CO4930260A1 - Metodos y composiciones para estimular el crecimiento de neuritas - Google Patents
Metodos y composiciones para estimular el crecimiento de neuritasInfo
- Publication number
- CO4930260A1 CO4930260A1 CO97066755A CO97066755A CO4930260A1 CO 4930260 A1 CO4930260 A1 CO 4930260A1 CO 97066755 A CO97066755 A CO 97066755A CO 97066755 A CO97066755 A CO 97066755A CO 4930260 A1 CO4930260 A1 CO 4930260A1
- Authority
- CO
- Colombia
- Prior art keywords
- straight
- branched
- alkyl
- alkenyl
- substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Una composición farmaceúticamente aceptable quecomprende: a) una cantidad neurotrofica de un compuesto que contiene la fórmula (I) y derivados farmaceúticamente aceptables de este, en donde: R1 B y D son independientemente: hidrógeno, Ar, alquilo (C1-C6) recto o ramificado, alquenilo o alquinilo (C2-C6) recto o ramificado, alquilo (C1-C6) recto o ramificado sustituido con cicloalquilo (C5- C7), alquenilo o alquinilo recto o ramificado (C3-C6) sustituido con cicloalquilo (C5-C7) alquilo recto o ramificado (C1-C6) sustituido con cicloalquilo (C5-C7), alquenilo o alquinilo recto o ramificado (C3-C6) sustituido con cicloalquenilo (C5-C7), alquilo recto o ramificado (C1-C6) sustituido con Ar, alquenilo o alquinilo recto o ramificado (C3-C6) sustituido con Ar; dado que R1 no es hidrógeno; en donde cualquiera de los grupos CH2 de dichas cadenas alquilo en R1 , B y D es opcionalmente reemplazado por O, S, SO, SO2 , o NR; en donde R es hidrógeno, alquilo recto o ramificado (C1-C6) alquenilo o alquinilo recto o ramificado (C3-C4), o alquilo puente (C1-C4). El alquilo puente (C1-C4), junto con el nitrógeno y un átomo de carbono de dicha cadena alquilo para formar un anillo, y en donde dicho anillo es opcionalmente fusionado a un Ar; En donde cada Ar es independientemente seleccionada de fenilo, 1-naftilo, 2-naftilo, indenilo, azulenilo, fluorenilo, antracenilo, 2-furilo, 3-furilo, 2-tienilo, 3-tienilo, 2-piridilo, 3-piridilo, 4- piridilo, pirrolilo, oxazolilo, thiazolilo, imidazolilo, pirazolilo, 2-pirazolinilo, - 2 -pirazolidinilo, isotriazolilo, 1,2,3-oxadiazolilo, 1,2,3-triazolilo, 1,2,4-tiadiazolilo, piridazinilo, pirimidinilo, pirazinilo, 1,3,5-triazinilo, 1,2,5-tritianilo, indolizinilo, indolilo, isoindolilo, 3H-indolilo, indolinilo, benzo [b] furanilo, benzo [b] tiofenilo, 1Hindazolilo, benzimidazolilo, benztiazolilo, purinilo, 4H- quinolizinilo, quinolinilo, 1,2,3,4-tetrahidro- isoquinolinilo, isoquinolinilo, 1,2,3,4-tetrahidro- isoquinolinilo, cinnolinilo, ftalazinilo, quinazolinilo, quinoxalinilo, 1,8-naftiridinilo, pteridinilo, carbazolilo, acridinilo, fenazinilo, fenotiazinilo y fenoxazinilo; y En donde cada Ar es opcionalmente e independientemente sustituido con uno a tres sustituyentes independientemente seleccionados de hidrógeno, halógeno, hidroxilo, nitro, -SO3 H, trifluorometilo, trifluorometoxi, alquilo recto o ramificado (C1-C6), O-(alquilo recto o ramificado (C1-C6), O-benzilo, O-fenilo, 1,2-metilenodioxi, -NR5 R6 , carboxilo, N-(alquilo recto o ramificado (C1-C6), N-(alquenilo recto o ramificado (C3-C5)) carboxamida, N,N- di(alquilo recto o ramificado (C1-C6)), N,N-di(alquenilo recto o ramificado (C3-C5)), carbozamida, morfolinilo, piperidinilo, O-M, CH2 -(CH2 )q -M, O-(CH2 )q - M,(CH2 )q -O-M, y CH=CH-M; en donde R5 y R6 son independientemente seleccionados del grupo que consiste de hidrógeno, alquilo, recto o ramificado (C1-C6), alquenilo o alquinilo recto o ramificado (C2-C6), benzilo o R5 y R son puestos juntos para formar un anillo heterocíclico de 5-7 miembros; M es seleccionado del grupo que consiste de 4-metoxifenilo, 2-piridilo, 3-piridilo, 4-piridilo, pirazilo, quinolilo, 3,5-dimetilisoxazoilo, 2- metiltioazoilo, tiazoilo, 2-tienilo, 3-tienilo, 4-tienilo y pirimidilo; y q es 0 - 2;J es seleccionado del grupo que consiste de alquilo recto o ramificado (C1AND#8209;C6), alquenilo o alquinilo recto o ramificado (C3AND#8209;C6), alquilo recto o ramificado (C1AND#8209;C6) sustituido con Ar, alquenilo o alquinilo recto o ramificado (C3AND#8209;C6) sustituido con Ar, y ciclohexilmetilo; K es seleccionado del grupo que consiste de alquilo recto o ramificado (C1AND#8209;C6), alquilo recto o ramificado (C1 AND#8209;C6 ) sustituido con Ar, alquenilo o alquinilo recto o ramificado (C2AND#8209;C6), o alquenilo o alquinilo recto o ramificado (C3AND#8209;C6) sustituido con Ar; J y K son tomados juntos con los átomos de nitrógeno y carbono a los cuales ellos están respectivamente unidos para formar un anillo heterocíclico de 5AND#8209;7 miembros que puede contener un heteroátomo seleccionado de O, S, SO y SO2 ; X es seleccionado del grupo que consiste de Ar, OR2 y AND#8209;NR3 R4 ; en donde R2 tiene la misma definición que R1 ; R3 y R4 independientemente tienen las mismas definiciones de B y D; o R3 y R4 pueden ser tomados juntos para formar un anillo alifático o aromático heterocíclico de 5AND#8209;7 miembros; y m es 0 ó 1 b) un factor neurotrópico; y c) un portador farmacéuticamente adecuado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/748,447 US5840736A (en) | 1996-11-13 | 1996-11-13 | Methods and compositions for stimulating neurite growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4930260A1 true CO4930260A1 (es) | 2000-06-27 |
Family
ID=25009484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97066755A CO4930260A1 (es) | 1996-11-13 | 1997-11-13 | Metodos y composiciones para estimular el crecimiento de neuritas |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US5840736A (es) |
| EP (1) | EP0946190B1 (es) |
| JP (1) | JP2001504470A (es) |
| KR (1) | KR100544451B1 (es) |
| CN (1) | CN1168442C (es) |
| AP (1) | AP9901518A0 (es) |
| AR (1) | AR011278A1 (es) |
| AT (1) | ATE250424T1 (es) |
| AU (1) | AU724833B2 (es) |
| BG (1) | BG64670B1 (es) |
| BR (1) | BR9712765A (es) |
| CA (1) | CA2270634A1 (es) |
| CO (1) | CO4930260A1 (es) |
| CZ (1) | CZ296058B6 (es) |
| DE (1) | DE69725169T2 (es) |
| DK (1) | DK0946190T3 (es) |
| EA (1) | EA004247B1 (es) |
| ES (1) | ES2206753T3 (es) |
| HK (1) | HK1022851A1 (es) |
| HU (1) | HU226728B1 (es) |
| IL (1) | IL129555A (es) |
| IN (1) | IN183740B (es) |
| IS (1) | IS2057B (es) |
| NO (1) | NO328030B1 (es) |
| NZ (1) | NZ335394A (es) |
| PL (1) | PL190903B1 (es) |
| PT (1) | PT946190E (es) |
| SK (1) | SK284535B6 (es) |
| TR (1) | TR199901034T2 (es) |
| TW (1) | TW513302B (es) |
| UA (1) | UA63926C2 (es) |
| WO (1) | WO1998020891A1 (es) |
| ZA (1) | ZA9710256B (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
| US6242468B1 (en) | 1997-02-27 | 2001-06-05 | Jia-He Li | Carbamate and urea compositions and neurotrophic uses |
| US6514686B2 (en) | 1997-04-28 | 2003-02-04 | The University Of British Columbia | Method and composition for modulating amyloidosis |
| US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
| US6852496B1 (en) | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
| US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
| US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
| AU1708099A (en) | 1998-06-03 | 1999-12-20 | Amgen, Inc. | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres |
| GEP20043368B (en) | 1998-07-17 | 2004-04-13 | Agouron Pharma | Compounds, Compositions, and Methods For Stimulating Neuronal Growth and Elongation |
| GB9815880D0 (en) | 1998-07-21 | 1998-09-16 | Pfizer Ltd | Heterocycles |
| US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
| US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
| US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
| US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
| US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
| US6228872B1 (en) | 1998-11-12 | 2001-05-08 | Bristol-Myers Squibb Company | Neurotrophic diamide and carbamate agents |
| DE69923998T2 (de) * | 1998-12-09 | 2006-04-27 | Chiron Corp., Emeryville | Verwendung eines neurologischen wirkstoffes zur herstellung eines medikamentes zur behandlung von erkrankungen des zentralen nervensystems |
| JP2002534414A (ja) * | 1999-01-08 | 2002-10-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | 医薬の製造に有用な中間体の形成方法 |
| AU6073300A (en) * | 1999-07-06 | 2001-01-22 | Vertex Pharmaceuticals Incorporated | N-heterocyclic derivatives with neuronal activity |
| US6734211B1 (en) | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
| MXPA02001095A (es) * | 1999-07-30 | 2002-08-20 | Vertex Pharma | Derivados de amina ciclicos y aciclicos. |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
| AU784347B2 (en) * | 1999-11-12 | 2006-03-16 | Alcon Inc. | Neurophilin ligands for treating ocular conditions |
| US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
| US7060676B2 (en) | 1999-12-20 | 2006-06-13 | Trustees Of Tufts College | T. cruzi-derived neurotrophic agents and methods of use therefor |
| AU1464101A (en) | 1999-12-21 | 2001-07-03 | Gpi Nil Holdings, Inc. | Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same |
| US6555573B2 (en) | 2000-12-21 | 2003-04-29 | The Quigley Corporation | Method and composition for the topical treatment of diabetic neuropathy |
| DK1575477T3 (da) * | 2001-05-25 | 2012-07-23 | Cornell Res Foundation Inc | Højaffinitetsligand til p75-neurotrofinreceptor |
| US20030203890A1 (en) * | 2001-05-29 | 2003-10-30 | Steiner Joseph P. | Method for treating nerve injury caused as a result of surgery |
| FR2825273B1 (fr) * | 2001-05-29 | 2006-11-24 | Oreal | Composition pour le traitement des signes cutanes du vieillissement |
| US20030118536A1 (en) * | 2001-11-06 | 2003-06-26 | Rosenbloom Richard A. | Topical compositions and methods for treatment of adverse effects of ionizing radiation |
| US7435725B2 (en) * | 2001-11-06 | 2008-10-14 | The Quigly Corporation | Oral compositions and methods for prevention, reduction and treatment of radiation injury |
| US20030105027A1 (en) * | 2001-11-06 | 2003-06-05 | Rosenbloom Richard A. | Nutritional supplements and methods for prevention, reduction and treatment of radiation injury |
| US7232798B2 (en) | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
| US20100247483A1 (en) * | 2001-11-13 | 2010-09-30 | Tran Loi H | Therapeutic agent composition and method of use |
| WO2003041655A2 (en) * | 2001-11-13 | 2003-05-22 | Loi Tran | Therapeutic agent composition and method of use |
| US7083813B2 (en) * | 2002-11-06 | 2006-08-01 | The Quigley Corporation | Methods for the treatment of peripheral neural and vascular ailments |
| US8841326B2 (en) | 2004-02-12 | 2014-09-23 | Stc.Unm | Therapeutic curcumin derivatives |
| AU2007210862A1 (en) * | 2006-02-02 | 2007-08-09 | Rinat Neuroscience Corp. | Methods for treating unwanted weight loss or eating disorders by administering a trkB agonist |
| EP1988920A1 (en) * | 2006-02-02 | 2008-11-12 | Rinat Neuroscience Corp. | Methods for treating obesity by administering a trkb antagonist |
| RU2009123491A (ru) * | 2006-12-20 | 2010-12-27 | Ринат Ньюросайенс Корпорейшн (Us) | АГОНИСТЫ TrkB ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ НАРУШЕНИЙ |
| US20090018151A1 (en) * | 2007-02-23 | 2009-01-15 | Ezekiel Fink | Topical Treatment of Peripheral diabetic complications |
| AU2019271189A1 (en) | 2018-05-15 | 2021-01-07 | Lloyd Hung Loi TRAN | Therapeutic agent composition and method of use, for treatment of mild cognitive impairment, depression, and psychological disorders |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5798355A (en) | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
| IL115685A (en) * | 1994-11-16 | 2000-08-31 | Vertex Pharma | Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
| US5543423A (en) * | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
| US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
| US5614547A (en) * | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
| US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
| US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5801197A (en) | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
| US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
| CN104718162B (zh) * | 2012-09-28 | 2017-11-21 | Dic株式会社 | α‑氧化铝微粒以及其制造方法 |
-
1996
- 1996-11-13 US US08/748,447 patent/US5840736A/en not_active Expired - Lifetime
-
1997
- 1997-11-13 CA CA002270634A patent/CA2270634A1/en not_active Abandoned
- 1997-11-13 PT PT97947533T patent/PT946190E/pt unknown
- 1997-11-13 EA EA199900464A patent/EA004247B1/ru not_active IP Right Cessation
- 1997-11-13 DK DK97947533T patent/DK0946190T3/da active
- 1997-11-13 TR TR1999/01034T patent/TR199901034T2/xx unknown
- 1997-11-13 UA UA99063268A patent/UA63926C2/uk unknown
- 1997-11-13 NZ NZ335394A patent/NZ335394A/en unknown
- 1997-11-13 TW TW086116911A patent/TW513302B/zh not_active IP Right Cessation
- 1997-11-13 ZA ZA9710256A patent/ZA9710256B/xx unknown
- 1997-11-13 AT AT97947533T patent/ATE250424T1/de not_active IP Right Cessation
- 1997-11-13 SK SK628-99A patent/SK284535B6/sk not_active IP Right Cessation
- 1997-11-13 KR KR1019997004186A patent/KR100544451B1/ko not_active IP Right Cessation
- 1997-11-13 CN CNB971802467A patent/CN1168442C/zh not_active Expired - Fee Related
- 1997-11-13 IN IN2149CA1997 patent/IN183740B/en unknown
- 1997-11-13 IL IL12955597A patent/IL129555A/xx not_active IP Right Cessation
- 1997-11-13 CZ CZ0168399A patent/CZ296058B6/cs not_active IP Right Cessation
- 1997-11-13 AR ARP970105318A patent/AR011278A1/es unknown
- 1997-11-13 DE DE69725169T patent/DE69725169T2/de not_active Expired - Lifetime
- 1997-11-13 ES ES97947533T patent/ES2206753T3/es not_active Expired - Lifetime
- 1997-11-13 WO PCT/US1997/020866 patent/WO1998020891A1/en active IP Right Grant
- 1997-11-13 PL PL333270A patent/PL190903B1/pl not_active IP Right Cessation
- 1997-11-13 JP JP52286598A patent/JP2001504470A/ja active Pending
- 1997-11-13 AU AU52589/98A patent/AU724833B2/en not_active Ceased
- 1997-11-13 EP EP97947533A patent/EP0946190B1/en not_active Expired - Lifetime
- 1997-11-13 HU HU0001219A patent/HU226728B1/hu not_active IP Right Cessation
- 1997-11-13 CO CO97066755A patent/CO4930260A1/es unknown
- 1997-11-13 AP APAP/P/1999/001518A patent/AP9901518A0/en unknown
- 1997-11-13 BR BR9712765-5A patent/BR9712765A/pt not_active IP Right Cessation
-
1998
- 1998-11-23 US US09/198,175 patent/US6172086B1/en not_active Expired - Lifetime
-
1999
- 1999-04-21 IS IS5032A patent/IS2057B/is unknown
- 1999-05-03 NO NO19992138A patent/NO328030B1/no not_active IP Right Cessation
- 1999-05-25 BG BG103429A patent/BG64670B1/bg unknown
-
2000
- 2000-04-05 HK HK00102067A patent/HK1022851A1/xx not_active IP Right Cessation
- 2000-10-03 US US09/678,265 patent/US6284778B1/en not_active Expired - Lifetime
Also Published As
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