CN1328573A - 交联的透明质酸和它在医药方面的应用 - Google Patents
交联的透明质酸和它在医药方面的应用 Download PDFInfo
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- CN1328573A CN1328573A CN99813143A CN99813143A CN1328573A CN 1328573 A CN1328573 A CN 1328573A CN 99813143 A CN99813143 A CN 99813143A CN 99813143 A CN99813143 A CN 99813143A CN 1328573 A CN1328573 A CN 1328573A
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- hyaluronic acid
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- hyaluronic
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
实验 | 交联剂(mol) | CMPJ量(g)(mol) | 交联度 | SD | NMR(13)(ppm) | IR(薄膜法)(cm-1) | 扫描电镜形貌 |
6 | 1,3-丙烷二胺(0.024) | 0.6g(1.210-3) | (100%) | 13.200 | 29.3/39.8(-CH2-CH2-CH2-丙烷二胺链接);172.5(-CO-NH-CH2-CH2-CH2-) | 1630(-CO-NH-):1560(-CO-NH-): | 均一的,波浪式的形貌 |
7 | 0,0’-1-双-(-2-二氨基丙基)PEG500(0.022) | 0.15g(6×10-4) | (50%) | 9.000 | 交替的平滑区和孔状区,数微米园形隆起部交替 | ||
8 | 0,0’-双-(2-氨基丙基)PEG800(0.022) | 0.15g(6×10-4) | (50%) | 6.100 | 两个形貌不同的区域,第一个是波浪式,第二个是孔状结构 | ||
9 | 1,6-二氨基己烷(0.023) | 0.15g(6×10-4) | (50%) | 8.000 | 169.46(-CO-NH-交联);74.04/76.80/83.17/80.41(-CH2-交联臂) | 1740(-COOH);1630(-CO-NH-);1610(-COO);1560(-CO-NH-); | 带有数微米隆起部的平滑表面 |
C-1 | C-2 | C-3 | C-4 | C-5 | X-C=0 | Y-CH3 | |
103.5 | 57.3 | 85.4 | 71.3 | 78.7 | 178.0 | 25.3 | ppm |
C-1’ | C-2’ | C-3’ | C-4’ | C-5’ | 6-C=0 | ||
105.9 | 75.2 | 76.4 | 82.8 | 78.6 | 176.2 | ppm | |
1-CH2 | 2-CH2 | 3-CH2 | 6’-C=0 | 交联 | |||
39.8 | 29.3 | 39.8 | 172.5 | ppm |
Claims (11)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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IT1998MI002440A IT1303735B1 (it) | 1998-11-11 | 1998-11-11 | Acidi ialuronici reticolati e loro usi medici. |
ITMI98A002440 | 1998-11-11 |
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CN1328573A true CN1328573A (zh) | 2001-12-26 |
CN1131241C CN1131241C (zh) | 2003-12-17 |
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CN99813143A Expired - Fee Related CN1131241C (zh) | 1998-11-11 | 1999-11-08 | 交联的透明质酸和它在医药方面的应用 |
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EP (1) | EP1144459B2 (zh) |
JP (1) | JP2002529550A (zh) |
KR (1) | KR100674177B1 (zh) |
CN (1) | CN1131241C (zh) |
AT (1) | ATE225371T1 (zh) |
AU (1) | AU757102B2 (zh) |
BR (1) | BR9915235A (zh) |
CA (1) | CA2350667A1 (zh) |
CZ (1) | CZ296842B6 (zh) |
DE (1) | DE69903351T3 (zh) |
DK (1) | DK1144459T4 (zh) |
ES (1) | ES2184521T5 (zh) |
HK (1) | HK1041011B (zh) |
HU (1) | HU229668B1 (zh) |
IL (1) | IL143063A0 (zh) |
IT (1) | IT1303735B1 (zh) |
NO (1) | NO20012315L (zh) |
NZ (1) | NZ511306A (zh) |
PT (1) | PT1144459E (zh) |
RU (1) | RU2230752C2 (zh) |
TR (1) | TR200101324T2 (zh) |
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CN100348654C (zh) * | 2003-02-27 | 2007-11-14 | 株式会社资生堂 | 含有乙酰化透明质酸的眼用药物组合物 |
CN1764482B (zh) * | 2003-04-04 | 2011-01-19 | 诺比尔生物研究所有限公司 | 血管支架 |
CN101056891B (zh) * | 2004-11-15 | 2010-05-26 | 株式会社资生堂 | 交联透明质酸凝胶的制备方法 |
CN101107270B (zh) * | 2004-11-24 | 2011-11-23 | 诺维信生物制药丹麦公司 | 用二乙烯基砜交联透明质酸的方法 |
CN102574930A (zh) * | 2009-09-28 | 2012-07-11 | 泰尔茂株式会社 | 活性酯化多糖及其制造方法 |
CN102574930B (zh) * | 2009-09-28 | 2014-09-03 | 泰尔茂株式会社 | 活性酯化多糖及其制造方法 |
CN105377898A (zh) * | 2013-04-24 | 2016-03-02 | 阿雅瓦尼公司 | 共交联磷酸盐化的和/或磷酸盐官能化的聚多糖类水凝胶 |
CN105473623A (zh) * | 2013-06-28 | 2016-04-06 | 盖尔德玛公司 | 用于制备交联的透明质酸产物的方法 |
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CN107469090A (zh) * | 2017-08-15 | 2017-12-15 | 浙江大学 | 可共载抗肿瘤药物和核酸药物的纳米载体及抗肿瘤药物纳米制剂 |
CN113906055A (zh) * | 2019-04-19 | 2022-01-07 | 卓英医疗有限责任公司 | 官能化的透明质酸的交联的聚合物及其在炎症状态的治疗中的用途 |
CN113906055B (zh) * | 2019-04-19 | 2023-09-26 | 卓英医疗有限责任公司 | 官能化的透明质酸的交联的聚合物及其在炎症状态的治疗中的用途 |
CN110684211A (zh) * | 2019-10-14 | 2020-01-14 | 宁夏妙朗生物科技有限公司 | 制备抵抗α-葡萄糖苷酶水解的交联右旋糖苷凝胶的方法 |
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