BG47034A3 - Метод за получаване на 7-//мета-заместени/-пеницилини/- -1-карба-1-детиацефалоспорини - Google Patents

Метод за получаване на 7-//мета-заместени/-пеницилини/- -1-карба-1-детиацефалоспорини

Info

Publication number
BG47034A3
BG47034A3 BG081345A BG8134587A BG47034A3 BG 47034 A3 BG47034 A3 BG 47034A3 BG 081345 A BG081345 A BG 081345A BG 8134587 A BG8134587 A BG 8134587A BG 47034 A3 BG47034 A3 BG 47034A3
Authority
BG
Bulgaria
Prior art keywords
dethiacephalosporins
carba
penicillins
meta
substituted
Prior art date
Application number
BG081345A
Other languages
Bulgarian (bg)
English (en)
Inventor
Robin Grey
John Webber
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of BG47034A3 publication Critical patent/BG47034A3/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D463/00Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16Nitrogen atoms
    • C07D463/18Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG081345A 1986-10-03 1987-10-02 Метод за получаване на 7-//мета-заместени/-пеницилини/- -1-карба-1-детиацефалоспорини BG47034A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91517386A 1986-10-03 1986-10-03

Publications (1)

Publication Number Publication Date
BG47034A3 true BG47034A3 (bg) 1990-04-16

Family

ID=25435354

Family Applications (1)

Application Number Title Priority Date Filing Date
BG081345A BG47034A3 (bg) 1986-10-03 1987-10-02 Метод за получаване на 7-//мета-заместени/-пеницилини/- -1-карба-1-детиацефалоспорини

Country Status (17)

Country Link
EP (1) EP0266896B1 (enExample)
JP (1) JPS6396186A (enExample)
KR (1) KR880005125A (enExample)
CN (1) CN87107149A (enExample)
AT (2) ATE79119T1 (enExample)
BG (1) BG47034A3 (enExample)
DE (1) DE3780909T2 (enExample)
DK (1) DK518487A (enExample)
FI (1) FI874311L (enExample)
GR (1) GR3005920T3 (enExample)
HU (1) HU200179B (enExample)
IE (1) IE872646L (enExample)
IL (1) IL84051A0 (enExample)
NZ (1) NZ222015A (enExample)
PL (1) PL151703B1 (enExample)
PT (1) PT85850B (enExample)
ZA (1) ZA877398B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89150A0 (en) * 1988-02-05 1989-09-10 Lilly Co Eli Crystalline beta-lactam solvate
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
RS20100015A (sr) 2001-01-26 2010-12-31 Schering Corporation Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije
PT1355644E (pt) 2001-01-26 2006-11-30 Schering Corp Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
IL157552A0 (en) 2001-03-28 2004-03-28 Schering Corp Enantioselective synthesis of azetidinone intermediate compounds
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
EP1429756B1 (en) 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
AU2003298513A1 (en) * 2002-05-14 2004-05-13 Northwestern University STERICALLY-AWKWARD Beta-LACTAMASE INHIBITORS
JP2006508188A (ja) 2002-11-06 2006-03-09 シェーリング コーポレイション 脱髄の処置のためのコレステロール吸収インヒビター
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
DE602004016123D1 (de) 2003-03-07 2008-10-09 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN102144992B (zh) * 2011-03-10 2013-04-10 浙江大学 苯基甘氨酸衍生物制备对金黄色葡萄球菌有抑菌和杀菌活性的抗菌剂的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697515A (en) * 1963-02-18 1972-10-10 Ciba Geigy Corp Process for splitting the 7-n-acyl group from cephalosporin compounds
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
NO155547C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Optisk aktive cefalosporin-analoge og salter derav samt fremgangsmaate for deres fremstilling.
JPS60174787A (ja) * 1984-02-21 1985-09-09 Kyowa Hakko Kogyo Co Ltd 3位置換カルバセフエム化合物
US4673737A (en) * 1985-08-02 1987-06-16 Harvard University 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof

Also Published As

Publication number Publication date
PT85850B (en) 1990-01-12
EP0266896B1 (en) 1992-08-05
AU7926987A (en) 1988-04-14
EP0266896A1 (en) 1988-05-11
FI874311A0 (fi) 1987-10-01
JPS6396186A (ja) 1988-04-27
KR880005125A (ko) 1988-06-28
HU200179B (en) 1990-04-28
PT85850A (en) 1987-11-01
CN87107149A (zh) 1988-05-18
PL268034A1 (en) 1988-09-01
DE3780909D1 (en) 1992-09-10
ATE79119T1 (de) 1992-08-15
DK518487D0 (da) 1987-10-02
PL151703B1 (en) 1990-09-28
FI874311A7 (fi) 1988-04-04
ATA257587A (de) 1988-11-15
DK518487A (da) 1988-04-04
AU591811B2 (en) 1989-12-14
GR3005920T3 (enExample) 1993-06-07
ZA877398B (en) 1989-05-30
FI874311L (fi) 1988-04-04
DE3780909T2 (de) 1993-03-04
IE872646L (en) 1988-04-03
HUT45053A (en) 1988-05-30
AT388377B (de) 1989-06-12
NZ222015A (en) 1989-10-27
IL84051A0 (en) 1988-03-31

Similar Documents

Publication Publication Date Title
DE3772429D1 (de) Pharmazeutisches praeparat zur behandlung von peridontalkrankheiten.
DE3876125D1 (de) Behandlung der menschlichen viralinfektion durch doppelstrang-rna, kombiniert mit viralen inhibitoren.
BG94837A (bg) О-метилни производни на азитромицин а, метод за тяхното получаване и приложението им като фармацевтични препарати
ATE123291T1 (de) Biologisch aktive bakterientötende/durchlässigkeitserhöhende proteinfragmente.
DE3775805D1 (de) Arzneimittel zur behandlung periodontaler erkrankungen.
ZM9387A1 (en) Treatment of diseases caused by viruses
NL7804815A (nl) Bereiding van geconcentreerde bacteriecultures voor "direct-vat-set" kaasbereiding.
FI885399A7 (fi) Uusi lääkevoide, menetelmä sen valmistamiseksi, tätä lääkevoidetta käy ttämällä aikaansaadut käyttömuodot sekä niiden valmistus
FI885256A0 (fi) Kalander med foerskjutbara lagerdelar.
DE3684755D1 (de) Behandlung von tieren mit il-2, zubereitungen dafuer und ihre herstellung.
DE3781652D1 (de) Zubereitung, geeignet fuer die behandlung von darmstoerungen.
DE3876769D1 (de) Mikrobiologische herstellung von 9-alpha-hydroxy-17-keto-steroiden.
ZA87685B (en) Phenylacetonitriles which are substituted by basic groups,their preparation and drugs containing these substances
ATE27157T1 (de) Cycloalkylderivate von benzisoselenazolonen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
BG44203A3 (en) Method for preparing of 2- oxyindol- 1- carboxamides
SE8404334L (sv) 16-fluoro-16,17-didehydro-prostanoider och forfarande for deras framstellning
FI864995A0 (fi) Med solenergi driven straolningsanordning foer medicinskt bruk.
FI872459A7 (fi) Farmaseuttinen valmiste bakteeri-infektioiden hoitoon.
ZA869156B (en) Phenylacetaldehydes substituted by basic groups,their preparation and drugs containing these compounds
PT84130A (fr) Procede de preparation de nouveaux derives de 3-alkoxyflavones et de leurs compositions therapeutiques
NL189260C (nl) Werkwijze voor de bereiding van (1r,5s) 6,6-dimethyl 4(r) ((s)-cyaan-(3'-fenoxyfenyl)methoxy)-3-oxabicyclo(3,1,0)-hexanon-2.
DK183788A (da) Fremgangsmaade til foroegelse af levedygtigheden af frysetoerrede, maelkesyreproducerende bakteriekulturkoncentrater
DE3163418D1 (en) 5-phenyltetrazoles substituted by basic groups, method for their preparation and their use as drugs
JPS5264494A (en) Preparation of fr-1923 substance
PT85076A (en) Method for the treatment of infections disease by administration of tumor necrosis factor-alpha