CR20130597A - Isoxazolinas como agentes terapèuticos - Google Patents

Isoxazolinas como agentes terapèuticos

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Publication number
CR20130597A
CR20130597A CR20130597A CR20130597A CR20130597A CR 20130597 A CR20130597 A CR 20130597A CR 20130597 A CR20130597 A CR 20130597A CR 20130597 A CR20130597 A CR 20130597A CR 20130597 A CR20130597 A CR 20130597A
Authority
CR
Costa Rica
Prior art keywords
therapèutic
isoxazolins
agents
compound
formula
Prior art date
Application number
CR20130597A
Other languages
English (en)
Inventor
David J Calderwood
Eric C Breinlinger
Steven L Swann
Subhendu Mukherjee
Venkata Srikanth Chitty
Siva Sanjeeva Rao Thunuguntla
Subramanya Seetharama Shastry Hosahalli
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47108012&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20130597(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of CR20130597A publication Critical patent/CR20130597A/es

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Un compuesto de fórmula (I)
CR20130597A 2011-04-30 2013-11-15 Isoxazolinas como agentes terapèuticos CR20130597A (es)

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX368078B (es) * 2012-11-21 2019-09-17 Zoetis Llc Sintesis de derivados de isoxazolina espirociclicos.
MX2016002742A (es) * 2013-09-05 2016-06-08 Abbvie Inc Metodos diaestereoselectivos para sintetizar compuestos.
EP3325465B1 (en) * 2015-07-17 2022-05-18 Syngenta Participations AG Pesticidally active pyrazole derivatives
EP3145168A1 (en) 2015-09-17 2017-03-22 Thomson Licensing An apparatus and a method for generating data representing a pixel beam
JP2020530850A (ja) * 2017-08-14 2020-10-29 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 殺有害生物および殺寄生生物ピラゾール−イソキサゾリン化合物
JP7233809B2 (ja) * 2018-09-04 2023-03-07 エフ. ホフマン-ラ ロシュ アーゲー 自己免疫疾患の処置のためのベンゾチアゾール化合物
EP4333819A1 (en) 2021-05-03 2024-03-13 Katholieke Universiteit Leuven Treatment of pharmacoresistant epilepsy

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
CO5170501A1 (es) 1999-04-14 2002-06-27 Novartis Ag AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO
ECSP003448A (es) 2000-04-27 2000-05-25 Azoles sustituidos
MXPA05001592A (es) 2002-08-09 2005-05-05 Astrazeneca Ab Oxadiazoles como moduladores de receptor-5 de glutamato metabotropico.
US20040067985A1 (en) * 2002-10-04 2004-04-08 Fortuna Haviv Method of inhibiting angiogenesis
PL375044A1 (en) 2002-11-02 2005-11-14 Sanofi-Aventis Deutschland Gmbh Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases
US7166609B2 (en) * 2002-11-02 2007-01-23 Sanofi-Aventis Deutschland Gmbh Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases
WO2004043349A2 (en) 2002-11-06 2004-05-27 Bristol-Myers Squibb Company Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
US20050004111A1 (en) * 2003-01-03 2005-01-06 Aventis Pharma Deutschland Gmbh Selective MMP-13 inhibitors
US20070259874A1 (en) * 2003-11-26 2007-11-08 Palle Venkata P Phosphodiesterase Inhibitors
JP4932495B2 (ja) 2004-01-23 2012-05-16 アムゲン インコーポレイテッド 化合物及び使用方法
CA2558848C (en) * 2004-03-05 2013-11-19 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and pesticide
DE102004023635A1 (de) 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
ZA200707125B (en) * 2005-01-25 2008-11-26 Synta Pharmaceuticals Corp Compounds for inflammation and immune-related uses
AU2006281497B2 (en) 2005-08-15 2012-06-07 F. Hoffmann-La Roche Ag Piperidine and piperazine derivatives as P2X3 antagonists
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
JP2009519937A (ja) * 2005-12-14 2009-05-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 無脊椎有害生物防除用イソオキサゾリン
CN101330828A (zh) * 2005-12-14 2008-12-24 杜邦公司 用于防治无脊椎害虫的异噁唑啉
WO2007069773A1 (en) 2005-12-15 2007-06-21 Shionogi & Co., Ltd. A pharmaceutical composition comprising an amide derivative
TWI412322B (zh) * 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
EP1981855A2 (en) * 2005-12-30 2008-10-22 Alantos Pharmaceuticals Holding, Inc. Substituted bis-amide metalloprotease inhibitors
KR20090005201A (ko) * 2006-04-20 2009-01-12 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충 방제용 피라졸린
TWI618544B (zh) 2006-12-26 2018-03-21 藍瑟斯醫學影像公司 使心臟神經分布顯像之配位體
WO2008154528A2 (en) * 2007-06-13 2008-12-18 E. I. Du Pont De Nemours And Company Isoxazoline insecticides
US20090035381A1 (en) 2007-08-01 2009-02-05 Stankus John J Electrospraying method for fabrication of particles and coatings and treatment methods thereof
AU2008281509A1 (en) 2007-08-02 2009-02-05 Pfizer Inc. Pyrimidine and pyridine derivatives and their pharmaceutical use and compositions
US8288393B2 (en) 2007-08-10 2012-10-16 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and pest control agent
JP2010538872A (ja) 2007-09-12 2010-12-16 ユニヴァーシティ オブ ワシントン 固体状態の気泡熱可塑性樹脂製品をブロー成形する方法
CA2703915C (en) 2007-10-31 2015-02-24 Merck Sharp & Dohme Corp. P2x3 receptor antagonists for treatment of pain
TWI411395B (zh) * 2007-12-24 2013-10-11 Syngenta Participations Ag 殺蟲化合物
JP2009286773A (ja) 2008-03-14 2009-12-10 Bayer Cropscience Ag 殺虫性縮環式アリール類
CN102089300B (zh) 2008-05-01 2014-06-18 生命医药公司 11β-羟基类固醇脱氢酶1的环状抑制剂
DK2299821T3 (en) 2008-06-10 2016-02-15 Abbvie Inc Tricyclic compounds
WO2010010187A1 (en) 2008-07-25 2010-01-28 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases
BRPI0917369A2 (pt) 2008-08-22 2015-08-04 Syngenta Participations Ag Compostos inseticidas
WO2010045191A2 (en) 2008-10-13 2010-04-22 Vuelogic, Llc Methods and systems for customer performance scoring
WO2010045190A1 (en) 2008-10-15 2010-04-22 Boehringer Ingelheim International Gmbh Fused heteroaryl diamide compounds useful as mmp-13 inhibitors
JP5592388B2 (ja) 2008-10-31 2014-09-17 メルク・シャープ・アンド・ドーム・コーポレーション 疼痛治療用のp2x3受容体アンタゴニスト技術分野
CN102256971B (zh) * 2008-12-19 2014-09-17 诺华股份有限公司 作为杀虫剂的异噁唑啉衍生物及其用途
CN102292331A (zh) * 2009-01-22 2011-12-21 先正达参股股份有限公司 杀虫化合物
JP2012522750A (ja) * 2009-04-01 2012-09-27 ビーエーエスエフ ソシエタス・ヨーロピア 無脊椎動物害虫を駆除するためのイソキサゾリン化合物
EP2417121A1 (en) 2009-04-10 2012-02-15 Pfizer Inc. 4, 5-dihydro-1h-pyrazole compounds and their pharmaceutical uses
GB0910003D0 (en) 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
FR2948939B1 (fr) 2009-08-05 2013-03-22 Pf Medicament Derives de 2h pyridazin-3-ones, leur preparation et leur application en therapeutique humaine
TWI487486B (zh) * 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
GB2481118A (en) 2010-06-09 2011-12-14 Syngenta Participations Ag Pesticidal mixtures comprising enantiomerically enriched isoxazoline derivatives
WO2011157654A1 (de) 2010-06-15 2011-12-22 Bayer Cropscience Ag Anthranilsäurediamid-derivate
DK178277B1 (da) 2010-06-18 2015-10-26 Novartis Tiergesundheit Ag Diaryloxazolinforbindelser til bekæmpelse af fiskelus
RU2013141413A (ru) * 2011-02-10 2015-03-20 Новартис Аг Производные изоксазолина для борьбы с беспозвоночными паразитами

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AU2012250979A1 (en) 2013-04-18
CL2013003125A1 (es) 2014-04-25
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RU2013152961A (ru) 2015-06-10
MX355996B (es) 2018-05-08
JP6101250B2 (ja) 2017-03-22
JP2014513122A (ja) 2014-05-29
PH12016500838A1 (en) 2016-09-26
DOP2013000251A (es) 2014-02-28
AU2015246181A1 (en) 2015-11-12
TW201247657A (en) 2012-12-01
EP2704712A4 (en) 2014-10-15
AR086113A1 (es) 2013-11-20
IL229081A0 (en) 2013-12-31
US9029409B2 (en) 2015-05-12
AU2012250979B2 (en) 2015-07-30
SG194696A1 (en) 2013-12-30
CA2834237A1 (en) 2012-11-08
CO6801765A2 (es) 2013-11-29
CN103764145A (zh) 2014-04-30
US20130023526A1 (en) 2013-01-24
MX2013012686A (es) 2013-12-02
ECSP13013026A (es) 2014-01-31
KR20140041512A (ko) 2014-04-04
GT201300267A (es) 2014-12-12
US20150297596A1 (en) 2015-10-22
UY34043A (es) 2012-10-31
MY163870A (en) 2017-10-31
WO2012151158A1 (en) 2012-11-08

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