EA199900464A1 - Способы и композиции для стимуляции роста невритов - Google Patents

Способы и композиции для стимуляции роста невритов

Info

Publication number
EA199900464A1
EA199900464A1 EA199900464A EA199900464A EA199900464A1 EA 199900464 A1 EA199900464 A1 EA 199900464A1 EA 199900464 A EA199900464 A EA 199900464A EA 199900464 A EA199900464 A EA 199900464A EA 199900464 A1 EA199900464 A1 EA 199900464A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
methods
neurites
stimulating growth
growth
Prior art date
Application number
EA199900464A
Other languages
English (en)
Other versions
EA004247B1 (ru
Inventor
Роберт Е. Зелле
Майкл Су
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25009484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199900464(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Вертекс Фармасьютикалз Инкорпорейтед filed Critical Вертекс Фармасьютикалз Инкорпорейтед
Publication of EA199900464A1 publication Critical patent/EA199900464A1/ru
Publication of EA004247B1 publication Critical patent/EA004247B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Настоящее изобретение относится к способам и фармацевтическим композициям для стимуляции роста невритов в нервных клетках. Эти композиции включают нейротрофическое количество соединения и нейротрофический фактор, такой как фактор роста нервной ткани (ФРН). Способы предусматривают обработку нервных клеток вышеуказанными композициями или композициями без нейротрофического фактора. Способы по данному изобретению могут использоваться для ускорения репарации повреждений нейронов, вызванных заболеванием или физической травмой.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900464A 1996-11-13 1997-11-13 Способы и композиции для стимуляции роста невритов EA004247B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/748,447 US5840736A (en) 1996-11-13 1996-11-13 Methods and compositions for stimulating neurite growth
PCT/US1997/020866 WO1998020891A1 (en) 1996-11-13 1997-11-13 Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors

Publications (2)

Publication Number Publication Date
EA199900464A1 true EA199900464A1 (ru) 2000-02-28
EA004247B1 EA004247B1 (ru) 2004-02-26

Family

ID=25009484

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900464A EA004247B1 (ru) 1996-11-13 1997-11-13 Способы и композиции для стимуляции роста невритов

Country Status (33)

Country Link
US (3) US5840736A (ru)
EP (1) EP0946190B1 (ru)
JP (1) JP2001504470A (ru)
KR (1) KR100544451B1 (ru)
CN (1) CN1168442C (ru)
AP (1) AP9901518A0 (ru)
AR (1) AR011278A1 (ru)
AT (1) ATE250424T1 (ru)
AU (1) AU724833B2 (ru)
BG (1) BG64670B1 (ru)
BR (1) BR9712765A (ru)
CA (1) CA2270634A1 (ru)
CO (1) CO4930260A1 (ru)
CZ (1) CZ296058B6 (ru)
DE (1) DE69725169T2 (ru)
DK (1) DK0946190T3 (ru)
EA (1) EA004247B1 (ru)
ES (1) ES2206753T3 (ru)
HK (1) HK1022851A1 (ru)
HU (1) HU226728B1 (ru)
IL (1) IL129555A (ru)
IN (1) IN183740B (ru)
IS (1) IS2057B (ru)
NO (1) NO328030B1 (ru)
NZ (1) NZ335394A (ru)
PL (1) PL190903B1 (ru)
PT (1) PT946190E (ru)
SK (1) SK284535B6 (ru)
TR (1) TR199901034T2 (ru)
TW (1) TW513302B (ru)
UA (1) UA63926C2 (ru)
WO (1) WO1998020891A1 (ru)
ZA (1) ZA9710256B (ru)

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US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US6242468B1 (en) 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
US6514686B2 (en) 1997-04-28 2003-02-04 The University Of British Columbia Method and composition for modulating amyloidosis
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US5968921A (en) * 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
CN1295561A (zh) 1998-06-03 2001-05-16 Gpinil控股公司 N－杂环羧酸或羧酸等排物的n－结合氨磺酰
PT1098897E (pt) 1998-07-17 2004-10-29 Agouron Pharma Compostos composicoes e metodos para estimular o crescimento e a elongacao neuronal
GB9815880D0 (en) 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6228872B1 (en) 1998-11-12 2001-05-08 Bristol-Myers Squibb Company Neurotrophic diamide and carbamate agents
ATE289800T1 (de) * 1998-12-09 2005-03-15 Chiron Corp Verwendung eines neurologischen wirkstoffes zur herstellung eines medikamentes zur behandlung von erkrankungen des zentralen nervensystems
AU2407400A (en) * 1999-01-08 2000-07-24 Vertex Pharmaceuticals Incorporated Process for the formation of intermediates useful for the preparation of pharmaceuticals
AU6073300A (en) 1999-07-06 2001-01-22 Vertex Pharmaceuticals Incorporated N-heterocyclic derivatives with neuronal activity
US6734211B1 (en) 1999-07-09 2004-05-11 Oregon Health & Sciences University Compositions and methods for promoting nerve regeneration
CA2379993A1 (en) * 1999-07-30 2001-02-08 Vertex Pharmaceuticals Incorporated Acyclic and cyclic amine derivatives
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
AR034103A1 (es) * 1999-11-12 2004-02-04 Alcon Inc Composicion farmaceutica que comprende ligandos de neurofilina para el tratamiento de condiciones oculares
US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
US7060676B2 (en) * 1999-12-20 2006-06-13 Trustees Of Tufts College T. cruzi-derived neurotrophic agents and methods of use therefor
AU1464101A (en) 1999-12-21 2001-07-03 Gpi Nil Holdings, Inc. Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
US6555573B2 (en) 2000-12-21 2003-04-29 The Quigley Corporation Method and composition for the topical treatment of diabetic neuropathy
EP1575477B1 (en) * 2001-05-25 2012-04-25 Cornell Research Foundation, Inc. HIGH AFFINITY LIGAND FOR p75 NEUROTROPHIN RECEPTOR
FR2825273B1 (fr) * 2001-05-29 2006-11-24 Oreal Composition pour le traitement des signes cutanes du vieillissement
EP1404325A2 (en) * 2001-05-29 2004-04-07 Guilford Pharmaceuticals Inc. Method for treating nerve injury caused by surgery
US20030105027A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US7435725B2 (en) * 2001-11-06 2008-10-14 The Quigly Corporation Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030118536A1 (en) * 2001-11-06 2003-06-26 Rosenbloom Richard A. Topical compositions and methods for treatment of adverse effects of ionizing radiation
AU2002363800A1 (en) * 2001-11-13 2003-05-26 Loi Tran Therapeutic agent composition and method of use
US7232798B2 (en) 2001-11-13 2007-06-19 Tran Loi H Neuroprotection and neuroegenisis by administering cyclic prolyl glycine
US20100247483A1 (en) * 2001-11-13 2010-09-30 Tran Loi H Therapeutic agent composition and method of use
US7083813B2 (en) * 2002-11-06 2006-08-01 The Quigley Corporation Methods for the treatment of peripheral neural and vascular ailments
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
BRPI0707482A2 (pt) * 2006-02-02 2011-05-03 Rinat Neuroscience Corp métodos para tratar perda indesejada de peso ou distúbios de alimentação por administração de um agonista de trkb, bem como uso de nt-4/5 e de um agonista de trkb
WO2007088479A1 (en) * 2006-02-02 2007-08-09 Rinat Neuroscience Corp. Methods for treating obesity by administering a trkb antagonist
RU2009123491A (ru) * 2006-12-20 2010-12-27 Ринат Ньюросайенс Корпорейшн (Us) АГОНИСТЫ TrkB ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ НАРУШЕНИЙ
US20090018151A1 (en) * 2007-02-23 2009-01-15 Ezekiel Fink Topical Treatment of Peripheral diabetic complications
US11090303B2 (en) 2018-05-15 2021-08-17 Lloyd Hung Loi Tran Therapeutic agent composition and method of use, for treatment of mild congnitive impairment, depression, and psychological disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798355A (en) 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
IL115685A (en) * 1994-11-16 2000-08-31 Vertex Pharma Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
US5543423A (en) * 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
US5696135A (en) * 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5801197A (en) 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5811434A (en) * 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
WO2014051091A1 (ja) * 2012-09-28 2014-04-03 Dic株式会社 α－アルミナ微粒子及びその製造方法

Also Published As

Publication number Publication date
SK62899A3 (en) 2000-04-10
ES2206753T3 (es) 2004-05-16
CZ296058B6 (cs) 2006-01-11
DE69725169T2 (de) 2004-07-15
PL190903B1 (pl) 2006-02-28
BG103429A (en) 2000-04-28
BR9712765A (pt) 1999-10-26
EA004247B1 (ru) 2004-02-26
US6284778B1 (en) 2001-09-04
HUP0001219A3 (en) 2001-12-28
CA2270634A1 (en) 1998-05-22
IL129555A (en) 2005-08-31
AR011278A1 (es) 2000-08-16
IS5032A (is) 1999-04-21
NZ335394A (en) 2000-06-23
EP0946190A1 (en) 1999-10-06
CN1168442C (zh) 2004-09-29
TW513302B (en) 2002-12-11
DK0946190T3 (da) 2003-12-08
EP0946190B1 (en) 2003-09-24
AP9901518A0 (en) 1999-06-30
PL333270A1 (en) 1999-11-22
WO1998020891A1 (en) 1998-05-22
KR20000068962A (ko) 2000-11-25
KR100544451B1 (ko) 2006-01-24
ATE250424T1 (de) 2003-10-15
US5840736A (en) 1998-11-24
PT946190E (pt) 2004-02-27
IS2057B (is) 2005-10-14
AU5258998A (en) 1998-06-03
IL129555A0 (en) 2000-02-29
HU226728B1 (en) 2009-08-28
AU724833B2 (en) 2000-09-28
NO992138D0 (no) 1999-05-03
NO992138L (no) 1999-07-13
HK1022851A1 (en) 2000-08-25
SK284535B6 (sk) 2005-06-02
CO4930260A1 (es) 2000-06-27
JP2001504470A (ja) 2001-04-03
TR199901034T2 (xx) 1999-07-21
BG64670B1 (bg) 2005-11-30
ZA9710256B (en) 1998-05-28
CN1239433A (zh) 1999-12-22
CZ168399A3 (cs) 1999-08-11
NO328030B1 (no) 2009-11-16
IN183740B (ru) 2000-04-01
UA63926C2 (ru) 2004-02-16
US6172086B1 (en) 2001-01-09
DE69725169D1 (de) 2003-10-30
HUP0001219A2 (hu) 2000-11-28

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU