CO6251293A2 - Compuestos de piridazina cristalino - Google Patents

Compuestos de piridazina cristalino

Info

Publication number
CO6251293A2
CO6251293A2 CO09144800A CO09144800A CO6251293A2 CO 6251293 A2 CO6251293 A2 CO 6251293A2 CO 09144800 A CO09144800 A CO 09144800A CO 09144800 A CO09144800 A CO 09144800A CO 6251293 A2 CO6251293 A2 CO 6251293A2
Authority
CO
Colombia
Prior art keywords
compound
crystalline compound
crystalline
composition
amorphous
Prior art date
Application number
CO09144800A
Other languages
English (en)
Inventor
Eric D Dowdy
Kenneth Kent
Norma Jacqueline Tom
Vahid Zia
Original Assignee
Puerstinger Gerhard
Gilead Sciences Inc
Leuven K U Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39790369&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6251293(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Puerstinger Gerhard, Gilead Sciences Inc, Leuven K U Res & Dev filed Critical Puerstinger Gerhard
Publication of CO6251293A2 publication Critical patent/CO6251293A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1.- Un compuesto cristalino de fórmula (1)y sus sales, los cuales están sustancialmente libres de compuesto (1) amorfo. 2.- El compuesto cristalino de la reivindicación 1 que tiene un comienzo endotérmico a alrededor de 235°C en el perfil de calorimetría de barrido diferencial (DSC). 3.- El compuesto cristalino de la reivindicación 2 que tiene un calor de fusión (DHf) de alrededor de 81 J/g (42 KJ/mole). 4.- El compuesto cristalino de la reivindicación 3 que tiene al menos un pico aproximado a un ángulo de difracción 2? (°) de alrededor de 17 medido mediante difractometría de rayos X en polvo. 5.- El compuesto cristalino de la reivindicación 1, el cual es la base libre. 6.- El compuesto cristalino de la reivindicación 1, en la forma de agujas o varillas. 7.- Una composición que comprende el compuesto cristalino de la reivindicación 1 conteniendo menos de alrededor del 40% en peso del compuesto (1) amorfo. 8.- Una composición que comprende el compuesto cristalino de la reivindicación 7, el cual contiene menos de alrededor del 10% en peso del compuesto (1) amorfo. 9.- Una composición que comprende el compuesto cristalino de la reivindicación 8, en donde el compuesto (1) cristalino contiene menos de alrededor de 100 ppm de cloruros. 10.- El compuesto cristalino de la reivindicación 1, el cual ha sido micronizado. 11.- El compuesto cristalino que es la base libre sustancialmente libre del compuesto (1) amorfo y alguna otra forma cristalina del compuesto (1). 12.- El compuesto cristalino de la reivindicación 1, el cual está sustancialmente libre de la sal cloruro del compuesto (1). 13.- Una composición que comprende el compuesto cristalino de la reivindicación 1 y un excipiente farmacéuticamente aceptable.
CO09144800A 2007-07-06 2009-12-17 Compuestos de piridazina cristalino CO6251293A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95859507P 2007-07-06 2007-07-06

Publications (1)

Publication Number Publication Date
CO6251293A2 true CO6251293A2 (es) 2011-02-21

Family

ID=39790369

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09144800A CO6251293A2 (es) 2007-07-06 2009-12-17 Compuestos de piridazina cristalino

Country Status (19)

Country Link
US (2) US8106054B2 (es)
EP (1) EP2170881A1 (es)
JP (2) JP5366944B2 (es)
KR (1) KR101229528B1 (es)
CN (1) CN101778847B (es)
AP (1) AP2593A (es)
AR (1) AR066158A1 (es)
AU (1) AU2008275756B2 (es)
BR (1) BRPI0814801A2 (es)
CA (1) CA2691917C (es)
CO (1) CO6251293A2 (es)
EA (2) EA201270275A1 (es)
EC (1) ECSP109919A (es)
IL (1) IL202694A0 (es)
MX (1) MX2009013833A (es)
TW (1) TWI447116B (es)
UA (1) UA99466C2 (es)
WO (1) WO2009009001A1 (es)
ZA (1) ZA201000826B (es)

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DK2094702T3 (en) 2006-12-14 2015-12-07 Gilead Sciences Inc viral inhibitors
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AU2010333656B2 (en) 2009-12-18 2015-08-27 Boehringer Ingelheim International Gmbh HCV combination therapy
EP2571882A1 (en) 2010-05-21 2013-03-27 Gilead Sciences, Inc. Heterocyclic flaviviridae virus inhibitors
NZ613370A (en) 2010-12-20 2015-05-29 Gilead Sciences Inc Combinations for treating hcv
US20120204871A1 (en) * 2011-02-10 2012-08-16 Julio Cesar Vega Stable, non-corrosive formulations for pressurized metered dose inhalers
DE202012013074U1 (de) 2011-09-16 2014-10-29 Gilead Pharmasset Lcc Zusammensetzungen zur Behandlung von HCV
SI2950786T1 (sl) 2013-01-31 2020-03-31 Gilead Pharmasset Llc Formulacija kombinacije dveh protivirusnih spojin
HRP20211456T1 (hr) 2014-12-26 2021-12-24 Emory University Protuvirusni derivati n4-hidroksicitidina
KR102248165B1 (ko) 2017-12-07 2021-05-06 에모리 유니버시티 N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도
CN114195812A (zh) * 2021-12-30 2022-03-18 大连联化化学有限公司 一种合成2,4-二三氟甲基苯硼酸的方法

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Also Published As

Publication number Publication date
KR20100044201A (ko) 2010-04-29
AR066158A1 (es) 2009-07-29
WO2009009001A1 (en) 2009-01-15
JP2010532757A (ja) 2010-10-14
ZA201000826B (en) 2010-11-24
CA2691917A1 (en) 2009-01-15
AP2009005078A0 (en) 2009-12-31
CN101778847A (zh) 2010-07-14
AU2008275756A1 (en) 2009-01-15
AU2008275756B2 (en) 2012-01-19
US20120108601A1 (en) 2012-05-03
KR101229528B1 (ko) 2013-02-04
TWI447116B (zh) 2014-08-01
AP2593A (en) 2013-02-07
CA2691917C (en) 2013-12-03
EA200971080A1 (ru) 2010-08-30
MX2009013833A (es) 2010-03-10
UA99466C2 (en) 2012-08-27
US8106054B2 (en) 2012-01-31
JP2013216695A (ja) 2013-10-24
US20090036460A1 (en) 2009-02-05
IL202694A0 (en) 2010-06-30
ECSP109919A (es) 2010-04-30
EP2170881A1 (en) 2010-04-07
EA018173B1 (ru) 2013-06-28
WO2009009001A9 (en) 2010-11-11
US8569488B2 (en) 2013-10-29
CN101778847B (zh) 2013-07-24
JP5366944B2 (ja) 2013-12-11
BRPI0814801A2 (pt) 2017-03-28
TW200918531A (en) 2009-05-01
EA201270275A1 (ru) 2012-09-28

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