CO6251314A2 - Procesos para la preparacion de pirazoles - Google Patents
Procesos para la preparacion de pirazolesInfo
- Publication number
- CO6251314A2 CO6251314A2 CO09142556A CO09142556A CO6251314A2 CO 6251314 A2 CO6251314 A2 CO 6251314A2 CO 09142556 A CO09142556 A CO 09142556A CO 09142556 A CO09142556 A CO 09142556A CO 6251314 A2 CO6251314 A2 CO 6251314A2
- Authority
- CO
- Colombia
- Prior art keywords
- hal
- process according
- formula
- compound
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 10
- 150000001875 compounds Chemical class 0.000 abstract 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
- 230000001590 oxidative effect Effects 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/76—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1.- Un proceso para la preparación de un compuesto de la fórmula (I)en la cual Hal y Hal' se seleccionan en forma independiente entre Cl y F, y R' se selecciona entre CI, F y H, el cual comprende hacer reaccionar un compuesto de la fórmula (II) con un reactivo Vilsmeieren la cual Hal, Hal' y R1 son tal como se definieron anteriormente. 2.- El proceso de acuerdo con la reivindicación 1, en el cual Hal y Hal' son F. 3.- El proceso de acuerdo con la reivindicación 1, en el cual Hal y Hal' son CI. 4.- El proceso de acuerdo con cualquiera de las reivindicaciones 1 a 3, en el cual R1 es H. 5.- El proceso de acuerdo con cualquiera de las reivindicaciones 1 a 3, en el cual R1 es F. 6.- El proceso de acuerdo con cualquiera de las reivindicaciones 1 a 5, el cual comprende el paso adicional de oxidar el compuesto de la fórmula (I) para proporcionar un ácido carboxílico de la fórmula (VI)en el cual Hal, Hal' y R1 son tal como se definieron en la reivindicación 1, o una sal del mismo. 7.- El proceso de acuerdo con la reivindicación 6, en el cual el oxidante es peróxido de hidrógeno. 8.- El proceso de acuerdo con la reivindicación 6 o 7, en el cual la oxidación se lleva a cabo en presencia de una base. 9.- El proceso de acuerdo con la reivindicación 3, 4 o 6, el cual comprende un paso de intercambio de halógenos para convertir Hal y Hal' de CI en F.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07012546A EP2008996A1 (en) | 2007-06-27 | 2007-06-27 | Process for the production of pyrazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6251314A2 true CO6251314A2 (es) | 2011-02-21 |
Family
ID=38812166
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09142558A CO6251313A2 (es) | 2007-06-27 | 2009-12-14 | Proceso para la preparacion de pirazoles |
CO09142556A CO6251314A2 (es) | 2007-06-27 | 2009-12-14 | Procesos para la preparacion de pirazoles |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO09142558A CO6251313A2 (es) | 2007-06-27 | 2009-12-14 | Proceso para la preparacion de pirazoles |
Country Status (18)
Country | Link |
---|---|
US (3) | US8269020B2 (es) |
EP (3) | EP2008996A1 (es) |
JP (2) | JP2010531315A (es) |
KR (2) | KR20100025531A (es) |
CN (3) | CN101796021A (es) |
AR (2) | AR067356A1 (es) |
AU (2) | AU2008267472A1 (es) |
BR (2) | BRPI0813903A2 (es) |
CA (2) | CA2690246A1 (es) |
CL (2) | CL2008001897A1 (es) |
CO (2) | CO6251313A2 (es) |
CR (2) | CR11161A (es) |
EC (2) | ECSP099817A (es) |
IL (2) | IL202419A0 (es) |
MX (2) | MX2009013591A (es) |
RU (2) | RU2010102135A (es) |
TW (2) | TW200916445A (es) |
WO (2) | WO2009000441A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2008996A1 (en) * | 2007-06-27 | 2008-12-31 | Syngeta Participations AG | Process for the production of pyrazoles |
EP2133341A1 (de) * | 2008-02-25 | 2009-12-16 | Bayer CropScience AG | Verfahren zur regioselektiven Synthese von 1-Alkyl-3-haloalkyl-pyrazol-4-carbonsäure-Derivaten |
KR20190080972A (ko) | 2008-09-30 | 2019-07-08 | 솔베이(소시에떼아노님) | 할로겐화 환형 화합물의 합성 방법 |
GB0908435D0 (en) * | 2009-05-15 | 2009-06-24 | Syngenta Ltd | Processes |
WO2012025469A1 (en) * | 2010-08-24 | 2012-03-01 | Solvay Sa | Improved process for the preparation of esters of 1-h-pyrazole-4-carboxylic acids |
FR2975992B1 (fr) * | 2011-06-01 | 2013-11-08 | Rhodia Operations | Procede de preparation d'un compose fluoromethylpyrazole sous forme acide carboxylique ou derivee |
FR2975990B1 (fr) * | 2011-06-01 | 2013-05-24 | Rhodia Operations | Procede de preparation d'un compose organique fluore |
DK2850066T3 (en) * | 2012-05-14 | 2016-04-25 | Bayer Cropscience Ag | PROCESS FOR THE PREPARATION OF 1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carboxylic acid chlorides |
US8871947B2 (en) | 2013-02-04 | 2014-10-28 | KingChem LLC | Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester |
JP6458022B2 (ja) | 2013-10-23 | 2019-01-23 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ハロゲンケトン類を製造する方法 |
CN103570623B (zh) * | 2013-11-12 | 2015-05-20 | 湖南化工研究院 | 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸的制备方法 |
US9139507B2 (en) | 2013-12-09 | 2015-09-22 | KingChem LLC. | Process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs |
CN103787977B (zh) * | 2014-01-21 | 2016-05-25 | 南通雅本化学有限公司 | 一种空气氧化制备3-氟代烷基-1-取代吡唑-4-羧酸的方法 |
CN105541716B (zh) * | 2015-03-26 | 2024-02-23 | Agc株式会社 | 吡唑衍生物的制造方法 |
CN104945325B (zh) * | 2015-06-19 | 2017-04-05 | 浙江永太科技股份有限公司 | 一种吡唑甲酸衍生物的制备方法 |
EP3312161B1 (en) * | 2015-06-19 | 2020-11-04 | Zhejiang Yongtai Technology Co., Ltd. | Method for preparing pyrazolecarboxylic acid derivative, and intermediate thereof |
CN106554311B (zh) * | 2015-09-28 | 2019-03-01 | 常州市卜弋科研化工有限公司 | 3-氟代烷基-1-甲基吡唑-4-羧酸的制备方法 |
WO2017054112A1 (zh) * | 2015-09-28 | 2017-04-06 | 常州市卜弋科研化工有限公司 | 3-氟代烷基-1-甲基吡唑-4-羧酸的制备方法 |
FI3797099T3 (fi) | 2018-05-21 | 2024-01-30 | Pi Industries Ltd | Menetelmä substituoitujen heterosyklisten yhdisteiden valmistamiseksi |
CN109232425A (zh) * | 2018-10-16 | 2019-01-18 | 山东省农药科学研究院 | 一种苯丙烯氟菌唑中间体3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸的合成方法 |
CN110577503A (zh) | 2019-08-02 | 2019-12-17 | 宿迁市科莱博生物化学有限公司 | 一种卤素取代化合物及其制备方法和应用 |
CN111303035A (zh) * | 2020-03-18 | 2020-06-19 | 徐州圣元化工有限公司 | 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸的制备方法 |
CN111233768B (zh) * | 2020-03-18 | 2021-08-03 | 徐州圣元化工有限公司 | 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸乙酯的制备方法 |
WO2022233129A1 (en) | 2021-05-05 | 2022-11-10 | Fujian Yongjing Technology Co., Ltd | New process for the synthesis of 5-fluoro-3- (difuoromethyl) -5-fluoro-1-methyl-1h-pyrazole-4-carboxylic acid derivatives and the free acid thereof |
CN114195715B (zh) * | 2021-12-31 | 2024-05-10 | 福建永晶科技股份有限公司 | 1-甲基-3-二氟甲基-4-吡唑酸和1-甲基-3-三氟甲基-4-吡唑酸的制备方法 |
CN117384096A (zh) * | 2023-12-13 | 2024-01-12 | 山东国邦药业有限公司 | 一种二氟吡唑酸的制备方法 |
CN117447401B (zh) * | 2023-12-26 | 2024-04-19 | 山东国邦药业有限公司 | 一种二氟吡唑酸的合成方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0759558B2 (ja) * | 1987-12-25 | 1995-06-28 | 三井東圧化学株式会社 | 1,3−ジアルキルピラゾール−4−アルデヒド類の製造法 |
JPH0759557B2 (ja) * | 1987-12-25 | 1995-06-28 | 三井東圧化学株式会社 | 1,3−ジアルキルピラゾール−4−アルデヒド誘導体の製造方法 |
JPH089599B2 (ja) * | 1988-08-02 | 1996-01-31 | 三井東圧化学株式会社 | ピラゾールカルボン酸類の製造方法 |
EP1565150A1 (fr) * | 2002-11-20 | 2005-08-24 | L'oreal | Utilisation d'un compose pyrazolcarboxamide pour stimuler la pousse des fibres keratiniques et/ou freiner leur chute |
DE10349500A1 (de) * | 2003-10-23 | 2005-06-02 | Bayer Cropscience Ag | Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern |
US7521462B2 (en) * | 2004-02-27 | 2009-04-21 | Eli Lilly And Company | 4-Amino-piperidine derivatives as monoamine uptake inhibitors |
EP1761498A1 (de) * | 2004-06-18 | 2007-03-14 | Basf Aktiengesellschaft | 1-methyl-3-difluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid |
CN101538268B (zh) * | 2004-08-18 | 2011-07-27 | 辉瑞有限公司 | C型肝炎病毒rna依赖型rna聚合酶的抑制剂、以及使用该抑制剂的组合物和治疗剂 |
EP1854788B8 (en) * | 2005-02-25 | 2012-12-26 | Sagami Chemical Research Institute | Method for producing 1-substituted-3-fluoroalkyl pyrazole-4-carboxylate |
CN101277938B (zh) * | 2005-09-16 | 2012-01-11 | 先正达参股股份有限公司 | 酰胺的制备方法 |
AR066802A1 (es) * | 2007-06-01 | 2009-09-16 | Basf Se | Procedimiento para la preparacion de (3-dihalometil-1-metil- pirazol-4-il) carboxamidas n-susttituidas |
EP2008996A1 (en) * | 2007-06-27 | 2008-12-31 | Syngeta Participations AG | Process for the production of pyrazoles |
-
2007
- 2007-06-27 EP EP07012546A patent/EP2008996A1/en not_active Ceased
-
2008
- 2008-06-16 MX MX2009013591A patent/MX2009013591A/es active IP Right Grant
- 2008-06-16 US US12/666,179 patent/US8269020B2/en active Active
- 2008-06-16 CA CA2690246A patent/CA2690246A1/en not_active Abandoned
- 2008-06-16 EP EP08773461A patent/EP2167461B1/en active Active
- 2008-06-16 CN CN200880021857A patent/CN101796021A/zh active Pending
- 2008-06-16 BR BRPI0813903-2A2A patent/BRPI0813903A2/pt not_active Application Discontinuation
- 2008-06-16 KR KR1020097026780A patent/KR20100025531A/ko not_active Application Discontinuation
- 2008-06-16 JP JP2010513718A patent/JP2010531315A/ja active Pending
- 2008-06-16 US US12/665,738 patent/US20100256390A1/en not_active Abandoned
- 2008-06-16 CN CN200880022057A patent/CN101687806A/zh active Pending
- 2008-06-16 AU AU2008267472A patent/AU2008267472A1/en not_active Abandoned
- 2008-06-16 AU AU2008267473A patent/AU2008267473A1/en not_active Abandoned
- 2008-06-16 CA CA002689218A patent/CA2689218A1/en not_active Abandoned
- 2008-06-16 WO PCT/EP2008/004829 patent/WO2009000441A1/en active Application Filing
- 2008-06-16 WO PCT/EP2008/004830 patent/WO2009000442A2/en active Application Filing
- 2008-06-16 MX MX2009013592A patent/MX2009013592A/es not_active Application Discontinuation
- 2008-06-16 EP EP08773462A patent/EP2170832A2/en not_active Withdrawn
- 2008-06-16 RU RU2010102135/04A patent/RU2010102135A/ru not_active Application Discontinuation
- 2008-06-16 CN CN2011103836384A patent/CN102516175A/zh active Pending
- 2008-06-16 JP JP2010513717A patent/JP5563449B2/ja active Active
- 2008-06-16 RU RU2010102137/04A patent/RU2010102137A/ru not_active Application Discontinuation
- 2008-06-16 BR BRPI0813284-4A patent/BRPI0813284B1/pt active IP Right Grant
- 2008-06-16 KR KR1020097026870A patent/KR20100025533A/ko not_active Application Discontinuation
- 2008-06-23 TW TW097123281A patent/TW200916445A/zh unknown
- 2008-06-23 TW TW097123280A patent/TW200914428A/zh unknown
- 2008-06-26 CL CL2008001897A patent/CL2008001897A1/es unknown
- 2008-06-26 CL CL2008001896A patent/CL2008001896A1/es unknown
- 2008-06-27 AR ARP080102805A patent/AR067356A1/es not_active Application Discontinuation
- 2008-06-27 AR ARP080102804A patent/AR067355A1/es not_active Application Discontinuation
-
2009
- 2009-11-30 IL IL202419A patent/IL202419A0/en unknown
- 2009-12-10 IL IL202664A patent/IL202664A/en active IP Right Grant
- 2009-12-14 CO CO09142558A patent/CO6251313A2/es not_active Application Discontinuation
- 2009-12-14 CO CO09142556A patent/CO6251314A2/es not_active Application Discontinuation
- 2009-12-14 CR CR11161A patent/CR11161A/es not_active Application Discontinuation
- 2009-12-14 CR CR11162A patent/CR11162A/es not_active Application Discontinuation
- 2009-12-18 EC EC2009009817A patent/ECSP099817A/es unknown
- 2009-12-18 EC EC2009009818A patent/ECSP099818A/es unknown
-
2012
- 2012-09-17 US US13/621,686 patent/US8785657B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6251314A2 (es) | Procesos para la preparacion de pirazoles | |
BR112014008061A2 (pt) | método para a produção enzimática de butadieno | |
CY1118310T1 (el) | Μεθοδοι παραγωγης κυκλοαλκυλκαρβοξυαμιδο-πυριδινο βενζοϊκων οξεων | |
JP2010090366A5 (es) | ||
DE602006018923D1 (de) | Verfahren zur herstellung von propylenoxid | |
AR066709A1 (es) | Proceso para la produccion de pirazoles | |
TW200621676A (en) | Selective oxidation of organic compounds | |
EA200801607A1 (ru) | Производные бензимидазолонкарбоновой кислоты | |
JP2008535789A5 (es) | ||
MY179568A (en) | Disinfectant composition and disinfecting method | |
ECSP077290A (es) | Derivados de isoxazolina y su uso como herbicidas | |
AR092001A1 (es) | Proceso para la prodccion de compuestos quimicos a partir de dioxido de carbono | |
FR2935968B1 (fr) | Procede pour la purification de chlorure d'hydrogene | |
MX2009011456A (es) | Aumento de la productividad de las plantas por combinacion de agentes quimicos con modificaciones transgenicas. | |
IT1301999B1 (it) | Catalizzatore, processo per la produzione di acqua ossigenata esuo impiego in processi di ossidazione. | |
EA201200652A1 (ru) | Способ получения кальцобутрола | |
AR059296A1 (es) | Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona. | |
DE602006005363D1 (de) | Nd chlorat | |
DE602006020779D1 (de) | Verfahren zur epoxidation von propen | |
JP2006188509A5 (es) | ||
DE60211758D1 (de) | Verfahren zur herstellung von sulfinylderivaten mittels oxidation der entsprechenden sulfide | |
AR080923A1 (es) | Proceso para la preparacion de amidas del acido pirazolcarboxilico | |
GT200300271A (es) | Derivados del acido isoftalico | |
WO2007099450A3 (en) | Process for the preparation of 2-nitro substituted benzoic acids | |
AR054873A1 (es) | Procedimiento para producir bepromolina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |