MA46996A - Conjugués comprenant un agoniste double de glp-1/glucagon, un lieur et de l'acide hyaluronique - Google Patents
Conjugués comprenant un agoniste double de glp-1/glucagon, un lieur et de l'acide hyaluroniqueInfo
- Publication number
- MA46996A MA46996A MA046996A MA46996A MA46996A MA 46996 A MA46996 A MA 46996A MA 046996 A MA046996 A MA 046996A MA 46996 A MA46996 A MA 46996A MA 46996 A MA46996 A MA 46996A
- Authority
- MA
- Morocco
- Prior art keywords
- lieur
- hyaluronic acid
- including double
- glucagon agonist
- conjugates including
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16306613 | 2016-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA46996A true MA46996A (fr) | 2019-10-09 |
Family
ID=57542941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA046996A MA46996A (fr) | 2016-12-02 | 2017-12-01 | Conjugués comprenant un agoniste double de glp-1/glucagon, un lieur et de l'acide hyaluronique |
Country Status (23)
Country | Link |
---|---|
US (2) | US10792367B2 (fr) |
EP (1) | EP3548090A1 (fr) |
JP (1) | JP2020503278A (fr) |
KR (1) | KR20190091482A (fr) |
CN (1) | CN110022902A (fr) |
AR (1) | AR110299A1 (fr) |
AU (1) | AU2017369723A1 (fr) |
BR (1) | BR112019011139A8 (fr) |
CA (1) | CA3045483A1 (fr) |
CL (1) | CL2019001466A1 (fr) |
CO (1) | CO2019006912A2 (fr) |
CR (1) | CR20190312A (fr) |
DO (1) | DOP2019000038A (fr) |
EA (1) | EA201991316A1 (fr) |
EC (1) | ECSP19046865A (fr) |
IL (1) | IL266973A (fr) |
MA (1) | MA46996A (fr) |
MX (1) | MX2019006432A (fr) |
PE (1) | PE20191472A1 (fr) |
PH (1) | PH12019501215A1 (fr) |
TW (1) | TW201832783A (fr) |
UY (1) | UY37505A (fr) |
WO (1) | WO2018100174A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
CN109069659B (zh) | 2016-03-01 | 2022-04-19 | 阿森迪斯药物骨疾病股份有限公司 | Pth前药 |
IL265591B2 (en) | 2016-09-29 | 2023-12-01 | Ascendis Pharma Bone Diseases As | Dosing regimen for a controlled-release PTH compound |
KR20230170810A (ko) | 2016-09-29 | 2023-12-19 | 아센디스 파마 본 디지즈 에이/에스 | 낮은 피크 대 트로프 비를 가진 pth 화합물 |
AR110299A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico |
IL269506B2 (en) | 2017-03-22 | 2024-04-01 | Genentech Inc | Hyaluronic acid cross-linked hydrogel preparations and methods |
RU2020109881A (ru) | 2017-08-09 | 2021-09-10 | Санофи | Агонисты рецепторов glp-1/глюкагона в лечении жировой болезни печени и стеатогепатита |
TW202015735A (zh) | 2018-05-30 | 2020-05-01 | 法商賽諾菲公司 | 包含glp-1/升糖素/gip三重受體促效劑、連接子及透明質酸之接合物 |
FR3084586B1 (fr) * | 2018-08-03 | 2020-11-06 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un compose amphiphile porteur de radicaux hydrophobes |
KR20230005289A (ko) | 2020-04-24 | 2023-01-09 | 베링거 인겔하임 인터내셔날 게엠베하 | 지방 간 질환 및 지방간염의 치료에서 장시간-작용성 glp-1/글루카곤 수용체 작용제로서 글루카곤 유사체 |
KR102225971B1 (ko) * | 2020-05-19 | 2021-03-10 | 주식회사 차메디텍 | 펩타이드 가교제를 이용한 히알루론산 기반의 하이드로겔 및 이의 제조 방법 |
JP2024529452A (ja) | 2021-07-30 | 2024-08-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 長時間作用型glp1/グルカゴン受容体アゴニストのための投薬レジメン |
CN114470170B (zh) * | 2022-02-22 | 2023-09-19 | 广州新济药业科技有限公司 | 一种司美格鲁肽可溶性微针组合物及其制备方法 |
WO2024165571A2 (fr) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibiteurs d'expression et/ou de fonction |
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EP1701981B1 (fr) * | 2003-12-30 | 2017-06-07 | Genzyme Corporation | Gels cohesifs de hyaluronane et/ou hylane reticules, leur preparation et utilisation |
US8143391B2 (en) * | 2004-09-07 | 2012-03-27 | Chugai Seiyaku Kabushiki Kaisha | Process for producing water-soluble hyaluronic acid modification |
CN102772787A (zh) | 2004-11-12 | 2012-11-14 | 诺和诺德公司 | 促胰岛素肽的稳定制剂 |
PT1817347T (pt) * | 2004-11-24 | 2017-07-21 | Albumedix As | Resumo |
PT1891105E (pt) | 2005-06-13 | 2012-06-27 | Imp Innovations Ltd | Análogos de oxintomodulina e seus efeitos sobre o comportamento da alimentação |
CA2628241C (fr) | 2005-11-07 | 2016-02-02 | Indiana University Research And Technology Corporation | Analogues de glucagon a solubilite et a stabilite physiologiques ameliorees |
TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
AU2008216265B2 (en) | 2007-02-15 | 2014-04-03 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
EP2164519A2 (fr) | 2007-06-08 | 2010-03-24 | Ascendis Pharma AS | Prodrogues polymériques d'exendin de longue durée d'action |
DK2158214T3 (da) | 2007-06-15 | 2011-12-05 | Zealand Pharma As | Glukagonanaloger |
EP2217701B9 (fr) | 2007-10-30 | 2015-02-18 | Indiana University Research and Technology Corporation | Antagonistes du glucagon |
SI2237799T1 (sl) | 2008-02-01 | 2019-07-31 | Ascendis Pharma A/S | Predzdravilo, ki obsega samo-cepljiv linker |
PT2279007T (pt) | 2008-04-29 | 2016-08-23 | Ascendis Pharma Growth Disorders Div As | Compostos recombinantes e peguilados da hormona de crescimento humana |
EP2676673B1 (fr) | 2008-06-17 | 2016-11-16 | Indiana University Research and Technology Corporation | Co-agonists du récepteur du glucagon/glp-1 |
BR122013025625B1 (pt) | 2008-10-17 | 2021-08-03 | Sanofi-Aventis Deutschland Gmbh | Composição farmacêutica, seu uso e método de preparação da mesma, kit e dispositivo |
CA2747197A1 (fr) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Analogues du glucagon |
CA2747112A1 (fr) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Analogues du glucagon |
KR20150116912A (ko) | 2008-12-15 | 2015-10-16 | 질랜드 파마 에이/에스 | 글루카곤 유사체 |
BRPI0823379A2 (pt) | 2008-12-15 | 2015-07-14 | Zealand Pharma As | Análogos de glucagon |
WO2010096052A1 (fr) | 2009-02-19 | 2010-08-26 | Merck Sharp & Dohme Corp. | Analogues d'oxyntomoduline |
CA2767792A1 (fr) | 2009-07-13 | 2011-01-20 | Zealand Pharma A/S | Analogues acyles du glucagon |
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SI2498801T1 (en) | 2009-11-13 | 2018-06-29 | Sanofi-Aventis Deutschland Gmbh | A pharmaceutical composition containing desPro36Exendin-4 (1-39) -Lys6-NH2 and methionine |
FR2952695B1 (fr) | 2009-11-13 | 2012-03-30 | Commissariat Energie Atomique | Reservoir de stockage d'hydrogene a hydrures metalliques |
WO2011075393A2 (fr) | 2009-12-18 | 2011-06-23 | Indiana University Research And Technology Corporation | Co-agonistes du récepteur du glucagon/glp-i |
JO2976B1 (en) | 2009-12-22 | 2016-03-15 | ايلي ليلي اند كومباني | Axentomodulin polypeptide |
AR079344A1 (es) | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad |
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AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
EP2578726B1 (fr) | 2010-05-31 | 2018-10-17 | JTEKT Corporation | Procédé de fabrication d'un élément revêtu |
JP5702376B2 (ja) | 2010-06-01 | 2015-04-15 | 本田技研工業株式会社 | Dc/dcコンバータの制御装置 |
UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
EP2438930A1 (fr) * | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Promédicaments comprenant un conjugué de liaison d'exendine |
SG10201605006XA (en) | 2011-06-17 | 2016-08-30 | Hanmi Science Co Ltd | A conjugate comprising oxyntomodulin and an immunoglobulin fragment, and use thereof |
AU2013284286A1 (en) | 2012-06-29 | 2015-02-05 | University Of South Australia | Fluid connection ports |
UA116217C2 (uk) * | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
CN104902919B (zh) | 2012-12-21 | 2018-11-20 | 赛诺菲 | Glp1/gip双重激动剂或glp1/gip/胰高血糖素三重激动剂 |
EA035688B1 (ru) | 2013-11-06 | 2020-07-27 | Зилэнд Фарма А/С | Соединения, которые представляют собой тройные агонисты глюкагона, glp-1 и gip |
EP3080151A1 (fr) * | 2013-12-13 | 2016-10-19 | Sanofi | Analogues peptidiques de l'exendine 4 |
WO2015086731A1 (fr) | 2013-12-13 | 2015-06-18 | Sanofi | Analogues peptidiques de l'exendine-4 en tant qu'agonistes mixtes des récepteurs glp-1/glucagon |
WO2015086733A1 (fr) | 2013-12-13 | 2015-06-18 | Sanofi | Agonistes mixtes des récepteurs du glp-1/glucagon |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
US10188759B2 (en) * | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
AR105319A1 (es) * | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
AR110299A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico |
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2017
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- 2017-11-30 TW TW106141763A patent/TW201832783A/zh unknown
- 2017-12-01 EP EP17822168.5A patent/EP3548090A1/fr active Pending
- 2017-12-01 CA CA3045483A patent/CA3045483A1/fr not_active Abandoned
- 2017-12-01 PE PE2019001081A patent/PE20191472A1/es unknown
- 2017-12-01 KR KR1020197018576A patent/KR20190091482A/ko active Search and Examination
- 2017-12-01 UY UY0001037505A patent/UY37505A/es not_active Application Discontinuation
- 2017-12-01 WO PCT/EP2017/081217 patent/WO2018100174A1/fr unknown
- 2017-12-01 JP JP2019529643A patent/JP2020503278A/ja not_active Abandoned
- 2017-12-01 CN CN201780074647.0A patent/CN110022902A/zh active Pending
- 2017-12-01 EA EA201991316A patent/EA201991316A1/ru unknown
- 2017-12-01 BR BR112019011139A patent/BR112019011139A8/pt not_active IP Right Cessation
- 2017-12-01 US US15/829,596 patent/US10792367B2/en active Active
- 2017-12-01 AU AU2017369723A patent/AU2017369723A1/en not_active Abandoned
- 2017-12-01 MA MA046996A patent/MA46996A/fr unknown
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- 2017-12-01 CR CR20190312A patent/CR20190312A/es unknown
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2019
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- 2019-05-31 PH PH12019501215A patent/PH12019501215A1/en unknown
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- 2019-07-01 EC ECSENADI201946865A patent/ECSP19046865A/es unknown
- 2019-10-28 US US16/665,785 patent/US11141489B2/en active Active
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US20180154005A1 (en) | 2018-06-07 |
ECSP19046865A (es) | 2019-07-31 |
BR112019011139A2 (pt) | 2019-10-01 |
JP2020503278A (ja) | 2020-01-30 |
CO2019006912A2 (es) | 2020-04-24 |
DOP2019000038A (es) | 2019-05-31 |
PH12019501215A1 (en) | 2019-08-19 |
CR20190312A (es) | 2019-09-11 |
EP3548090A1 (fr) | 2019-10-09 |
US11141489B2 (en) | 2021-10-12 |
CL2019001466A1 (es) | 2019-10-11 |
CN110022902A (zh) | 2019-07-16 |
IL266973A (en) | 2019-07-31 |
BR112019011139A8 (pt) | 2020-03-24 |
EA201991316A1 (ru) | 2019-10-31 |
KR20190091482A (ko) | 2019-08-06 |
US10792367B2 (en) | 2020-10-06 |
WO2018100174A1 (fr) | 2018-06-07 |
MX2019006432A (es) | 2019-08-21 |
UY37505A (es) | 2018-06-29 |
AR110299A1 (es) | 2019-03-13 |
CA3045483A1 (fr) | 2018-06-07 |
US20200155688A1 (en) | 2020-05-21 |
AU2017369723A1 (en) | 2019-07-18 |
PE20191472A1 (es) | 2019-10-16 |
TW201832783A (zh) | 2018-09-16 |
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