KR101069948B1 - 녹내장 및 근시 치료용 벤조 [ｇ] 퀴놀린 유도체 - Google Patents

녹내장 및 근시 치료용 벤조 [ｇ] 퀴놀린 유도체 Download PDF

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Publication number
KR101069948B1
KR101069948B1 KR1020047000232A KR20047000232A KR101069948B1 KR 101069948 B1 KR101069948 B1 KR 101069948B1 KR 1020047000232 A KR1020047000232 A KR 1020047000232A KR 20047000232 A KR20047000232 A KR 20047000232A KR 101069948 B1 KR101069948 B1 KR 101069948B1
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KR
South Korea
Prior art keywords
formula
myopia
compound
benzo
methyl
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Expired - Fee Related
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KR1020047000232A
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English (en)
Korean (ko)
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KR20040013126A (ko
Inventor
루돌프 마크스타인
페터 굴
에스테반 폼보 빌라
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노파르티스 아게
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Publication of KR20040013126A publication Critical patent/KR20040013126A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020047000232A 2001-07-09 2002-07-08 녹내장 및 근시 치료용 벤조 [ｇ] 퀴놀린 유도체 Expired - Fee Related KR101069948B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01116553.7 2001-07-09
EP01116553 2001-07-09
PCT/EP2002/007594 WO2003006458A1 (en) 2001-07-09 2002-07-08 Benzo [g] quinoline derivatives for treating glaucoma and myopia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020097025779A Division KR20100007983A (ko) 2001-07-09 2002-07-08 녹내장 및 근시 치료용 벤조 [ｇ] 퀴놀린 유도체

Publications (2)

Publication Number Publication Date
KR20040013126A KR20040013126A (ko) 2004-02-11
KR101069948B1 true KR101069948B1 (ko) 2011-10-04

Family

ID=8177978

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020097025779A Ceased KR20100007983A (ko) 2001-07-09 2002-07-08 녹내장 및 근시 치료용 벤조 [ｇ] 퀴놀린 유도체
KR1020047000232A Expired - Fee Related KR101069948B1 (ko) 2001-07-09 2002-07-08 녹내장 및 근시 치료용 벤조 [ｇ] 퀴놀린 유도체

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020097025779A Ceased KR20100007983A (ko) 2001-07-09 2002-07-08 녹내장 및 근시 치료용 벤조 [ｇ] 퀴놀린 유도체

Country Status (25)

Country Link
US (1) US7105528B2 (enExample)
EP (1) EP1419149B1 (enExample)
JP (2) JP5006505B2 (enExample)
KR (2) KR20100007983A (enExample)
CN (1) CN1293071C (enExample)
AR (1) AR036131A1 (enExample)
AT (1) ATE443060T1 (enExample)
AU (1) AU2002328856B2 (enExample)
BR (1) BR0210894A (enExample)
CA (1) CA2452920C (enExample)
DE (1) DE60233740D1 (enExample)
EC (1) ECSP024377A (enExample)
ES (1) ES2330732T3 (enExample)
HU (1) HUP0400833A3 (enExample)
IL (2) IL159255A0 (enExample)
MX (1) MXPA03012039A (enExample)
MY (1) MY130656A (enExample)
NO (1) NO327549B1 (enExample)
NZ (1) NZ530314A (enExample)
PE (1) PE20030240A1 (enExample)
PL (1) PL208284B1 (enExample)
PT (1) PT1419149E (enExample)
RU (1) RU2300532C2 (enExample)
WO (1) WO2003006458A1 (enExample)
ZA (1) ZA200309642B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG24415A (en) * 2002-03-07 2009-05-25 Novartis Ag Quinoline derivatives
MXPA06002484A (es) * 2003-09-05 2006-06-20 Novartis Ag Composiciones que comprenden derivados de benzo[g]quinolina y derivados de prostaglandina.
RU2438670C1 (ru) * 2010-12-24 2012-01-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО "РостГМУ" Минздравсоцразвития России) Способ лечения ишемического варианта первичной открытоугольной глаукомы у лиц с миопической рефракцией
KR102712887B1 (ko) 2017-11-24 2024-10-02 하. 룬드벡 아크티에셀스카브 파킨슨병의 치료에 사용하기 위한 새로운 카테콜아민 전구약물
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
CN113677675B (zh) 2019-05-21 2024-07-26 H.隆德贝克有限公司 用于治疗帕金森病的新儿茶酚胺前药
JP7562562B2 (ja) 2019-05-21 2024-10-07 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
US12398106B2 (en) 2019-05-21 2025-08-26 H. Lundbeck A/S Catecholamine carbamate prodrugs for use in the treatment of parkinson's disease
EP3972970A1 (en) 2019-05-21 2022-03-30 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998001444A1 (en) * 1996-07-08 1998-01-15 Novartis Ag BENZO[g]QUINOLINE DERIVATIVES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4114325A1 (de) 1991-05-02 1992-11-05 Sandoz Ag Octahydrobenzo(g)chinolin, seine herstellung und verwendung
US5262422A (en) * 1991-05-02 1993-11-16 Sandoz Ltd. Octahydrobenzo[g]quinoline
GB9326010D0 (en) * 1993-12-21 1994-02-23 Sandoz Ltd Improvements in or relating to organic compounds
TW357143B (en) * 1995-07-07 1999-05-01 Novartis Ag Benzo[g]quinoline derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998001444A1 (en) * 1996-07-08 1998-01-15 Novartis Ag BENZO[g]QUINOLINE DERIVATIVES

Also Published As

Publication number Publication date
RU2004102398A (ru) 2005-07-10
KR20040013126A (ko) 2004-02-11
WO2003006458A1 (en) 2003-01-23
NZ530314A (en) 2005-08-26
PL365254A1 (en) 2004-12-27
CA2452920C (en) 2010-03-30
US20040171628A1 (en) 2004-09-02
JP2010024243A (ja) 2010-02-04
EP1419149A1 (en) 2004-05-19
ECSP024377A (es) 2004-08-27
RU2300532C2 (ru) 2007-06-10
PL208284B1 (pl) 2011-04-29
HUP0400833A3 (en) 2010-03-29
AR036131A1 (es) 2004-08-11
ES2330732T3 (es) 2009-12-15
IL159255A0 (en) 2004-06-01
IL159255A (en) 2010-05-17
JP5006505B2 (ja) 2012-08-22
HK1066211A1 (en) 2005-03-18
JP2004538278A (ja) 2004-12-24
CN1293071C (zh) 2007-01-03
AU2002328856B2 (en) 2005-08-04
NO327549B1 (no) 2009-08-10
PE20030240A1 (es) 2003-04-16
PT1419149E (pt) 2009-11-25
US7105528B2 (en) 2006-09-12
DE60233740D1 (de) 2009-10-29
BR0210894A (pt) 2004-06-22
EP1419149B1 (en) 2009-09-16
HUP0400833A2 (hu) 2004-07-28
MXPA03012039A (es) 2004-03-26
CA2452920A1 (en) 2003-01-23
CN1525969A (zh) 2004-09-01
ATE443060T1 (de) 2009-10-15
NO20040059L (no) 2004-01-07
MY130656A (en) 2007-07-31
KR20100007983A (ko) 2010-01-22
ZA200309642B (en) 2004-10-04

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