CN1293071C - 用于治疗青光眼和近视的苯并[g]喹啉衍生物 - Google Patents

用于治疗青光眼和近视的苯并[g]喹啉衍生物 Download PDF

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Publication number
CN1293071C
CN1293071C CNB028138619A CN02813861A CN1293071C CN 1293071 C CN1293071 C CN 1293071C CN B028138619 A CNB028138619 A CN B028138619A CN 02813861 A CN02813861 A CN 02813861A CN 1293071 C CN1293071 C CN 1293071C
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CN
China
Prior art keywords
compound
formula
myopia
acid addition
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028138619A
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English (en)
Chinese (zh)
Other versions
CN1525969A (zh
Inventor
R·马克施泰因
P·古尔
E·庞博维拉尔
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Novartis AG
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Novartis AG
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Publication of CN1525969A publication Critical patent/CN1525969A/zh
Application granted granted Critical
Publication of CN1293071C publication Critical patent/CN1293071C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB028138619A 2001-07-09 2002-07-08 用于治疗青光眼和近视的苯并[g]喹啉衍生物 Expired - Fee Related CN1293071C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01116553 2001-07-09
EP01116553.7 2001-07-09

Publications (2)

Publication Number Publication Date
CN1525969A CN1525969A (zh) 2004-09-01
CN1293071C true CN1293071C (zh) 2007-01-03

Family

ID=8177978

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028138619A Expired - Fee Related CN1293071C (zh) 2001-07-09 2002-07-08 用于治疗青光眼和近视的苯并[g]喹啉衍生物

Country Status (25)

Country Link
US (1) US7105528B2 (enExample)
EP (1) EP1419149B1 (enExample)
JP (2) JP5006505B2 (enExample)
KR (2) KR101069948B1 (enExample)
CN (1) CN1293071C (enExample)
AR (1) AR036131A1 (enExample)
AT (1) ATE443060T1 (enExample)
AU (1) AU2002328856B2 (enExample)
BR (1) BR0210894A (enExample)
CA (1) CA2452920C (enExample)
DE (1) DE60233740D1 (enExample)
EC (1) ECSP024377A (enExample)
ES (1) ES2330732T3 (enExample)
HU (1) HUP0400833A3 (enExample)
IL (2) IL159255A0 (enExample)
MX (1) MXPA03012039A (enExample)
MY (1) MY130656A (enExample)
NO (1) NO327549B1 (enExample)
NZ (1) NZ530314A (enExample)
PE (1) PE20030240A1 (enExample)
PL (1) PL208284B1 (enExample)
PT (1) PT1419149E (enExample)
RU (1) RU2300532C2 (enExample)
WO (1) WO2003006458A1 (enExample)
ZA (1) ZA200309642B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG24415A (en) * 2002-03-07 2009-05-25 Novartis Ag Quinoline derivatives
CA2536874A1 (en) * 2003-09-05 2005-03-17 Novartis Ag Compositions comprising benzo (g) quinoline derivatives and prostaglandin derivatives
RU2438670C1 (ru) * 2010-12-24 2012-01-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО "РостГМУ" Минздравсоцразвития России) Способ лечения ишемического варианта первичной открытоугольной глаукомы у лиц с миопической рефракцией
AR113908A1 (es) 2017-11-24 2020-06-24 H Lundbeck As Profármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
JP7696829B2 (ja) 2019-05-21 2025-06-23 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するためのカテコールアミンカルバメートプロドラッグ
US12384765B2 (en) 2019-05-21 2025-08-12 H. Lundbeck A/S Catecholamine prodrugs for use in the treatment of Parkinson's Disease
WO2020234275A1 (en) 2019-05-21 2020-11-26 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's diseases
WO2020234276A1 (en) 2019-05-21 2020-11-26 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262422A (en) * 1991-05-02 1993-11-16 Sandoz Ltd. Octahydrobenzo[g]quinoline
CN1109332A (zh) * 1993-12-21 1995-10-04 山道士有限公司 苯并[g]喹啉的新用途
CN1225093A (zh) * 1996-07-08 1999-08-04 诺瓦提斯公司 苯并[g]喹啉衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4114325A1 (de) 1991-05-02 1992-11-05 Sandoz Ag Octahydrobenzo(g)chinolin, seine herstellung und verwendung
TW357143B (en) * 1995-07-07 1999-05-01 Novartis Ag Benzo[g]quinoline derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262422A (en) * 1991-05-02 1993-11-16 Sandoz Ltd. Octahydrobenzo[g]quinoline
CN1109332A (zh) * 1993-12-21 1995-10-04 山道士有限公司 苯并[g]喹啉的新用途
CN1225093A (zh) * 1996-07-08 1999-08-04 诺瓦提斯公司 苯并[g]喹啉衍生物

Also Published As

Publication number Publication date
CA2452920C (en) 2010-03-30
KR20100007983A (ko) 2010-01-22
PT1419149E (pt) 2009-11-25
NO327549B1 (no) 2009-08-10
JP2010024243A (ja) 2010-02-04
NO20040059L (no) 2004-01-07
IL159255A0 (en) 2004-06-01
KR20040013126A (ko) 2004-02-11
CA2452920A1 (en) 2003-01-23
CN1525969A (zh) 2004-09-01
NZ530314A (en) 2005-08-26
MXPA03012039A (es) 2004-03-26
AR036131A1 (es) 2004-08-11
RU2004102398A (ru) 2005-07-10
EP1419149A1 (en) 2004-05-19
PE20030240A1 (es) 2003-04-16
ES2330732T3 (es) 2009-12-15
US20040171628A1 (en) 2004-09-02
HUP0400833A2 (hu) 2004-07-28
ATE443060T1 (de) 2009-10-15
PL365254A1 (en) 2004-12-27
JP5006505B2 (ja) 2012-08-22
DE60233740D1 (de) 2009-10-29
IL159255A (en) 2010-05-17
PL208284B1 (pl) 2011-04-29
BR0210894A (pt) 2004-06-22
ZA200309642B (en) 2004-10-04
KR101069948B1 (ko) 2011-10-04
US7105528B2 (en) 2006-09-12
EP1419149B1 (en) 2009-09-16
ECSP024377A (es) 2004-08-27
WO2003006458A1 (en) 2003-01-23
AU2002328856B2 (en) 2005-08-04
JP2004538278A (ja) 2004-12-24
MY130656A (en) 2007-07-31
HUP0400833A3 (en) 2010-03-29
RU2300532C2 (ru) 2007-06-10
HK1066211A1 (en) 2005-03-18

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Free format text: FORMER NAME: NOVARTIS AG

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