CO4930260A1 - Metodos y composiciones para estimular el crecimiento de neuritas - Google Patents

Metodos y composiciones para estimular el crecimiento de neuritas

Info

Publication number
CO4930260A1
CO4930260A1 CO97066755A CO97066755A CO4930260A1 CO 4930260 A1 CO4930260 A1 CO 4930260A1 CO 97066755 A CO97066755 A CO 97066755A CO 97066755 A CO97066755 A CO 97066755A CO 4930260 A1 CO4930260 A1 CO 4930260A1
Authority
CO
Colombia
Prior art keywords
straight
branched
alkyl
alkenyl
substituted
Prior art date
Application number
CO97066755A
Other languages
English (en)
Spanish (es)
Inventor
Robert E Zelle
Michael Su
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25009484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO4930260(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of CO4930260A1 publication Critical patent/CO4930260A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/185Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CO97066755A 1996-11-13 1997-11-13 Metodos y composiciones para estimular el crecimiento de neuritas CO4930260A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/748,447 US5840736A (en) 1996-11-13 1996-11-13 Methods and compositions for stimulating neurite growth

Publications (1)

Publication Number Publication Date
CO4930260A1 true CO4930260A1 (es) 2000-06-27

Family

ID=25009484

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97066755A CO4930260A1 (es) 1996-11-13 1997-11-13 Metodos y composiciones para estimular el crecimiento de neuritas

Country Status (32)

Country Link
US (3) US5840736A (instruction)
EP (1) EP0946190B1 (instruction)
JP (1) JP2001504470A (instruction)
KR (1) KR100544451B1 (instruction)
CN (1) CN1168442C (instruction)
AP (1) AP9901518A0 (instruction)
AR (1) AR011278A1 (instruction)
AT (1) ATE250424T1 (instruction)
AU (1) AU724833B2 (instruction)
BG (1) BG64670B1 (instruction)
BR (1) BR9712765A (instruction)
CA (1) CA2270634A1 (instruction)
CO (1) CO4930260A1 (instruction)
CZ (1) CZ296058B6 (instruction)
DE (1) DE69725169T2 (instruction)
DK (1) DK0946190T3 (instruction)
EA (1) EA004247B1 (instruction)
ES (1) ES2206753T3 (instruction)
HU (1) HU226728B1 (instruction)
IL (1) IL129555A (instruction)
IN (1) IN183740B (instruction)
IS (1) IS2057B (instruction)
NO (1) NO328030B1 (instruction)
NZ (1) NZ335394A (instruction)
PL (1) PL190903B1 (instruction)
PT (1) PT946190E (instruction)
SK (1) SK284535B6 (instruction)
TR (1) TR199901034T2 (instruction)
TW (1) TW513302B (instruction)
UA (1) UA63926C2 (instruction)
WO (1) WO1998020891A1 (instruction)
ZA (1) ZA9710256B (instruction)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5780484A (en) * 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds
US6242468B1 (en) 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
US6514686B2 (en) 1997-04-28 2003-02-04 The University Of British Columbia Method and composition for modulating amyloidosis
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US5968921A (en) 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
EA200001247A1 (ru) 1998-06-03 2001-08-27 Джи Пи Ай Нил Холдингс, Инк. N-связанные сульфонамиды n-гетероциклических карбоновых кислот или изостеры карбоновых кислот
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
ATE268772T1 (de) 1998-07-17 2004-06-15 Agouron Pharma Verbindungen und zusammensetzungen um neurales wachstum und streckung zu stimulieren
GB9815880D0 (en) 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6228872B1 (en) * 1998-11-12 2001-05-08 Bristol-Myers Squibb Company Neurotrophic diamide and carbamate agents
DE69923998T2 (de) * 1998-12-09 2006-04-27 Chiron Corp., Emeryville Verwendung eines neurologischen wirkstoffes zur herstellung eines medikamentes zur behandlung von erkrankungen des zentralen nervensystems
WO2000040557A1 (en) * 1999-01-08 2000-07-13 Vertex Pharmaceuticals Incorporated Process for the formation of intermediates useful for the preparation of pharmaceuticals
EP1196389A1 (en) 1999-07-06 2002-04-17 Vertex Pharmaceuticals Incorporated N-heterocyclic derivatives with neuronal activity
US6734211B1 (en) * 1999-07-09 2004-05-11 Oregon Health & Sciences University Compositions and methods for promoting nerve regeneration
WO2001008685A1 (en) * 1999-07-30 2001-02-08 Vertex Pharmaceuticals Incorporated Acyclic and cyclic amine derivatives
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
ES2269206T3 (es) * 1999-11-12 2007-04-01 Alcon, Inc. Ligandos de neurofilina para tratar trastornos oculares.
US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
US7060676B2 (en) * 1999-12-20 2006-06-13 Trustees Of Tufts College T. cruzi-derived neurotrophic agents and methods of use therefor
DE60026568D1 (de) 1999-12-21 2006-05-04 Mgi Gp Inc Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung
US6555573B2 (en) 2000-12-21 2003-04-29 The Quigley Corporation Method and composition for the topical treatment of diabetic neuropathy
ATE554784T1 (de) * 2001-05-25 2012-05-15 Cornell Res Foundation Inc Hochaffiner ligand für p75 neurotrophin-rezeptor
FR2825273B1 (fr) * 2001-05-29 2006-11-24 Oreal Composition pour le traitement des signes cutanes du vieillissement
EP1404325A2 (en) * 2001-05-29 2004-04-07 Guilford Pharmaceuticals Inc. Method for treating nerve injury caused by surgery
US20030118536A1 (en) * 2001-11-06 2003-06-26 Rosenbloom Richard A. Topical compositions and methods for treatment of adverse effects of ionizing radiation
US20030105027A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US7435725B2 (en) * 2001-11-06 2008-10-14 The Quigly Corporation Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20100247483A1 (en) * 2001-11-13 2010-09-30 Tran Loi H Therapeutic agent composition and method of use
US7232798B2 (en) 2001-11-13 2007-06-19 Tran Loi H Neuroprotection and neuroegenisis by administering cyclic prolyl glycine
AU2002363800A1 (en) * 2001-11-13 2003-05-26 Loi Tran Therapeutic agent composition and method of use
US7083813B2 (en) * 2002-11-06 2006-08-01 The Quigley Corporation Methods for the treatment of peripheral neural and vascular ailments
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
EP1988923A1 (en) * 2006-02-02 2008-11-12 Rinat Neuroscience Corp. Methods for treating unwanted weight loss or eating disorders by administering a trkb agonist
WO2007088479A1 (en) * 2006-02-02 2007-08-09 Rinat Neuroscience Corp. Methods for treating obesity by administering a trkb antagonist
EP2114436A1 (en) * 2006-12-20 2009-11-11 Rinat Neuroscience Corp. Trkb agonists for treating autoimmune disorders
US20090018151A1 (en) * 2007-02-23 2009-01-15 Ezekiel Fink Topical Treatment of Peripheral diabetic complications
CN112423774A (zh) 2018-05-15 2021-02-26 L·H·L·特兰 用于治疗轻度认知障碍、抑郁和心理障碍的治疗剂组成及使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798355A (en) 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
US5543423A (en) * 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
IL115685A (en) * 1994-11-16 2000-08-31 Vertex Pharma Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
US5696135A (en) * 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US6037370A (en) 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5811434A (en) * 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
CN104718162B (zh) * 2012-09-28 2017-11-21 Dic株式会社 α‑氧化铝微粒以及其制造方法

Also Published As

Publication number Publication date
PT946190E (pt) 2004-02-27
PL333270A1 (en) 1999-11-22
TR199901034T2 (xx) 1999-07-21
US5840736A (en) 1998-11-24
BR9712765A (pt) 1999-10-26
KR20000068962A (ko) 2000-11-25
IS2057B (is) 2005-10-14
IS5032A (is) 1999-04-21
AU724833B2 (en) 2000-09-28
CZ296058B6 (cs) 2006-01-11
UA63926C2 (uk) 2004-02-16
IN183740B (instruction) 2000-04-01
EP0946190A1 (en) 1999-10-06
CN1168442C (zh) 2004-09-29
HK1022851A1 (en) 2000-08-25
JP2001504470A (ja) 2001-04-03
TW513302B (en) 2002-12-11
ATE250424T1 (de) 2003-10-15
EA199900464A1 (ru) 2000-02-28
WO1998020891A1 (en) 1998-05-22
NO992138D0 (no) 1999-05-03
EP0946190B1 (en) 2003-09-24
NO328030B1 (no) 2009-11-16
IL129555A (en) 2005-08-31
ZA9710256B (en) 1998-05-28
HUP0001219A2 (hu) 2000-11-28
AR011278A1 (es) 2000-08-16
HU226728B1 (en) 2009-08-28
US6284778B1 (en) 2001-09-04
DE69725169T2 (de) 2004-07-15
BG103429A (en) 2000-04-28
DE69725169D1 (de) 2003-10-30
IL129555A0 (en) 2000-02-29
BG64670B1 (bg) 2005-11-30
SK284535B6 (sk) 2005-06-02
CA2270634A1 (en) 1998-05-22
SK62899A3 (en) 2000-04-10
KR100544451B1 (ko) 2006-01-24
HUP0001219A3 (en) 2001-12-28
AP9901518A0 (en) 1999-06-30
DK0946190T3 (da) 2003-12-08
CZ168399A3 (cs) 1999-08-11
PL190903B1 (pl) 2006-02-28
NO992138L (no) 1999-07-13
CN1239433A (zh) 1999-12-22
AU5258998A (en) 1998-06-03
NZ335394A (en) 2000-06-23
US6172086B1 (en) 2001-01-09
EA004247B1 (ru) 2004-02-26
ES2206753T3 (es) 2004-05-16

Similar Documents

Publication Publication Date Title
CO4930260A1 (es) Metodos y composiciones para estimular el crecimiento de neuritas
CO5080733A1 (es) Metodos y composiciones para estimular el crecimiento de neuritas
CO4920219A1 (es) Metodos y composiciones para estimular el crecimiento de neuritas
CO5080734A1 (es) Compuestos amino que poseen actividad neuronal
RU97110114A (ru) Новые производные аминокислот с повышенной активностью против множественной лекарственной устойчивости
BR9803883A (pt) Derivado de amida.
AR036045A1 (es) Amidas de acidos antranilicos con cadena lateral de heteroarilsulfonilo, su empleo para la preparacion de un medicamento, asi como composiciones farmaceuticas que las contienen
NO302570B1 (no) Substituerte pipekolinsyrederivater som HIV-protease-inhibitorer, farmasöytiske blandinger inneholdende dem og anvendelser av derivatene
BR0212829A (pt) Derivados de 1,8-naftiridina e seu uso para tratar diabetes e distúrbios relacionados
BR9106330A (pt) Tiofeno sulfonamidas uteis como inibidores da anidrase carbonica
CO4950619A1 (es) Derivados de acido arilsulfonil hidroxamico
ES2044829T3 (es) Metodo y composiciones para la inhibicion de alteraciones asociadas con las lesiones oxidativas de los tejidos.
AR006867A1 (es) Composición topica para la piel que comprende un compuesto oxa-diácido, su uso para preparar un medicamento para tratar condiciones de la piel y métodos cosméticos no terapéuticos para el pulido de la piel y para suavizar el cabello que aplican dicho compuesto.
AR029806A1 (es) Derivados de fenilo, proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de la composicion farmaceutica y usos de estos derivados
UA41297C2 (uk) Похідні індолу, фармацевтична композиція і спосіб лікування
ES2059391T3 (es) Derivados de dihidropiridina, su preparacion y su uso.
ES2174579T3 (es) Nuevos derivados benzotiofenicos, benzofuranicos e indolicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2102154T3 (es) Inhibicion de trombina.
CY1105125T1 (el) Χρηση αναστολεων ακετυλοχολινεστepασης για την παρασκευη φαρμακευτικων συνθεσεων για τη θepαπευτικη αντιμετωπιση συνδρομων λειτουργικων και/ή οργανικων πονων
ES2134939T3 (es) Derivados de peptidilo como inhibidores de metaloproteinas.
AU677868B2 (en) New naphthalene derivatives, processes for their preparation and the pharmaceutical compositions which contain them
ES2059489T3 (es) Derivados bencimidazol 1-alkil sustituidos.
NO984740L (no) Isatinderivater som acetylcholinesteraseinhibitorer og analgetiske midler
AR002745A1 (es) 5,6-DIHIDRO-9H-PIRAZOL[3,4-c]-1,2,4-TRIAZOL [4,3-a] PIRIDINAS TRICICLICAS Y COMPOSICIONES FARMACEUTICAS CONTENIENDO LAS MISMAS.
NO930499L (no) Benzimidazolderivater, fremgangsmaate for deres fremstilling og deres anvendelse