2014-12-18 EA EA201691108A patent/EA201691108A1/ru unknown
- 2014-12-18 ES ES14827431T patent/ES2728079T3/es active Active
- 2014-12-18 AP AP2016009293A patent/AP2016009293A0/en unknown
- 2014-12-18 SG SG11201604936TA patent/SG11201604936TA/en unknown
- 2014-12-18 TN TN2016000239A patent/TN2016000239A1/en unknown
- 2014-12-18 CA CA2933299A patent/CA2933299A1/en not_active Abandoned
- 2014-12-18 KR KR1020167016258A patent/KR20160098269A/ko not_active Application Discontinuation
- 2014-12-18 GE GEAP201414180A patent/GEP201706764B/en unknown
- 2014-12-18 PE PE2016000825A patent/PE20160855A1/es not_active Application Discontinuation
- 2014-12-18 MX MX2016007945A patent/MX2016007945A/es unknown
- 2014-12-18 JP JP2016541407A patent/JP6419832B2/ja active Active
- 2014-12-18 RU RU2016125315A patent/RU2016125315A/ru unknown
- 2014-12-18 US US15/105,647 patent/US9701665B2/en active Active
- 2014-12-18 AU AU2014368601A patent/AU2014368601B2/en not_active Expired - Fee Related
- 2014-12-18 CN CN201480068495.XA patent/CN105829300B/zh active Active
- 2014-12-18 CR CR20160282A patent/CR20160282A/es unknown
- 2014-12-18 US US14/574,425 patent/US20150175584A1/en not_active Abandoned
- 2014-12-18 BR BR112016013946A patent/BR112016013946A8/pt not_active IP Right Cessation
- 2014-12-18 WO PCT/EP2014/078475 patent/WO2015091805A1/en active Application Filing
-
2016
- 2016-06-14 CL CL2016001488A patent/CL2016001488A1/es unknown
- 2016-06-15 SV SV2016005220A patent/SV2016005220A/es unknown
- 2016-06-15 IL IL246230A patent/IL246230A0/en not_active IP Right Cessation
- 2016-06-16 PH PH12016501173A patent/PH12016501173A1/en unknown
- 2016-06-17 DO DO2016000152A patent/DOP2016000152A/es unknown
- 2016-07-18 EC ECIEPI201661208A patent/ECSP16061208A/es unknown
-
2017
- 2017-06-05 US US15/614,104 patent/US10030007B2/en active Active
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |