CN1615841A - 紫杉醇-海藻酸钠微球血管栓塞剂及其制备 - Google Patents
紫杉醇-海藻酸钠微球血管栓塞剂及其制备 Download PDFInfo
- Publication number
- CN1615841A CN1615841A CNA2004100744643A CN200410074464A CN1615841A CN 1615841 A CN1615841 A CN 1615841A CN A2004100744643 A CNA2004100744643 A CN A2004100744643A CN 200410074464 A CN200410074464 A CN 200410074464A CN 1615841 A CN1615841 A CN 1615841A
- Authority
- CN
- China
- Prior art keywords
- sodium alginate
- paclitaxel
- micro ball
- vascular embolism
- embolism agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (10)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100744643A CN1319525C (zh) | 2004-09-16 | 2004-09-16 | 紫杉醇-海藻酸钠微球血管栓塞剂及其制备 |
CA2577589A CA2577589C (en) | 2004-09-16 | 2005-03-16 | Vascular embolus of paclitaxel-sodium alginate microsphere and its preparation |
JP2007531568A JP2008513381A (ja) | 2004-09-16 | 2005-03-16 | パクリタキセル−アルギン酸ナトリウムマイクロスフェア血管塞栓剤及びその製造方法 |
ES05714849.6T ES2553130T3 (es) | 2004-09-16 | 2005-03-16 | Émbolo vascular de microesferas de alginato de sodio-paclitaxel y su preparación |
EP05714849.6A EP1797874B1 (en) | 2004-09-16 | 2005-03-16 | Vascular embolus of paclitaxel-sodium alginate microsphere and its preparation |
US11/660,553 US20080020052A1 (en) | 2004-09-16 | 2005-03-16 | Vascular Embolus Of Paclitaxel-Sodium Alginate Microsphere And Its Preparation |
KR1020077008633A KR100915601B1 (ko) | 2004-09-16 | 2005-03-16 | 파클리탁셀-소디움 알지네이트 마이크로스피어의 혈관색전제 및 그 제조방법 |
PCT/CN2005/000320 WO2006029554A1 (fr) | 2004-09-16 | 2005-03-16 | Microcapsules d'alginate de sodium contenant du paclitaxel qui permet de traiter un embole vasculaire |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100744643A CN1319525C (zh) | 2004-09-16 | 2004-09-16 | 紫杉醇-海藻酸钠微球血管栓塞剂及其制备 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1615841A true CN1615841A (zh) | 2005-05-18 |
CN1319525C CN1319525C (zh) | 2007-06-06 |
Family
ID=34765357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100744643A Active CN1319525C (zh) | 2004-09-16 | 2004-09-16 | 紫杉醇-海藻酸钠微球血管栓塞剂及其制备 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20080020052A1 (zh) |
EP (1) | EP1797874B1 (zh) |
JP (1) | JP2008513381A (zh) |
KR (1) | KR100915601B1 (zh) |
CN (1) | CN1319525C (zh) |
CA (1) | CA2577589C (zh) |
ES (1) | ES2553130T3 (zh) |
WO (1) | WO2006029554A1 (zh) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100438915C (zh) * | 2006-08-08 | 2008-12-03 | 四川大学 | 靶向性纳米药物载体及其制备方法 |
CN100518719C (zh) * | 2006-07-05 | 2009-07-29 | 中国科学院大连化学物理研究所 | 一种复合基质的多功能动脉栓塞剂的制备方法 |
WO2010124654A1 (zh) * | 2009-04-30 | 2010-11-04 | 北京圣医耀科技发展有限责任公司 | 含抗血管瘤药物海藻酸钠微球血管栓塞剂及制备方法和应用 |
WO2011147185A1 (zh) * | 2010-05-28 | 2011-12-01 | 北京宏医耀科技发展有限公司 | 免疫抑制剂j2-海藻酸钠微球、制备方法和用途 |
CN103432080A (zh) * | 2013-05-07 | 2013-12-11 | 哈尔滨工程大学 | 可显影载药纳米银海藻酸钠微球血管栓塞剂及其制备方法 |
CN103536970A (zh) * | 2013-10-25 | 2014-01-29 | 北京大学 | 一种栓塞材料及其制备方法和用途 |
CN103861157A (zh) * | 2012-12-17 | 2014-06-18 | 中国科学院大连化学物理研究所 | 一种基于海藻酸钆的mri显影栓塞微球 |
CN107185029A (zh) * | 2017-05-24 | 2017-09-22 | 南京大学 | 一种包裹载药纳米材料的高分子水凝胶栓塞微球及其制备方法和应用 |
CN108452368A (zh) * | 2018-05-08 | 2018-08-28 | 天津市肿瘤医院(天津医科大学肿瘤医院) | 一种海藻酸钠载药栓塞微球及其制备方法和装置 |
CN108795921A (zh) * | 2017-04-28 | 2018-11-13 | 南京理工大学 | 一种海藻酸钙多相微载体的制备方法 |
CN108785733A (zh) * | 2018-08-01 | 2018-11-13 | 江苏红豆杉药业有限公司 | 一种紫杉醇-无水乙醇肿瘤栓塞剂及其制备方法 |
CN110279671A (zh) * | 2019-08-08 | 2019-09-27 | 江苏红豆杉药业有限公司 | 一种紫杉醇抗胃癌纳米微球胶囊剂及其制备方法 |
CN110292574A (zh) * | 2019-08-02 | 2019-10-01 | 江苏红豆杉药业有限公司 | 一种抗肠癌药物组合物及其应用 |
CN110507601A (zh) * | 2019-08-28 | 2019-11-29 | 哈尔滨贝科德糖生物科技有限公司 | 一种紫杉醇负载红松松塔多糖-a凝胶及其制备方法与应用 |
CN111803698A (zh) * | 2014-02-14 | 2020-10-23 | 波士顿科学国际有限公司 | 具有治疗剂释放的快速降解栓塞颗粒 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101163735B1 (ko) * | 2005-04-15 | 2012-07-09 | 후단 유니버시티 머터니티 호스피탈 | 부인과 약물-함유 소디움 알지네이트의 마이크로스피어혈관 색전제 및 그 제조방법 |
US8481075B2 (en) * | 2007-12-13 | 2013-07-09 | Beijing Shengyiyao Science & Technology Development Co. Ltd. | Preparation and application of biodegradable-material-made microsphere vascular embolus containing liposome-encapsulated cytokines |
US8168224B2 (en) * | 2007-12-19 | 2012-05-01 | Beijing Shengyiyao Science & Technology Development Co., Ltd. | Sodium alginate microsphere vascular embolus containing water-soluble drug and preparation and application thereof |
CN101536986B (zh) * | 2009-04-16 | 2011-05-04 | 北京圣医耀科技发展有限责任公司 | 含索拉非尼的海藻酸钠靶向缓释微球血管栓塞剂及其制备和应用 |
JP6956091B2 (ja) | 2016-08-26 | 2021-10-27 | 哲治 奥野 | 微小ナノ化薬剤およびその利用 |
CN109906088A (zh) | 2016-08-26 | 2019-06-18 | 奥野哲治 | 微血管血流减少剂及其应用 |
CN108578758A (zh) * | 2018-08-01 | 2018-09-28 | 江苏红豆杉药业有限公司 | 一种多西他赛-无水乙醇肿瘤栓塞剂及其制备方法 |
KR102288833B1 (ko) * | 2019-09-11 | 2021-08-13 | 주식회사 메피온 | 자가 팽창형 색전물질의 제조 방법 |
JP7430904B2 (ja) | 2020-04-07 | 2024-02-14 | 国立大学法人 岡山大学 | 塞栓物質の作製方法、塞栓物質および塞栓物質作製用キット |
CN111454379B (zh) * | 2020-04-22 | 2021-12-10 | 广东海洋大学 | 一种n-亚苄基海藻酸钠腙化合物及其制备方法和应用 |
Family Cites Families (23)
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US4956128A (en) * | 1984-05-25 | 1990-09-11 | Connaught Laboratories Limited | Droplet generation |
JP3534780B2 (ja) * | 1992-01-31 | 2004-06-07 | テルモ株式会社 | 血管塞栓剤 |
US6749868B1 (en) * | 1993-02-22 | 2004-06-15 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
US5895757A (en) * | 1993-06-30 | 1999-04-20 | Pope; Edward J. A. | Encapsulation of living tissue cells in inorganic microspheres prepared from an organosilicon |
US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
AU713276B2 (en) * | 1996-05-23 | 1999-11-25 | Samyang Corporation | Locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof |
US6432449B1 (en) * | 1998-05-18 | 2002-08-13 | Amgen Inc. | Biodegradable sustained-release alginate gels |
US6124131A (en) * | 1998-08-25 | 2000-09-26 | The Johns Hopkins University School Of Medicine | Mutant hypoxia inducible factor-1 HIF-1 |
KR20010002589A (ko) * | 1999-06-16 | 2001-01-15 | 김윤 | 생리활성물질 함유 생분해성 고분자 마이크로스피어의 제조방법 |
CZ20023333A3 (cs) * | 2000-04-10 | 2003-06-18 | Teva Pharmaceutical Industries Ltd. | Léčivo pro léčení rakoviny |
US6881420B2 (en) * | 2000-06-23 | 2005-04-19 | Teva Pharmaceutical Industries Ltd. | Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation |
BR0107147A (pt) * | 2000-08-09 | 2002-06-18 | Panacea Biotec Ltd | Composições farmacêuticas de drogas anti-tuberculosas e processo para as suas preparações |
CN1106845C (zh) * | 2000-08-17 | 2003-04-30 | 洪宏 | 海藻酸钠固态微球血管栓塞剂的生产工艺 |
US7008633B2 (en) * | 2000-12-18 | 2006-03-07 | Board Of Regents, The University Of Texas System | Local regional chemotherapy and radiotherapy using in situ hydrogel |
WO2003007914A2 (en) * | 2001-07-19 | 2003-01-30 | Guilford Pharmaceuticals, Inc. | Biocompatible polymer containing composition for treatment of prostate cancers |
CN1399958A (zh) * | 2001-07-27 | 2003-03-05 | 潘君琦 | 一种紫杉醇纳米磁性靶向制剂及其制备方法 |
CA2457526A1 (en) * | 2001-08-29 | 2003-03-13 | Umd, Inc. | Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy |
KR20030023369A (ko) * | 2001-09-13 | 2003-03-19 | 한국과학기술연구원 | 화학색전용 파클리탁셀 유성 조성물, 그의 제형 및 제조방법 |
US7622299B2 (en) * | 2002-02-22 | 2009-11-24 | University Of Washington | Bioengineered tissue substitutes |
AU2003259723B2 (en) * | 2002-08-09 | 2009-04-23 | Boston Scientific Limited | Embolization |
US20040076582A1 (en) * | 2002-08-30 | 2004-04-22 | Dimatteo Kristian | Agent delivery particle |
JP4686970B2 (ja) * | 2002-10-29 | 2011-05-25 | 東レ株式会社 | 血管塞栓材料 |
KR20040066548A (ko) * | 2003-01-20 | 2004-07-27 | 코오롱제약주식회사 | 생리활성펩타이드의 국소투여용 서방성 마이크로스피어 및그 제조방법 |
-
2004
- 2004-09-16 CN CNB2004100744643A patent/CN1319525C/zh active Active
-
2005
- 2005-03-16 CA CA2577589A patent/CA2577589C/en not_active Expired - Fee Related
- 2005-03-16 JP JP2007531568A patent/JP2008513381A/ja active Pending
- 2005-03-16 US US11/660,553 patent/US20080020052A1/en not_active Abandoned
- 2005-03-16 ES ES05714849.6T patent/ES2553130T3/es active Active
- 2005-03-16 KR KR1020077008633A patent/KR100915601B1/ko active IP Right Grant
- 2005-03-16 EP EP05714849.6A patent/EP1797874B1/en not_active Not-in-force
- 2005-03-16 WO PCT/CN2005/000320 patent/WO2006029554A1/zh active Application Filing
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100518719C (zh) * | 2006-07-05 | 2009-07-29 | 中国科学院大连化学物理研究所 | 一种复合基质的多功能动脉栓塞剂的制备方法 |
CN100438915C (zh) * | 2006-08-08 | 2008-12-03 | 四川大学 | 靶向性纳米药物载体及其制备方法 |
WO2010124654A1 (zh) * | 2009-04-30 | 2010-11-04 | 北京圣医耀科技发展有限责任公司 | 含抗血管瘤药物海藻酸钠微球血管栓塞剂及制备方法和应用 |
WO2011147185A1 (zh) * | 2010-05-28 | 2011-12-01 | 北京宏医耀科技发展有限公司 | 免疫抑制剂j2-海藻酸钠微球、制备方法和用途 |
CN103861157A (zh) * | 2012-12-17 | 2014-06-18 | 中国科学院大连化学物理研究所 | 一种基于海藻酸钆的mri显影栓塞微球 |
CN103432080A (zh) * | 2013-05-07 | 2013-12-11 | 哈尔滨工程大学 | 可显影载药纳米银海藻酸钠微球血管栓塞剂及其制备方法 |
CN103536970A (zh) * | 2013-10-25 | 2014-01-29 | 北京大学 | 一种栓塞材料及其制备方法和用途 |
CN103536970B (zh) * | 2013-10-25 | 2016-06-08 | 北京大学 | 一种栓塞材料及其制备方法和用途 |
CN111803698A (zh) * | 2014-02-14 | 2020-10-23 | 波士顿科学国际有限公司 | 具有治疗剂释放的快速降解栓塞颗粒 |
CN108795921A (zh) * | 2017-04-28 | 2018-11-13 | 南京理工大学 | 一种海藻酸钙多相微载体的制备方法 |
CN107185029A (zh) * | 2017-05-24 | 2017-09-22 | 南京大学 | 一种包裹载药纳米材料的高分子水凝胶栓塞微球及其制备方法和应用 |
CN108452368A (zh) * | 2018-05-08 | 2018-08-28 | 天津市肿瘤医院(天津医科大学肿瘤医院) | 一种海藻酸钠载药栓塞微球及其制备方法和装置 |
CN108785733A (zh) * | 2018-08-01 | 2018-11-13 | 江苏红豆杉药业有限公司 | 一种紫杉醇-无水乙醇肿瘤栓塞剂及其制备方法 |
CN110292574A (zh) * | 2019-08-02 | 2019-10-01 | 江苏红豆杉药业有限公司 | 一种抗肠癌药物组合物及其应用 |
CN110279671A (zh) * | 2019-08-08 | 2019-09-27 | 江苏红豆杉药业有限公司 | 一种紫杉醇抗胃癌纳米微球胶囊剂及其制备方法 |
CN110507601A (zh) * | 2019-08-28 | 2019-11-29 | 哈尔滨贝科德糖生物科技有限公司 | 一种紫杉醇负载红松松塔多糖-a凝胶及其制备方法与应用 |
CN110507601B (zh) * | 2019-08-28 | 2022-03-25 | 哈尔滨贝科德糖生物科技有限公司 | 一种紫杉醇负载红松松塔多糖-a凝胶及其制备方法与应用 |
Also Published As
Publication number | Publication date |
---|---|
JP2008513381A (ja) | 2008-05-01 |
KR20070053350A (ko) | 2007-05-23 |
EP1797874B1 (en) | 2015-11-04 |
CN1319525C (zh) | 2007-06-06 |
WO2006029554A1 (fr) | 2006-03-23 |
CA2577589C (en) | 2010-05-25 |
ES2553130T3 (es) | 2015-12-04 |
CA2577589A1 (en) | 2006-03-23 |
US20080020052A1 (en) | 2008-01-24 |
KR100915601B1 (ko) | 2009-09-07 |
EP1797874A1 (en) | 2007-06-20 |
EP1797874A4 (en) | 2012-09-12 |
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