CN1953779B - 吸入装置 - Google Patents
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Abstract
本发明公开了一种用于粉末药剂的吸入装置(1)。所述装置(1)包括:体部(5),所述体部具有用于保持容纳有待吸入的粉末药剂的胶囊的凹部(50);至少一个空气通道(90),所述空气通道设置成与所述凹部(50)相切;口部(30),所述口部包括同轴设置的吸入通道(70),所述吸入通道与所述体部(5)的所述凹部(50)相连通。所述体部(5)具有一对相对的由弹簧(105)偏压的按钮(40),每个按钮都包括至少一个刺穿元件(95),用于当胶囊装填入凹部(50)中时刺穿胶囊。当空气通过空气通道(90)被吸入到凹部(50)中并在其中涡旋时,药剂从刺破的胶囊中释放出来。口部(30)可枢转地连接在所述体部(5)的边缘上,以便所述口部可以围绕与所述吸入装置(1)的纵向轴线垂直的轴线在打开装填位置与关闭给药位置之间枢转。
Description
技术领域
本发明涉及一种吸入装置,尤其用于输送用于治疗呼吸道疾病例如哮喘和慢性阻塞性肺病的粉末形式的药剂。
背景技术
已知本领域内有多种干粉吸入装置(DPI),但它们在使用和制造方面都不完全令人满意,因此需要改进。
发明内容
第一方面,本发明涉及一种用于粉末药剂的吸入装置,该吸入装置包括:体部,所述体部具有用于保持容纳有粉末药剂的胶囊的凹部;至少一个空气通道,所述空气通道设置成与所述凹部相切;口部,所述口部包括同轴设置的吸入通道,该吸入通道与所述体部的凹部相连通;以及胶囊刺穿装置,所述胶囊刺穿装置位于所述体部上,用于在胶囊装填入凹部时刺穿胶囊,以便当空气通过空气通道而被吸入到凹部中并在其中涡旋时释放药剂;所述吸入装置的特征在于,所述胶囊刺穿装置包括一对相对的由弹簧偏压的按钮,每个按钮都包括至少一个刺穿元件,并且所述口部可枢转地连接在所述体部的边缘上,以便所述口部可以围绕与所述吸入装置的纵向轴线垂直的轴线在打开装填位置与关闭给药位置之间枢转。
优选地,所述刺穿元件是针或尖钉。
优选地,所述凹部形成为允许胶囊围绕吸入装置的纵向轴线在凹部内旋转。
优选地,所述体部包括两个或多个将所述口部固定到所述体部的边缘上的互锁的体部部分。
优选地,所述胶囊容纳有适于通过肺部吸入来治疗哮喘和慢性阻塞性肺病的粉末药剂。
第二方面,本发明涉及将如上描述的吸入装置用于服用适于通过肺部吸入来治疗哮喘和慢性阻塞性肺病的粉末药剂。
在整个说明书以及所附的权利要求中,除了上下文另有要求外,词语“包括”应当理解为包含指明的整数或整数集合,但不排除任何其它的整数或整数集合。
附图说明
图1是从本发明的吸入装置的优选实施例的一侧观察到的前透视图,口部处于其关闭位置;
图2是从图1所示的吸入装置的一侧观察到的前透视图,口部处于其打开位置;
图3是同一吸入装置的体部的后透视图,口部被移掉,以示出所述体部的内部结构;
图4是所述吸入装置的体部的前透视图,用虚轮廓线示出体部,以便示出胶囊刺穿机构;
图5是吸入装置的前透视图,可移除的盖安装在口部以及吸入装置体部上部的上面;
图6是可移除的盖的仰视图。
具体实施方式
下面将参考附图中示出的本发明吸入装置的优选实施例对该装置进行描述。
图1中所示的本发明的吸入装置1的优选实施例具有体部5,该体部5具有前部10、后部15、第一侧部20和第二侧部25。体部5由两个互锁的体部部分形成。所述装置1具有口部30,该口部可枢转地连接在体部5的后部15上,并可以在打开位置和关闭位置之间运动。在图1中,口部30处于其关闭位置。所述装置还具有一对进气口32。一对按钮35和40从体部5的侧部20和25伸出来,下面将对所述按钮的作用进行阐述。
图2示出当口部30处于其打开位置时的吸入装置1的优选实施例。当口部处于其打开位置时,使用者可以将容纳有药剂的胶囊(未示出)装入胶囊室45内,该胶囊室形成于体部5的凹部50内。该凹部50具有圆形横截面,下面将说明使用圆形横截面的目的。
口部30包括凸缘55和管子60。凸缘55具有多孔板或格栅65,该多孔板或格栅使得可以进入形成于管子60内的同轴设置的吸入通道70。
该口部的管子60可以是任何实用长度,然而通常希望其长度为最小值,因为这可以减小粉末沉积和积聚在吸入通道70上的面积。这还有助于减小清洁该装置的需求。管子60优选为大致圆柱形的,并且在其内部形成的吸入通道70的截面优选为大致圆形的或大致椭圆形的,从而,使用时,在凹部中涡旋并携带药剂的空气继续涡旋,从而穿过吸入通道70并进入使用者的口中。
该口部通过铰链件75可枢转地连接在体部5的后部15上。该铰链件形成为,允许口部围绕与所述吸入装置的纵向轴线垂直的轴线在其打开位置和其关闭位置之间运动。通过将所述口部以上述方式铰接到所述吸入装置的体部上,使用者可以通过用一只手抓体部5-例如,将拇指放在体部5的前部10上并且食指放在体部5的后部15上,然后用另一只手或者也许下巴、或者甚至某一固定物体-例如架子或桌子-向后推口部30的管子60,简单方便地打开所述装置,以装填胶囊。这种结构避免了一些使用者在试图打开市场上买到的吸入器时经历的很多实际困难。特别是对于老人、虚弱的人、残疾人、或者由于一些其它原因损害了手的灵巧性而难以或者也许甚至不可能抓住某些吸入器或者使用需要旋转或其它扭转动作来打开的吸入器的使用者而言,尤其如此。
铰链件优选形成为,允许口部在不需要施加过大力矩的情况下枢转,并消除在口部处于关闭位置时口部30的凸缘55与体部5之间的任何间隙或者至少基本上将该间隙减小到最小。该铰链件提供了可靠的连接,从而口部不易与体部分离。这可以通过将铰链件设置在两个互锁的体部部件(未示出)内来实现。当使用者的手没有良好的运动技巧时,这尤其重要。这样也能防止口部丢失。
图3最清楚地示出体部5的内部结构。图3是示出具有凹部50的胶囊室45的后透视图。体部5的后部15具有凹槽80,该凹槽有助于使用者区分所述装置的后部和所述装置的前部。所述体部具有一对相对的轴槽85,所述轴槽容纳有从口部30的铰链件75伸出来的铰链轴(未示出)。
在体部5与口部30(处于其关闭给药位置时)的凸缘55之间形成有一对空气通道90,所述空气通道连通所述装置的外表面上的进气口32和所述装置内的凹部50。这些空气通道90设置成与凹部50相切,下面将说明这样设置的目的。
使用时,使用者使口部30从如上所述的其关闭位置(图1中所示)运动到其打开位置(图2中所示),并且将容纳有待服用的粉状药剂的胶囊(未示出)放置在凹部50的胶囊室45中。所述装置上可以设置有合适的标记,以向使用者说明如何使口部运动到其打开位置以及应将胶囊放置在哪里。然后,使用者使口部向回运动到其准备给药的关闭位置。使用者基本同时按压按钮35和按钮40,以致动胶囊刺穿机构。图4示出该机构。
如图4所示,所述胶囊刺穿机构包括一对从按钮35和40向内伸出的针或尖钉95。尖端优选形成为皮下注射器针头的形状,并且可以是倾斜的(即,斜切成一角度)或对称地变尖,以便干净地并以最小的阻力刺穿胶囊。针的相对取向用于限制在刺穿过程中胶囊在胶囊室中的运动,因此确保了干净和有效的刺穿。尖端的形状也可以有助于限制胶囊在胶囊室中的运动。例如,在钉的尖端是倾斜的并且斜面朝向胶囊室45的底部的情况下,在钉刺穿胶囊时,胶囊往往会被推向胶囊室45的底部。每个按钮35、40都可以在通道(未示出)内横向滑动。在每种情况下,按钮都由约束在衬套(未示出)上的弹簧105向外推动。当使用者不再对按钮35和40施加压力时,该弹簧确保了钉95从刺穿的胶囊中缩回。每个按钮都具有一对抵靠在相应通道内壁上的台肩110,以防止按钮完全滑出通道。按钮上设置有抓持元件115,以有助于使用者在同时压下按钮以刺穿胶囊时牢牢抓住按钮。
一旦胶囊被针95刺穿,胶囊内的药剂就可以通过肺部吸入进行服用。使用者应该释放按钮以允许针95从刺穿的胶囊中缩回,然后例如通过再次将拇指放在体部的前部10上并且食指放在体部的后部15上,使用者再次抓住所述装置的体部。使用者通过以下方式服用药剂:完全呼出气体,将口部30插入口中,使嘴唇和牙齿密封地包围所述口部,并且快速且深深地吸气。这个动作使周围的空气通过进气口32沿着空气通道90进入凹部50而被吸入所述装置。空气通道90设置成大致与凹部50相切,从而冲入凹部的空气在凹部50中形成涡流。凹部中的这个涡流使刺穿的胶囊从胶囊室45上升,并使胶囊围绕吸入装置的纵向轴线快速地旋转。凹部50具有大致圆形的横截面,以容纳旋转的胶囊。胶囊的长度略小于凹部50的直径,所以胶囊端部与凹部50的侧壁反复撞击,这使得粉末药剂通过胶囊端部的穿孔从胶囊内被吸出来,而胶囊本身的旋转运动有助于反复撞击。粉末药剂随着空气穿过多孔板65并沿着口部30的吸入通道70运动。限定这些通道、凹部以及管子的壁部形成有平滑的曲线,以使空气阻力降至最小,从而将使用者吸入药剂所需要的力气降至最小。多孔板或格栅65防止了胶囊被向上吸入到管子60中。
如果需要,则重复吸入动作。由于胶囊外壳是透明的,所以胶囊用完时更易于看见,当胶囊用完时,使用者使口部从其关闭(给药)位置运动到其打开(装填)位置,并将用完的胶囊丢弃。然后,所述装置准备好重新装填容纳有希望的药剂的新胶囊并再次使用。
所述装置的优选实施例具有可移除的盖120,该可移除的盖具有前部125和后部130。这示于图5和图6中。
如图5所示,盖120形成为卡接配合在体部5上,并且完全覆盖住口部30以及体部5的上部。通过在盖120的前部125的下边缘处并且如果希望的话在体部5的前部10上设置凹进部,形成手指接触凹部132。这在视觉上和触感上给予使用者以暗示:通过用一只手抓住体部,将另一只手的手指-最方便地,拇指-插入手指接触凹部132中,并将盖120从体部5上轻轻地撬开,可以将盖120从体部5上拔下来。
图6是盖120的仰视图。如图6所示,盖120的后部130包括有槽区135,该有槽区有助于使用者区分所述装置的后部和所述装置的前部,并鼓励使用者以最方便使用所述装置的方式确定所述装置的方向。当使用者有视觉障碍时,这尤其重要。盖120的有槽区135的轮廓形成为与体部5的凹槽80相交并互补。
如果希望的话,在盖120的内表面上设置一组口部引导件140,当盖120置于所述装置的口部30和体部5上时,所述口部引导件与口部30的管子60相接合。如果希望的话,在盖120的内表面上邻近其开口设置一组肋145,当盖120置于所述装置上时,所述肋与吸入装置的体部5相接合。口部引导件140和肋145用于增大盖的强度,并有助于防止盖例如在储存或运输过程中无意地与所述体部分离。这是很重要的,因为许多使用吸入装置的人无论去哪儿都经常在某种包中与许多其它东西一起随身携带它们。鉴于此,所述盖具有平滑的轮廓。
本发明的吸入装置可以由任何合适的材料制成,例如诸如丙烯腈-丁二烯-苯乙烯(ABS)、甲基丙烯酸甲酯-丙烯腈-丁二烯-苯乙烯(MABS)或抗静电材料等硬塑料材料。如果希望的话,材料是基本上透明的,以有助于使用者更易于看见和了解所述装置是如何工作的。这有利于使用者以正确的方式使用所述装置,并且在整个治疗过程中以上述方式继续使用所述装置,即,提高了服从性(compliance)。
本发明的吸入装置中使用的胶囊容纳有适于吸入的粉末药剂。药剂优选适于治疗哮喘或慢性阻塞性肺病,例如一种或多种支气管扩张药、消炎药或其组合。优选的支气管扩张药包括:诸如沙丁胺醇(舒喘宁)、沙美特罗、福莫特罗及其药用盐等β-2肾上腺素受体激动剂以及结合在本文中作为参考的WO 00/75114或WO 04/16601中的式I所表示的化合物(自由、盐或溶剂合物形式);以及诸如溴化异丙托品、溴化氧托品、噻托溴铵(tiotropium)、格隆溴铵及其药用盐等抗毒蕈碱剂以及结合在本文中作为参考的WO 04/96800或WO 05/00815中的式I所表示的化合物(盐或两性离子形式)。优选的消炎药包括类甾醇,尤其是诸如布地缩松、倍氯美松双丙酸酯、丙酸氟地松、环缩松或糠酸毛他松等糖皮质激素或者结合在本文中作为参考的WO 02/00679中所述的类甾醇。
以上描述了一种吸入装置及其优选实施例。在实施本发明时,应当理解可以改变各种部件的用法和结构以满足具体要求。
Claims (5)
1.一种用于粉末药剂的吸入装置,包括:
体部,所述体部具有用于保持容纳有待吸入的粉末药剂的胶囊的凹部;
至少一个空气通道,所述空气通道设置成与所述凹部相切;
口部,所述口部包括同轴设置的吸入通道,所述吸入通道与所述体部的所述凹部相连通;
胶囊刺穿装置,所述胶囊刺穿装置位于所述体部上,用于刺破装填在所述凹部中的胶囊,以便当空气通过所述空气通道而被吸入到所述凹部中并在所述凹部中涡旋时药剂被释放;以及
可移除的盖;所述吸入装置的特征在于,所述胶囊刺穿装置包括一对相对的由弹簧偏压的按钮,每个所述按钮都包括至少一个刺穿元件,所述口部通过铰链机构可枢转地连接在所述体部的后边缘上,以便使用者在所述口部上施加推力能够使所述口部围绕与所述吸入装置的纵向轴线垂直的轴线在打开装填位置与关闭给药位置之间枢转;所述铰链机构包括一对在所述体部内的相对的轴槽以及位于所述口部上的铰链件,所述轴槽容纳从所述铰链件伸出来的铰链轴;所述体部的后部包括凹槽,以帮助使用者区分所述吸入装置的后部和前部;所述盖包括位于所述盖的内表面上邻近所述盖的开口的肋,所述肋与所述吸入装置的体部相接合;所述盖还包括位于所述盖的前部下边缘处的手指接触凹部。
2.如权利要求1所述的吸入装置,其特征在于,所述刺穿元件是针或尖钉。
3.如权利要求1或2所述的吸入装置,其特征在于,所述凹部形成为允许所述胶囊围绕所述吸入装置的纵向轴线在所述凹部内旋转。
4.如权利要求1或2所述的吸入装置,其特征在于,所述吸入装置容纳有装有粉末药剂的胶囊。
5.如权利要求4所述的吸入装置,其特征在于,所述药剂适于通过肺部吸入来治疗哮喘或慢性阻塞性肺病。
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GBGB0410712.4A GB0410712D0 (en) | 2004-05-13 | 2004-05-13 | Organic compounds |
GB0410712.4 | 2004-05-13 | ||
PCT/EP2005/005182 WO2005113042A1 (en) | 2004-05-13 | 2005-05-12 | Inhaler device |
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CN1953779A CN1953779A (zh) | 2007-04-25 |
CN1953779B true CN1953779B (zh) | 2011-04-13 |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3991761A (en) * | 1974-03-18 | 1976-11-16 | Salvatore Cocozza | Inhaler for powdered medicaments |
US5685294A (en) * | 1989-08-17 | 1997-11-11 | Boehringer Ingelheim Kg | Powder inhaler having magazine storage and a hinged mouthpiece |
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