CN1294126C - N－苯基芳基磺酰胺化合物、包括该化合物作为活性成分的药物组合物、该化合物的合成中间体及其制备方法 - Google Patents

N－苯基芳基磺酰胺化合物、包括该化合物作为活性成分的药物组合物、该化合物的合成中间体及其制备方法 Download PDF

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Publication number
CN1294126C
CN1294126C CNB028097904A CN02809790A CN1294126C CN 1294126 C CN1294126 C CN 1294126C CN B028097904 A CNB028097904 A CN B028097904A CN 02809790 A CN02809790 A CN 02809790A CN 1294126 C CN1294126 C CN 1294126C
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methyl
amino
isobutyl
alkylsulfonyl
phenyl
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Expired - Fee Related
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Chinese (zh)
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CN1509278A (zh
Inventor
长绳厚志
斋藤哲二
小林馨
丸山隆幸
中井义彦
桥本信介
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Ono Pharmaceutical Co Ltd
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Ono Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
CNB028097904A 2001-03-12 2002-03-11 N－苯基芳基磺酰胺化合物、包括该化合物作为活性成分的药物组合物、该化合物的合成中间体及其制备方法 Expired - Fee Related CN1294126C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP68498/2001 2001-03-12
JP2001068498 2001-03-12
JP281569/2001 2001-09-17
JP2001281569 2001-09-17
JP2002007760 2002-01-16
JP7760/2002 2002-01-16

Publications (2)

Publication Number Publication Date
CN1509278A CN1509278A (zh) 2004-06-30
CN1294126C true CN1294126C (zh) 2007-01-10

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CNB028097904A Expired - Fee Related CN1294126C (zh) 2001-03-12 2002-03-11 N－苯基芳基磺酰胺化合物、包括该化合物作为活性成分的药物组合物、该化合物的合成中间体及其制备方法

Country Status (24)

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US (3) US7235667B2 (enExample)
EP (2) EP1612208B1 (enExample)
JP (3) JP3555620B2 (enExample)
KR (1) KR100886854B1 (enExample)
CN (1) CN1294126C (enExample)
AT (2) ATE522513T1 (enExample)
AU (1) AU2002238855B2 (enExample)
BR (1) BR0208027A (enExample)
CA (1) CA2439604C (enExample)
CZ (1) CZ304035B6 (enExample)
DE (1) DE60220255T2 (enExample)
DK (2) DK1369419T3 (enExample)
ES (1) ES2286230T3 (enExample)
HU (1) HU230056B1 (enExample)
IL (2) IL157701A0 (enExample)
MX (1) MXPA03008134A (enExample)
NO (1) NO329682B1 (enExample)
NZ (1) NZ528120A (enExample)
PL (1) PL218750B1 (enExample)
PT (2) PT1369419E (enExample)
RU (1) RU2299202C2 (enExample)
TW (1) TWI317359B (enExample)
WO (1) WO2002072564A1 (enExample)
ZA (1) ZA200306884B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070906A1 (en) * 2004-01-21 2005-08-04 Novartis Ag Organic compounds
CN102076660B (zh) * 2008-06-23 2014-01-08 安斯泰来制药有限公司 磺胺化合物或其盐

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022549A1 (ja) * 2002-09-09 2004-03-18 Ono Pharmaceutical Co., Ltd. ４−メチル−１，３−チアゾール−２−イルスルホニルハライドの製造方法
CN100408570C (zh) * 2003-01-29 2008-08-06 阿斯特兰德英国有限公司 Ep4受体拮抗剂
GB0317500D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Treatment of bph
JPWO2005000356A1 (ja) * 2003-06-27 2006-08-03 小野薬品工業株式会社 尿路疾患治療剤
JPWO2006004115A1 (ja) * 2004-07-05 2008-04-24 中外製薬株式会社 過活動膀胱治療剤
JP2008189549A (ja) * 2005-05-12 2008-08-21 Astellas Pharma Inc カルボン酸誘導体またはその塩
JP2009057282A (ja) * 2005-12-19 2009-03-19 Astellas Pharma Inc カルボン酸誘導体又はその塩
TW200817319A (en) * 2006-08-10 2008-04-16 Astellas Pharma Inc Sulfonamide compound or salt thereof
BRPI0807942A2 (pt) * 2007-02-16 2014-07-01 Ono Pharmaceutical Co Agente terapêutico para distúrbio de excreção urinária
CN101790517B (zh) * 2007-08-01 2013-08-21 大正制药株式会社 抑制s1p1结合的物质
SG176464A1 (en) * 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
TW201107309A (en) * 2009-07-27 2011-03-01 Kissei Pharmaceutical Indole derivatives, or the pharmaceutically acceptable salts
EP2598481B1 (en) 2010-07-26 2016-08-31 Bristol-Myers Squibb Company Sulfonamide compounds useful as cyp17 inhibitors
JP5363636B2 (ja) * 2011-10-21 2013-12-11 ファイザー・リミテッド 新規な塩および医学的使用
US20140039004A1 (en) * 2012-07-31 2014-02-06 Ono Pharmaceutical Co., Ltd. Method of treating of gastroesophageal reflux disease
ES2709005T3 (es) * 2014-04-30 2019-04-12 Ind Penalver Sl Cabezal concéntrico programable para la aplicación líquida en tapas multiformato
MA43231B1 (fr) * 2015-11-13 2020-08-31 Dae Woong Pharma Bloqueur des canaux sodiques
RU2659955C1 (ru) * 2017-10-26 2018-07-04 Галина Ильхамовна Лукина Способ диагностики высоких гастроэзофагеальных рефлюксов

Citations (4)

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US4066636A (en) * 1976-02-02 1978-01-03 Fuji Photo Film Co., Ltd. Method of hardening gelatin
CH615600A5 (en) * 1975-12-06 1980-02-15 Pfersee Chem Fab Process for preparing stable, aqueous emulsions of water-insoluble substances
CN1247529A (zh) * 1996-12-18 2000-03-15 小野药品工业株式会社 磺酰胺和羧酰胺衍生物和含这种化合物作活性成分的药物
WO2000069465A1 (en) * 1999-05-12 2000-11-23 Ono Pharmaceutical Co., Ltd. Anticancer agents containing ep1 antagonists as the active ingredient

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DE2419923A1 (de) * 1973-04-28 1974-11-28 Fujisawa Pharmaceutical Co Sulfonsaeureester, verfahren zu deren herstellung und verwendung derselben als kondensationsmittel
JPS5748534B2 (enExample) 1974-03-04 1982-10-16
JPH05293469A (ja) 1992-04-17 1993-11-09 Toda Constr Co Ltd 滅菌精製水の製造方法およびその装置
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
WO2001008674A1 (en) 1999-07-29 2001-02-08 Ono Pharmaceutical Co., Ltd. Sulfonamide derivatives and remedies for allodynia
WO2002072145A1 (en) 2001-03-14 2002-09-19 Ono Pharmaceutical Co., Ltd. Remedies for depression containing ep1 antagonist as the active ingredient

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH615600A5 (en) * 1975-12-06 1980-02-15 Pfersee Chem Fab Process for preparing stable, aqueous emulsions of water-insoluble substances
US4066636A (en) * 1976-02-02 1978-01-03 Fuji Photo Film Co., Ltd. Method of hardening gelatin
CN1247529A (zh) * 1996-12-18 2000-03-15 小野药品工业株式会社 磺酰胺和羧酰胺衍生物和含这种化合物作活性成分的药物
WO2000069465A1 (en) * 1999-05-12 2000-11-23 Ono Pharmaceutical Co., Ltd. Anticancer agents containing ep1 antagonists as the active ingredient

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070906A1 (en) * 2004-01-21 2005-08-04 Novartis Ag Organic compounds
CN102076660B (zh) * 2008-06-23 2014-01-08 安斯泰来制药有限公司 磺胺化合物或其盐

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RU2299202C2 (ru) 2007-05-20
RU2003127677A (ru) 2005-03-27
JP2006028193A (ja) 2006-02-02
IL157701A0 (en) 2004-03-28
IL157701A (en) 2010-06-30
EP1612208B1 (en) 2011-08-31
ZA200306884B (en) 2005-03-30
US20050124672A1 (en) 2005-06-09
US7235667B2 (en) 2007-06-26
DK1612208T3 (da) 2011-12-12
JP2004149545A (ja) 2004-05-27
DE60220255D1 (de) 2007-07-05
CA2439604C (en) 2012-05-01
CZ20032452A3 (cs) 2003-11-12
HU230056B1 (hu) 2015-06-29
US7629369B2 (en) 2009-12-08
PL365100A1 (en) 2004-12-27
US8088802B2 (en) 2012-01-03
MXPA03008134A (es) 2004-03-10
EP1369419A1 (en) 2003-12-10
US20100041708A1 (en) 2010-02-18
ATE362924T1 (de) 2007-06-15
ES2286230T3 (es) 2007-12-01
JPWO2002072564A1 (ja) 2004-07-02
EP1612208A3 (en) 2006-12-06
PL218750B1 (pl) 2015-01-30
NZ528120A (en) 2006-05-26
BR0208027A (pt) 2004-12-28
EP1369419B1 (en) 2007-05-23
HUP0400155A3 (en) 2007-05-02
TWI317359B (en) 2009-11-21
WO2002072564A1 (en) 2002-09-19
KR100886854B1 (ko) 2009-03-05
DK1369419T3 (da) 2007-09-24
DE60220255T2 (de) 2008-01-17
KR20030082978A (ko) 2003-10-23
AU2002238855B2 (en) 2007-12-06
ATE522513T1 (de) 2011-09-15
CZ304035B6 (cs) 2013-08-28
JP3741120B2 (ja) 2006-02-01
PT1612208E (pt) 2011-10-12
JP3555620B2 (ja) 2004-08-18
NO20034007D0 (no) 2003-09-10
NO329682B1 (no) 2010-11-29
PT1369419E (pt) 2007-08-16
CA2439604A1 (en) 2002-09-19
CN1509278A (zh) 2004-06-30
NO20034007L (no) 2003-11-12
JP4432051B2 (ja) 2010-03-17
EP1612208A2 (en) 2006-01-04
US20060030713A1 (en) 2006-02-09
EP1369419A4 (en) 2005-03-16
HUP0400155A2 (hu) 2004-08-30

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