CR20130616A - Amidas-2-piridina útiles como agonistas cb2 - Google Patents

Amidas-2-piridina útiles como agonistas cb2

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Publication number
CR20130616A
CR20130616A CR20130616A CR20130616A CR20130616A CR 20130616 A CR20130616 A CR 20130616A CR 20130616 A CR20130616 A CR 20130616A CR 20130616 A CR20130616 A CR 20130616A CR 20130616 A CR20130616 A CR 20130616A
Authority
CR
Costa Rica
Prior art keywords
piridina
amidas
agonists
useful
compound
Prior art date
Application number
CR20130616A
Other languages
English (en)
Inventor
Paul Hebeisen
Gasch Tanja Schulz
Zhiwei Wang
Matthias Nettekoven
Atsushi Kimbara
Wulun Yang
Evans Mark Rogers
Marco Prunotto
Caterina Bissantz
Stephan Roever
Qingping Liu
Christoph Ullmer
Uwe Grether
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20130616A publication Critical patent/CR20130616A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

La invención se refiere a un compuesto de la fórmula en la que de R1 a R4 tienen los significados definidos en la descripción y en las reivindicaciones. El compuesto de la fórmula (I) puede utilizarse como medicamento.
CR20130616A 2011-06-10 2012-06-07 Amidas-2-piridina útiles como agonistas cb2 CR20130616A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011075606 2011-06-10
PCT/EP2012/060785 WO2012168350A1 (en) 2011-06-10 2012-06-07 Pyridin- 2 -amides useful as cb2 agonists

Publications (1)

Publication Number Publication Date
CR20130616A true CR20130616A (es) 2018-01-26

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CR20130616A CR20130616A (es) 2011-06-10 2012-06-07 Amidas-2-piridina útiles como agonistas cb2

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EP (2) EP3072886B1 (es)
JP (3) JP5997265B2 (es)
KR (1) KR20140042848A (es)
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AR (1) AR086881A1 (es)
AU (2) AU2012266369B2 (es)
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