MX2019007803A - Compuestos de pirazolopirimidinona sustituida como inhibidores de fosfodiesterasas 2 (pde2). - Google Patents

Compuestos de pirazolopirimidinona sustituida como inhibidores de fosfodiesterasas 2 (pde2).

Info

Publication number
MX2019007803A
MX2019007803A MX2019007803A MX2019007803A MX2019007803A MX 2019007803 A MX2019007803 A MX 2019007803A MX 2019007803 A MX2019007803 A MX 2019007803A MX 2019007803 A MX2019007803 A MX 2019007803A MX 2019007803 A MX2019007803 A MX 2019007803A
Authority
MX
Mexico
Prior art keywords
disorders
treating
cognitive
methods
pde2 inhibitors
Prior art date
Application number
MX2019007803A
Other languages
English (en)
Inventor
Gomez Laurent
Francois Vernier William
Original Assignee
Dart Neuroscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dart Neuroscience Llc filed Critical Dart Neuroscience Llc
Publication of MX2019007803A publication Critical patent/MX2019007803A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Una entidad química de la fórmula (I): (ver fórmula) en donde V, W, Y, y Z, tiene cualquiera de los valores descritos en la presente, y composiciones que comprenden estas entidades químicas; métodos para elaborarlas; y su uso en una amplia variedad de método, que incluyen estudios cinéticos metabólicos y de reacción; detección y técnicas de imagenología; tratamientos radioactivos; modulación y tratamiento de trastornos mediados por actividad de PDE2; tratamiento de trastornos neurológicos, trastornos CNS, demencia, trastornos cognitivos, trastornos neurodegenerativos, y pérdidas de función por trauma; aumento de la eficiencia de entrenamiento cognitivo y motriz, que incluye rehabilitación de apoplejía o TBI; y tratamiento de trastornos periféricos, que incluyen trastornos hematológicos, cardiovasculares, gastroenterológicos, dermatológicos, inflamatorios y dolor.
MX2019007803A 2016-12-28 2017-12-22 Compuestos de pirazolopirimidinona sustituida como inhibidores de fosfodiesterasas 2 (pde2). MX2019007803A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662439823P 2016-12-28 2016-12-28
PCT/US2017/068229 WO2018125810A1 (en) 2016-12-28 2017-12-22 Substituted pyrazolopyrimidinone compounds as pde2 inhibitors

Publications (1)

Publication Number Publication Date
MX2019007803A true MX2019007803A (es) 2019-08-29

Family

ID=60991640

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007803A MX2019007803A (es) 2016-12-28 2017-12-22 Compuestos de pirazolopirimidinona sustituida como inhibidores de fosfodiesterasas 2 (pde2).

Country Status (9)

Country Link
US (2) US10981916B2 (es)
EP (1) EP3562828A1 (es)
JP (1) JP7111720B2 (es)
KR (1) KR102590848B1 (es)
CN (1) CN110337437B (es)
AU (1) AU2017388054B2 (es)
CA (1) CA3047408A1 (es)
MX (1) MX2019007803A (es)
WO (1) WO2018125810A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110337437B (zh) 2016-12-28 2023-02-03 达特神经科学有限公司 作为pde2抑制剂的取代的吡唑并嘧啶酮化合物
JP7254078B2 (ja) 2017-11-27 2023-04-07 ダート・ニューロサイエンス・エルエルシー Ｐｄｅ１阻害剤としての置換フラノピリミジン化合物

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Also Published As

Publication number Publication date
AU2017388054B2 (en) 2022-03-24
JP2020503333A (ja) 2020-01-30
EP3562828A1 (en) 2019-11-06
AU2017388054A1 (en) 2019-07-04
KR20190097258A (ko) 2019-08-20
US11999738B2 (en) 2024-06-04
CA3047408A1 (en) 2018-07-05
CN110337437A (zh) 2019-10-15
CN110337437B (zh) 2023-02-03
US20200148685A1 (en) 2020-05-14
JP7111720B2 (ja) 2022-08-02
US10981916B2 (en) 2021-04-20
US20210340145A1 (en) 2021-11-04
KR102590848B1 (ko) 2023-10-19
WO2018125810A1 (en) 2018-07-05

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