HU200179B - Process for producing 7-square brackets open/meta-substituted/-phenylglycine-amido square brackets closed-1-carba-1-dethiacefems - Google Patents
Process for producing 7-square brackets open/meta-substituted/-phenylglycine-amido square brackets closed-1-carba-1-dethiacefems Download PDFInfo
- Publication number
- HU200179B HU200179B HU874452A HU445287A HU200179B HU 200179 B HU200179 B HU 200179B HU 874452 A HU874452 A HU 874452A HU 445287 A HU445287 A HU 445287A HU 200179 B HU200179 B HU 200179B
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- amino
- acid
- compound
- chloro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Cephalosporin Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91517386A | 1986-10-03 | 1986-10-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT45053A HUT45053A (en) | 1988-05-30 |
| HU200179B true HU200179B (en) | 1990-04-28 |
Family
ID=25435354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU874452A HU200179B (en) | 1986-10-03 | 1987-10-02 | Process for producing 7-square brackets open/meta-substituted/-phenylglycine-amido square brackets closed-1-carba-1-dethiacefems |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0266896B1 (enExample) |
| JP (1) | JPS6396186A (enExample) |
| KR (1) | KR880005125A (enExample) |
| CN (1) | CN87107149A (enExample) |
| AT (2) | ATE79119T1 (enExample) |
| BG (1) | BG47034A3 (enExample) |
| DE (1) | DE3780909T2 (enExample) |
| DK (1) | DK518487A (enExample) |
| FI (1) | FI874311L (enExample) |
| GR (1) | GR3005920T3 (enExample) |
| HU (1) | HU200179B (enExample) |
| IE (1) | IE872646L (enExample) |
| IL (1) | IL84051A0 (enExample) |
| NZ (1) | NZ222015A (enExample) |
| PL (1) | PL151703B1 (enExample) |
| PT (1) | PT85850B (enExample) |
| ZA (1) | ZA877398B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0327364A1 (en) * | 1988-02-05 | 1989-08-09 | Eli Lilly And Company | Crystalline beta-lactam solvate |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| IL156445A0 (en) | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| KR20070120617A (ko) | 2001-01-26 | 2007-12-24 | 쉐링 코포레이션 | 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물 |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| BRPI0208384B1 (pt) | 2001-03-28 | 2016-05-31 | Merck Sharp & Dohme | síntese enantiosseletiva de compostos intermediários de azetidinona |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| EP1429756B1 (en) | 2001-09-21 | 2006-11-22 | Schering Corporation | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US20030236243A1 (en) * | 2002-05-14 | 2003-12-25 | Shoichet Brian K. | Sterically-awkward beta-lactamase inhibitors |
| CA2504916A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| DE602004018617D1 (de) | 2003-03-07 | 2009-02-05 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| WO2004081004A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| CN102144992B (zh) * | 2011-03-10 | 2013-04-10 | 浙江大学 | 苯基甘氨酸衍生物制备对金黄色葡萄球菌有抑菌和杀菌活性的抗菌剂的用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3697515A (en) * | 1963-02-18 | 1972-10-10 | Ciba Geigy Corp | Process for splitting the 7-n-acyl group from cephalosporin compounds |
| NO155548C (no) * | 1979-02-10 | 1987-04-15 | Kyowa Hakko Kogyo Kk | Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger. |
| JPS5672698A (en) * | 1979-11-14 | 1981-06-16 | Kyowa Hakko Kogyo Co Ltd | Preparation of optically active cephalosporin analogue |
| NO155547C (no) * | 1979-02-10 | 1987-04-15 | Kyowa Hakko Kogyo Kk | Optisk aktive cefalosporin-analoge og salter derav samt fremgangsmaate for deres fremstilling. |
| JPS60174787A (ja) * | 1984-02-21 | 1985-09-09 | Kyowa Hakko Kogyo Co Ltd | ３位置換カルバセフエム化合物 |
| US4673737A (en) * | 1985-08-02 | 1987-06-16 | Harvard University | 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof |
-
1987
- 1987-10-01 DE DE8787308713T patent/DE3780909T2/de not_active Expired - Fee Related
- 1987-10-01 AT AT87308713T patent/ATE79119T1/de not_active IP Right Cessation
- 1987-10-01 PT PT85850A patent/PT85850B/pt unknown
- 1987-10-01 ZA ZA877398A patent/ZA877398B/xx unknown
- 1987-10-01 CN CN198787107149A patent/CN87107149A/zh active Pending
- 1987-10-01 FI FI874311A patent/FI874311L/fi not_active IP Right Cessation
- 1987-10-01 NZ NZ222015A patent/NZ222015A/xx unknown
- 1987-10-01 IL IL84051A patent/IL84051A0/xx unknown
- 1987-10-01 EP EP87308713A patent/EP0266896B1/en not_active Expired - Lifetime
- 1987-10-02 IE IE872646A patent/IE872646L/xx unknown
- 1987-10-02 HU HU874452A patent/HU200179B/hu not_active IP Right Cessation
- 1987-10-02 KR KR870011038A patent/KR880005125A/ko not_active Withdrawn
- 1987-10-02 BG BG081345A patent/BG47034A3/xx unknown
- 1987-10-02 DK DK518487A patent/DK518487A/da not_active Application Discontinuation
- 1987-10-02 JP JP62250552A patent/JPS6396186A/ja active Pending
- 1987-10-02 PL PL1987268034A patent/PL151703B1/pl unknown
- 1987-10-08 AT AT0257587A patent/AT388377B/de active
-
1992
- 1992-10-08 GR GR920402240T patent/GR3005920T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE79119T1 (de) | 1992-08-15 |
| BG47034A3 (bg) | 1990-04-16 |
| AT388377B (de) | 1989-06-12 |
| PT85850B (en) | 1990-01-12 |
| PL268034A1 (en) | 1988-09-01 |
| HUT45053A (en) | 1988-05-30 |
| DE3780909T2 (de) | 1993-03-04 |
| PL151703B1 (en) | 1990-09-28 |
| KR880005125A (ko) | 1988-06-28 |
| AU591811B2 (en) | 1989-12-14 |
| DE3780909D1 (en) | 1992-09-10 |
| EP0266896A1 (en) | 1988-05-11 |
| JPS6396186A (ja) | 1988-04-27 |
| FI874311A0 (fi) | 1987-10-01 |
| DK518487A (da) | 1988-04-04 |
| EP0266896B1 (en) | 1992-08-05 |
| ZA877398B (en) | 1989-05-30 |
| DK518487D0 (da) | 1987-10-02 |
| AU7926987A (en) | 1988-04-14 |
| GR3005920T3 (enExample) | 1993-06-07 |
| IL84051A0 (en) | 1988-03-31 |
| CN87107149A (zh) | 1988-05-18 |
| FI874311A7 (fi) | 1988-04-04 |
| IE872646L (en) | 1988-04-03 |
| FI874311L (fi) | 1988-04-04 |
| NZ222015A (en) | 1989-10-27 |
| ATA257587A (de) | 1988-11-15 |
| PT85850A (en) | 1987-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |