CN87107149A - 7-[(间位取代的)苯基甘氨酸]1-碳代-1-去硫头孢菌素 - Google Patents

7-[(间位取代的)苯基甘氨酸]1-碳代-1-去硫头孢菌素 Download PDF

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Publication number
CN87107149A
CN87107149A CN198787107149A CN87107149A CN87107149A CN 87107149 A CN87107149 A CN 87107149A CN 198787107149 A CN198787107149 A CN 198787107149A CN 87107149 A CN87107149 A CN 87107149A CN 87107149 A CN87107149 A CN 87107149A
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CN
China
Prior art keywords
carba
formula
amino
chloro
compounds
Prior art date
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Pending
Application number
CN198787107149A
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English (en)
Chinese (zh)
Inventor
罗宾·戴维·格雷·床珀
约翰·阿伦·韦伯
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Eli Lilly and Co
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Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN87107149A publication Critical patent/CN87107149A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN198787107149A 1986-10-03 1987-10-01 7-[(间位取代的)苯基甘氨酸]1-碳代-1-去硫头孢菌素 Pending CN87107149A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91517386A 1986-10-03 1986-10-03
US06/915,173 1986-10-03

Publications (1)

Publication Number Publication Date
CN87107149A true CN87107149A (zh) 1988-05-18

Family

ID=25435354

Family Applications (1)

Application Number Title Priority Date Filing Date
CN198787107149A Pending CN87107149A (zh) 1986-10-03 1987-10-01 7-[(间位取代的)苯基甘氨酸]1-碳代-1-去硫头孢菌素

Country Status (17)

Country Link
EP (1) EP0266896B1 (enExample)
JP (1) JPS6396186A (enExample)
KR (1) KR880005125A (enExample)
CN (1) CN87107149A (enExample)
AT (2) ATE79119T1 (enExample)
BG (1) BG47034A3 (enExample)
DE (1) DE3780909T2 (enExample)
DK (1) DK518487A (enExample)
FI (1) FI874311L (enExample)
GR (1) GR3005920T3 (enExample)
HU (1) HU200179B (enExample)
IE (1) IE872646L (enExample)
IL (1) IL84051A0 (enExample)
NZ (1) NZ222015A (enExample)
PL (1) PL151703B1 (enExample)
PT (1) PT85850B (enExample)
ZA (1) ZA877398B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102144992A (zh) * 2011-03-10 2011-08-10 浙江大学 苯基甘氨酸衍生物对金黄色葡萄球菌有抑菌和杀菌活性

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227842A (en) * 1988-02-05 1990-12-21 Lilly Co Eli Crystalline 2.5-hydrate form of a beta-lactam
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
NZ526532A (en) 2001-01-26 2005-01-28 Schering Corp The use of substituted azetidinone compounds for the treatment of sitosterolemia
SI1413331T1 (sl) 2001-01-26 2008-02-29 Schering Corp Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
ES2245733T3 (es) 2001-03-28 2006-01-16 Schering Corporation Sintesis enantioselectiva de compuestos intermedios de azetidinona.
WO2003026643A2 (en) 2001-09-21 2003-04-03 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
WO2004037163A2 (en) * 2002-05-14 2004-05-06 Northwestern University STERICALLY-AWKWARD β-LACTAMASE INHIBITORS
CA2504878A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
EP1601668B1 (en) 2003-03-07 2008-08-27 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
US7192944B2 (en) 2003-03-07 2007-03-20 Schering Corp. Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697515A (en) * 1963-02-18 1972-10-10 Ciba Geigy Corp Process for splitting the 7-n-acyl group from cephalosporin compounds
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
NO155547C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Optisk aktive cefalosporin-analoge og salter derav samt fremgangsmaate for deres fremstilling.
JPS60174787A (ja) * 1984-02-21 1985-09-09 Kyowa Hakko Kogyo Co Ltd ３位置換カルバセフエム化合物
US4673737A (en) * 1985-08-02 1987-06-16 Harvard University 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102144992A (zh) * 2011-03-10 2011-08-10 浙江大学 苯基甘氨酸衍生物对金黄色葡萄球菌有抑菌和杀菌活性
CN102144992B (zh) * 2011-03-10 2013-04-10 浙江大学 苯基甘氨酸衍生物制备对金黄色葡萄球菌有抑菌和杀菌活性的抗菌剂的用途

Also Published As

Publication number Publication date
HUT45053A (en) 1988-05-30
EP0266896B1 (en) 1992-08-05
BG47034A3 (bg) 1990-04-16
EP0266896A1 (en) 1988-05-11
DK518487D0 (da) 1987-10-02
PT85850B (en) 1990-01-12
ATE79119T1 (de) 1992-08-15
DK518487A (da) 1988-04-04
HU200179B (en) 1990-04-28
DE3780909T2 (de) 1993-03-04
AT388377B (de) 1989-06-12
GR3005920T3 (enExample) 1993-06-07
FI874311A7 (fi) 1988-04-04
AU7926987A (en) 1988-04-14
ATA257587A (de) 1988-11-15
IL84051A0 (en) 1988-03-31
FI874311A0 (fi) 1987-10-01
ZA877398B (en) 1989-05-30
KR880005125A (ko) 1988-06-28
IE872646L (en) 1988-04-03
PT85850A (en) 1987-11-01
PL268034A1 (en) 1988-09-01
FI874311L (fi) 1988-04-04
DE3780909D1 (en) 1992-09-10
AU591811B2 (en) 1989-12-14
NZ222015A (en) 1989-10-27
JPS6396186A (ja) 1988-04-27
PL151703B1 (en) 1990-09-28

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