CN1308375C - 类脂－聚合物轭合物组合物 - Google Patents

类脂－聚合物轭合物组合物 Download PDF

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Publication number
CN1308375C
CN1308375C CNB028127358A CN02812735A CN1308375C CN 1308375 C CN1308375 C CN 1308375C CN B028127358 A CNB028127358 A CN B028127358A CN 02812735 A CN02812735 A CN 02812735A CN 1308375 C CN1308375 C CN 1308375C
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CN
China
Prior art keywords
polymer
poly
lipid
dodasuc
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028127358A
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English (en)
Chinese (zh)
Other versions
CN1520435A (zh
Inventor
J·M·麦特瑟拉
W·E·翰尼克
T·德温格尔
L·W·T·德博尔
C·欧瑟伦
G·斯托姆
P·布鲁恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Europe BV
Original Assignee
Yamanouchi Europe BV
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Filing date
Publication date
Application filed by Yamanouchi Europe BV filed Critical Yamanouchi Europe BV
Publication of CN1520435A publication Critical patent/CN1520435A/zh
Application granted granted Critical
Publication of CN1308375C publication Critical patent/CN1308375C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB028127358A 2001-06-01 2002-06-03 类脂－聚合物轭合物组合物 Expired - Fee Related CN1308375C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202107.7 2001-06-01
EP01202107 2001-06-01

Publications (2)

Publication Number Publication Date
CN1520435A CN1520435A (zh) 2004-08-11
CN1308375C true CN1308375C (zh) 2007-04-04

Family

ID=8180408

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB02812734XA Expired - Fee Related CN1271116C (zh) 2001-06-01 2002-06-03 类脂－聚合物轭合物
CNB028127358A Expired - Fee Related CN1308375C (zh) 2001-06-01 2002-06-03 类脂－聚合物轭合物组合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNB02812734XA Expired - Fee Related CN1271116C (zh) 2001-06-01 2002-06-03 类脂－聚合物轭合物

Country Status (20)

Country Link
US (3) US20040254352A1 (enExample)
EP (2) EP1392756B1 (enExample)
JP (2) JP2004527585A (enExample)
KR (2) KR100874847B1 (enExample)
CN (2) CN1271116C (enExample)
AT (2) ATE416214T1 (enExample)
BR (2) BR0209695A (enExample)
CA (2) CA2448856A1 (enExample)
CZ (2) CZ20033480A3 (enExample)
DE (2) DE60230137D1 (enExample)
EE (2) EE200300598A (enExample)
ES (2) ES2282439T3 (enExample)
HR (2) HRP20030975A2 (enExample)
HU (2) HUP0400171A2 (enExample)
MX (2) MXPA03011050A (enExample)
NO (2) NO20035263D0 (enExample)
PL (2) PL367479A1 (enExample)
SK (2) SK15972003A3 (enExample)
WO (2) WO2002098951A2 (enExample)
ZA (2) ZA200308937B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE416214T1 (de) * 2001-06-01 2008-12-15 Astellas Pharma Europ B V Zusammensetzungen enthaltend lipid-polymer konjugate
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
EP1393720A1 (en) * 2002-08-27 2004-03-03 Universiteit Utrecht Vesicle-encapsulated corticosteroids for treatment of cancer
SG113442A1 (en) * 2002-11-29 2005-08-29 Agency Science Tech & Res Improved temperature sensitive micelles
FR2855521B1 (fr) 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
EP1481683A1 (en) * 2003-05-30 2004-12-01 Yamanouchi Pharmaceutical Co. Ltd. P-selectin targeting ligand and compositions thereof
SE527505C2 (sv) * 2003-06-10 2006-03-28 Anna Imberg Komposita material och partiklar
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
US20100036093A1 (en) * 2006-05-09 2010-02-11 Osaka University Cholesterolamine-introduced poly-gamma-glutamic acid derivative
JP4936312B2 (ja) * 2006-07-20 2012-05-23 株式会社島津製作所 新規な両親媒性物質、それを用いた薬剤搬送システム及び分子イメージングシステム
JP5258189B2 (ja) * 2006-11-09 2013-08-07 学校法人 関西大学 柔軟性生分解性ポリマー
ITRM20070327A1 (it) * 2007-06-11 2008-12-12 Univ Palermo Vettori colloidali a struttura poliamminoacidica per il rilascio orale di peptidi e proteine e relativo metodo di produzione.
US20090285882A1 (en) * 2008-04-22 2009-11-19 Jochen Weiss Stabilized Liposome Compositions and Related Methods of Use
KR101695836B1 (ko) 2010-04-13 2017-01-16 (주)아모레퍼시픽 경피흡수용 고분자-리포좀 나노복합체 조성물 및 그 제조방법
ES2385995B2 (es) * 2011-01-10 2013-05-21 Universidade De Santiago De Compostela Nanocápsulas con cubierta polimérica
US9993427B2 (en) * 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
WO2019172362A1 (ja) * 2018-03-07 2019-09-12 公益財団法人川崎市産業振興財団 刺激応答性ポリマー
WO2023282296A1 (ja) * 2021-07-07 2023-01-12 日油株式会社 ｐＨ応答性脂質誘導体
WO2024232832A1 (en) * 2023-05-11 2024-11-14 Agency For Science, Technology And Research A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound and related methods thereof
WO2025021942A1 (en) 2023-07-27 2025-01-30 Bracco Suisse Sa Ultrasound responsive vesicles containing lipid-polyamino acid conjugates
WO2025031991A1 (en) * 2023-08-04 2025-02-13 Polypeptide Therapeutic Solutions, S.L. Stealth-stabilized sulfur-containing lipo/polyamino acids
WO2025080209A1 (en) * 2023-10-10 2025-04-17 Agency For Science, Technology And Research A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound and related methods thereof
WO2025090023A1 (en) * 2023-10-24 2025-05-01 Agency For Science, Technology And Research A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound, and related methods thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1139386A (zh) * 1994-11-22 1997-01-01 勃勒柯研究有限公司 微胶囊，制造方法和其应用
US5631018A (en) * 1993-03-03 1997-05-20 Sequus Pharmaceuticals, Inc. Lipid-polymer conjugates and liposomes
WO1999061512A1 (en) * 1998-05-23 1999-12-02 University Of Strathclyde Polyamino acid vesicles
CN1295465A (zh) * 1998-04-02 2001-05-16 阿尔扎有限公司 脂质体组合物和喹诺酮的给药方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0657722B2 (ja) * 1986-05-27 1994-08-03 三菱化成株式会社 水溶性ポリマ−組成物
US5149794A (en) * 1990-11-01 1992-09-22 State Of Oregon Covalent lipid-drug conjugates for drug targeting
US6197332B1 (en) * 1997-08-13 2001-03-06 Chiron Corporation Lipid-conjugated polyamide compounds and related compositions and methods thereof
ATE416214T1 (de) * 2001-06-01 2008-12-15 Astellas Pharma Europ B V Zusammensetzungen enthaltend lipid-polymer konjugate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631018A (en) * 1993-03-03 1997-05-20 Sequus Pharmaceuticals, Inc. Lipid-polymer conjugates and liposomes
CN1139386A (zh) * 1994-11-22 1997-01-01 勃勒柯研究有限公司 微胶囊，制造方法和其应用
CN1295465A (zh) * 1998-04-02 2001-05-16 阿尔扎有限公司 脂质体组合物和喹诺酮的给药方法
WO1999061512A1 (en) * 1998-05-23 1999-12-02 University Of Strathclyde Polyamino acid vesicles

Also Published As

Publication number Publication date
US20040241222A1 (en) 2004-12-02
EE200300596A (et) 2004-02-16
ES2318027T3 (es) 2009-05-01
HUP0400171A2 (en) 2007-02-28
WO2002098951A3 (en) 2003-02-20
US20100145018A1 (en) 2010-06-10
HUP0400174A2 (en) 2007-02-28
PL367479A1 (en) 2005-02-21
EP1392756B1 (en) 2007-02-14
KR20040027512A (ko) 2004-04-01
CN1271116C (zh) 2006-08-23
DE60218154T2 (de) 2007-10-31
MXPA03011049A (es) 2004-06-25
ES2282439T3 (es) 2007-10-16
ZA200308937B (en) 2004-11-17
WO2002098951A2 (en) 2002-12-12
CZ20033480A3 (cs) 2004-07-14
CN1602326A (zh) 2005-03-30
EP1392755A1 (en) 2004-03-03
CA2448858A1 (en) 2002-12-12
DE60230137D1 (de) 2009-01-15
HRP20030976A2 (en) 2005-08-31
NO20035263D0 (no) 2003-11-27
SK15982003A3 (sk) 2004-06-08
ATE416214T1 (de) 2008-12-15
PL369455A1 (en) 2005-04-18
CZ20033479A3 (cs) 2004-07-14
ATE353927T1 (de) 2007-03-15
DE60218154D1 (de) 2007-03-29
KR100894852B1 (ko) 2009-04-24
JP2004527586A (ja) 2004-09-09
NO20035264D0 (no) 2003-11-27
BR0209695A (pt) 2005-01-11
MXPA03011050A (es) 2004-06-25
JP2004527585A (ja) 2004-09-09
KR100874847B1 (ko) 2008-12-19
HRP20030975A2 (en) 2005-08-31
KR20040027513A (ko) 2004-04-01
EP1392756A2 (en) 2004-03-03
US20040254352A1 (en) 2004-12-16
BR0209699A (pt) 2005-02-01
EP1392755B1 (en) 2008-12-03
CN1520435A (zh) 2004-08-11
CA2448856A1 (en) 2002-12-12
EE200300598A (et) 2004-02-16
SK15972003A3 (sk) 2004-06-08
ZA200308938B (en) 2004-11-17
WO2002098952A1 (en) 2002-12-12

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SE01 Entry into force of request for substantive examination
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070404

Termination date: 20100603