CO6430439A2 - Agonistas del receptor de esfingosina -1- fosfato - Google Patents
Agonistas del receptor de esfingosina -1- fosfatoInfo
- Publication number
- CO6430439A2 CO6430439A2 CO12027713A CO12027713A CO6430439A2 CO 6430439 A2 CO6430439 A2 CO 6430439A2 CO 12027713 A CO12027713 A CO 12027713A CO 12027713 A CO12027713 A CO 12027713A CO 6430439 A2 CO6430439 A2 CO 6430439A2
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- phosphate
- receptor agonists
- disclosed
- diseases
- Prior art date
Links
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 title 1
- WWUZIQQURGPMPG-BXDGKWANSA-N (2R,3S,4Z)-2-aminooctadec-4-ene-1,3-diol Chemical compound CCCCCCCCCCCCC\C=C/[C@H](O)[C@H](N)CO WWUZIQQURGPMPG-BXDGKWANSA-N 0.000 title 1
- 229910019142 PO4 Inorganic materials 0.000 title 1
- 239000010452 phosphate Substances 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108091006027 G proteins Proteins 0.000 abstract 1
- 102000030782 GTP binding Human genes 0.000 abstract 1
- 108091000058 GTP-Binding Proteins 0.000 abstract 1
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23205409P | 2009-08-07 | 2009-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6430439A2 true CO6430439A2 (es) | 2012-04-30 |
Family
ID=43029859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO12027713A CO6430439A2 (es) | 2009-08-07 | 2012-02-16 | Agonistas del receptor de esfingosina -1- fosfato |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8399451B2 (https=) |
| EP (1) | EP2462139B1 (https=) |
| JP (1) | JP5602230B2 (https=) |
| KR (1) | KR20120108963A (https=) |
| CN (1) | CN102548989A (https=) |
| AR (1) | AR077819A1 (https=) |
| AU (1) | AU2010279354A1 (https=) |
| BR (1) | BR112012002824A2 (https=) |
| CA (1) | CA2770194A1 (https=) |
| CL (1) | CL2012000326A1 (https=) |
| CO (1) | CO6430439A2 (https=) |
| EA (1) | EA201270266A1 (https=) |
| ES (1) | ES2533095T3 (https=) |
| MX (1) | MX2012001160A (https=) |
| PE (1) | PE20120732A1 (https=) |
| SG (1) | SG177691A1 (https=) |
| TW (1) | TW201109323A (https=) |
| WO (1) | WO2011017578A1 (https=) |
| ZA (1) | ZA201200641B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2079734A1 (en) * | 2006-10-25 | 2009-07-22 | NeuroSearch A/S | Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators |
| WO2011133734A1 (en) * | 2010-04-23 | 2011-10-27 | Bristol-Myers Squibb Company | 4 - (5 - isoxazolyl or 5 - pyrrazolyl -1,2,4- oxadiazol - 3 - yl) -mandelic acid amides as sphingosin- 1 - phosphate 1 rreceptor agonists |
| JP5788507B2 (ja) | 2010-07-20 | 2015-09-30 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 置換３−フェニル−１，２，４−オキサジアゾール化合物 |
| EP2619190B1 (en) | 2010-09-24 | 2015-08-12 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds and their use as s1p1 agonists |
| WO2012061459A1 (en) | 2010-11-03 | 2012-05-10 | Bristol-Myers Squibb Company | Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases |
| TWI613182B (zh) | 2013-02-21 | 2018-02-01 | 必治妥美雅史谷比公司 | 雙環化合物 |
| TWI689487B (zh) | 2014-08-20 | 2020-04-01 | 美商必治妥美雅史谷比公司 | 經取代雙環化合物 |
| PY1974248A (es) * | 2018-09-13 | 2020-08-21 | Syngenta Participations Ag | Compuestos de azol-amida pesticidamente activos |
| CN114181276A (zh) * | 2021-12-17 | 2022-03-15 | 安徽大学 | 硫酯肽合成方法 |
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| ATE448193T1 (de) * | 2002-01-18 | 2009-11-15 | Merck & Co Inc | ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATE, PHOSPHONATE UND TETRAZOLE ALS EDG REZEPTORAGONISTENß |
| US20050070506A1 (en) * | 2002-01-18 | 2005-03-31 | Doherty George A. | Selective s1p1/edg1 receptor agonists |
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| SI2291080T1 (sl) | 2008-05-14 | 2015-11-30 | The Scripps Research Institute | Novi modulatorji sfingosinskih fosfatnih receptorjev |
| WO2010041655A1 (ja) | 2008-10-06 | 2010-04-15 | 昭和電工株式会社 | 触媒およびその製造方法ならびにその用途 |
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| EP2210890A1 (en) | 2009-01-19 | 2010-07-28 | Almirall, S.A. | Oxadiazole derivatives as S1P1 receptor agonists |
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| JP2012515787A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | 自己免疫疾患および炎症性疾患の処置におけるｓ１ｐアゴニストとしての置換オキサジアゾール誘導体 |
| EP2389377B1 (en) | 2009-01-23 | 2014-07-16 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
| JP5669363B2 (ja) | 2009-03-31 | 2015-02-12 | 昭和電工株式会社 | 樹脂組成物及びこれで処理された紙又は繊維加工品 |
| WO2010113528A1 (en) | 2009-04-03 | 2010-10-07 | Panasonic Corporation | Mobile communication method, mobile communication system, and corresponding apparatus |
-
2010
- 2010-08-05 US US12/850,892 patent/US8399451B2/en active Active
- 2010-08-06 AU AU2010279354A patent/AU2010279354A1/en not_active Abandoned
- 2010-08-06 SG SG2012003430A patent/SG177691A1/en unknown
- 2010-08-06 PE PE2012000174A patent/PE20120732A1/es not_active Application Discontinuation
- 2010-08-06 WO PCT/US2010/044627 patent/WO2011017578A1/en not_active Ceased
- 2010-08-06 MX MX2012001160A patent/MX2012001160A/es not_active Application Discontinuation
- 2010-08-06 JP JP2012523967A patent/JP5602230B2/ja not_active Expired - Fee Related
- 2010-08-06 AR ARP100102904A patent/AR077819A1/es not_active Application Discontinuation
- 2010-08-06 TW TW099126390A patent/TW201109323A/zh unknown
- 2010-08-06 CN CN2010800453726A patent/CN102548989A/zh active Pending
- 2010-08-06 CA CA2770194A patent/CA2770194A1/en not_active Abandoned
- 2010-08-06 KR KR1020127005901A patent/KR20120108963A/ko not_active Withdrawn
- 2010-08-06 BR BR112012002824A patent/BR112012002824A2/pt not_active IP Right Cessation
- 2010-08-06 EP EP10742067.1A patent/EP2462139B1/en not_active Not-in-force
- 2010-08-06 EA EA201270266A patent/EA201270266A1/ru unknown
- 2010-08-06 ES ES10742067.1T patent/ES2533095T3/es active Active
-
2012
- 2012-01-24 ZA ZA2012/00641A patent/ZA201200641B/en unknown
- 2012-02-07 CL CL2012000326A patent/CL2012000326A1/es unknown
- 2012-02-16 CO CO12027713A patent/CO6430439A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US8399451B2 (en) | 2013-03-19 |
| PE20120732A1 (es) | 2012-06-20 |
| AU2010279354A1 (en) | 2012-02-09 |
| JP5602230B2 (ja) | 2014-10-08 |
| TW201109323A (en) | 2011-03-16 |
| CN102548989A (zh) | 2012-07-04 |
| ZA201200641B (en) | 2013-06-26 |
| CA2770194A1 (en) | 2011-02-10 |
| AR077819A1 (es) | 2011-09-28 |
| CL2012000326A1 (es) | 2012-10-19 |
| JP2013501729A (ja) | 2013-01-17 |
| ES2533095T3 (es) | 2015-04-07 |
| WO2011017578A1 (en) | 2011-02-10 |
| EP2462139A1 (en) | 2012-06-13 |
| BR112012002824A2 (pt) | 2019-09-24 |
| EA201270266A1 (ru) | 2012-07-30 |
| US20110190255A1 (en) | 2011-08-04 |
| SG177691A1 (en) | 2012-02-28 |
| EP2462139B1 (en) | 2015-01-14 |
| MX2012001160A (es) | 2012-02-13 |
| KR20120108963A (ko) | 2012-10-05 |
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