DE69725169D1 - Zusammensetzungen und verfahren zur anregung des wachstums von neuriten - Google Patents

Zusammensetzungen und verfahren zur anregung des wachstums von neuriten

Info

Publication number
DE69725169D1
DE69725169D1 DE69725169T DE69725169T DE69725169D1 DE 69725169 D1 DE69725169 D1 DE 69725169D1 DE 69725169 T DE69725169 T DE 69725169T DE 69725169 T DE69725169 T DE 69725169T DE 69725169 D1 DE69725169 D1 DE 69725169D1
Authority
DE
Germany
Prior art keywords
neurites
growth
compositions
increasing
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69725169T
Other languages
English (en)
Other versions
DE69725169T2 (de
Inventor
E Zelle
Michael Su
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25009484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69725169(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of DE69725169D1 publication Critical patent/DE69725169D1/de
Application granted granted Critical
Publication of DE69725169T2 publication Critical patent/DE69725169T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69725169T 1996-11-13 1997-11-13 Zusammensetzungen und verfahren zur anregung des wachstums von neuriten Expired - Lifetime DE69725169T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/748,447 US5840736A (en) 1996-11-13 1996-11-13 Methods and compositions for stimulating neurite growth
US748447 1996-11-13
PCT/US1997/020866 WO1998020891A1 (en) 1996-11-13 1997-11-13 Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors

Publications (2)

Publication Number Publication Date
DE69725169D1 true DE69725169D1 (de) 2003-10-30
DE69725169T2 DE69725169T2 (de) 2004-07-15

Family

ID=25009484

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69725169T Expired - Lifetime DE69725169T2 (de) 1996-11-13 1997-11-13 Zusammensetzungen und verfahren zur anregung des wachstums von neuriten

Country Status (33)

Country Link
US (3) US5840736A (de)
EP (1) EP0946190B1 (de)
JP (1) JP2001504470A (de)
KR (1) KR100544451B1 (de)
CN (1) CN1168442C (de)
AP (1) AP9901518A0 (de)
AR (1) AR011278A1 (de)
AT (1) ATE250424T1 (de)
AU (1) AU724833B2 (de)
BG (1) BG64670B1 (de)
BR (1) BR9712765A (de)
CA (1) CA2270634A1 (de)
CO (1) CO4930260A1 (de)
CZ (1) CZ296058B6 (de)
DE (1) DE69725169T2 (de)
DK (1) DK0946190T3 (de)
EA (1) EA004247B1 (de)
ES (1) ES2206753T3 (de)
HK (1) HK1022851A1 (de)
HU (1) HU226728B1 (de)
IL (1) IL129555A (de)
IN (1) IN183740B (de)
IS (1) IS2057B (de)
NO (1) NO328030B1 (de)
NZ (1) NZ335394A (de)
PL (1) PL190903B1 (de)
PT (1) PT946190E (de)
SK (1) SK284535B6 (de)
TR (1) TR199901034T2 (de)
TW (1) TW513302B (de)
UA (1) UA63926C2 (de)
WO (1) WO1998020891A1 (de)
ZA (1) ZA9710256B (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US6242468B1 (en) 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
US6514686B2 (en) 1997-04-28 2003-02-04 The University Of British Columbia Method and composition for modulating amyloidosis
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US5968921A (en) 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
AU1708099A (en) 1998-06-03 1999-12-20 Amgen, Inc. N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
GEP20043368B (en) 1998-07-17 2004-04-13 Agouron Pharma Compounds, Compositions, and Methods For Stimulating Neuronal Growth and Elongation
GB9815880D0 (en) 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
US6228872B1 (en) 1998-11-12 2001-05-08 Bristol-Myers Squibb Company Neurotrophic diamide and carbamate agents
DE69923998T2 (de) * 1998-12-09 2006-04-27 Chiron Corp., Emeryville Verwendung eines neurologischen wirkstoffes zur herstellung eines medikamentes zur behandlung von erkrankungen des zentralen nervensystems
JP2002534414A (ja) * 1999-01-08 2002-10-15 バーテックス ファーマシューティカルズ インコーポレイテッド 医薬の製造に有用な中間体の形成方法
AU6073300A (en) * 1999-07-06 2001-01-22 Vertex Pharmaceuticals Incorporated N-heterocyclic derivatives with neuronal activity
US6734211B1 (en) 1999-07-09 2004-05-11 Oregon Health & Sciences University Compositions and methods for promoting nerve regeneration
MXPA02001095A (es) * 1999-07-30 2002-08-20 Vertex Pharma Derivados de amina ciclicos y aciclicos.
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
AU784347B2 (en) * 1999-11-12 2006-03-16 Alcon Inc. Neurophilin ligands for treating ocular conditions
US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
US7060676B2 (en) 1999-12-20 2006-06-13 Trustees Of Tufts College T. cruzi-derived neurotrophic agents and methods of use therefor
AU1464101A (en) 1999-12-21 2001-07-03 Gpi Nil Holdings, Inc. Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
US6555573B2 (en) 2000-12-21 2003-04-29 The Quigley Corporation Method and composition for the topical treatment of diabetic neuropathy
DK1575477T3 (da) * 2001-05-25 2012-07-23 Cornell Res Foundation Inc Højaffinitetsligand til p75-neurotrofinreceptor
US20030203890A1 (en) * 2001-05-29 2003-10-30 Steiner Joseph P. Method for treating nerve injury caused as a result of surgery
FR2825273B1 (fr) * 2001-05-29 2006-11-24 Oreal Composition pour le traitement des signes cutanes du vieillissement
US20030118536A1 (en) * 2001-11-06 2003-06-26 Rosenbloom Richard A. Topical compositions and methods for treatment of adverse effects of ionizing radiation
US7435725B2 (en) * 2001-11-06 2008-10-14 The Quigly Corporation Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030105027A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US7232798B2 (en) 2001-11-13 2007-06-19 Tran Loi H Neuroprotection and neuroegenisis by administering cyclic prolyl glycine
US20100247483A1 (en) * 2001-11-13 2010-09-30 Tran Loi H Therapeutic agent composition and method of use
WO2003041655A2 (en) * 2001-11-13 2003-05-22 Loi Tran Therapeutic agent composition and method of use
US7083813B2 (en) * 2002-11-06 2006-08-01 The Quigley Corporation Methods for the treatment of peripheral neural and vascular ailments
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
AU2007210862A1 (en) * 2006-02-02 2007-08-09 Rinat Neuroscience Corp. Methods for treating unwanted weight loss or eating disorders by administering a trkB agonist
EP1988920A1 (de) * 2006-02-02 2008-11-12 Rinat Neuroscience Corp. Verfahren zur behandlung von fettsucht durch verabreichung eines trkb-antagonisten
RU2009123491A (ru) * 2006-12-20 2010-12-27 Ринат Ньюросайенс Корпорейшн (Us) АГОНИСТЫ TrkB ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ НАРУШЕНИЙ
US20090018151A1 (en) * 2007-02-23 2009-01-15 Ezekiel Fink Topical Treatment of Peripheral diabetic complications
AU2019271189A1 (en) 2018-05-15 2021-01-07 Lloyd Hung Loi TRAN Therapeutic agent composition and method of use, for treatment of mild cognitive impairment, depression, and psychological disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798355A (en) 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
IL115685A (en) * 1994-11-16 2000-08-31 Vertex Pharma Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
US5543423A (en) * 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
US5696135A (en) * 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5801197A (en) 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5811434A (en) * 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
CN104718162B (zh) * 2012-09-28 2017-11-21 Dic株式会社 α‑氧化铝微粒以及其制造方法

Also Published As

Publication number Publication date
ATE250424T1 (de) 2003-10-15
US6284778B1 (en) 2001-09-04
CZ296058B6 (cs) 2006-01-11
PT946190E (pt) 2004-02-27
HU226728B1 (en) 2009-08-28
BG103429A (en) 2000-04-28
CO4930260A1 (es) 2000-06-27
TR199901034T2 (xx) 1999-07-21
IS2057B (is) 2005-10-14
KR20000068962A (ko) 2000-11-25
US6172086B1 (en) 2001-01-09
IN183740B (de) 2000-04-01
EA004247B1 (ru) 2004-02-26
US5840736A (en) 1998-11-24
AR011278A1 (es) 2000-08-16
BR9712765A (pt) 1999-10-26
IL129555A (en) 2005-08-31
NO992138L (no) 1999-07-13
SK284535B6 (sk) 2005-06-02
UA63926C2 (uk) 2004-02-16
ZA9710256B (en) 1998-05-28
SK62899A3 (en) 2000-04-10
EP0946190B1 (de) 2003-09-24
DE69725169T2 (de) 2004-07-15
EA199900464A1 (ru) 2000-02-28
CA2270634A1 (en) 1998-05-22
ES2206753T3 (es) 2004-05-16
HK1022851A1 (en) 2000-08-25
NO992138D0 (no) 1999-05-03
AU5258998A (en) 1998-06-03
BG64670B1 (bg) 2005-11-30
CN1239433A (zh) 1999-12-22
NZ335394A (en) 2000-06-23
HUP0001219A2 (hu) 2000-11-28
HUP0001219A3 (en) 2001-12-28
PL333270A1 (en) 1999-11-22
WO1998020891A1 (en) 1998-05-22
TW513302B (en) 2002-12-11
CZ168399A3 (cs) 1999-08-11
IS5032A (is) 1999-04-21
AU724833B2 (en) 2000-09-28
IL129555A0 (en) 2000-02-29
NO328030B1 (no) 2009-11-16
JP2001504470A (ja) 2001-04-03
KR100544451B1 (ko) 2006-01-24
DK0946190T3 (da) 2003-12-08
PL190903B1 (pl) 2006-02-28
CN1168442C (zh) 2004-09-29
AP9901518A0 (en) 1999-06-30
EP0946190A1 (de) 1999-10-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition