HUP0400155A2 - N-fenil-arilszulfonamidok, intermediereik, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents

N-fenil-arilszulfonamidok, intermediereik, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra

Info

Publication number
HUP0400155A2
HUP0400155A2 HU0400155A HUP0400155A HUP0400155A2 HU P0400155 A2 HUP0400155 A2 HU P0400155A2 HU 0400155 A HU0400155 A HU 0400155A HU P0400155 A HUP0400155 A HU P0400155A HU P0400155 A2 HUP0400155 A2 HU P0400155A2
Authority
HU
Hungary
Prior art keywords
compound
methyl
group
processes
producing
Prior art date
Application number
HU0400155A
Other languages
English (en)
Inventor
Shinsuke Hashimoto
Kaoru Kobayashi
Takayuki Maruyama
Atsushi Naganawa
Yoshihiko Nakai
Tetsuji Saitoh
Original Assignee
Ono Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co., Ltd. filed Critical Ono Pharmaceutical Co., Ltd.
Publication of HUP0400155A2 publication Critical patent/HUP0400155A2/hu
Publication of HUP0400155A3 publication Critical patent/HUP0400155A3/hu
Publication of HU230056B1 publication Critical patent/HU230056B1/hu

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/70Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/04Drugs for disorders of the urinary system for urolithiasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

A találmány tárgyát az általános képletű vegyületek - ahol R1 -COOH stb. csoport; R2 hidrogénatom, metilcsoport, stb.; R3 és R4 metil- és metilcsoport kombinációja, stb.; R5 izopropilcsoport, stb.; Ar tiazolil-, piridil-, 5-metil-2- furil-csoport, mindegyik adott esetben metilcsoporttal szubsztituált; n értéke 0 vagy 1 - szintézisintermediereik, az előállításukra szolgáló eljárás és alkalmazásuk képezik. Az (I) általános képletű vegyületek egy prosztaglandin E2 receptorhoz, különösen egy EP1 altípusú receptorhoz kapcsolódnak és azt antagonizálják. A vegyületet a protein- kötés kevéssé befolyásolja, így kielégítő az in vivo aktivitása. Ezért fájdalomcsillapítók, láz elleni szerek, gyakori vizelés és/vagy az alsó húgyúti rendszerbetegségek tünetegyüttesének, vagy ráknak a megelőzésére, vagy kezelésére szolgáló gyógyszerkészítmények hatóanyagaiként alkalmazhatók. Ó
HU0400155A 2001-03-12 2002-03-11 N-fenil-arilszulfonamidok, intermediereik, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra HU230056B1 (hu)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2001068498 2001-03-12
JP2001-68498 2001-03-12
JP2001-281569 2001-09-17
JP2001281569 2001-09-17
JP2002007760 2002-01-16
JP2002-7760 2002-01-16
PCT/JP2002/002245 WO2002072564A1 (fr) 2001-03-12 2002-03-11 Compose de n-phenylarylsulfonamide, medicament contenant le compose en tant que principe actif, intermediaire pour le compose et ses procedes de production

Publications (3)

Publication Number Publication Date
HUP0400155A2 true HUP0400155A2 (hu) 2004-08-30
HUP0400155A3 HUP0400155A3 (en) 2007-05-02
HU230056B1 HU230056B1 (hu) 2015-06-29

Family

ID=27346214

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400155A HU230056B1 (hu) 2001-03-12 2002-03-11 N-fenil-arilszulfonamidok, intermediereik, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra

Country Status (24)

Country Link
US (3) US7235667B2 (hu)
EP (2) EP1612208B1 (hu)
JP (3) JP3555620B2 (hu)
KR (1) KR100886854B1 (hu)
CN (1) CN1294126C (hu)
AT (2) ATE522513T1 (hu)
AU (1) AU2002238855B2 (hu)
BR (1) BR0208027A (hu)
CA (1) CA2439604C (hu)
CZ (1) CZ304035B6 (hu)
DE (1) DE60220255T2 (hu)
DK (2) DK1369419T3 (hu)
ES (1) ES2286230T3 (hu)
HU (1) HU230056B1 (hu)
IL (2) IL157701A0 (hu)
MX (1) MXPA03008134A (hu)
NO (1) NO329682B1 (hu)
NZ (1) NZ528120A (hu)
PL (1) PL218750B1 (hu)
PT (2) PT1369419E (hu)
RU (1) RU2299202C2 (hu)
TW (1) TWI317359B (hu)
WO (1) WO2002072564A1 (hu)
ZA (1) ZA200306884B (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003264388A1 (en) * 2002-09-09 2004-03-29 Ono Pharmaceutical Co., Ltd. Process for producing 4-methyl-1,3-thiazol-2-ylsulfonyl halide
AU2004207675B2 (en) * 2003-01-29 2010-05-20 Asterand Uk Acquisition Limited EP4 receptor antagonists
GB0317500D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Treatment of bph
WO2005000356A1 (ja) * 2003-06-27 2005-01-06 Ono Pharmaceutical Co., Ltd. 尿路疾患治療剤
GB0401334D0 (en) * 2004-01-21 2004-02-25 Novartis Ag Organic compounds
WO2006004115A1 (ja) * 2004-07-05 2006-01-12 Chugai Seiyaku Kabushiki Kaisha 過活動膀胱治療剤
JP2008189549A (ja) * 2005-05-12 2008-08-21 Astellas Pharma Inc カルボン酸誘導体またはその塩
JP2009057282A (ja) * 2005-12-19 2009-03-19 Astellas Pharma Inc カルボン酸誘導体又はその塩
TW200817319A (en) 2006-08-10 2008-04-16 Astellas Pharma Inc Sulfonamide compound or salt thereof
CA2677769C (en) * 2007-02-16 2016-01-19 Ono Pharmaceutical Co., Ltd. Therapeutic agent for urinary excretion disorder
JP5311057B2 (ja) * 2007-08-01 2013-10-09 大正製薬株式会社 S1p1結合阻害物質
EP2116618A1 (en) * 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
CN102076660B (zh) 2008-06-23 2014-01-08 安斯泰来制药有限公司 磺胺化合物或其盐
TW201107309A (en) * 2009-07-27 2011-03-01 Kissei Pharmaceutical Indole derivatives, or the pharmaceutically acceptable salts
CN103209960A (zh) * 2010-07-26 2013-07-17 百时美施贵宝公司 用作cyp17抑制剂的磺酰胺化合物
JP5363636B2 (ja) * 2011-10-21 2013-12-11 ファイザー・リミテッド 新規な塩および医学的使用
US20140039004A1 (en) 2012-07-31 2014-02-06 Ono Pharmaceutical Co., Ltd. Method of treating of gastroesophageal reflux disease
JP6103893B2 (ja) * 2012-11-15 2017-03-29 サントリー食品インターナショナル株式会社 コーヒーオイルの製造方法
DK3138633T3 (en) * 2014-04-30 2019-03-18 Ind Penalver Sl Programmable concentric head for applying liquid to lids with different designs
RS60927B1 (sr) * 2015-11-13 2020-11-30 Daewoong Pharmaceutical Co Ltd Blokator natrijumovih kanala
RU2659955C1 (ru) * 2017-10-26 2018-07-04 Галина Ильхамовна Лукина Способ диагностики высоких гастроэзофагеальных рефлюксов

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2419923A1 (de) * 1973-04-28 1974-11-28 Fujisawa Pharmaceutical Co Sulfonsaeureester, verfahren zu deren herstellung und verwendung derselben als kondensationsmittel
JPS5748534B2 (hu) 1974-03-04 1982-10-16
DE2555048A1 (de) * 1975-12-06 1977-06-30 Pfersee Chem Fab Verfahren und vorrichtung zur herstellung bestaendiger, waessriger emulsionen wasserunloeslicher substanzen
JPS5293469A (en) * 1976-02-02 1977-08-05 Fuji Photo Film Co Ltd Method of curing gelatin
JPH05293469A (ja) 1992-04-17 1993-11-09 Toda Constr Co Ltd 滅菌精製水の製造方法およびその装置
TW523506B (en) * 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
WO2000069465A1 (fr) * 1999-05-12 2000-11-23 Ono Pharmaceutical Co., Ltd. Agents anticancereux contenant des antagonistes de ep1 en tant que principe actif
AU6180600A (en) 1999-07-29 2001-02-19 Ono Pharmaceutical Co. Ltd. Sulfonamide derivatives and remedies for allodynia
JP4175113B2 (ja) * 2001-03-14 2008-11-05 小野薬品工業株式会社 Ep1アンタゴニストを有効成分として含有するうつ病の治療剤

Also Published As

Publication number Publication date
ATE362924T1 (de) 2007-06-15
JP2006028193A (ja) 2006-02-02
EP1612208B1 (en) 2011-08-31
US7629369B2 (en) 2009-12-08
ATE522513T1 (de) 2011-09-15
EP1612208A2 (en) 2006-01-04
IL157701A0 (en) 2004-03-28
MXPA03008134A (es) 2004-03-10
KR20030082978A (ko) 2003-10-23
DK1369419T3 (da) 2007-09-24
HU230056B1 (hu) 2015-06-29
JPWO2002072564A1 (ja) 2004-07-02
WO2002072564A1 (fr) 2002-09-19
NZ528120A (en) 2006-05-26
CZ304035B6 (cs) 2013-08-28
AU2002238855B2 (en) 2007-12-06
PL365100A1 (en) 2004-12-27
EP1369419A1 (en) 2003-12-10
DE60220255D1 (de) 2007-07-05
PT1369419E (pt) 2007-08-16
CA2439604C (en) 2012-05-01
EP1369419A4 (en) 2005-03-16
TWI317359B (en) 2009-11-21
PT1612208E (pt) 2011-10-12
IL157701A (en) 2010-06-30
US7235667B2 (en) 2007-06-26
US20050124672A1 (en) 2005-06-09
BR0208027A (pt) 2004-12-28
HUP0400155A3 (en) 2007-05-02
NO20034007D0 (no) 2003-09-10
RU2299202C2 (ru) 2007-05-20
DE60220255T2 (de) 2008-01-17
ZA200306884B (en) 2005-03-30
CN1294126C (zh) 2007-01-10
NO20034007L (no) 2003-11-12
JP3555620B2 (ja) 2004-08-18
US20060030713A1 (en) 2006-02-09
JP4432051B2 (ja) 2010-03-17
US20100041708A1 (en) 2010-02-18
US8088802B2 (en) 2012-01-03
KR100886854B1 (ko) 2009-03-05
JP2004149545A (ja) 2004-05-27
ES2286230T3 (es) 2007-12-01
JP3741120B2 (ja) 2006-02-01
RU2003127677A (ru) 2005-03-27
PL218750B1 (pl) 2015-01-30
CA2439604A1 (en) 2002-09-19
EP1612208A3 (en) 2006-12-06
CN1509278A (zh) 2004-06-30
EP1369419B1 (en) 2007-05-23
CZ20032452A3 (cs) 2003-11-12
NO329682B1 (no) 2010-11-29
DK1612208T3 (da) 2011-12-12

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