CO6670591A2 - Derivados de 6- cicloalquil -1-5 dihidro-pirazol(3.4-d)pirimidin -4-onas y sus uso como inhibidores de pde9a - Google Patents

Derivados de 6- cicloalquil -1-5 dihidro-pirazol(3.4-d)pirimidin -4-onas y sus uso como inhibidores de pde9a

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Publication number
CO6670591A2
CO6670591A2 CO13028601A CO13028601A CO6670591A2 CO 6670591 A2 CO6670591 A2 CO 6670591A2 CO 13028601 A CO13028601 A CO 13028601A CO 13028601 A CO13028601 A CO 13028601A CO 6670591 A2 CO6670591 A2 CO 6670591A2
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CO
Colombia
Prior art keywords
medicaments
cycloalkyl
pde9a
pyrimidin
pyrazole
Prior art date
Application number
CO13028601A
Other languages
English (en)
Inventor
Niklas Heine
Christian Eickmeier
Marco Ferrara
Riccardo Giovannini
Holger Rosenbrock
Gerhard Schaenzle
Original Assignee
Boehringer Ingelheim Int
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Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CO6670591A2 publication Critical patent/CO6670591A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Diabetes (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
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  • Psychology (AREA)
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  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
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  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

La invención se refiere a nuevas 6-cicloalquil-pirazolopirimidinonas según la fórmula (I).en donde R’ es un grupo heteroarilo aromático de 5 o 6 eslabones, R2 es un sustituyente opcional, D es ciclopentilo, ciclohexilo, tetrahidrofuranilo, tetrahidropiranilo o 2-, 3- o 4- piridilo, opcionalmente sustituidos, m = 1 o 2 y n es 0, 1 o 2. Los nuevos compuestos son para usar como la entidad activa de medicamentos o para la fabricación de medicamentos respectivamente, en particular medicamentos para el tratamiento de estados relacionados con déficits en la percepción, concentración, aprendizaje o memoria. Tales estados pueden por ejemplo estar asociados con la enfermedad de Alzheimer, esquizofrenia y otras enfermedades. Los nuevos compuestos son también por ejemplo para la fabricación de medicamentos y/o para uso en el tratamiento de estas enfermedades, en particular para el impedimento cognitivo asociado con dicha enfermedad. El compuesto de la invención muestra propiedades inhibitorias de PDE9.
CO13028601A 2010-08-12 2013-02-12 Derivados de 6- cicloalquil -1-5 dihidro-pirazol(3.4-d)pirimidin -4-onas y sus uso como inhibidores de pde9a CO6670591A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10172597 2010-08-12
EP11154397 2011-02-14

Publications (1)

Publication Number Publication Date
CO6670591A2 true CO6670591A2 (es) 2013-05-15

Family

ID=45567392

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13028601A CO6670591A2 (es) 2010-08-12 2013-02-12 Derivados de 6- cicloalquil -1-5 dihidro-pirazol(3.4-d)pirimidin -4-onas y sus uso como inhibidores de pde9a

Country Status (30)

Country Link
US (2) US8912201B2 (es)
EP (2) EP3053924A1 (es)
JP (1) JP5756176B2 (es)
KR (1) KR101918909B1 (es)
CN (2) CN105541849B (es)
AP (1) AP2012006631A0 (es)
AR (1) AR082667A1 (es)
AU (1) AU2011288503C1 (es)
BR (1) BR112013003097B1 (es)
CA (1) CA2807687C (es)
CL (1) CL2013000368A1 (es)
CO (1) CO6670591A2 (es)
DK (1) DK2603511T3 (es)
EA (1) EA024984B1 (es)
ES (1) ES2626006T3 (es)
GE (1) GEP20156217B (es)
HK (1) HK1178539A1 (es)
HU (1) HUE033378T2 (es)
IL (1) IL223347A (es)
MX (1) MX344770B (es)
MY (1) MY170189A (es)
NZ (1) NZ603725A (es)
PE (1) PE20130602A1 (es)
PL (1) PL2603511T3 (es)
SG (1) SG187081A1 (es)
TN (1) TN2013000051A1 (es)
TW (1) TWI510490B (es)
UA (1) UA110347C2 (es)
UY (1) UY33556A (es)
WO (1) WO2012020022A1 (es)

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