HUP0001219A2 - Neurotrofikus hatású vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Neurotrofikus hatású vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0001219A2 HUP0001219A2 HU0001219A HUP0001219A HUP0001219A2 HU P0001219 A2 HUP0001219 A2 HU P0001219A2 HU 0001219 A HU0001219 A HU 0001219A HU P0001219 A HUP0001219 A HU P0001219A HU P0001219 A2 HUP0001219 A2 HU P0001219A2
- Authority
- HU
- Hungary
- Prior art keywords
- pharmaceutical compositions
- methyl
- compositions containing
- containing compounds
- neurotrophic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000508 neurotrophic effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 3-(3-pyridyl)propyl- Chemical group 0.000 abstract 4
- 108010025020 Nerve Growth Factor Proteins 0.000 abstract 3
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 abstract 2
- 102000015336 Nerve Growth Factor Human genes 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229940053128 nerve growth factor Drugs 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 abstract 1
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 abstract 1
- 102000007072 Nerve Growth Factors Human genes 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 230000014511 neuron projection development Effects 0.000 abstract 1
- 239000003900 neurotrophic factor Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
A találmány tárgya gyógyszerkészítmény idegsejtekben a neuritfejlődésserkentésére. A találmány szerinti gyógyszerkészítmény komponensei:(a) egy neurotrofikus mennyiségű (I) általános képletű vegyület - aholelőnyösen B és D hidrogénatom, 3-(3-piridil)-propil-, 2-(4-piridil)-etil-, 2-(3-imidazolil)-etil- vagy fenetilcsoport; R1 metil-, benzil-, 4-klór- vagy 4-fluor-benzil-csoport vagy (1H-imidazolil)-metil-csoport; J metilcsoport; K benzil-, 4-klór-benzil- vagy izopropilcsoport; X 3,4,5-trimetoxi-fenil-csoport; és m 0 vagy 1, előnyösen 0 - vagy valamely gyógyszerészetileg elfogadhatószármazéka; b) egy neurotrofikus faktor, előnyösen idegnövekedésifaktor (NGF); és c) egy gyógyszerészetileg elfogadható hordozó. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/748,447 US5840736A (en) | 1996-11-13 | 1996-11-13 | Methods and compositions for stimulating neurite growth |
PCT/US1997/020866 WO1998020891A1 (en) | 1996-11-13 | 1997-11-13 | Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0001219A2 true HUP0001219A2 (hu) | 2000-11-28 |
HUP0001219A3 HUP0001219A3 (en) | 2001-12-28 |
HU226728B1 HU226728B1 (en) | 2009-08-28 |
Family
ID=25009484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0001219A HU226728B1 (en) | 1996-11-13 | 1997-11-13 | Pharmaceutical compositions containing compounds of neurotrophic effect |
Country Status (33)
Country | Link |
---|---|
US (3) | US5840736A (hu) |
EP (1) | EP0946190B1 (hu) |
JP (1) | JP2001504470A (hu) |
KR (1) | KR100544451B1 (hu) |
CN (1) | CN1168442C (hu) |
AP (1) | AP9901518A0 (hu) |
AR (1) | AR011278A1 (hu) |
AT (1) | ATE250424T1 (hu) |
AU (1) | AU724833B2 (hu) |
BG (1) | BG64670B1 (hu) |
BR (1) | BR9712765A (hu) |
CA (1) | CA2270634A1 (hu) |
CO (1) | CO4930260A1 (hu) |
CZ (1) | CZ296058B6 (hu) |
DE (1) | DE69725169T2 (hu) |
DK (1) | DK0946190T3 (hu) |
EA (1) | EA004247B1 (hu) |
ES (1) | ES2206753T3 (hu) |
HK (1) | HK1022851A1 (hu) |
HU (1) | HU226728B1 (hu) |
IL (1) | IL129555A (hu) |
IN (1) | IN183740B (hu) |
IS (1) | IS2057B (hu) |
NO (1) | NO328030B1 (hu) |
NZ (1) | NZ335394A (hu) |
PL (1) | PL190903B1 (hu) |
PT (1) | PT946190E (hu) |
SK (1) | SK284535B6 (hu) |
TR (1) | TR199901034T2 (hu) |
TW (1) | TW513302B (hu) |
UA (1) | UA63926C2 (hu) |
WO (1) | WO1998020891A1 (hu) |
ZA (1) | ZA9710256B (hu) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US6242468B1 (en) | 1997-02-27 | 2001-06-05 | Jia-He Li | Carbamate and urea compositions and neurotrophic uses |
US6514686B2 (en) | 1997-04-28 | 2003-02-04 | The University Of British Columbia | Method and composition for modulating amyloidosis |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6852496B1 (en) | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
US5968921A (en) * | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
CN1295561A (zh) | 1998-06-03 | 2001-05-16 | Gpinil控股公司 | N-杂环羧酸或羧酸等排物的n-结合氨磺酰 |
PT1098897E (pt) | 1998-07-17 | 2004-10-29 | Agouron Pharma | Compostos composicoes e metodos para estimular o crescimento e a elongacao neuronal |
GB9815880D0 (en) | 1998-07-21 | 1998-09-16 | Pfizer Ltd | Heterocycles |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
US6228872B1 (en) | 1998-11-12 | 2001-05-08 | Bristol-Myers Squibb Company | Neurotrophic diamide and carbamate agents |
ATE289800T1 (de) * | 1998-12-09 | 2005-03-15 | Chiron Corp | Verwendung eines neurologischen wirkstoffes zur herstellung eines medikamentes zur behandlung von erkrankungen des zentralen nervensystems |
AU2407400A (en) * | 1999-01-08 | 2000-07-24 | Vertex Pharmaceuticals Incorporated | Process for the formation of intermediates useful for the preparation of pharmaceuticals |
AU6073300A (en) | 1999-07-06 | 2001-01-22 | Vertex Pharmaceuticals Incorporated | N-heterocyclic derivatives with neuronal activity |
US6734211B1 (en) | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
CA2379993A1 (en) * | 1999-07-30 | 2001-02-08 | Vertex Pharmaceuticals Incorporated | Acyclic and cyclic amine derivatives |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
AR034103A1 (es) * | 1999-11-12 | 2004-02-04 | Alcon Inc | Composicion farmaceutica que comprende ligandos de neurofilina para el tratamiento de condiciones oculares |
US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
US7060676B2 (en) * | 1999-12-20 | 2006-06-13 | Trustees Of Tufts College | T. cruzi-derived neurotrophic agents and methods of use therefor |
AU1464101A (en) | 1999-12-21 | 2001-07-03 | Gpi Nil Holdings, Inc. | Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same |
US6555573B2 (en) | 2000-12-21 | 2003-04-29 | The Quigley Corporation | Method and composition for the topical treatment of diabetic neuropathy |
EP1575477B1 (en) * | 2001-05-25 | 2012-04-25 | Cornell Research Foundation, Inc. | HIGH AFFINITY LIGAND FOR p75 NEUROTROPHIN RECEPTOR |
FR2825273B1 (fr) * | 2001-05-29 | 2006-11-24 | Oreal | Composition pour le traitement des signes cutanes du vieillissement |
EP1404325A2 (en) * | 2001-05-29 | 2004-04-07 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
US20030105027A1 (en) * | 2001-11-06 | 2003-06-05 | Rosenbloom Richard A. | Nutritional supplements and methods for prevention, reduction and treatment of radiation injury |
US7435725B2 (en) * | 2001-11-06 | 2008-10-14 | The Quigly Corporation | Oral compositions and methods for prevention, reduction and treatment of radiation injury |
US20030118536A1 (en) * | 2001-11-06 | 2003-06-26 | Rosenbloom Richard A. | Topical compositions and methods for treatment of adverse effects of ionizing radiation |
AU2002363800A1 (en) * | 2001-11-13 | 2003-05-26 | Loi Tran | Therapeutic agent composition and method of use |
US7232798B2 (en) | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
US20100247483A1 (en) * | 2001-11-13 | 2010-09-30 | Tran Loi H | Therapeutic agent composition and method of use |
US7083813B2 (en) * | 2002-11-06 | 2006-08-01 | The Quigley Corporation | Methods for the treatment of peripheral neural and vascular ailments |
US8841326B2 (en) | 2004-02-12 | 2014-09-23 | Stc.Unm | Therapeutic curcumin derivatives |
BRPI0707482A2 (pt) * | 2006-02-02 | 2011-05-03 | Rinat Neuroscience Corp | métodos para tratar perda indesejada de peso ou distúbios de alimentação por administração de um agonista de trkb, bem como uso de nt-4/5 e de um agonista de trkb |
WO2007088479A1 (en) * | 2006-02-02 | 2007-08-09 | Rinat Neuroscience Corp. | Methods for treating obesity by administering a trkb antagonist |
RU2009123491A (ru) * | 2006-12-20 | 2010-12-27 | Ринат Ньюросайенс Корпорейшн (Us) | АГОНИСТЫ TrkB ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ НАРУШЕНИЙ |
US20090018151A1 (en) * | 2007-02-23 | 2009-01-15 | Ezekiel Fink | Topical Treatment of Peripheral diabetic complications |
US11090303B2 (en) | 2018-05-15 | 2021-08-17 | Lloyd Hung Loi Tran | Therapeutic agent composition and method of use, for treatment of mild congnitive impairment, depression, and psychological disorders |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5798355A (en) | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
IL115685A (en) * | 1994-11-16 | 2000-08-31 | Vertex Pharma | Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
US5543423A (en) * | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5614547A (en) * | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5801197A (en) | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
WO2014051091A1 (ja) * | 2012-09-28 | 2014-04-03 | Dic株式会社 | α-アルミナ微粒子及びその製造方法 |
-
1996
- 1996-11-13 US US08/748,447 patent/US5840736A/en not_active Expired - Lifetime
-
1997
- 1997-11-13 ES ES97947533T patent/ES2206753T3/es not_active Expired - Lifetime
- 1997-11-13 IN IN2149CA1997 patent/IN183740B/en unknown
- 1997-11-13 BR BR9712765-5A patent/BR9712765A/pt not_active IP Right Cessation
- 1997-11-13 HU HU0001219A patent/HU226728B1/hu not_active IP Right Cessation
- 1997-11-13 CO CO97066755A patent/CO4930260A1/es unknown
- 1997-11-13 CN CNB971802467A patent/CN1168442C/zh not_active Expired - Fee Related
- 1997-11-13 SK SK628-99A patent/SK284535B6/sk not_active IP Right Cessation
- 1997-11-13 NZ NZ335394A patent/NZ335394A/en unknown
- 1997-11-13 EA EA199900464A patent/EA004247B1/ru not_active IP Right Cessation
- 1997-11-13 PL PL333270A patent/PL190903B1/pl not_active IP Right Cessation
- 1997-11-13 DE DE69725169T patent/DE69725169T2/de not_active Expired - Lifetime
- 1997-11-13 PT PT97947533T patent/PT946190E/pt unknown
- 1997-11-13 ZA ZA9710256A patent/ZA9710256B/xx unknown
- 1997-11-13 TR TR1999/01034T patent/TR199901034T2/xx unknown
- 1997-11-13 UA UA99063268A patent/UA63926C2/uk unknown
- 1997-11-13 JP JP52286598A patent/JP2001504470A/ja active Pending
- 1997-11-13 AR ARP970105318A patent/AR011278A1/es unknown
- 1997-11-13 AU AU52589/98A patent/AU724833B2/en not_active Ceased
- 1997-11-13 KR KR1019997004186A patent/KR100544451B1/ko not_active IP Right Cessation
- 1997-11-13 AP APAP/P/1999/001518A patent/AP9901518A0/en unknown
- 1997-11-13 AT AT97947533T patent/ATE250424T1/de not_active IP Right Cessation
- 1997-11-13 EP EP97947533A patent/EP0946190B1/en not_active Expired - Lifetime
- 1997-11-13 DK DK97947533T patent/DK0946190T3/da active
- 1997-11-13 TW TW086116911A patent/TW513302B/zh not_active IP Right Cessation
- 1997-11-13 IL IL12955597A patent/IL129555A/xx not_active IP Right Cessation
- 1997-11-13 CZ CZ0168399A patent/CZ296058B6/cs not_active IP Right Cessation
- 1997-11-13 WO PCT/US1997/020866 patent/WO1998020891A1/en active IP Right Grant
- 1997-11-13 CA CA002270634A patent/CA2270634A1/en not_active Abandoned
-
1998
- 1998-11-23 US US09/198,175 patent/US6172086B1/en not_active Expired - Lifetime
-
1999
- 1999-04-21 IS IS5032A patent/IS2057B/is unknown
- 1999-05-03 NO NO19992138A patent/NO328030B1/no not_active IP Right Cessation
- 1999-05-25 BG BG103429A patent/BG64670B1/bg unknown
-
2000
- 2000-04-05 HK HK00102067A patent/HK1022851A1/xx not_active IP Right Cessation
- 2000-10-03 US US09/678,265 patent/US6284778B1/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of definitive patent protection due to non-payment of fees |