ECSP024377A - Derivados de benzo (g) quinolina - Google Patents

Derivados de benzo (g) quinolina

Info

Publication number
ECSP024377A
ECSP024377A EC2002004377A ECSP024377A ECSP024377A EC SP024377 A ECSP024377 A EC SP024377A EC 2002004377 A EC2002004377 A EC 2002004377A EC SP024377 A ECSP024377 A EC SP024377A EC SP024377 A ECSP024377 A EC SP024377A
Authority
EC
Ecuador
Prior art keywords
quinolina
benzo
derivatives
formula
myopia
Prior art date
Application number
EC2002004377A
Other languages
English (en)
Inventor
Peter Gull
Esteban Pombo-Villar
Rudolf Markstein
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP024377A publication Critical patent/ECSP024377A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona un compuesto de la formula I: en donde A, B, X,Y, y R1 son como se definen en la descripción, y un proceso para la preparación del mismo. Los compuestos de la fórmula I son útiles como productos farmacéuticos para el tratamiento de glaucoma y miopia.
EC2002004377A 2001-07-09 2002-12-11 Derivados de benzo (g) quinolina ECSP024377A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01116553 2001-07-09

Publications (1)

Publication Number Publication Date
ECSP024377A true ECSP024377A (es) 2004-08-27

Family

ID=8177978

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2002004377A ECSP024377A (es) 2001-07-09 2002-12-11 Derivados de benzo (g) quinolina

Country Status (25)

Country Link
US (1) US7105528B2 (es)
EP (1) EP1419149B1 (es)
JP (2) JP5006505B2 (es)
KR (2) KR101069948B1 (es)
CN (1) CN1293071C (es)
AR (1) AR036131A1 (es)
AT (1) ATE443060T1 (es)
AU (1) AU2002328856B2 (es)
BR (1) BR0210894A (es)
CA (1) CA2452920C (es)
DE (1) DE60233740D1 (es)
EC (1) ECSP024377A (es)
ES (1) ES2330732T3 (es)
HU (1) HUP0400833A3 (es)
IL (2) IL159255A0 (es)
MX (1) MXPA03012039A (es)
MY (1) MY130656A (es)
NO (1) NO327549B1 (es)
NZ (1) NZ530314A (es)
PE (1) PE20030240A1 (es)
PL (1) PL208284B1 (es)
PT (1) PT1419149E (es)
RU (1) RU2300532C2 (es)
WO (1) WO2003006458A1 (es)
ZA (1) ZA200309642B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG24415A (en) * 2002-03-07 2009-05-25 Novartis Ag Quinoline derivatives
CA2536874A1 (en) * 2003-09-05 2005-03-17 Novartis Ag Compositions comprising benzo (g) quinoline derivatives and prostaglandin derivatives
RU2438670C1 (ru) * 2010-12-24 2012-01-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО "РостГМУ" Минздравсоцразвития России) Способ лечения ишемического варианта первичной открытоугольной глаукомы у лиц с миопической рефракцией
US10729710B2 (en) 2017-11-24 2020-08-04 H. Lundbeck A/S Catecholamine prodrugs for use in the treatment of Parkinson's disease
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
WO2020234277A1 (en) 2019-05-21 2020-11-26 H. Lundbeck A/S Catecholamine carbamate prodrugs for use in the treatment of parkinson s disease
EP3972970A1 (en) 2019-05-21 2022-03-30 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease
EP3972971A1 (en) 2019-05-21 2022-03-30 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's diseases
EP3972959A1 (en) 2019-05-21 2022-03-30 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4114325A1 (de) 1991-05-02 1992-11-05 Sandoz Ag Octahydrobenzo(g)chinolin, seine herstellung und verwendung
US5262422A (en) * 1991-05-02 1993-11-16 Sandoz Ltd. Octahydrobenzo[g]quinoline
GB9326010D0 (en) * 1993-12-21 1994-02-23 Sandoz Ltd Improvements in or relating to organic compounds
TW357143B (en) * 1995-07-07 1999-05-01 Novartis Ag Benzo[g]quinoline derivatives
TW378209B (en) * 1996-07-08 2000-01-01 Novartis Ag Benzo[g]quinoline derivatives, their preparation and the pharmaceutical composition containing them

Also Published As

Publication number Publication date
ES2330732T3 (es) 2009-12-15
MY130656A (en) 2007-07-31
CN1293071C (zh) 2007-01-03
CA2452920C (en) 2010-03-30
JP2010024243A (ja) 2010-02-04
IL159255A (en) 2010-05-17
MXPA03012039A (es) 2004-03-26
DE60233740D1 (de) 2009-10-29
HUP0400833A2 (hu) 2004-07-28
ATE443060T1 (de) 2009-10-15
RU2300532C2 (ru) 2007-06-10
NO327549B1 (no) 2009-08-10
BR0210894A (pt) 2004-06-22
PT1419149E (pt) 2009-11-25
HUP0400833A3 (en) 2010-03-29
WO2003006458A1 (en) 2003-01-23
JP5006505B2 (ja) 2012-08-22
NZ530314A (en) 2005-08-26
HK1066211A1 (en) 2005-03-18
EP1419149B1 (en) 2009-09-16
JP2004538278A (ja) 2004-12-24
US20040171628A1 (en) 2004-09-02
ZA200309642B (en) 2004-10-04
AU2002328856B2 (en) 2005-08-04
EP1419149A1 (en) 2004-05-19
CN1525969A (zh) 2004-09-01
NO20040059L (no) 2004-01-07
KR101069948B1 (ko) 2011-10-04
RU2004102398A (ru) 2005-07-10
PL208284B1 (pl) 2011-04-29
KR20100007983A (ko) 2010-01-22
US7105528B2 (en) 2006-09-12
KR20040013126A (ko) 2004-02-11
IL159255A0 (en) 2004-06-01
PE20030240A1 (es) 2003-04-16
PL365254A1 (en) 2004-12-27
CA2452920A1 (en) 2003-01-23
AR036131A1 (es) 2004-08-11

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