HUP0001652A2 - Oxadiazolszármazékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Oxadiazolszármazékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0001652A2
HUP0001652A2 HU0001652A HUP0001652A HUP0001652A2 HU P0001652 A2 HUP0001652 A2 HU P0001652A2 HU 0001652 A HU0001652 A HU 0001652A HU P0001652 A HUP0001652 A HU P0001652A HU P0001652 A2 HUP0001652 A2 HU P0001652A2
Authority
HU
Hungary
Prior art keywords
oxadiazole derivatives
processes
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU0001652A
Other languages
English (en)
Inventor
Wolf-Dietrich Bechtel
Michael Brenner
Raffaele Cesana
Helmut Ensinger
Roland Maier
Rainer Palluk
Uwe Pschorn
Angelo Sagrada
Thomas Weiser
Marion Wienrich
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of HUP0001652A2 publication Critical patent/HUP0001652A2/hu
Publication of HUP0001652A3 publication Critical patent/HUP0001652A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A találmány tárgyát az (I) általános képletű oxadiazolszármazékok -ahol a szubsztituensek jelentése többek között: X és Y oxigén- vagynitrogénatom, azzal a megszorítással, hogy X és Y mindig különbözőjelentésű, Z szubsztituált fenil-, piridil-, furil-, tienil- vagykondenzált vázas heterociklusos csoport, és R1 szubsztituált fenil-,cikloalkil-, spiroalkilcsoport - eljárás az előállításukra, valamint aneurodegeneratív betegségek és a különböző eredetű agyi ischaemiakezelésére alkalmas gyógyszerkészítmények hatóanyagaként valófelhasználásuk képezi. Ó
HU0001652A 1996-10-18 1997-10-15 Oxadiazole derivatives, processes for their preparation, their use and pharmaceutical compositions containing them HUP0001652A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19643037A DE19643037A1 (de) 1996-10-18 1996-10-18 Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel

Publications (2)

Publication Number Publication Date
HUP0001652A2 true HUP0001652A2 (hu) 2001-01-29
HUP0001652A3 HUP0001652A3 (en) 2002-12-28

Family

ID=7809114

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001652A HUP0001652A3 (en) 1996-10-18 1997-10-15 Oxadiazole derivatives, processes for their preparation, their use and pharmaceutical compositions containing them

Country Status (32)

Country Link
US (1) US6277872B1 (hu)
EP (1) EP0934288B1 (hu)
JP (1) JP3333523B2 (hu)
KR (1) KR20000049253A (hu)
CN (1) CN1086698C (hu)
AR (1) AR008496A1 (hu)
AT (1) ATE315034T1 (hu)
AU (1) AU737552B2 (hu)
BG (1) BG103251A (hu)
BR (1) BR9714354A (hu)
CA (1) CA2268954C (hu)
CO (1) CO4920253A1 (hu)
CZ (1) CZ138099A3 (hu)
DE (2) DE19643037A1 (hu)
EE (1) EE9900147A (hu)
ES (1) ES2256880T3 (hu)
HK (1) HK1020956A1 (hu)
HR (1) HRP970553A2 (hu)
HU (1) HUP0001652A3 (hu)
ID (1) ID18613A (hu)
IL (1) IL129315A0 (hu)
NO (1) NO312512B1 (hu)
NZ (1) NZ335598A (hu)
PE (1) PE11199A1 (hu)
PL (1) PL332432A1 (hu)
RU (1) RU2182905C2 (hu)
SK (1) SK49999A3 (hu)
TR (1) TR199900848T2 (hu)
TW (1) TW413678B (hu)
WO (1) WO1998017652A1 (hu)
YU (1) YU40997A (hu)
ZA (1) ZA979220B (hu)

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RU2319701C2 (ru) * 2001-02-21 2008-03-20 Астразенека Аб ГЕТЕРОПОЛИЦИКЛИЧЕСКОЕ СОЕДИНЕНИЕ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ МЕТАБОТРОПНЫХ ГЛЮТАМАТНЫХ РЕЦЕПТОРОВ mGluR ГРУППЫ I
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MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
WO2004018463A2 (en) 2002-08-23 2004-03-04 Rigel Pharmaceuticals, Inc. Pyridyl substituted heterocycles useful for treating or preventing hcv infection
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
US7115642B2 (en) 2003-05-02 2006-10-03 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection
EP1620412A2 (en) 2003-05-02 2006-02-01 Rigel Pharmaceuticals, Inc. Heterocyclic compounds and hydro isomers thereof
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
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NZ547965A (en) 2003-12-24 2009-12-24 Prosidion Ltd 1,2,4-Oxadiazole derivatives as GPCR receptor agonists
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
JPWO2006109876A1 (ja) * 2005-04-08 2008-11-20 エーザイ・アール・アンド・ディー・マネジメント株式会社 不随意運動治療剤
WO2007027230A2 (en) 2005-05-02 2007-03-08 Rigel Pharmaceuticals, Inc. Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses
GB0510142D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds A1
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US9045442B2 (en) * 2007-12-21 2015-06-02 University Of Notre Dame Du Lac Antibacterial compounds and methods of using same
AU2009266098B2 (en) 2008-06-09 2015-01-22 Ludwig-Maximilians-Universitat Munchen New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases
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RU2641293C2 (ru) * 2012-08-24 2018-01-17 Тревентис Корпорейшн Бензофуразановые антимилоидные соединения и способы
PT3110812T (pt) 2014-02-27 2019-07-10 Treventis Corp Compostos antiamiloide contendo benzofurazano
CN106231905B (zh) 2014-04-24 2019-04-09 住友化学株式会社 二芳基-唑化合物
CA2962431A1 (en) 2014-09-25 2016-03-31 University Of Notre Dame Du Lac Non-beta lactam antibiotics
CN107286174B (zh) * 2016-04-11 2020-08-18 上海勋和医药科技有限公司 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用
US11168062B2 (en) 2016-09-12 2021-11-09 University Of Notre Dame Du Lac Compounds for the treatment of Clostridium difficile infection
JP7283699B2 (ja) 2017-05-12 2023-05-30 マックス－プランク－ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 黒色腫の治療または予防において使用するためのフェニル－ヘテロ環－フェニル誘導体
US10676467B2 (en) 2017-06-30 2020-06-09 Washington University Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
US20220023275A1 (en) 2018-12-14 2022-01-27 Eisai R&D Management Co., Ltd. Aqueous Based Pharmaceutical Formulations of 1,2-Dihydropyridine Compounds
WO2023042887A1 (ja) 2021-09-15 2023-03-23 国立大学法人 琉球大学 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物
EP4403185A1 (en) 2021-09-15 2024-07-24 University of The Ryukyus Pharmaceutical composition for treating cognitive decline or for treating overweightness or obesity
EP4173485A1 (en) 2021-10-27 2023-05-03 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Protein aggregation inhibiting compounds for plant disease control

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Also Published As

Publication number Publication date
US6277872B1 (en) 2001-08-21
NZ335598A (en) 2001-06-29
NO312512B1 (no) 2002-05-21
BG103251A (en) 2000-02-29
TW413678B (en) 2000-12-01
NO991815D0 (no) 1999-04-16
CN1233245A (zh) 1999-10-27
PE11199A1 (es) 1999-03-03
PL332432A1 (en) 1999-09-13
IL129315A0 (en) 2000-02-17
HK1020956A1 (en) 2000-05-26
CA2268954A1 (en) 1998-04-30
WO1998017652A1 (de) 1998-04-30
ZA979220B (en) 1998-04-20
SK49999A3 (en) 1999-11-08
RU2182905C2 (ru) 2002-05-27
YU40997A (sh) 2000-10-30
CA2268954C (en) 2006-06-13
AU737552B2 (en) 2001-08-23
ID18613A (id) 1998-04-23
ES2256880T3 (es) 2006-07-16
CO4920253A1 (es) 2000-05-29
AR008496A1 (es) 2000-01-19
JP2000505089A (ja) 2000-04-25
EE9900147A (et) 1999-12-15
EP0934288B1 (de) 2006-01-04
JP3333523B2 (ja) 2002-10-15
EP0934288A1 (de) 1999-08-11
CZ138099A3 (cs) 1999-11-17
HUP0001652A3 (en) 2002-12-28
HRP970553A2 (en) 1998-08-31
AU4867697A (en) 1998-05-15
DE59712543D1 (de) 2006-03-30
DE19643037A1 (de) 1998-04-23
ATE315034T1 (de) 2006-02-15
BR9714354A (pt) 2000-04-11
CN1086698C (zh) 2002-06-26
NO991815L (no) 1999-04-16
TR199900848T2 (xx) 1999-06-21
KR20000049253A (ko) 2000-07-25

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