EA201991316A1 - Конъюгаты, содержащие двойной агонист glp-1/глюкагона, линкер и гиалуроновую кислоту - Google Patents

Конъюгаты, содержащие двойной агонист glp-1/глюкагона, линкер и гиалуроновую кислоту

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EA201991316A1
EA201991316A1 EA201991316A EA201991316A EA201991316A1 EA 201991316 A1 EA201991316 A1 EA 201991316A1 EA 201991316 A EA201991316 A EA 201991316A EA 201991316 A EA201991316 A EA 201991316A EA 201991316 A1 EA201991316 A1 EA 201991316A1
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Prior art keywords
glp
linker
receptor agonist
glucagon receptor
hyaluronic acid
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EA201991316A
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English (en)
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    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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Abstract

Настоящее изобретение относится к конъюгату или его фармацевтически приемлемой соли, содержащим агонист рецептора GLP-1/глюкагона, линкер и гидрогель на основе гиалуроновой кислоты, несущей группы -L-L-L-Y-R, где Y представляет собой фрагмент агониста рецептора GLP-1/глюкагона; и при этом -L представляет собой линкерный фрагмент формулы (Ia)где пунктирная линия указывает на присоединение к одной из аминогрупп фрагмента агониста рецептора GLP-1/глюкагона посредством образования амидной связи. Настоящее изобретение дополнительно относится к фармацевтическим композициям, содержащим указанные конъюгаты, а также к их применению в качестве лекарственного препарата для лечения или предупреждения заболеваний или нарушений, которые можно лечить с помощью агониста рецептора GLP-1/глюкагона.
EA201991316A 2016-12-02 2017-12-01 Конъюгаты, содержащие двойной агонист glp-1/глюкагона, линкер и гиалуроновую кислоту EA201991316A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16306613 2016-12-02
PCT/EP2017/081217 WO2018100174A1 (en) 2016-12-02 2017-12-01 Conjugates comprising an glp-1/glucagon dual agonist, a linker and hyaluronic acid

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EA201991316A1 true EA201991316A1 (ru) 2019-10-31

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EA201991316A EA201991316A1 (ru) 2016-12-02 2017-12-01 Конъюгаты, содержащие двойной агонист glp-1/глюкагона, линкер и гиалуроновую кислоту

Country Status (23)

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US (2) US10792367B2 (ru)
EP (1) EP3548090A1 (ru)
JP (1) JP2020503278A (ru)
KR (1) KR20190091482A (ru)
CN (1) CN110022902A (ru)
AR (1) AR110299A1 (ru)
AU (1) AU2017369723A1 (ru)
BR (1) BR112019011139A8 (ru)
CA (1) CA3045483A1 (ru)
CL (1) CL2019001466A1 (ru)
CO (1) CO2019006912A2 (ru)
CR (1) CR20190312A (ru)
DO (1) DOP2019000038A (ru)
EA (1) EA201991316A1 (ru)
EC (1) ECSP19046865A (ru)
IL (1) IL266973A (ru)
MA (1) MA46996A (ru)
MX (1) MX2019006432A (ru)
PE (1) PE20191472A1 (ru)
PH (1) PH12019501215A1 (ru)
TW (1) TW201832783A (ru)
UY (1) UY37505A (ru)
WO (1) WO2018100174A1 (ru)

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