CN1615440A - 含有血管生成素－样蛋白质3angptl3的组合物及其使用方法 - Google Patents

含有血管生成素－样蛋白质3angptl3的组合物及其使用方法 Download PDF

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Publication number
CN1615440A
CN1615440A CNA028271920A CN02827192A CN1615440A CN 1615440 A CN1615440 A CN 1615440A CN A028271920 A CNA028271920 A CN A028271920A CN 02827192 A CN02827192 A CN 02827192A CN 1615440 A CN1615440 A CN 1615440A
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angptl3
tissue
liver
human
amino acid
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Chinese (zh)
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纳波莱昂内·费拉拉
汉斯-彼得·格伯
乔·科沃尔斯基
玛丽亚·T·皮萨巴罗
丹尼尔·E·舍曼
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Genentech Inc
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Genentech Inc
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

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CNA028271920A 2001-11-16 2002-11-13 含有血管生成素－样蛋白质3angptl3的组合物及其使用方法 Pending CN1615440A (zh)

Applications Claiming Priority (2)

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US33242901P 2001-11-16 2001-11-16
US60/332,429 2001-11-16

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CN2010102426068A Pending CN101905024A (zh) 2001-11-16 2002-11-13 含有血管生成素-样蛋白质3angptl3的组合物及其使用方法

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US (3) US7267819B2 (enExample)
EP (1) EP1451578B1 (enExample)
JP (2) JP5105696B2 (enExample)
KR (2) KR101012904B1 (enExample)
CN (2) CN1615440A (enExample)
AU (1) AU2002348286B2 (enExample)
CA (1) CA2464542C (enExample)
ES (1) ES2429034T3 (enExample)
IL (2) IL161542A0 (enExample)
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101852805A (zh) * 2009-03-31 2010-10-06 浙江大学 Angptl3作为卵巢癌的诊断标记物的用途
CN102625830A (zh) * 2009-07-14 2012-08-01 斯克里普斯研究所 间充质干细胞分化
CN101855241B (zh) * 2006-12-08 2013-11-06 莱克康制药公司 针对angptl3的单克隆抗体
CN105021827A (zh) * 2015-07-17 2015-11-04 北京大学第一医院 检测血清血管生成素样蛋白2含量的物质在制备检测肝脏炎症和纤维化程度产品中的应用
CN110938144A (zh) * 2019-11-27 2020-03-31 上海市闵行区中心医院 一种抗angptl3单克隆抗体及其在制备治疗肾病综合征药物中的用途
CN111122872A (zh) * 2019-11-20 2020-05-08 中山大学附属第一医院 血管生成素样蛋白7在心力衰竭预后评估中的应用

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US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP1451578B1 (en) 2001-11-16 2013-08-21 Genentech, Inc. Use of angptl3 antagonists for the treatment of liver diseases
AU2004266043B2 (en) * 2003-08-21 2007-09-20 Duchesnay Inc. Micronutrient supplement
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
US7371384B2 (en) * 2004-07-20 2008-05-13 Genentech, Inc. Compositions and methods of using angiopoietin-like 4 protein antibody
PT1771474E (pt) 2004-07-20 2010-05-03 Genentech Inc Inibidores de proteína 4 do tipo angiopoietina, combinações e sua utilização
US7807645B2 (en) 2005-09-23 2010-10-05 The Regents Of The University Of California Method of treating degenerative disorders of the nervous system by administration of fibrinogen fragment
WO2009128077A1 (en) * 2008-04-14 2009-10-22 Hadasit Medical Research Services And Development Ltd. Stable cell binding chimeric peptides
EP2521556B1 (en) 2010-01-08 2018-05-30 Ionis Pharmaceuticals, Inc. Modulation of angiopoietin-like 3 expression
AU2015200969A1 (en) * 2010-01-08 2015-03-19 Ionis Pharmaceuticals, Inc. Modulation of angiopoietin-like 3 expression
CA2773101C (en) * 2010-02-02 2018-08-21 Arizona Board Of Regents Controlled tunnel gap device for sequencing polymers
US20130330752A1 (en) * 2011-01-29 2013-12-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JO3412B1 (ar) 2011-06-17 2019-10-20 Regeneron Pharma أجسام مضادة ل angptl3 واستخداماتها
CA2862485C (en) * 2012-01-24 2021-05-11 Inter-K Pty Limited Peptide agents for cancer therapy
UY35368A (es) * 2013-03-08 2014-10-31 Irm Llc Péptidos y composiciones para el tratamiento de daño articular
US9301971B2 (en) 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
CN104062432B (zh) * 2013-03-22 2016-01-20 中山大学 ang2在制备ECTC血管类型肝癌诊断试剂及治疗药物中的应用
PE20152002A1 (es) 2013-05-01 2016-01-21 Isis Pharmaceuticals Inc Composiciones y metodos para modular la expresion de ttr y vhb
CN105814204B (zh) 2013-12-24 2020-04-28 Ionis制药公司 促血管生成素样3表达的调节
ES2844593T3 (es) 2014-05-01 2021-07-22 Ionis Pharmaceuticals Inc Composiciones y procedimientos para modular la expresión de la angiopoyetina de tipo 3
KR20250078597A (ko) 2015-11-06 2025-06-02 아이오니스 파마수티컬즈, 인코포레이티드 아포리포프로테인 (a) 발현 조정
CN108779159B (zh) * 2016-02-04 2022-12-30 瑞泽恩制药公司 具有经改造的angptl8基因的非人动物
KR102456731B1 (ko) 2016-03-03 2022-10-24 리제너론 파아마슈티컬스, 인크. Pcsk9 억제제를 angptl3 억제제와 병용하여 투여함으로써 고지혈증을 갖는 환자를 치료하기 위한 방법
AU2018331383B2 (en) 2017-09-14 2024-12-05 Arrowhead Pharmaceuticals, Inc. RNAi agents and compositions for inhibiting expression of angiopoietin-like 3 (ANGPTL3), and methods of use
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
WO2020099482A2 (en) * 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Angptl 3 oligonucleotides influencing the regulation of the fatty acid metabolism
TWI747098B (zh) * 2018-12-21 2021-11-21 美商美國禮來大藥廠 抗angptl3/8複合物抗體及其使用方法
US12559551B2 (en) 2019-05-24 2026-02-24 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-ANGPTL3 antibodies
MX2022000094A (es) * 2019-07-04 2022-04-27 Cadila Healthcare Ltd Vacuna a base de angptl3 para el tratamiento de enfermedad hepática.
US20240141029A1 (en) * 2021-03-05 2024-05-02 Anji Pharmaceuticals Inc. Methods and compositions for treating sepsis
CN114934021B (zh) * 2022-04-21 2023-08-08 复旦大学附属儿科医院 一种Angptl3敲除的鼠永生化足细胞系及其应用
CN120254294B (zh) * 2025-06-05 2025-09-09 南昌大学第一附属医院 Angptl3在乙肝相关慢加急性肝衰竭预后中的应用

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WO1999055869A1 (en) * 1998-04-27 1999-11-04 Zymogenetics, Inc. Novel polypeptide growth factors and materials and methods for making them
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences
KR20010104373A (ko) * 1999-03-08 2001-11-24 제넨테크, 인크. 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
EP1451578B1 (en) 2001-11-16 2013-08-21 Genentech, Inc. Use of angptl3 antagonists for the treatment of liver diseases

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101855241B (zh) * 2006-12-08 2013-11-06 莱克康制药公司 针对angptl3的单克隆抗体
CN101852805A (zh) * 2009-03-31 2010-10-06 浙江大学 Angptl3作为卵巢癌的诊断标记物的用途
WO2010111892A1 (zh) * 2009-03-31 2010-10-07 浙江大学 Angptl3作为卵巢癌的诊断标记物的用途
CN101852805B (zh) * 2009-03-31 2015-04-01 浙江大学 Angptl3作为卵巢癌的诊断标记物的用途
CN102625830A (zh) * 2009-07-14 2012-08-01 斯克里普斯研究所 间充质干细胞分化
CN102625830B (zh) * 2009-07-14 2016-03-02 斯克里普斯研究所 间充质干细胞分化
CN105601728A (zh) * 2009-07-14 2016-05-25 斯克里普斯研究所 间充质干细胞分化
CN105601728B (zh) * 2009-07-14 2020-01-10 斯克里普斯研究所 间充质干细胞分化
CN105021827A (zh) * 2015-07-17 2015-11-04 北京大学第一医院 检测血清血管生成素样蛋白2含量的物质在制备检测肝脏炎症和纤维化程度产品中的应用
CN111122872A (zh) * 2019-11-20 2020-05-08 中山大学附属第一医院 血管生成素样蛋白7在心力衰竭预后评估中的应用
CN110938144A (zh) * 2019-11-27 2020-03-31 上海市闵行区中心医院 一种抗angptl3单克隆抗体及其在制备治疗肾病综合征药物中的用途

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AU2002348286B2 (en) 2008-04-03
IL161542A0 (en) 2004-09-27
KR101012904B1 (ko) 2011-02-08
JP5105696B2 (ja) 2012-12-26
CA2464542A1 (en) 2003-05-30
ZA200403070B (en) 2005-06-29
IL203894A (en) 2013-09-30
WO2003044172A2 (en) 2003-05-30
JP2010100624A (ja) 2010-05-06
CN101905024A (zh) 2010-12-08
CA2464542C (en) 2015-01-20
US7267819B2 (en) 2007-09-11
ES2429034T3 (es) 2013-11-12
NO20042410L (no) 2004-06-09
EP1451578B1 (en) 2013-08-21
NZ532852A (en) 2006-08-31
JP2005521643A (ja) 2005-07-21
WO2003044172B1 (en) 2004-03-18
US20090098117A1 (en) 2009-04-16
EP1451578A4 (en) 2006-02-01
WO2003044172A3 (en) 2003-11-20
US8541376B2 (en) 2013-09-24
US20070134250A1 (en) 2007-06-14
MXPA04004609A (es) 2004-08-12
AU2002348286A1 (en) 2003-06-10
KR20100029861A (ko) 2010-03-17
US20030215451A1 (en) 2003-11-20
EP1451578A2 (en) 2004-09-01
KR20050044485A (ko) 2005-05-12
NO336021B1 (no) 2015-04-20

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