CO6251314A2 - Procesos para la preparacion de pirazoles - Google Patents

Procesos para la preparacion de pirazoles

Info

Publication number
CO6251314A2
CO6251314A2 CO09142556A CO09142556A CO6251314A2 CO 6251314 A2 CO6251314 A2 CO 6251314A2 CO 09142556 A CO09142556 A CO 09142556A CO 09142556 A CO09142556 A CO 09142556A CO 6251314 A2 CO6251314 A2 CO 6251314A2
Authority
CO
Colombia
Prior art keywords
hal
process according
formula
compound
preparation
Prior art date
Application number
CO09142556A
Other languages
English (en)
Inventor
Martin Charles Bowden
Brian David Gott
David Anthony Jackson
Iacob Gutsu
Original Assignee
Syngenta Participations Ag
Syngenta Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38812166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6251314(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syngenta Participations Ag, Syngenta Ltd filed Critical Syngenta Participations Ag
Publication of CO6251314A2 publication Critical patent/CO6251314A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/76—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1.- Un proceso para la preparación de un compuesto de la fórmula (I)en la cual Hal y Hal' se seleccionan en forma independiente entre Cl y F, y R' se selecciona entre CI, F y H, el cual comprende hacer reaccionar un compuesto de la fórmula (II) con un reactivo Vilsmeieren la cual Hal, Hal' y R1 son tal como se definieron anteriormente. 2.- El proceso de acuerdo con la reivindicación 1, en el cual Hal y Hal' son F. 3.- El proceso de acuerdo con la reivindicación 1, en el cual Hal y Hal' son CI. 4.- El proceso de acuerdo con cualquiera de las reivindicaciones 1 a 3, en el cual R1 es H. 5.- El proceso de acuerdo con cualquiera de las reivindicaciones 1 a 3, en el cual R1 es F. 6.- El proceso de acuerdo con cualquiera de las reivindicaciones 1 a 5, el cual comprende el paso adicional de oxidar el compuesto de la fórmula (I) para proporcionar un ácido carboxílico de la fórmula (VI)en el cual Hal, Hal' y R1 son tal como se definieron en la reivindicación 1, o una sal del mismo. 7.- El proceso de acuerdo con la reivindicación 6, en el cual el oxidante es peróxido de hidrógeno. 8.- El proceso de acuerdo con la reivindicación 6 o 7, en el cual la oxidación se lleva a cabo en presencia de una base. 9.- El proceso de acuerdo con la reivindicación 3, 4 o 6, el cual comprende un paso de intercambio de halógenos para convertir Hal y Hal' de CI en F.
CO09142556A 2007-06-27 2009-12-14 Procesos para la preparacion de pirazoles CO6251314A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07012546A EP2008996A1 (en) 2007-06-27 2007-06-27 Process for the production of pyrazoles

Publications (1)

Publication Number Publication Date
CO6251314A2 true CO6251314A2 (es) 2011-02-21

Family

ID=38812166

Family Applications (2)

Application Number Title Priority Date Filing Date
CO09142558A CO6251313A2 (es) 2007-06-27 2009-12-14 Proceso para la preparacion de pirazoles
CO09142556A CO6251314A2 (es) 2007-06-27 2009-12-14 Procesos para la preparacion de pirazoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CO09142558A CO6251313A2 (es) 2007-06-27 2009-12-14 Proceso para la preparacion de pirazoles

Country Status (18)

Country Link
US (3) US20100256390A1 (es)
EP (3) EP2008996A1 (es)
JP (2) JP5563449B2 (es)
KR (2) KR20100025533A (es)
CN (3) CN101796021A (es)
AR (2) AR067355A1 (es)
AU (2) AU2008267473A1 (es)
BR (2) BRPI0813903A2 (es)
CA (2) CA2689218A1 (es)
CL (2) CL2008001897A1 (es)
CO (2) CO6251313A2 (es)
CR (2) CR11161A (es)
EC (2) ECSP099818A (es)
IL (2) IL202419A0 (es)
MX (2) MX2009013592A (es)
RU (2) RU2010102135A (es)
TW (2) TW200914428A (es)
WO (2) WO2009000441A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2008996A1 (en) * 2007-06-27 2008-12-31 Syngeta Participations AG Process for the production of pyrazoles
EP2133341A1 (de) * 2008-02-25 2009-12-16 Bayer CropScience AG Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten
KR20160131129A (ko) 2008-09-30 2016-11-15 솔베이(소시에떼아노님) 할로겐화 환형 화합물의 합성 방법
GB0908435D0 (en) * 2009-05-15 2009-06-24 Syngenta Ltd Processes
WO2012025469A1 (en) * 2010-08-24 2012-03-01 Solvay Sa Improved process for the preparation of esters of 1-h-pyrazole-4-carboxylic acids
FR2975992B1 (fr) * 2011-06-01 2013-11-08 Rhodia Operations Procede de preparation d'un compose fluoromethylpyrazole sous forme acide carboxylique ou derivee
FR2975990B1 (fr) * 2011-06-01 2013-05-24 Rhodia Operations Procede de preparation d'un compose organique fluore
KR102006518B1 (ko) * 2012-05-14 2019-08-01 바이엘 크롭사이언스 악티엔게젤샤프트 1-알킬-3-플루오로알킬-1h-피라졸-4-카르복실산 클로라이드의 제조 방법
US8871947B2 (en) 2013-02-04 2014-10-28 KingChem LLC Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester
WO2015059067A1 (de) 2013-10-23 2015-04-30 Bayer Cropscience Ag Verfahren zur herstellung von halogenketonen
CN103570623B (zh) * 2013-11-12 2015-05-20 湖南化工研究院 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸的制备方法
US9139507B2 (en) 2013-12-09 2015-09-22 KingChem LLC. Process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs
CN103787977B (zh) 2014-01-21 2016-05-25 南通雅本化学有限公司 一种空气氧化制备3-氟代烷基-1-取代吡唑-4-羧酸的方法
CN105541716B (zh) 2015-03-26 2024-02-23 Ａｇｃ株式会社 吡唑衍生物的制造方法
CN104945325B (zh) * 2015-06-19 2017-04-05 浙江永太科技股份有限公司 一种吡唑甲酸衍生物的制备方法
US10407413B2 (en) 2015-06-19 2019-09-10 Zhejiang Yongtai Technology Co., Ltd. Method for preparing pyrazolecarboxylic acid derivative, and intermediate thereof
CN106554311B (zh) * 2015-09-28 2019-03-01 常州市卜弋科研化工有限公司 3-氟代烷基-1-甲基吡唑-4-羧酸的制备方法
WO2017054112A1 (zh) * 2015-09-28 2017-04-06 常州市卜弋科研化工有限公司 3-氟代烷基-1-甲基吡唑-4-羧酸的制备方法
CN112041303A (zh) 2018-05-21 2020-12-04 Pi工业有限公司 制备取代的杂环化合物的方法
CN109232425A (zh) * 2018-10-16 2019-01-18 山东省农药科学研究院 一种苯丙烯氟菌唑中间体3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸的合成方法
CN110577503A (zh) 2019-08-02 2019-12-17 宿迁市科莱博生物化学有限公司 一种卤素取代化合物及其制备方法和应用
CN111303035A (zh) * 2020-03-18 2020-06-19 徐州圣元化工有限公司 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸的制备方法
CN111233768B (zh) * 2020-03-18 2021-08-03 徐州圣元化工有限公司 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸乙酯的制备方法
WO2022233129A1 (en) 2021-05-05 2022-11-10 Fujian Yongjing Technology Co., Ltd New process for the synthesis of 5-fluoro-3- (difuoromethyl) -5-fluoro-1-methyl-1h-pyrazole-4-carboxylic acid derivatives and the free acid thereof
CN114195715B (zh) * 2021-12-31 2024-05-10 福建永晶科技股份有限公司 1-甲基-3-二氟甲基-4-吡唑酸和1-甲基-3-三氟甲基-4-吡唑酸的制备方法
CN117384096A (zh) * 2023-12-13 2024-01-12 山东国邦药业有限公司 一种二氟吡唑酸的制备方法
CN117447401B (zh) * 2023-12-26 2024-04-19 山东国邦药业有限公司 一种二氟吡唑酸的合成方法

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JPH0759557B2 (ja) * 1987-12-25 1995-06-28 三井東圧化学株式会社 １，３−ジアルキルピラゾール−４−アルデヒド誘導体の製造方法
JPH0759558B2 (ja) * 1987-12-25 1995-06-28 三井東圧化学株式会社 １，３−ジアルキルピラゾール−４−アルデヒド類の製造法
JPH089599B2 (ja) * 1988-08-02 1996-01-31 三井東圧化学株式会社 ピラゾールカルボン酸類の製造方法
JP2006519755A (ja) * 2002-11-20 2006-08-31 ロレアル ピラゾール−カルボキシアミドを含有する毛髪の手入れ用又は睫毛用の組成物、毛髪及び睫毛の成長を刺激し、及び／又は抜毛を防止するためのそれらの使用
DE10349500A1 (de) * 2003-10-23 2005-06-02 Bayer Cropscience Ag Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern
EP1735302B1 (en) * 2004-02-27 2010-06-16 Eli Lilly And Company 4-amino-piperidine derivatives as monoamine uptake inhibitors
PE20060096A1 (es) * 2004-06-18 2006-03-16 Basf Ag (orto-fenil)-anilidas de acido 1-metil-3-difluorometil-pirazol-4-carboxilico como agentes fungicidas
RS51794B (en) * 2004-08-18 2011-12-31 Pfizer Inc. RNA SUBSTITUTE RNA POLYMERASE INHIBITORS OF HEPATITIS C VIRUS AND COMPOSITIONS AND TREATMENTS USING THEM
WO2006090778A1 (ja) * 2005-02-25 2006-08-31 Sagami Chemical Research Center １－置換－３－フルオロアルキルピラゾール－４－カルボン酸エステルの製造方法
EP2253623B1 (en) * 2005-09-16 2013-10-23 Syngenta Participations AG. New crystal form of a pyrazole fungicide
EP2164831B1 (de) * 2007-06-01 2013-07-17 Basf Se Verfahren zur herstellung n-substituierter (3-dihalomethyl-1-methyl-pyrazol-4-yl)carboxamide
EP2008996A1 (en) * 2007-06-27 2008-12-31 Syngeta Participations AG Process for the production of pyrazoles

Also Published As

Publication number Publication date
AU2008267472A1 (en) 2008-12-31
US8269020B2 (en) 2012-09-18
US20100240907A1 (en) 2010-09-23
JP5563449B2 (ja) 2014-07-30
US20100256390A1 (en) 2010-10-07
EP2170832A2 (en) 2010-04-07
ECSP099817A (es) 2010-01-29
EP2167461B1 (en) 2012-08-08
KR20100025531A (ko) 2010-03-09
WO2009000442A8 (en) 2010-01-21
RU2010102137A (ru) 2011-08-10
CN102516175A (zh) 2012-06-27
CN101687806A (zh) 2010-03-31
RU2010102135A (ru) 2011-08-10
ECSP099818A (es) 2010-01-29
CN101796021A (zh) 2010-08-04
WO2009000441A1 (en) 2008-12-31
BRPI0813284A8 (pt) 2017-04-04
CR11161A (es) 2010-05-19
AU2008267473A1 (en) 2008-12-31
MX2009013592A (es) 2010-01-20
WO2009000442A3 (en) 2009-07-23
CR11162A (es) 2010-04-21
WO2009000441A8 (en) 2010-01-14
BRPI0813903A2 (pt) 2014-12-30
BRPI0813284A2 (pt) 2014-12-30
CL2008001896A1 (es) 2009-03-06
CL2008001897A1 (es) 2009-01-02
EP2167461A1 (en) 2010-03-31
IL202664A (en) 2014-07-31
US8785657B2 (en) 2014-07-22
EP2008996A1 (en) 2008-12-31
CA2689218A1 (en) 2008-12-31
AR067355A1 (es) 2009-10-07
JP2010531314A (ja) 2010-09-24
IL202419A0 (en) 2010-06-30
TW200916445A (en) 2009-04-16
AR067356A1 (es) 2009-10-07
BRPI0813284B1 (pt) 2017-10-31
IL202664A0 (en) 2010-06-30
US20130023668A1 (en) 2013-01-24
KR20100025533A (ko) 2010-03-09
TW200914428A (en) 2009-04-01
JP2010531315A (ja) 2010-09-24
WO2009000442A2 (en) 2008-12-31
MX2009013591A (es) 2010-01-20
CO6251313A2 (es) 2011-02-21
CA2690246A1 (en) 2008-12-31

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