CN1646559A - 治疗阿尔茨海默氏病的免疫学方法及组合物 - Google Patents
治疗阿尔茨海默氏病的免疫学方法及组合物 Download PDFInfo
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Abstract
Description
抑制研究 | ||||
免疫原 | 总样品数 | 聚集 | 解聚集 | 毒性 |
未免疫 | 18 | 0/18 | 0/18 | 0/18 |
Aβ42 | 34 | 27/34 | 26/34 | 22/30 |
IAPP | 17 | 4/17 | 1/17 | 2/11 |
行号 | 残基数目1 5 10 15 | 所用蛋白酶 |
1 | D A E F R H D S G Y E V H H Q KSEQ ID NO:22 | 胰蛋白酶 |
2 | D A E F R H D S G Y E V H H Q KSEQ ID NO:22 | 胰蛋白酶和Lys-C蛋白酶 |
3 | D A E F R H D S G Y ESEQ ID NO:23 | 金黄色葡萄球菌的Glu-C蛋白酶 |
4 | D A E F R H D S G YSEQ ID NO:24 | α-糜蛋白酶 |
5 | F R H D S G YSEQ ID NO:1 | α-糜蛋白酶和氨基肽酶M |
实施例 | SEQ ID NO: | 抗原肽序列 |
9 | 25 | FFLLTRILTIPQSLD-GGFRHDSGYG |
10 | 26 | KKLRRLLYMIYMSGLAVRVHVSKEEQYYDY-GGFRHDSGYG |
11 | 27 | KKQYIKANSKFIGITE-GGFRHDSGYG |
12 | 28 | KKFNNFTVSFWLRVPKVSASHL-GGFRHDSGYG |
13 | 29 | YMSGLAVRVHVSKEE-GGFRHDSGYG |
14 | 30 | YDPNYLRTDSDKDRFLQTMVKLFNRIK-GGFRHDSGYG |
15 | 31 | GAYARCPNGTRALTVAELRGNAEL-GGFRHDSGYG |
16 | 32 | LSEIKGVIVHRLEGV-GGFRHDSGYG |
17 | 33 | GILESRGIKARITHVDTESY-GGFRHDSGYG |
18 | 34 | WVRDIIDDFTNESSQKT-GGFRHDSGYG |
19 | 35 | DVSTIVPYIGPALNHV-GGFRHDSGYG |
20 | 36 | ALNIWDRFDVFCTLGATTGGYLKGNS-GGFRHDSGYG |
21 | 37 | DSETADNLEKTVAALSILPGHGC-GGFRHDSGYG |
22 | 38 | EEIVAQSIALSSLMVAQAIPLVGELVDIGFAATNFVESC-GGFRHDSGYG |
23 | 39 | DHEKKHAKMEKASSVFNVVNS-GGFRHDSGYG |
24 | 40 | KWFKTNAPNGVDEKHRH-GGFRHDSGYG |
25 | 41 | GLQGKHADAVKAKG-GGFRHDSGYG |
26 | 42 | GLAAGLVGMAADAMVEDVN-GGFRHDSGYG |
27 | 43 | STETGNQHHYQTRVVSNANK-GGFRHDSGYG |
28 | 44 | STETGNQHHYQTRVVSNANK-GFRHDSGYG |
29 | 45 | STETGNQHHYQTRVVSNANK-FRHDSGY |
30 | 46 | STETGNQHHYQTRVVSNANK-FRHDSGY |
31 | 47 | GGFRHDSGYGG-STETGNQHHYQTRVVSNANK |
32 | 48 | GGFRHDSGYG-STETGNQHHYQTRVVSNANK |
33 | 49 | GGFRHDSGY-STETGNQHHYQTRVVSNANK |
34 | 50 | FRHDSGYGG-STETGNQHHYQTRVVSNANK |
35 | 51 | FRHDSGYG-STETGNQHHYQTRVVSNANK |
残基数目1 5 1015 | |
D A E F R H D S G Y | Aβ42表位切割物的Maldi/ESI呈递给AB的蛋白酶产物 |
D A E F R H D S G Y E V H HQ K | 胰蛋白酶及Lys-C-蛋白酶表位切割片段 |
D A E F R H D S G Y E | 金黄色葡萄球菌Glu-C蛋白酶 |
D A E F R H D S G Y | α-糜蛋白酶 |
F R H D S G Y | α-糜蛋白酶(Y10)和氨基肽酶M(D1、A2及E3) |
Claims (19)
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US37391402P | 2002-04-19 | 2002-04-19 | |
US60/373,914 | 2002-04-19 |
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CN1646559A true CN1646559A (zh) | 2005-07-27 |
CN100360555C CN100360555C (zh) | 2008-01-09 |
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CNB038088584A Expired - Fee Related CN100360555C (zh) | 2002-04-19 | 2003-04-07 | 治疗阿尔茨海默氏病的免疫学方法及组合物 |
Country Status (18)
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US (5) | US20030232758A1 (zh) |
EP (2) | EP1497321B1 (zh) |
JP (3) | JP4662719B2 (zh) |
KR (1) | KR100994748B1 (zh) |
CN (1) | CN100360555C (zh) |
AT (1) | ATE514707T1 (zh) |
AU (1) | AU2003218560B2 (zh) |
CA (1) | CA2481952C (zh) |
ES (1) | ES2368907T3 (zh) |
HK (2) | HK1158665A1 (zh) |
IL (3) | IL164643A0 (zh) |
MX (1) | MXPA04010255A (zh) |
NO (2) | NO335192B1 (zh) |
NZ (1) | NZ536064A (zh) |
PL (1) | PL209696B1 (zh) |
SG (1) | SG173214A1 (zh) |
WO (1) | WO2003089460A1 (zh) |
ZA (1) | ZA200408811B (zh) |
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