CN1812973B - 可用作蛋白激酶抑制剂的吲唑化合物 - Google Patents

可用作蛋白激酶抑制剂的吲唑化合物 Download PDF

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Publication number
CN1812973B
CN1812973B CN038056127A CN03805612A CN1812973B CN 1812973 B CN1812973 B CN 1812973B CN 038056127 A CN038056127 A CN 038056127A CN 03805612 A CN03805612 A CN 03805612A CN 1812973 B CN1812973 B CN 1812973B
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independently selected
optionally substituted
nitrogen
ring
oxygen
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CN038056127A
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Chinese (zh)
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CN1812973A (zh
Inventor
H·宾奇
G·布伦奇利
J·M·C·戈利克
R·尼格特尔
M·莫蒂默尔
S·帕特尔
A·拉瑟福德
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Urology & Nephrology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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CN038056127A 2002-01-25 2003-01-23 可用作蛋白激酶抑制剂的吲唑化合物 Expired - Fee Related CN1812973B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35159702P 2002-01-25 2002-01-25
US60/351,597 2002-01-25
PCT/US2003/002096 WO2003064397A1 (en) 2002-01-25 2003-01-23 Indazole compounds useful as protein kinase inhibitors

Publications (2)

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CN1812973A CN1812973A (zh) 2006-08-02
CN1812973B true CN1812973B (zh) 2010-12-22

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CN038056127A Expired - Fee Related CN1812973B (zh) 2002-01-25 2003-01-23 可用作蛋白激酶抑制剂的吲唑化合物

Country Status (15)

Country Link
US (1) US7041687B2 (https=)
EP (3) EP2295413A1 (https=)
JP (2) JP4718118B2 (https=)
KR (2) KR20100119902A (https=)
CN (1) CN1812973B (https=)
AR (1) AR038202A1 (https=)
AU (1) AU2003212833C1 (https=)
CA (1) CA2473986C (https=)
IL (1) IL163117A (https=)
MX (1) MXPA04007126A (https=)
NO (1) NO328041B1 (https=)
PL (1) PL371512A1 (https=)
RU (1) RU2004125852A (https=)
TW (1) TW200306819A (https=)
WO (1) WO2003064397A1 (https=)

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