CN1313465C - 杂多环化合物及其用于制备代谢性谷氨酸受体拮抗剂的应用 - Google Patents
杂多环化合物及其用于制备代谢性谷氨酸受体拮抗剂的应用 Download PDFInfo
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- CN1313465C CN1313465C CNB008145024A CN00814502A CN1313465C CN 1313465 C CN1313465 C CN 1313465C CN B008145024 A CNB008145024 A CN B008145024A CN 00814502 A CN00814502 A CN 00814502A CN 1313465 C CN1313465 C CN 1313465C
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- diazole
- pyridyl
- phenyl
- cyano
- pyridine
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| CN105143214A (zh) * | 2013-02-15 | 2015-12-09 | 孟山都技术公司 | 用于控制线虫害虫的3,5-二取代的-4,5-二氢-1,2,4-噁二唑 |
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| US6916821B2 (en) | 2001-04-02 | 2005-07-12 | Brown University | Methods of treating disorders with Group I mGluR antagonists |
| AU2002307049A1 (en) * | 2001-04-02 | 2002-10-15 | Brown University Research Foundation | Use of mglur5 antagonists in the manufacture of a medicament in the treatment of autism, mental retardation, schizophrenia |
| JP4299139B2 (ja) * | 2001-12-18 | 2009-07-22 | メルク エンド カムパニー インコーポレーテッド | 代謝型グルタミン酸受容体−５のヘテロアリール置換トリアゾールモジュレータ |
| JP4286146B2 (ja) * | 2001-12-18 | 2009-06-24 | メルク エンド カムパニー インコーポレーテッド | メタボトロピックグルタミン酸受容体−５のヘテロアリール置換ピラゾール系調節剤 |
| AU2002360621B2 (en) * | 2001-12-19 | 2007-01-25 | Merck & Co., Inc. | heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5 |
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| TW200812986A (en) * | 2002-08-09 | 2008-03-16 | Nps Pharma Inc | New compounds |
| CN1894241A (zh) | 2002-08-09 | 2007-01-10 | 阿斯利康(瑞典)有限公司 | 作为代谢型谷氨酸受体－5调节剂的“1,2,4” 噁二唑 |
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| NZ547965A (en) * | 2003-12-24 | 2009-12-24 | Prosidion Ltd | 1,2,4-Oxadiazole derivatives as GPCR receptor agonists |
| BRPI0507495A (pt) * | 2004-02-18 | 2007-07-10 | Astrazeneca Ab | composto, composição farmacêutica, uso do composto método para o tratamento de distúrbios mediados por mglur5, e, método para inibir a ativação de receptores de mglur5 |
| US7585881B2 (en) | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| JP2007523181A (ja) * | 2004-02-18 | 2007-08-16 | アストラゼネカ アクチボラグ | ポリヘテロ環式化合物、および、代謝型グルタミン酸受容体アンタゴニストとしてのそれらの使用 |
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| CN1980901A (zh) * | 2004-06-30 | 2007-06-13 | 万有制药株式会社 | 联芳基衍生物 |
| KR100621192B1 (ko) * | 2004-10-13 | 2006-09-19 | 한국화학연구원 | 무스카린 수용체 작용물질로서 작용하는1,2,3,4-테트라하이드로피리미디닐-1,2,4-옥사다이아졸유도체와 이의 제조방법 |
| JP4557685B2 (ja) | 2004-11-15 | 2010-10-06 | 独立行政法人理化学研究所 | 蛍光蛋白質 |
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| SI1907382T1 (sl) | 2005-07-26 | 2015-10-30 | Bial-Portela & Ca S.A., | Nitrokateholni derivati kot inhibitorji COMT |
| UY29796A1 (es) | 2005-09-29 | 2007-04-30 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor |
| RU2425834C2 (ru) | 2005-11-08 | 2011-08-10 | Ф. Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ ТИАЗОЛО[4,5-c]ПИРИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ mGluR5 |
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| AU2007236707C1 (en) | 2006-04-03 | 2012-05-24 | Astellas Pharma Inc. | Hetero compound |
| EP1845097A1 (en) | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazole derivatives as COMT inhibitors |
| WO2008028903A2 (en) * | 2006-09-04 | 2008-03-13 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
| MY149853A (en) | 2006-09-07 | 2013-10-31 | Actelion Pharmaceuticals Ltd | Pyridin-4-yl derivatives as immunomodulating agents |
| AR062684A1 (es) | 2006-09-08 | 2008-11-26 | Actelion Pharmaceuticals Ltd | Compuestos derivados de piridin-3- ilo, composicion farmaceutica que los contiene, y uso de los mismos en la preparacion de medicamentos |
| JP5250556B2 (ja) | 2006-09-21 | 2013-07-31 | アクテリオン ファーマシューティカルズ リミテッド | フェニル誘導体及びそれらの免疫調節薬としての使用 |
| ES2597705T3 (es) | 2007-01-31 | 2017-01-20 | Bial - Portela & Ca., S.A. | Derivados de nitrocatecol como inhibidores de COMT administrados con un régimen de dosificación específico |
| DK2125797T3 (da) | 2007-03-16 | 2014-02-10 | Actelion Pharmaceuticals Ltd | Aminopyridinderivater som s1p1/edg1-receptoragonister |
| HRP20110449T1 (hr) | 2007-08-17 | 2011-07-31 | Actelion Pharmaceuticals Ltd. | Derivati piridina kao modulatori receptora s1p1/edg1 |
| JP2011502148A (ja) | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのｐ２ｘ３受容体アンタゴニスト |
| ES2449749T3 (es) | 2007-11-01 | 2014-03-21 | Actelion Pharmaceuticals Ltd. | Nuevos derivados de pirimidina |
| MX2010006033A (es) * | 2007-12-20 | 2010-07-16 | Bayer Schering Pharma Ag | 4-(4-ciano-2-tioaril)dihidropirimidinonas y su uso. |
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| CN105143214B (zh) * | 2013-02-15 | 2018-04-03 | 孟山都技术公司 | 用于控制线虫害虫的3,5‑二取代的‑4,5‑二氢‑1,2,4‑噁二唑 |
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