CL2013003125A1 - Compuestos derivados de isoxazolinas inhibidores mps; composicion farmaceutica que los comprende; kit farmaceutico; y uso en el tratamiento de una enfermedad tales como osteoartritis, artritis reumatoide, artritis juvenil, artritis psoriasica, lupus eritematoso sistemico, entre otras. - Google Patents
Compuestos derivados de isoxazolinas inhibidores mps; composicion farmaceutica que los comprende; kit farmaceutico; y uso en el tratamiento de una enfermedad tales como osteoartritis, artritis reumatoide, artritis juvenil, artritis psoriasica, lupus eritematoso sistemico, entre otras.Info
- Publication number
- CL2013003125A1 CL2013003125A1 CL2013003125A CL2013003125A CL2013003125A1 CL 2013003125 A1 CL2013003125 A1 CL 2013003125A1 CL 2013003125 A CL2013003125 A CL 2013003125A CL 2013003125 A CL2013003125 A CL 2013003125A CL 2013003125 A1 CL2013003125 A1 CL 2013003125A1
- Authority
- CL
- Chile
- Prior art keywords
- arthritis
- isoxazolines
- mps
- osteoarthritis
- inhibitor
- Prior art date
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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JP (1) | JP6101250B2 (es) |
KR (1) | KR20140041512A (es) |
CN (1) | CN103764145A (es) |
AR (1) | AR086113A1 (es) |
AU (2) | AU2012250979B2 (es) |
CA (1) | CA2834237A1 (es) |
CL (1) | CL2013003125A1 (es) |
CO (1) | CO6801765A2 (es) |
CR (1) | CR20130597A (es) |
DO (1) | DOP2013000251A (es) |
EC (1) | ECSP13013026A (es) |
GT (1) | GT201300267A (es) |
IL (1) | IL229081A0 (es) |
MX (1) | MX355996B (es) |
MY (1) | MY163870A (es) |
PE (1) | PE20141190A1 (es) |
PH (1) | PH12016500838A1 (es) |
RU (1) | RU2013152961A (es) |
SG (1) | SG194696A1 (es) |
TW (1) | TW201247657A (es) |
UY (1) | UY34043A (es) |
WO (1) | WO2012151158A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9593126B2 (en) * | 2012-11-21 | 2017-03-14 | Zoetis Services Llc | Synthesis of spirocyclic isoxazoline derivatives |
EP3041838A1 (en) * | 2013-09-05 | 2016-07-13 | AbbVie Inc. | Diastereoselective methods for synthesizing isoxazole compounds |
EP3325465B1 (en) * | 2015-07-17 | 2022-05-18 | Syngenta Participations AG | Pesticidally active pyrazole derivatives |
EP3145168A1 (en) | 2015-09-17 | 2017-03-22 | Thomson Licensing | An apparatus and a method for generating data representing a pixel beam |
HUE061497T2 (hu) * | 2017-08-14 | 2023-07-28 | Boehringer Ingelheim Animal Health Usa Inc | Peszticid és paraziticid hatású pirazol-izoxazolin vegyületek |
WO2020048583A1 (en) * | 2018-09-04 | 2020-03-12 | F. Hoffmann-La Roche Ag | Benzothiazole compounds for the treatment of autoimmune diseases |
JP2024518377A (ja) | 2021-05-03 | 2024-05-01 | カトリック ユニヴェルシテット ルーヴェン | 薬剤耐性癲癇の治療 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
CO5170501A1 (es) | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
ECSP003448A (es) | 2000-04-27 | 2000-05-25 | Azoles sustituidos | |
EP1536790A2 (en) | 2002-08-09 | 2005-06-08 | AstraZeneca AB | Oxadiazoles as modulators of metabotropic glutamate receptor-5 |
US20040067985A1 (en) * | 2002-10-04 | 2004-04-08 | Fortuna Haviv | Method of inhibiting angiogenesis |
DE50309381D1 (de) | 2002-11-02 | 2008-04-24 | Sanofi Aventis Deutschland | Neue pyrimidin-4,6-dicarbons urediamide zur selektiven inhibierung von kollagenasen |
US7166609B2 (en) * | 2002-11-02 | 2007-01-23 | Sanofi-Aventis Deutschland Gmbh | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases |
AU2003301903A1 (en) * | 2002-11-06 | 2004-06-03 | Bristol-Myers Squibb Company | Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme |
US20050004111A1 (en) * | 2003-01-03 | 2005-01-06 | Aventis Pharma Deutschland Gmbh | Selective MMP-13 inhibitors |
EP1694655A2 (en) * | 2003-11-26 | 2006-08-30 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
BRPI0507373A (pt) | 2004-01-23 | 2007-07-10 | Amgen Inc | compostos e método de uso |
ES2526614T3 (es) * | 2004-03-05 | 2015-01-13 | Nissan Chemical Industries, Ltd. | Compuesto de benzamida sustituida con isoxazolina y agente de control de organismos nocivos |
DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
CA2595855C (en) * | 2005-01-25 | 2017-07-04 | Synta Pharmaceuticals Corp. | Pyrazine compounds for inflammation and immune-related uses |
CA2618340C (en) | 2005-08-15 | 2013-11-19 | F.Hoffmann-La Roche Ag | Piperidine and piperazine derivatives as p2x3 antagonists |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
US20090143410A1 (en) * | 2005-12-14 | 2009-06-04 | Kanu Maganbhai Patel | Isoxazolines for Controlling Invertebrate Pests |
CN101330828A (zh) * | 2005-12-14 | 2008-12-24 | 杜邦公司 | 用于防治无脊椎害虫的异噁唑啉 |
WO2007069773A1 (en) | 2005-12-15 | 2007-06-21 | Shionogi & Co., Ltd. | A pharmaceutical composition comprising an amide derivative |
US20070155739A1 (en) * | 2005-12-30 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Substituted bis-amide metalloprotease inhibitors |
TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
BRPI0710403A2 (pt) * | 2006-04-20 | 2011-08-09 | Du Pont | composto composição, composição de controle, de pulverização, de isca, dispositivo de armadilha, métodos de controle, métodos de proteção, semente tratada, composição de proteção |
TWI549692B (zh) | 2006-12-26 | 2016-09-21 | 藍瑟斯醫學影像公司 | 使心臟神經分布顯像之配位體 |
MX2009013469A (es) * | 2007-06-13 | 2010-01-20 | Du Pont | Insecticidas de isoxazolina. |
US20090035381A1 (en) | 2007-08-01 | 2009-02-05 | Stankus John J | Electrospraying method for fabrication of particles and coatings and treatment methods thereof |
EP2185537A1 (en) * | 2007-08-02 | 2010-05-19 | Pfizer Inc. | Pyrimidine and pyridine derivatives and their pharmaceutical use and compositions |
US8288393B2 (en) | 2007-08-10 | 2012-10-16 | Nippon Soda Co., Ltd. | Nitrogen-containing heterocyclic compound and pest control agent |
JP2010538872A (ja) | 2007-09-12 | 2010-12-16 | ユニヴァーシティ オブ ワシントン | 固体状態の気泡熱可塑性樹脂製品をブロー成形する方法 |
ES2553412T3 (es) | 2007-10-31 | 2015-12-09 | Merck Sharp & Dohme Corp. | Antagonistas del receptor P2X3 para el tratamiento del dolor |
TWI411395B (zh) | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
JP2009286773A (ja) | 2008-03-14 | 2009-12-10 | Bayer Cropscience Ag | 殺虫性縮環式アリール類 |
JP5301563B2 (ja) | 2008-05-01 | 2013-09-25 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター |
WO2009152133A1 (en) | 2008-06-10 | 2009-12-17 | Abbott Laboratories | Novel tricyclic compounds |
WO2010010187A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
WO2010020522A1 (en) * | 2008-08-22 | 2010-02-25 | Syngenta Participations Ag | Insecticidal compounds |
WO2010045191A2 (en) | 2008-10-13 | 2010-04-22 | Vuelogic, Llc | Methods and systems for customer performance scoring |
WO2010045190A1 (en) | 2008-10-15 | 2010-04-22 | Boehringer Ingelheim International Gmbh | Fused heteroaryl diamide compounds useful as mmp-13 inhibitors |
CA2741666C (en) | 2008-10-31 | 2017-04-11 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
MX2011006568A (es) * | 2008-12-19 | 2011-08-03 | Novartis Ag | Compuestos organicos. |
US20110288089A1 (en) * | 2009-01-22 | 2011-11-24 | Syngenta Crop Protection Llc | Insecticidal compounds |
WO2010112545A1 (en) | 2009-04-01 | 2010-10-07 | Basf Se | Isoxazoline compounds for combating invertebrate pests |
JP2012523405A (ja) | 2009-04-10 | 2012-10-04 | ファイザー・インク | 4,5−ジヒドロ−1h−ピラゾール化合物およびその薬学的使用 |
GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
FR2948939B1 (fr) | 2009-08-05 | 2013-03-22 | Pf Medicament | Derives de 2h pyridazin-3-ones, leur preparation et leur application en therapeutique humaine |
TWI487486B (zh) * | 2009-12-01 | 2015-06-11 | Syngenta Participations Ag | 以異唑啉衍生物為主之殺蟲化合物 |
GB2481118A (en) | 2010-06-09 | 2011-12-14 | Syngenta Participations Ag | Pesticidal mixtures comprising enantiomerically enriched isoxazoline derivatives |
CN103068813B (zh) * | 2010-06-15 | 2016-02-24 | 拜耳知识产权有限责任公司 | 邻氨基苯甲酸二酰胺衍生物 |
DK178277B1 (da) | 2010-06-18 | 2015-10-26 | Novartis Tiergesundheit Ag | Diaryloxazolinforbindelser til bekæmpelse af fiskelus |
AR085354A1 (es) | 2011-02-10 | 2013-09-25 | Novartis Ag | Derivados de isoxazol para control de pestes invertebrados |
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2012
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- 2012-04-27 UY UY34043A patent/UY34043A/es not_active Application Discontinuation
- 2012-04-30 JP JP2014509340A patent/JP6101250B2/ja not_active Expired - Fee Related
- 2012-04-30 EP EP12779959.1A patent/EP2704712A4/en not_active Withdrawn
- 2012-04-30 WO PCT/US2012/035832 patent/WO2012151158A1/en active Application Filing
- 2012-04-30 CN CN201280031389.5A patent/CN103764145A/zh active Pending
- 2012-04-30 PE PE2013002428A patent/PE20141190A1/es not_active Application Discontinuation
- 2012-04-30 SG SG2013080379A patent/SG194696A1/en unknown
- 2012-04-30 AU AU2012250979A patent/AU2012250979B2/en not_active Ceased
- 2012-04-30 CA CA 2834237 patent/CA2834237A1/en not_active Abandoned
- 2012-04-30 MY MYPI2013702036A patent/MY163870A/en unknown
- 2012-04-30 KR KR20137031865A patent/KR20140041512A/ko not_active Application Discontinuation
- 2012-04-30 RU RU2013152961/04A patent/RU2013152961A/ru not_active Application Discontinuation
- 2012-04-30 TW TW101115419A patent/TW201247657A/zh unknown
- 2012-04-30 MX MX2013012686A patent/MX355996B/es active IP Right Grant
- 2012-04-30 US US13/460,158 patent/US9029409B2/en active Active
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2013
- 2013-10-24 IL IL229081A patent/IL229081A0/en unknown
- 2013-10-29 DO DO2013000251A patent/DOP2013000251A/es unknown
- 2013-10-29 CL CL2013003125A patent/CL2013003125A1/es unknown
- 2013-10-30 GT GT201300267A patent/GT201300267A/es unknown
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- 2013-11-15 CR CR20130597A patent/CR20130597A/es unknown
- 2013-11-15 EC ECSP13013026 patent/ECSP13013026A/es unknown
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2015
- 2015-04-27 US US14/696,680 patent/US20150297596A1/en not_active Abandoned
- 2015-10-26 AU AU2015246181A patent/AU2015246181A1/en not_active Abandoned
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2016
- 2016-05-05 PH PH12016500838A patent/PH12016500838A1/en unknown
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UY34043A (es) | 2012-10-31 |
EP2704712A4 (en) | 2014-10-15 |
GT201300267A (es) | 2014-12-12 |
CO6801765A2 (es) | 2013-11-29 |
US20150297596A1 (en) | 2015-10-22 |
JP6101250B2 (ja) | 2017-03-22 |
MX355996B (es) | 2018-05-08 |
AU2015246181A1 (en) | 2015-11-12 |
EP2704712A1 (en) | 2014-03-12 |
DOP2013000251A (es) | 2014-02-28 |
CR20130597A (es) | 2014-02-24 |
TW201247657A (en) | 2012-12-01 |
AU2012250979A1 (en) | 2013-04-18 |
KR20140041512A (ko) | 2014-04-04 |
MY163870A (en) | 2017-10-31 |
PH12016500838A1 (en) | 2016-09-26 |
US20130023526A1 (en) | 2013-01-24 |
SG194696A1 (en) | 2013-12-30 |
MX2013012686A (es) | 2013-12-02 |
CA2834237A1 (en) | 2012-11-08 |
JP2014513122A (ja) | 2014-05-29 |
ECSP13013026A (es) | 2014-01-31 |
IL229081A0 (en) | 2013-12-31 |
WO2012151158A1 (en) | 2012-11-08 |
AR086113A1 (es) | 2013-11-20 |
PE20141190A1 (es) | 2014-10-12 |
RU2013152961A (ru) | 2015-06-10 |
US9029409B2 (en) | 2015-05-12 |
AU2012250979B2 (en) | 2015-07-30 |
CN103764145A (zh) | 2014-04-30 |
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