MX368078B - Sintesis de derivados de isoxazolina espirociclicos. - Google Patents

Sintesis de derivados de isoxazolina espirociclicos.

Info

Publication number
MX368078B
MX368078B MX2015006458A MX2015006458A MX368078B MX 368078 B MX368078 B MX 368078B MX 2015006458 A MX2015006458 A MX 2015006458A MX 2015006458 A MX2015006458 A MX 2015006458A MX 368078 B MX368078 B MX 368078B
Authority
MX
Mexico
Prior art keywords
synthesis
isoxazoline derivatives
spirocyclic isoxazoline
spirocyclic
derivatives
Prior art date
Application number
MX2015006458A
Other languages
English (en)
Other versions
MX2015006458A (es
Inventor
Sean D W Greenwood
Timothy L Stuk
Original Assignee
Zoetis Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Llc filed Critical Zoetis Llc
Publication of MX2015006458A publication Critical patent/MX2015006458A/es
Publication of MX368078B publication Critical patent/MX368078B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención indica un procedimiento mejorado de preparación de derivados de isoxazolina espirocíclicos de Fórmula (I) (ver Fórmula) en la que "*", R1a, R1b y R1c son tal como se describen en el presente documento.
MX2015006458A 2012-11-21 2013-11-20 Sintesis de derivados de isoxazolina espirociclicos. MX368078B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261729022P 2012-11-21 2012-11-21
PCT/US2013/070959 WO2014081800A1 (en) 2012-11-21 2013-11-20 Synthesis of spirocyclic isoxazoline derivatives

Publications (2)

Publication Number Publication Date
MX2015006458A MX2015006458A (es) 2015-08-14
MX368078B true MX368078B (es) 2019-09-17

Family

ID=49753486

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015006458A MX368078B (es) 2012-11-21 2013-11-20 Sintesis de derivados de isoxazolina espirociclicos.

Country Status (11)

Country Link
US (1) US9593126B2 (es)
EP (2) EP4056572A1 (es)
JP (1) JP6234471B2 (es)
CN (1) CN104918944B (es)
AU (1) AU2013348091B2 (es)
BR (1) BR112015011740B1 (es)
CA (1) CA2892344C (es)
ES (1) ES2916805T3 (es)
MX (1) MX368078B (es)
PL (1) PL2922854T3 (es)
WO (1) WO2014081800A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014039489A1 (en) * 2012-09-07 2014-03-13 Zoetis Llc Spirocyclic derivatives as antiparasitic agents
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2017153217A1 (en) 2016-03-09 2017-09-14 Basf Se Spirocyclic derivatives
AR108184A1 (es) 2016-04-06 2018-07-25 Merial Inc Proceso para preparar compuestos de isoxazolina
WO2017201134A1 (en) * 2016-05-20 2017-11-23 Avista Pharma Solutions, Inc. Synthetic process and novel intermediates
WO2018071535A1 (en) 2016-10-14 2018-04-19 Merial, Inc. Pesticidal and parasiticidal vinyl isoxazoline compounds
WO2018162312A1 (en) * 2017-03-10 2018-09-13 Basf Se Spirocyclic derivatives
HUE061497T2 (hu) 2017-08-14 2023-07-28 Boehringer Ingelheim Animal Health Usa Inc Peszticid és paraziticid hatású pirazol-izoxazolin vegyületek
CA3118033A1 (en) * 2018-11-06 2020-05-14 Basf Se Process for preparation of optically enriched isoxazolines
CN116194450A (zh) 2020-07-24 2023-05-30 礼蓝美国公司 用于制备异噁唑啉化合物及其中间体的工艺
CN113548989A (zh) * 2021-07-14 2021-10-26 浙江倍合德制药有限公司 一种4-硝基苯基-2-甲磺酰基乙酸酯的制备工艺及其生产线
CA3224701A1 (en) 2021-08-11 2023-02-16 Jingdan Hu Process for making diaryl isoxazoline derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091432A (en) * 1990-03-28 1992-02-25 Glasky Alvin J 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use
WO2004113347A1 (en) * 2003-06-20 2004-12-29 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
EP2601190B1 (en) 2010-08-05 2018-07-04 Zoetis Services LLC Isoxazoline derivatives as antiparasitic agents
RS54860B1 (sr) * 2011-03-10 2016-10-31 Zoetis Services Llc Spirociklični derivati izoksazolina kao antiparazitska sredstva
US9167013B2 (en) * 2011-03-10 2015-10-20 Telefonaktiebolaget L M Ericsson (Publ) Method and apparatus for prioritizing media within an electronic conference according to utilization settings at respective conference participants
AR086113A1 (es) * 2011-04-30 2013-11-20 Abbott Lab Isoxazolinas como agentes terapeuticos
TWM424868U (en) 2011-09-02 2012-03-21 yi-zhen Huang Baby walker

Also Published As

Publication number Publication date
JP2016500106A (ja) 2016-01-07
WO2014081800A1 (en) 2014-05-30
PL2922854T3 (pl) 2022-07-18
CN104918944A (zh) 2015-09-16
JP6234471B2 (ja) 2017-11-22
MX2015006458A (es) 2015-08-14
BR112015011740A2 (pt) 2017-07-11
BR112015011740B1 (pt) 2020-04-14
CA2892344A1 (en) 2014-05-30
AU2013348091B2 (en) 2017-04-13
AU2013348091A1 (en) 2015-06-04
ES2916805T3 (es) 2022-07-06
CN104918944B (zh) 2017-05-10
US20150291612A1 (en) 2015-10-15
US9593126B2 (en) 2017-03-14
EP4056572A1 (en) 2022-09-14
EP2922854A1 (en) 2015-09-30
EP2922854B1 (en) 2022-05-04
AU2013348091A8 (en) 2015-07-09
CA2892344C (en) 2017-06-06

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