CO6251265A2 - Compuestos de pirazol y uso como inhibidores raf - Google Patents
Compuestos de pirazol y uso como inhibidores rafInfo
- Publication number
- CO6251265A2 CO6251265A2 CO10010171A CO10010171A CO6251265A2 CO 6251265 A2 CO6251265 A2 CO 6251265A2 CO 10010171 A CO10010171 A CO 10010171A CO 10010171 A CO10010171 A CO 10010171A CO 6251265 A2 CO6251265 A2 CO 6251265A2
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- heteroaryl
- cycloheteroalkyl
- cycloalkyl
- membered
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- En otra realización, la presente invención es un compuesto de Fórmula (II)en la que:X es N o CR7;R1 es H, alquilo C1-C6, alquenilo C2-C8, alquinilo C2-C8, cicloalquilo C3-C8, arilo C6-C14, cicloheteroalquilo C2-C9 o heteroarilo C2-C9, donde cada uno de dichos alquilo C1-C6, alquenilo C2-C8, alquinilo C2-C8, cicloalquilo C3-C8, arilo C6-C14, cicloheteroalquilo C2-C9 y heteroarilo C2-C9 está opcionalmente sustituido con uno o más R8;R2 es cicloheteroalquilo C2-C9 o heteroarilo C2-C9, donde cada uno de dichos cicloheteroalquilo C2-C9 y heteroarilo C5-C14 está opcionalmente sustituido con uno o más R8; u opcionalmente cuando R2 es heteroarilo C2-C9, los átomos de hidrógeno sobre 2 átomos adyacentes cualquiera en el anillo pueden combinarse para formar un cicloalquilo de 5-7 miembros opcionalmente sustituido con uno o más R8, un cicloheteroalquilo de 5-7 miembros opcionalmente sustituido con uno o más R8 o un heteroarilo de 5-7 miembros opcionalmente sustituido con uno o más R8;R3 es H o -NR9R10; o cuando X es CR7, R3 puede combinarse con R7 para formar un heteroarilo de 5-7 miembros opcionalmente sustituido con uno o más R8, cicloheteroalquilo de 5-7 miembros opcionalmente sustituido con uno o más R8, fenilo opcionalmente sustituido con uno o más R8 o cicloalquilo de 5-7 miembros opcionalmente sustituido con uno o más R8; cada uno de R4, R5, R6, R7 es independientemente H, -NR11R12, -CN, -C(O)R11, -C(O)OR11, -NO2, -SR11, -S(O)2R11, -OR11, alquilo C1-C6, alquenilo C2-C8, alquinilo C2-C8, cicloalquilo C3-C8, arilo C6-C14, cicloheteroalquilo C2-C9 o heteroarilo C2-C9, donde cada uno de dichos alquilo C1-C6, alquenilo C2-C8, alquinilo C2-C8, cicloalquilo C3-C8, arilo C6-C14, cicloheteroalquilo C2-C9 o heteroarilo C2-C9 está opcionalmente sustituido con uno o más R8; cada R8 es independientemente -OR11, flúor, cloro, bromo, oxo, ciano, -NR13R14, -C(O)N(R13R14), -C(O)R13, -C(O)OR13, -NO2, alquilo C1-C6, alquenilo C2-C8, alquinilo C2-C8, cicloalquilo C3-C8, arilo C6-C14, ...
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95323507P | 2007-08-01 | 2007-08-01 | |
US8005408P | 2008-07-11 | 2008-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6251265A2 true CO6251265A2 (es) | 2011-02-21 |
Family
ID=40122511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10010171A CO6251265A2 (es) | 2007-08-01 | 2010-02-01 | Compuestos de pirazol y uso como inhibidores raf |
Country Status (24)
Country | Link |
---|---|
US (1) | US7772246B2 (es) |
EP (1) | EP2183243A2 (es) |
JP (1) | JP4792126B2 (es) |
KR (1) | KR20100038119A (es) |
CN (1) | CN101815712A (es) |
AP (1) | AP2010005167A0 (es) |
AR (1) | AR067759A1 (es) |
AU (1) | AU2008281543A1 (es) |
BR (1) | BRPI0815042A2 (es) |
CA (1) | CA2695114A1 (es) |
CL (1) | CL2008002255A1 (es) |
CO (1) | CO6251265A2 (es) |
CR (1) | CR11241A (es) |
DO (1) | DOP2010000047A (es) |
EA (1) | EA201000113A1 (es) |
EC (1) | ECSP109922A (es) |
MA (1) | MA31574B1 (es) |
PA (1) | PA8791801A1 (es) |
PE (1) | PE20090952A1 (es) |
SV (1) | SV2010003472A (es) |
TN (1) | TN2010000052A1 (es) |
TW (1) | TW200911243A (es) |
UY (1) | UY31260A1 (es) |
WO (1) | WO2009016460A2 (es) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2430539C (en) * | 2000-12-05 | 2010-07-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
BRPI0619817B8 (pt) | 2005-12-13 | 2021-05-25 | Incyte Corp | composto 3-ciclopentil-3-[4-(7h-pirrol[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]propanonitrila e sua composição |
MX2009013402A (es) | 2007-06-13 | 2010-02-24 | Incyte Corp | Sales de inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3-d]piri midin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo. |
BRPI0917540A2 (pt) | 2008-08-05 | 2015-11-17 | Daiichi Sankyo Co Ltd | composto, sal farmacologicamente aceitavél, composição farmacêutica, e, uso de um composto ou sal farmacologicamente aceitável |
CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
CA2743134A1 (en) | 2008-11-10 | 2010-05-14 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
EP3354650B1 (en) | 2008-12-19 | 2022-02-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
WO2010100127A1 (en) | 2009-03-04 | 2010-09-10 | Novartis Ag | Disubstituted imidazole derivatives as modulators of raf kinase |
BRPI1012159B1 (pt) | 2009-05-22 | 2022-01-25 | Incyte Holdings Corporation | Compostos derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d] pirimidinas e pirrol-3-il-pirrolo[2,3-d] pirimidinas como inibidores de janus cinase, composições farmacêuticas compreendendo os referidos compostos e usos dos mesmos |
EP2432472B1 (en) | 2009-05-22 | 2019-10-02 | Incyte Holdings Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
JO3002B1 (ar) * | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
RU2538204C2 (ru) * | 2009-09-10 | 2015-01-10 | Ф.Хоффманн-Ля Рош Аг | Ингибиторы jak |
EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
EP4036088B1 (en) * | 2010-03-10 | 2024-04-03 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
US8969356B2 (en) | 2010-05-12 | 2015-03-03 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
EP2569284B1 (en) | 2010-05-12 | 2015-07-08 | Vertex Pharmaceuticals Incorporated | 2-aminopyridine derivatives useful as inhibitors of atr kinase |
US8962631B2 (en) | 2010-05-12 | 2015-02-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
WO2011143423A2 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
JP5836367B2 (ja) | 2010-05-12 | 2015-12-24 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼ阻害剤として有用な化合物 |
EP2569287B1 (en) | 2010-05-12 | 2014-07-09 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
EP3087972A1 (en) | 2010-05-21 | 2016-11-02 | Incyte Holdings Corporation | Topical formulation for a jak inhibitor |
MX2013000103A (es) | 2010-06-23 | 2013-06-13 | Vertex Pharma | Derivados de pirrolo-pirazina utiles como inhibidores de cinasa art. |
US8779150B2 (en) * | 2010-07-21 | 2014-07-15 | Hoffmann-La Roche Inc. | Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide |
JP5917545B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としてのシクロブチル置換ピロロピリジンおよびピロロピリミジン誘導体 |
CA2818545C (en) | 2010-11-19 | 2019-04-16 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
US8791112B2 (en) | 2011-03-30 | 2014-07-29 | Arrien Pharmaceuticals Llc | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors |
MX2013011450A (es) | 2011-04-05 | 2014-02-03 | Vertex Pharma | Compuestos de aminopirazina utiles como inhibidores de la cinasa ataxia telangiectasia mutada y rad3 relacionados (atr). |
AU2012273164B2 (en) | 2011-06-20 | 2015-05-28 | Incyte Holdings Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors |
JP2014522818A (ja) | 2011-06-22 | 2014-09-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
WO2012178123A1 (en) | 2011-06-22 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
CA2850564A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
US8853217B2 (en) | 2011-09-30 | 2014-10-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
RS59337B1 (sr) | 2011-09-30 | 2019-10-31 | Vertex Pharma | Postupak za izradu jedinjenja, korisnih kao inhibitori atr kinaze |
RU2018108589A (ru) | 2011-09-30 | 2019-02-25 | Вертекс Фармасьютикалз Инкорпорейтед | Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr |
US8765751B2 (en) | 2011-09-30 | 2014-07-01 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
EP2776420A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
EP2776429A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
EP2776422A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
US8841449B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
EP2776421A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
EP2776037B1 (en) | 2011-11-11 | 2019-01-09 | Novartis AG | Method of treating a proliferative disease |
JP6216325B2 (ja) | 2011-11-23 | 2017-10-18 | ノバルティス アーゲー | 医薬製剤 |
CN103159736B (zh) * | 2011-12-10 | 2015-05-13 | 通化济达医药有限公司 | 取代的吡唑激酶抑制剂 |
SI2833973T1 (en) | 2012-04-05 | 2018-04-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase and their combination therapy |
US9193733B2 (en) | 2012-05-18 | 2015-11-24 | Incyte Holdings Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
DK2904406T3 (en) | 2012-10-04 | 2018-06-18 | Vertex Pharma | METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE |
WO2014062604A1 (en) | 2012-10-16 | 2014-04-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
IL291391B (en) | 2012-11-15 | 2022-11-01 | Incyte Holdings Corp | Sustained release dosage forms of roxolitinib |
BR112015012454B1 (pt) | 2012-12-07 | 2022-07-05 | Vertex Pharmaceuticals Incorporated | Compostos inibidores de atr quinase, seu uso e composição farmacêutica compreendendo os mesmos |
KR101701663B1 (ko) * | 2013-01-18 | 2017-02-01 | 에프. 호프만-라 로슈 아게 | 3-치환된 피라졸 및 dlk 억제제로서의 용도 |
RU2654483C2 (ru) | 2013-02-20 | 2018-05-21 | ЭлДжи КЕМ, ЛТД. | Агонисты рецептора сфингозин-1-фосфата, способы их получения и фармацевтические композиции, содержащие эти соединения в качестве активного средства |
AU2014223334C1 (en) | 2013-03-01 | 2018-10-18 | Amgen Inc. | Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
PT2964650T (pt) | 2013-03-06 | 2019-02-26 | Incyte Holdings Corp | Processos e intermediários para a preparação de um inibidor de jak |
EP2970286A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
CA2903293C (en) * | 2013-03-15 | 2020-10-13 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
MX2016001639A (es) | 2013-08-07 | 2016-10-07 | Incyte Corp | Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1). |
SG11201600977XA (en) | 2013-08-21 | 2016-03-30 | Alios Biopharma Inc | Antiviral compounds |
CN103626767A (zh) * | 2013-12-04 | 2014-03-12 | 上海药明康德新药开发有限公司 | 区域选择性的氮杂吲哚及其合成方法 |
CN105934435B (zh) | 2013-12-06 | 2019-02-22 | 沃泰克斯药物股份有限公司 | 用作atr激酶抑制剂的化合物,其制备,及其放射性标记的衍生物 |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
CN107074863B (zh) | 2014-06-05 | 2019-12-03 | 沃泰克斯药物股份有限公司 | Atr激酶抑制剂的制备方法及其不同的固体形式 |
SG11201610500WA (en) | 2014-06-17 | 2017-01-27 | Vertex Pharma | Method for treating cancer using a combination of chk1 and atr inhibitors |
CA2957544C (en) | 2014-08-08 | 2023-01-24 | Amgen Inc. | Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use |
CN105777743A (zh) * | 2014-12-19 | 2016-07-20 | 奥浦顿(上海)医药科技有限公司 | 一种吡唑并[3,4-b]吡啶类化合物中间体的制备方法和应用 |
EP3355926A4 (en) | 2015-09-30 | 2019-08-21 | Vertex Pharmaceuticals Inc. | METHOD FOR THE TREATMENT OF CANCER WITH A COMBINATION OF DNA DAMAGING AGENTS AND ATR INHIBITORS |
CN106187899B (zh) * | 2016-06-28 | 2019-07-16 | 绍兴文理学院 | 一种氟代氮杂芳烃的合成方法 |
JP7076741B2 (ja) * | 2016-12-27 | 2022-05-30 | 国立研究開発法人理化学研究所 | Bmpシグナル阻害化合物 |
CN110545853A (zh) * | 2017-04-28 | 2019-12-06 | 石英治疗有限公司 | Raf降解偶联化合物 |
US10717735B2 (en) | 2017-10-13 | 2020-07-21 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
RS63312B1 (sr) | 2018-01-30 | 2022-07-29 | Incyte Corp | Procesi za pripremu (1-(3-fluoro-2-(trifluorometil)izonikotinil)piperidin-4-on) |
MX2020010322A (es) | 2018-03-30 | 2022-11-30 | Incyte Corp | Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak). |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
CN109575019B (zh) * | 2018-12-26 | 2020-04-14 | 苏州闻智生物科技有限公司 | 一种5-溴-7-氮杂吲哚的制备方法 |
US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
JP2023509260A (ja) | 2019-08-14 | 2023-03-08 | インサイト・コーポレイション | Cdk2阻害剤としてのイミダゾリルピリミジニルアミン化合物 |
KR20220099970A (ko) | 2019-10-11 | 2022-07-14 | 인사이트 코포레이션 | Cdk2 억제제로서의 이환식 아민 |
WO2021120890A1 (en) | 2019-12-20 | 2021-06-24 | Novartis Ag | Pyrazolyl derivatives useful as anti-cancer agents |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
PE20231743A1 (es) | 2020-08-18 | 2023-10-31 | Incyte Corp | Proceso e intermediarios para preparar un inhibidor de jak |
KR20230095923A (ko) | 2020-08-18 | 2023-06-29 | 인사이트 코포레이션 | Jak1 억제제를 제조하기 위한 공정 및 중간체 |
CA3199295A1 (en) * | 2020-10-30 | 2022-05-05 | Novartis Ag | New crystalline forms of a kras g12c inhibitor compound |
US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
CN114557977A (zh) * | 2022-02-16 | 2022-05-31 | 北京康立生医药技术开发有限公司 | 一种治疗肠癌的药物的制备方法、制剂及纯度分析方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2306108A (en) | 1995-10-13 | 1997-04-30 | Merck & Co Inc | Treatment of Raf-mediated cancers with imidazole derivatives |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
ES2239596T3 (es) * | 1999-06-03 | 2005-10-01 | Teikoku Hormone Mfg. Co., Ltd. | Compuestos de pirazol sustituidos. |
AU7922100A (en) | 1999-10-25 | 2001-05-08 | Basf Aktiengesellschaft | Agrochemical compositions containing pyrazoles as the active agents and use of said compositions as plant protection agents with a fungicidal action |
JP2004521915A (ja) * | 2001-02-02 | 2004-07-22 | グラクソ グループ リミテッド | Tgf過剰発現に対するピラゾール誘導体 |
EP1363904A1 (en) * | 2001-02-02 | 2003-11-26 | Glaxo Group Limited | Pyrazoles as tgf inhibitors |
WO2002092573A2 (en) * | 2001-05-16 | 2002-11-21 | Vertex Pharmaceuticals Incorporated | Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases |
DE60222804T2 (de) * | 2001-12-21 | 2008-07-03 | Vernalis (Cambridge) Ltd., Abington | 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung |
TW200400960A (en) | 2002-06-05 | 2004-01-16 | Pharmacia Corp | Novel pyrazoles and their use as P38 kinase inhibitors |
GB0215844D0 (en) * | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
MXPA05002376A (es) * | 2002-09-18 | 2005-05-23 | Pfizer Prod Inc | Nuevos compuestos de pirazol como inhibidores del factor de crecimiento transformante (tgf). |
CL2004000234A1 (es) * | 2003-02-12 | 2005-04-15 | Biogen Idec Inc | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid |
EP1809636A1 (en) | 2004-10-19 | 2007-07-25 | Arqule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase |
WO2006072828A2 (en) | 2005-01-07 | 2006-07-13 | Pfizer Products Inc. | Heteroaromatic quinoline compounds and their use as pde10 inhibitors |
CA2643066A1 (en) | 2006-03-16 | 2007-09-20 | Pfizer Products Inc. | Pyrazole compounds |
WO2007123892A2 (en) | 2006-04-17 | 2007-11-01 | Arqule Inc. | Raf inhibitors and their uses |
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2008
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- 2008-07-21 AP AP2010005167A patent/AP2010005167A0/en unknown
- 2008-07-21 CN CN200880109854A patent/CN101815712A/zh active Pending
- 2008-07-21 AU AU2008281543A patent/AU2008281543A1/en not_active Abandoned
- 2008-07-21 WO PCT/IB2008/001952 patent/WO2009016460A2/en active Application Filing
- 2008-07-21 CA CA2695114A patent/CA2695114A1/en not_active Abandoned
- 2008-07-21 EA EA201000113A patent/EA201000113A1/ru unknown
- 2008-07-21 JP JP2010518763A patent/JP4792126B2/ja not_active Expired - Fee Related
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- 2008-07-21 EP EP08788934A patent/EP2183243A2/en not_active Withdrawn
- 2008-07-30 US US12/182,977 patent/US7772246B2/en not_active Expired - Fee Related
- 2008-07-31 CL CL2008002255A patent/CL2008002255A1/es unknown
- 2008-07-31 AR ARP080103325A patent/AR067759A1/es not_active Application Discontinuation
- 2008-07-31 TW TW097129016A patent/TW200911243A/zh unknown
- 2008-07-31 PE PE2008001290A patent/PE20090952A1/es not_active Application Discontinuation
- 2008-07-31 UY UY31260A patent/UY31260A1/es not_active Application Discontinuation
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- 2010-02-01 DO DO2010000047A patent/DOP2010000047A/es unknown
- 2010-02-01 CO CO10010171A patent/CO6251265A2/es not_active Application Discontinuation
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AP2010005167A0 (en) | 2010-02-28 |
US7772246B2 (en) | 2010-08-10 |
UY31260A1 (es) | 2009-03-02 |
WO2009016460A8 (en) | 2009-10-15 |
BRPI0815042A2 (pt) | 2015-02-10 |
ECSP109922A (es) | 2010-03-31 |
JP4792126B2 (ja) | 2011-10-12 |
TN2010000052A1 (fr) | 2011-09-26 |
PA8791801A1 (es) | 2009-03-31 |
SV2010003472A (es) | 2011-03-23 |
PE20090952A1 (es) | 2009-07-19 |
WO2009016460A2 (en) | 2009-02-05 |
AR067759A1 (es) | 2009-10-21 |
AU2008281543A1 (en) | 2009-02-05 |
KR20100038119A (ko) | 2010-04-12 |
EA201000113A1 (ru) | 2010-08-30 |
MA31574B1 (fr) | 2010-08-02 |
WO2009016460A3 (en) | 2009-03-26 |
JP2010535189A (ja) | 2010-11-18 |
CL2008002255A1 (es) | 2009-04-17 |
CR11241A (es) | 2010-04-27 |
CN101815712A (zh) | 2010-08-25 |
DOP2010000047A (es) | 2010-04-15 |
EP2183243A2 (en) | 2010-05-12 |
US20090221608A1 (en) | 2009-09-03 |
TW200911243A (en) | 2009-03-16 |
CA2695114A1 (en) | 2009-02-05 |
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