AR085150A1 - Agentes moduladores de s1p - Google Patents

Agentes moduladores de s1p

Info

Publication number
AR085150A1
AR085150A1 ARP120100381A ARP120100381A AR085150A1 AR 085150 A1 AR085150 A1 AR 085150A1 AR P120100381 A ARP120100381 A AR P120100381A AR P120100381 A ARP120100381 A AR P120100381A AR 085150 A1 AR085150 A1 AR 085150A1
Authority
AR
Argentina
Prior art keywords
alkyl
haloalkyl
hydrogen
butylcyclohexyloxy
naphthalen
Prior art date
Application number
ARP120100381A
Other languages
English (en)
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of AR085150A1 publication Critical patent/AR085150A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
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    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49

Abstract

Los compuestos de la fórmula (1) pueden modular la actividad de los receptores de S1P.Reivindicación 1: Un compuesto de la fórmula (1), en donde: A1 es -CH= o -N=; A2 es -CH= o -N=; A3 es -CH2-, -CH= o -N=; A4 es -CH2-, -CH= o -N=; A5 es -CH2-, -CH= o -N=; A6 es -CH= o -N=; W es -O-, CR5- o -CHR5-; R5 es hidrógeno, halo, alquilo o haloalquilo; Cy es un grupo cicloalquilo de 4 a 7 miembros, un grupo cicloalquenilo de 4 a 7 miembros o Cy es un grupo heterocicloalquenilo de 4 a 7 miembros que tiene 1 heteroátomo que es O; en donde Cy está opcionalmente sustituido con uno a cuatro R1; cada R1, de modo independiente, es halo, alquilo, haloalquilo, hidroxialquilo, cicloalquilo, trialquilsililo, alcoxi, cicloalcoxi, alcoxialquilo, cicloalcoxialquilo o arilo o dos R1, tomados juntos, son alquileno C1-5; L1 es -C(O)- o -C(R3)2-; cada R3, de modo independiente, es hidrógeno, alquilo o haloalquilo; x es 0, 1, 2, 3, 4 ó 5; y es 0, 1, 2, 3, 4 ó 5; en donde la suma de x e y es 4 ó 5; cada Ra y cada Rb, de modo independiente, es hidrógeno, halo, hidroxi, -CO2Rc, alquilo o arilo; R2 es -(CH2)nCO2Rc, en donde n es 0 ó 1; Rc es hidrógeno, alquilo, haloalquilo, cicloalquilo o arilo; siempre que el compuesto no sea ácido 1-((2-(trans-4-ter-butilciclohexiloxi)naftalen-6-il)metil)piperidin-4-carboxílico, ácido 1-((2-(trans-4-ter-butilciclohexiloxi)naftalen-6-il)metil)piperidin-3R-carboxílico o ácido 1-((2-(trans-4-ter-butilciclohexiloxi)naftalen-6-il)metil)piperidin-3S-carboxílico; o una de sus sales farmacéuticamente aceptables.
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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
CA2954376C (en) 2006-10-16 2019-06-11 Bionomics Limited Novel anxiolytic compounds
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
WO2011094008A1 (en) 2010-01-27 2011-08-04 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
PL2672823T3 (pl) 2011-02-07 2017-02-28 Biogen Ma Inc. Czynniki modulujące działanie receptora s1p
US20140051701A1 (en) * 2011-03-02 2014-02-20 Bionomics Limited Methods of treating a disease or condition of the central nervous system
EP2511275A1 (en) * 2011-04-12 2012-10-17 Bioprojet Novel piperidinyl monocarboxylic acids as S1P1 receptor agonists
ES2684995T3 (es) 2012-07-27 2018-10-05 Biogen Ma Inc. Derivados del ácido 2-(1-(1-(6-((ciclohexil)oxi)-5-(trifluorometil)naftalen-2-il)etil)piperidin-3-il)acético como moduladores de la autotaxina (atx) para el tratamiento de inflamaciones y trastornos autoinmunes
KR102127025B1 (ko) * 2012-07-27 2020-06-25 비오겐 엠에이 아이엔씨. S1p 조절제 및/또는 atx 조절제인 화합물들
EA028364B1 (ru) 2012-07-27 2017-11-30 Биоген Айдек Ма Инк. Аутотаксин-модулирующие соединения
ES2691793T3 (es) 2012-08-06 2018-11-28 Biogen Ma Inc. Derivados de naftaleno 1,5,6-sustituidos como moduladores de receptor de 1-fosfato de esfingosina (S1P) y/o autotaxina (ATX) para tratar trastornos inflamatorios y autoinmunitarios
ES2660287T3 (es) 2012-08-06 2018-03-21 Biogen Ma Inc. Compuestos que son agentes moduladores de s1p y/o agentes moduladores de atx
US20150220693A1 (en) 2012-08-13 2015-08-06 Biogen Idec Ma Inc. Disease progression parameters and uses thereof for evaluating multiple sclerosis
CN109364250A (zh) 2012-10-09 2019-02-22 比奥根Ma公司 联合治疗及用于治疗脱髓鞘病症的用途
ES2749467T3 (es) 2012-11-20 2020-03-20 Biogen Ma Inc Agentes moduladores de S1p y/o ATX
WO2014120764A1 (en) 2013-01-29 2014-08-07 Biogen Idec Ma Inc. S1p modulating agents
WO2015063604A2 (en) 2013-11-01 2015-05-07 Imberti Luisa BIOMARKERS PREDICTIVE OF THERAPEUTIC RESPONSIVENESS TO IFNβ AND USES THEREOF
EP3228615B1 (en) * 2014-12-04 2021-01-20 ONO Pharmaceutical Co., Ltd. Dihydronaphthalene derivatives useful in the treatment of s1p5-mediated diseases
NZ734220A (en) 2015-01-06 2022-01-28 Arena Pharm Inc Methods of treating conditions related to the s1p1 receptor
WO2016112270A1 (en) 2015-01-08 2016-07-14 Biogen Ma Inc. Lingo-1 antagonists and uses for treatment of demyelinating disorders
AU2016270373A1 (en) 2015-06-05 2018-01-04 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
IL285890B (en) 2015-06-22 2022-07-01 Arena Pharm Inc Slate-free crystal of the arginine salt of (Ar)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-4,3,2,1-tetrahydro-cyclopent[b]indole-3-yl ) acetic acid
AU2017297404A1 (en) 2016-07-13 2019-01-24 Biogen Ma Inc. Dosage regimens of LINGO-1 antagonists and uses for treatment of demyelinating disorders
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
CA3053416A1 (en) * 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
JP2020507611A (ja) 2017-02-16 2020-03-12 アリーナ ファーマシューティカルズ， インコーポレイテッド 原発性胆汁性胆管炎の治療のための化合物および方法
EA201992878A1 (ru) * 2017-06-05 2020-05-08 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Соединения для лечения болезни хантингтона
TWI789495B (zh) 2018-02-22 2023-01-11 日商小野藥品工業股份有限公司 具有ｓ1ｐ5受體作動活性的化合物
KR102540720B1 (ko) * 2020-02-18 2023-06-08 재단법인 아산사회복지재단 천식 또는 기관지염 예방 또는 치료용 약학적 조성물
JP2023538066A (ja) 2020-08-19 2023-09-06 バイオジェン・エムエイ・インコーポレイテッド 高コレステロール血症の治療方法
EP4199927A1 (en) 2020-08-19 2023-06-28 Biogen MA Inc. Methods for treating remitting multiple sclerosis
RU2765464C1 (ru) * 2021-05-20 2022-01-31 Федеральное государственное бюджетное учреждение науки Институт органической химии им. Н.Д. Зеленского Российской академии наук (ИОХ РАН) Способ получения эфиров пиперидин-4,4-дикарбоновых кислот

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
FR2555571B1 (fr) 1983-11-28 1986-11-28 Interna Rech Dermatolo Centre Derives du naphtalene, leur procede de preparation et leur application dans le domaine therapeutique
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US5219837A (en) 1990-06-21 1993-06-15 Trustees Of The University Of Pennsylvania Method of stimulating myelination of cells
IL135495A (en) 1995-09-28 2002-12-01 Hoechst Ag Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid
CA2472713C (en) 2002-01-18 2011-07-19 Merck & Co., Inc. N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists
DE60329073D1 (de) 2002-01-18 2009-10-15 Merck & Co Inc Edg-rezeptoragonisten
WO2003061567A2 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
EP1944026B1 (en) 2002-05-16 2013-06-26 Novartis AG Use of EDG receptor binding agents in cancer
AU2003276043A1 (en) 2002-06-17 2003-12-31 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
GB0217152D0 (en) 2002-07-24 2002-09-04 Novartis Ag Organic compounds
RU2356896C2 (ru) 2003-04-16 2009-05-27 Ф.Хоффманн-Ля Рош Аг Производные хиназолина
US7060697B2 (en) 2003-05-19 2006-06-13 Irm Llc Immunosuppressant compounds and compositions
AR044402A1 (es) 2003-05-19 2005-09-14 Irm Llc Compuestos heterociclicos y su uso como inmunodepresores. composiciones farmaceuticas que los contienen.
CN102977016B (zh) 2003-06-06 2015-01-14 菲布罗根有限公司 含氮杂芳基化合物及其在增加内源性促红细胞生成素中的用途
CN1874991A (zh) 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
KR20110140139A (ko) 2003-08-29 2011-12-30 오노 야꾸힝 고교 가부시키가이샤 Ｓ１ｐ 수용체 결합능을 갖는 화합물 및 그 의약 용도
EP1541143A1 (en) 2003-12-09 2005-06-15 Graffinity Pharmaceuticals Aktiengesellschaft Dpp-iv inhibitors
GB0500020D0 (en) 2005-01-04 2005-02-09 Novartis Ag Organic compounds
GB0401332D0 (en) * 2004-01-21 2004-02-25 Novartis Ag Organic compounds
JPWO2005082905A1 (ja) 2004-02-26 2007-08-02 協和醗酵工業株式会社 二環性複素環化合物
JP4708046B2 (ja) 2004-03-05 2011-06-22 トヨタ自動車株式会社 脱蛋白質化天然ゴムラテックスの製造方法
JP5315611B2 (ja) 2004-06-23 2013-10-16 小野薬品工業株式会社 Ｓ１ｐ受容体結合能を有する化合物およびその用途
EP1826197B1 (en) 2004-12-13 2012-01-18 Ono Pharmaceutical Co., Ltd. Aminocarboxylic acid derivative and medicinal use thereof
WO2006080477A1 (en) 2005-01-25 2006-08-03 Tanabe Seiyaku Co., Ltd. Norvaline derivative and method for preparation thereof
EP1863463A1 (en) 2005-02-14 2007-12-12 University Of Virginia Patent Foundation Sphingosine 1-phosphate agonists comprising cycloalkanes and 5-membered heterocycles substitued by amino and phenyl groups
AR055319A1 (es) 2005-03-17 2007-08-15 Wyeth Corp Derivados de isoquinoleina, composiciones farmaceuticas y usos
US7919519B2 (en) * 2005-11-23 2011-04-05 Epix Pharmaceuticals Inc. S1P receptor modulating compounds and use thereof
JP2007169194A (ja) * 2005-12-21 2007-07-05 Kyorin Pharmaceut Co Ltd ジオキサフォスフォリナン誘導体とその付加塩及びスフィンゴシン−１−リン酸（ｓ１ｐ１，ｓ１ｐ４）受容体作動薬
WO2007092638A1 (en) 2006-02-09 2007-08-16 University Of Virginia Patent Foundation Bicyclic sphingosine 1-phosphate analogs
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
EA200901551A1 (ru) * 2007-05-22 2010-06-30 Новартис Аг Бензамиды, применимые в качестве модуляторов рецептора s1p
JP2010536791A (ja) 2007-08-15 2010-12-02 ユニバーシティ オブ バージニア パテント ファンデーション 二環式スフィンゴシン１−リン酸アナログ
EP2364088B1 (en) * 2008-10-30 2014-04-16 Biogen Idec MA Inc. Bicyclic aryl sphingosine 1-phosphate analogs
ES2613739T3 (es) * 2008-10-30 2017-05-25 Biogen Ma Inc. Análogos heterobicíclicos de 1-fosfato de esfingosina
UA107360C2 (en) * 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
PL2672823T3 (pl) 2011-02-07 2017-02-28 Biogen Ma Inc. Czynniki modulujące działanie receptora s1p

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