RS55073B1 - Piridin-2-amidi korisni kao cb2 agonisti - Google Patents
Piridin-2-amidi korisni kao cb2 agonistiInfo
- Publication number
- RS55073B1 RS55073B1 RS20160666A RSP20160666A RS55073B1 RS 55073 B1 RS55073 B1 RS 55073B1 RS 20160666 A RS20160666 A RS 20160666A RS P20160666 A RSP20160666 A RS P20160666A RS 55073 B1 RS55073 B1 RS 55073B1
- Authority
- RS
- Serbia
- Prior art keywords
- pyridin
- agonists
- amides useful
- amides
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011075606 | 2011-06-10 | ||
PCT/EP2012/060785 WO2012168350A1 (en) | 2011-06-10 | 2012-06-07 | Pyridin- 2 -amides useful as cb2 agonists |
EP12725834.1A EP2718266B9 (en) | 2011-06-10 | 2012-06-07 | Pyridin-2-amides useful as cb2 agonists |
Publications (2)
Publication Number | Publication Date |
---|---|
RS55073B1 true RS55073B1 (sr) | 2016-12-30 |
RS55073B9 RS55073B9 (sr) | 2019-07-31 |
Family
ID=46208600
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20160666A RS55073B9 (sr) | 2011-06-10 | 2012-06-07 | Piridin-2-amidi korisni kao cb2 agonisti |
RS20180645A RS57262B1 (sr) | 2011-06-10 | 2012-06-07 | Piridin -2- amidi upotrebljivi kao cb2 agonisti |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20180645A RS57262B1 (sr) | 2011-06-10 | 2012-06-07 | Piridin -2- amidi upotrebljivi kao cb2 agonisti |
Country Status (36)
Country | Link |
---|---|
US (2) | US9321727B2 (sr) |
EP (2) | EP3072886B1 (sr) |
JP (3) | JP5997265B2 (sr) |
KR (1) | KR20140042848A (sr) |
CN (2) | CN103608332B (sr) |
AR (1) | AR086881A1 (sr) |
AU (2) | AU2012266369B2 (sr) |
BR (1) | BR112013031463A2 (sr) |
CA (1) | CA2835745A1 (sr) |
CL (1) | CL2013003486A1 (sr) |
CO (1) | CO6811864A2 (sr) |
CR (1) | CR20130616A (sr) |
CY (1) | CY1117878T1 (sr) |
DK (2) | DK2718266T3 (sr) |
EA (2) | EA023287B1 (sr) |
EC (1) | ECSP13013074A (sr) |
ES (2) | ES2588327T3 (sr) |
HK (1) | HK1231465A1 (sr) |
HR (2) | HRP20161064T2 (sr) |
HU (2) | HUE037666T2 (sr) |
IL (2) | IL229685B (sr) |
LT (1) | LT3072886T (sr) |
MA (1) | MA35245B1 (sr) |
MX (1) | MX339992B (sr) |
MY (1) | MY184978A (sr) |
PE (2) | PE20180037A1 (sr) |
PH (1) | PH12016501375A1 (sr) |
PL (2) | PL2718266T3 (sr) |
PT (2) | PT3072886T (sr) |
RS (2) | RS55073B9 (sr) |
SG (1) | SG10201604687QA (sr) |
SI (2) | SI2718266T1 (sr) |
TR (1) | TR201808273T4 (sr) |
TW (1) | TWI567062B (sr) |
UA (1) | UA114087C2 (sr) |
WO (1) | WO2012168350A1 (sr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9321727B2 (en) * | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
MX2015007156A (es) * | 2012-12-07 | 2015-10-14 | Hoffmann La Roche | Piridina-2-amidas utiles como agonistas receptores de canabinoides 2 (cb2). |
PE20151060A1 (es) | 2012-12-07 | 2015-07-25 | Hoffmann La Roche | Nuevos derivados de pirazina como agonistas del receptor cb2 |
US9303012B2 (en) * | 2012-12-07 | 2016-04-05 | Hoffman-La Roche Inc. | Pyridine-2-amides useful as CB2 agonists |
CN104837831B (zh) * | 2012-12-07 | 2017-10-31 | 霍夫曼-拉罗奇有限公司 | 新的吡啶衍生物 |
WO2014135507A1 (en) | 2013-03-07 | 2014-09-12 | F. Hoffmann-La Roche Ag | Novel pyrazol derivatives |
DK2978755T3 (en) | 2013-03-26 | 2018-03-05 | Hoffmann La Roche | Hitherto unknown pyridine derivatives |
CA2907691A1 (en) | 2013-05-02 | 2014-11-06 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists |
KR20210145303A (ko) | 2013-05-02 | 2021-12-01 | 에프. 호프만-라 로슈 아게 | Cb2 수용체 작용제로서의 퓨린 유도체 |
KR20160106627A (ko) * | 2013-12-30 | 2016-09-12 | 라이프에스씨아이 파마슈티컬스, 인크. | 치료적 억제 화합물 |
WO2015150438A1 (en) * | 2014-04-04 | 2015-10-08 | F. Hoffmann-La Roche Ag | 5,6-disubstituted pyridine-2-carboxamides as cannabinoid receptor agonists |
CA2943013A1 (en) * | 2014-04-04 | 2015-10-08 | F. Hoffmann-La Roche Ag | Pyridine-2-amides useful as cb2 agonists |
CN104004006B (zh) * | 2014-05-15 | 2016-04-06 | 广州康瑞泰药业有限公司 | 一种3,6-二氢-2h-吡喃-4-硼酸频哪醇酯的合成方法 |
CN104003934B (zh) * | 2014-06-13 | 2016-04-13 | 西华大学 | 6-氯-3-氟-2-吡啶甲酸的合成 |
GB201415569D0 (en) * | 2014-09-03 | 2014-10-15 | C4X Discovery Ltd | Therapeutic Compounds |
JP6800968B2 (ja) | 2015-10-23 | 2020-12-16 | ナビター ファーマシューティカルズ, インコーポレイテッド | セストリン−gator2相互作用のモジュレーターおよびその使用 |
WO2017089389A1 (en) * | 2015-11-26 | 2017-06-01 | F. Hoffmann-La Roche Ag | Trypanosomes inhibitors |
CN116102449A (zh) * | 2015-12-09 | 2023-05-12 | 豪夫迈·罗氏有限公司 | 作为大麻素受体2激动剂的苯基衍生物 |
GB201601703D0 (en) | 2016-01-29 | 2016-03-16 | C4X Discovery Ltd | Therapeutic compounds |
AU2017275657B2 (en) | 2016-06-02 | 2021-08-19 | Novartis Ag | Potassium channel modulators |
US9975886B1 (en) | 2017-01-23 | 2018-05-22 | Cadent Therapeutics, Inc. | Potassium channel modulators |
JP7179015B2 (ja) | 2017-04-26 | 2022-11-28 | ナビター ファーマシューティカルズ, インコーポレイテッド | Sestrin-GATOR2相互座用のモジュレーターおよびその使用 |
AR112199A1 (es) | 2017-06-20 | 2019-10-02 | Hoffmann La Roche | Derivados de piridina como agonistas inversos del receptor cannabinoide 2 |
SG11202009103WA (en) * | 2018-06-27 | 2020-10-29 | Hoffmann La Roche | Novel pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2 |
WO2020002280A1 (en) * | 2018-06-27 | 2020-01-02 | F. Hoffmann-La Roche Ag | Novel azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2 |
JP7454512B2 (ja) | 2018-06-27 | 2024-03-22 | エフ. ホフマン-ラ ロシュ アーゲー | 優先的カンナビノイド2アゴニストとしてのピリジン及びピラジン誘導体 |
US20200085810A1 (en) * | 2018-07-26 | 2020-03-19 | Hoffmann-La Roche Inc. | Compounds for use in treating kidney disorders |
EP3870158A4 (en) | 2018-10-24 | 2022-08-10 | Navitor Pharmaceuticals, Inc. | POLYMORPHIC COMPOUNDS AND USES THEREOF |
CN109665982B (zh) * | 2019-01-22 | 2022-07-08 | 深圳市第二人民医院 | 奈非西坦中间体2-吡咯烷酮的合成方法 |
AU2020376950A1 (en) | 2019-11-01 | 2022-06-09 | Navitor Pharmaceuticals, Inc. | Methods of treatment using an mTORC1 modulator |
EP4125831A4 (en) * | 2020-03-23 | 2024-05-08 | Praxis Prec Medicines Inc | KCNT1 INHIBITORS AND METHODS OF USE |
AU2021341508A1 (en) | 2020-09-10 | 2023-05-25 | Precirix N.V. | Antibody fragment against fap |
US11773088B2 (en) | 2020-11-02 | 2023-10-03 | Praxis Precision Medicines, Inc. | KCNT1 inhibitors and methods of use |
WO2022272062A1 (en) * | 2021-06-24 | 2022-12-29 | Reservoir Neuroscience, Inc. | Ep2 antagonist compounds |
WO2023169984A1 (en) * | 2022-03-11 | 2023-09-14 | Syngenta Crop Protection Ag | Herbicidal compounds |
WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
WO2023213801A1 (en) | 2022-05-02 | 2023-11-09 | Precirix N.V. | Pre-targeting |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9005965D0 (en) | 1990-03-16 | 1990-05-09 | Shell Int Research | Herbicidal carboxamide derivatives |
GB9025828D0 (en) * | 1990-11-28 | 1991-01-09 | Shell Int Research | Herbicidal carboxamide derivatives |
DK0516069T3 (da) * | 1991-05-31 | 1996-05-13 | Sumitomo Pharma | Leukotrien B4-antagonister |
TW226012B (sr) * | 1991-11-19 | 1994-07-01 | Dunlena Pty Ltd | |
GB2277930A (en) | 1993-05-11 | 1994-11-16 | Shell Int Research | Herbicidal picolinamide derivatives |
JP2005531520A (ja) * | 2002-03-28 | 2005-10-20 | メルク エンド カムパニー インコーポレーテッド | 置換2,3−ジフェニルピリジン類 |
FR2838438A1 (fr) | 2002-04-11 | 2003-10-17 | Sanofi Synthelabo | Derives de diphenylpyridine,leur preparation, les compositions pharmaceutiques en contenant |
AU2003265398A1 (en) | 2002-08-09 | 2004-02-25 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
GB0222493D0 (en) | 2002-09-27 | 2002-11-06 | Glaxo Group Ltd | Compounds |
AU2005215379A1 (en) | 2004-02-12 | 2005-09-01 | Merck & Co., Inc. | Bipyridyl amides as modulators of metabotropic glutamate receptor-5 |
EP1770085A4 (en) * | 2004-07-21 | 2010-09-22 | Mitsui Chemicals Agro Inc | DIAMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND FUNGICIDE CONTAINING THE DERIVATIVE AS ACTIVE INGREDIENT |
MX2007012213A (es) | 2005-04-06 | 2007-12-10 | Hoffmann La Roche | Derivados de piridin-3-carboxamida como agonistas inversos de canabinoides. |
US20060235028A1 (en) | 2005-04-14 | 2006-10-19 | Li James J | Inhibitors of 11-beta hydroxysteroid dehydrogenase type I |
WO2007011760A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
JP5028484B2 (ja) | 2006-06-28 | 2012-09-19 | グラクソ グループ リミテッド | Gpr38受容体媒介疾患の治療に有用なピペラジニル誘導体 |
JP5030114B2 (ja) * | 2006-09-25 | 2012-09-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体をモジュレートする化合物 |
DE602007006531D1 (de) * | 2006-10-04 | 2010-06-24 | Hoffmann La Roche | Pyrazin-2-carboxamid-derivate als cb2-rezeptormodulatoren |
MX2009009304A (es) | 2007-03-01 | 2009-11-18 | Novartis Ag | Inhibidores de cinasa pim y metodos para su uso. |
SE535157C2 (sv) * | 2010-07-14 | 2012-05-02 | Fairchild Semiconductor | Konduktivitetsmodulering i en bipolär transistor i kiselkarbid |
WO2012031817A1 (en) | 2010-09-09 | 2012-03-15 | F. Hoffmann-La Roche Ag | Determination of abca1 protein levels in cells |
US9321727B2 (en) * | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
-
2012
- 2012-06-01 US US13/486,057 patent/US9321727B2/en active Active
- 2012-06-07 PT PT161650171T patent/PT3072886T/pt unknown
- 2012-06-07 MY MYPI2013702388A patent/MY184978A/en unknown
- 2012-06-07 KR KR1020147000592A patent/KR20140042848A/ko not_active Application Discontinuation
- 2012-06-07 EA EA201391822A patent/EA023287B1/ru not_active IP Right Cessation
- 2012-06-07 PE PE2017002309A patent/PE20180037A1/es unknown
- 2012-06-07 SI SI201230619A patent/SI2718266T1/sl unknown
- 2012-06-07 MX MX2013014564A patent/MX339992B/es active IP Right Grant
- 2012-06-07 UA UAA201400124A patent/UA114087C2/uk unknown
- 2012-06-07 RS RS20160666A patent/RS55073B9/sr unknown
- 2012-06-07 JP JP2014514063A patent/JP5997265B2/ja not_active Expired - Fee Related
- 2012-06-07 CA CA2835745A patent/CA2835745A1/en not_active Abandoned
- 2012-06-07 EP EP16165017.1A patent/EP3072886B1/en not_active Not-in-force
- 2012-06-07 EP EP12725834.1A patent/EP2718266B9/en not_active Not-in-force
- 2012-06-07 EA EA201591527A patent/EA027247B1/ru not_active IP Right Cessation
- 2012-06-07 HU HUE16165017A patent/HUE037666T2/hu unknown
- 2012-06-07 PT PT127258341T patent/PT2718266T/pt unknown
- 2012-06-07 HU HUE12725834A patent/HUE027669T2/en unknown
- 2012-06-07 CN CN201280028511.3A patent/CN103608332B/zh not_active Expired - Fee Related
- 2012-06-07 ES ES12725834.1T patent/ES2588327T3/es active Active
- 2012-06-07 LT LTEP16165017.1T patent/LT3072886T/lt unknown
- 2012-06-07 BR BR112013031463A patent/BR112013031463A2/pt not_active Application Discontinuation
- 2012-06-07 TR TR2018/08273T patent/TR201808273T4/tr unknown
- 2012-06-07 PL PL12725834.1T patent/PL2718266T3/pl unknown
- 2012-06-07 DK DK12725834.1T patent/DK2718266T3/en active
- 2012-06-07 ES ES16165017.1T patent/ES2673614T3/es active Active
- 2012-06-07 WO PCT/EP2012/060785 patent/WO2012168350A1/en active Application Filing
- 2012-06-07 CN CN201610618035.0A patent/CN106349156B/zh not_active Expired - Fee Related
- 2012-06-07 AU AU2012266369A patent/AU2012266369B2/en not_active Ceased
- 2012-06-07 RS RS20180645A patent/RS57262B1/sr unknown
- 2012-06-07 SI SI201231315T patent/SI3072886T1/en unknown
- 2012-06-07 SG SG10201604687QA patent/SG10201604687QA/en unknown
- 2012-06-07 PE PE2013002773A patent/PE20141583A1/es active IP Right Grant
- 2012-06-07 CR CR20130616A patent/CR20130616A/es unknown
- 2012-06-07 DK DK16165017.1T patent/DK3072886T3/en active
- 2012-06-07 PL PL16165017T patent/PL3072886T3/pl unknown
- 2012-06-08 TW TW101120778A patent/TWI567062B/zh not_active IP Right Cessation
- 2012-06-08 AR ARP120102046A patent/AR086881A1/es unknown
-
2013
- 2013-11-28 IL IL229685A patent/IL229685B/en active IP Right Grant
- 2013-11-29 CO CO13281333A patent/CO6811864A2/es not_active Application Discontinuation
- 2013-12-05 CL CL2013003486A patent/CL2013003486A1/es unknown
- 2013-12-06 MA MA36535A patent/MA35245B1/fr unknown
- 2013-12-10 EC ECSP13013074 patent/ECSP13013074A/es unknown
-
2016
- 2016-01-21 US US15/002,681 patent/US20160137606A1/en not_active Abandoned
- 2016-07-12 PH PH12016501375A patent/PH12016501375A1/en unknown
- 2016-08-03 CY CY20161100762T patent/CY1117878T1/el unknown
- 2016-08-22 HR HRP20161064TT patent/HRP20161064T2/hr unknown
- 2016-08-25 JP JP2016164396A patent/JP6349360B2/ja not_active Expired - Fee Related
-
2017
- 2017-02-06 AU AU2017200801A patent/AU2017200801B2/en not_active Expired - Fee Related
- 2017-05-17 HK HK17104953.8A patent/HK1231465A1/zh not_active IP Right Cessation
-
2018
- 2018-01-10 IL IL256826A patent/IL256826B/en not_active IP Right Cessation
- 2018-06-04 JP JP2018106773A patent/JP6484746B2/ja not_active Expired - Fee Related
- 2018-06-08 HR HRP20180897TT patent/HRP20180897T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20180897T1 (hr) | Derivati piridin-2-amida korisni kao cb2-agonisti | |
HRP20171459T1 (hr) | Piridin-2-amidi korisni kao agonisti cb2 | |
HRP20171445T1 (hr) | Piridin-2-amidi korisni kao agonisti cb2 | |
HK1203196A1 (en) | Substituted benzylpyrazoles | |
HK1190707A1 (zh) | 作為 激動劑的 -氨基-吡啶類 | |
GB2503849B (en) | Intrinsically-calibrated tribometer | |
EP2663331A4 (en) | NEW USES | |
GB201119167D0 (en) | Novel bachteriophages | |
ZA201402298B (en) | Heterocyclylpyri (mi)dinylpyrazole as fungicidals | |
GB201116152D0 (en) | Cannabinoid-2-receptor agonists | |
GB201116151D0 (en) | Cannabinoid-2-receptor agonists | |
GB201113206D0 (en) | Novel uses | |
GB201107365D0 (en) | Find my car-Carlocator | |
GB201109229D0 (en) | New uses | |
GB201107854D0 (en) | Novel 5-hydroxy-5-aryl-pyrrol-2-ones | |
GB201113923D0 (en) | Novel combinations |