CN1106845C - 海藻酸钠固态微球血管栓塞剂的生产工艺 - Google Patents
海藻酸钠固态微球血管栓塞剂的生产工艺 Download PDFInfo
- Publication number
- CN1106845C CN1106845C CN 00123459 CN00123459A CN1106845C CN 1106845 C CN1106845 C CN 1106845C CN 00123459 CN00123459 CN 00123459 CN 00123459 A CN00123459 A CN 00123459A CN 1106845 C CN1106845 C CN 1106845C
- Authority
- CN
- China
- Prior art keywords
- sodium alginate
- state
- present
- vascular suppository
- suppository
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 239000000661 sodium alginate Substances 0.000 title claims abstract description 15
- 235000010413 sodium alginate Nutrition 0.000 title claims abstract description 15
- 229940005550 sodium alginate Drugs 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 11
- 230000002792 vascular Effects 0.000 title claims abstract description 10
- 239000000829 suppository Substances 0.000 title claims abstract description 9
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 7
- 239000001110 calcium chloride Substances 0.000 claims abstract description 6
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 2
- 239000003643 water by type Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 210000001367 artery Anatomy 0.000 abstract description 2
- 239000007787 solid Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000009443 Vascular Malformations Diseases 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 201000011066 hemangioma Diseases 0.000 abstract 1
- 201000004108 hypersplenism Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007711 solidification Methods 0.000 abstract 1
- 230000008023 solidification Effects 0.000 abstract 1
- 208000005189 Embolism Diseases 0.000 description 5
- 208000001435 Thromboembolism Diseases 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- -1 iron ion Chemical class 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00123459 CN1106845C (zh) | 2000-08-17 | 2000-08-17 | 海藻酸钠固态微球血管栓塞剂的生产工艺 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00123459 CN1106845C (zh) | 2000-08-17 | 2000-08-17 | 海藻酸钠固态微球血管栓塞剂的生产工艺 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1283463A CN1283463A (zh) | 2001-02-14 |
CN1106845C true CN1106845C (zh) | 2003-04-30 |
Family
ID=4589889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 00123459 Expired - Fee Related CN1106845C (zh) | 2000-08-17 | 2000-08-17 | 海藻酸钠固态微球血管栓塞剂的生产工艺 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1106845C (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1319525C (zh) * | 2004-09-16 | 2007-06-06 | 北京圣医耀科技发展有限责任公司 | 紫杉醇-海藻酸钠微球血管栓塞剂及其制备 |
CN101077424B (zh) * | 2006-05-25 | 2011-04-06 | 范恒华 | 一种血管粘接吻合密封胶及试剂盒 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1313156C (zh) * | 2004-02-06 | 2007-05-02 | 北京圣医耀科技发展有限责任公司 | 含妇科药物的海藻酸钠微球血管栓塞剂及其制备方法 |
EP1870089A4 (en) * | 2005-04-15 | 2012-10-03 | Beijing Shengyiyao Science & Technology Dev Co Ltd | GYNECOLOGIC DRUG-MOISTURIZED MICROBALL VASCULAR SUPPOSITORIUM FROM SODIUM ALGINATE AND ITS MANUFACTURING PROCESS |
CN1876177B (zh) * | 2005-06-06 | 2011-06-01 | 北京圣医耀科技发展有限责任公司 | 含有脂质体细胞因子的生物降解材料的微球血管栓塞剂及其制备和应用 |
CN108992431B (zh) * | 2018-09-30 | 2020-10-09 | 重庆医科大学附属永川医院 | 一种多柔比星栓塞微球及其制备方法 |
CN115245143B (zh) * | 2022-07-06 | 2024-06-28 | 上海市中西医结合医院 | 一种动脉闭塞性疾病动物模型的构建方法 |
-
2000
- 2000-08-17 CN CN 00123459 patent/CN1106845C/zh not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1319525C (zh) * | 2004-09-16 | 2007-06-06 | 北京圣医耀科技发展有限责任公司 | 紫杉醇-海藻酸钠微球血管栓塞剂及其制备 |
CN101077424B (zh) * | 2006-05-25 | 2011-04-06 | 范恒华 | 一种血管粘接吻合密封胶及试剂盒 |
Also Published As
Publication number | Publication date |
---|---|
CN1283463A (zh) | 2001-02-14 |
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PB01 | Publication | ||
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ASS | Succession or assignment of patent right |
Owner name: BEIJING SENGYIYAO TECHNOLOGY DEVELOPMENT CO., LTD Free format text: FORMER OWNER: ZHANG XINGUO Effective date: 20010904 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20010904 Address after: 100071, room 98, 228 Fengtai Road, Beijing, Fengtai District Applicant after: Beijing Shengyiyao Science & Technology Development Co., Ltd. Address before: 100039 No. 69, Yongding Road, Haibin District, Beijing Applicant before: Zhang Xinguo |
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ASS | Succession or assignment of patent right |
Owner name: HONG HONG; LU GE Free format text: FORMER OWNER: BEIJING SENGYIYAO TECHNOLOGY DEVELOPMENT CO., LTD. Effective date: 20020104 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20020104 Applicant after: Hong Hong Applicant after: Lu Ge Applicant before: Beijing Shengyiyao Science & Technology Development Co., Ltd. |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20030430 Termination date: 20190817 |
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CF01 | Termination of patent right due to non-payment of annual fee |