PT1419149E - Derivados de benzo[g]quinolina para o tratamento de glaucoma e miopia - Google Patents

Derivados de benzo[g]quinolina para o tratamento de glaucoma e miopia Download PDF

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Publication number
PT1419149E
PT1419149E PT02764648T PT02764648T PT1419149E PT 1419149 E PT1419149 E PT 1419149E PT 02764648 T PT02764648 T PT 02764648T PT 02764648 T PT02764648 T PT 02764648T PT 1419149 E PT1419149 E PT 1419149E
Authority
PT
Portugal
Prior art keywords
myopia
benzo
quinoline derivatives
treating glaucoma
glaucoma
Prior art date
Application number
PT02764648T
Other languages
English (en)
Inventor
Peter Gull
Esteban Pombo Villar
Rudolf Markstein
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1419149E publication Critical patent/PT1419149E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT02764648T 2001-07-09 2002-07-08 Derivados de benzo[g]quinolina para o tratamento de glaucoma e miopia PT1419149E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01116553 2001-07-09

Publications (1)

Publication Number Publication Date
PT1419149E true PT1419149E (pt) 2009-11-25

Family

ID=8177978

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02764648T PT1419149E (pt) 2001-07-09 2002-07-08 Derivados de benzo[g]quinolina para o tratamento de glaucoma e miopia

Country Status (26)

Country Link
US (1) US7105528B2 (pt)
EP (1) EP1419149B1 (pt)
JP (2) JP5006505B2 (pt)
KR (2) KR101069948B1 (pt)
CN (1) CN1293071C (pt)
AR (1) AR036131A1 (pt)
AT (1) ATE443060T1 (pt)
AU (1) AU2002328856B2 (pt)
BR (1) BR0210894A (pt)
CA (1) CA2452920C (pt)
DE (1) DE60233740D1 (pt)
EC (1) ECSP024377A (pt)
ES (1) ES2330732T3 (pt)
HK (1) HK1066211A1 (pt)
HU (1) HUP0400833A3 (pt)
IL (2) IL159255A0 (pt)
MX (1) MXPA03012039A (pt)
MY (1) MY130656A (pt)
NO (1) NO327549B1 (pt)
NZ (1) NZ530314A (pt)
PE (1) PE20030240A1 (pt)
PL (1) PL208284B1 (pt)
PT (1) PT1419149E (pt)
RU (1) RU2300532C2 (pt)
WO (1) WO2003006458A1 (pt)
ZA (1) ZA200309642B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG24415A (en) * 2002-03-07 2009-05-25 Novartis Ag Quinoline derivatives
BRPI0414149A (pt) * 2003-09-05 2006-10-31 Novartis Ag composições compreendendo derivados de benzo(g)-quinolina e derivados de prostaglandina
PE20211290A1 (es) 2017-11-24 2021-07-20 H Lundbeck As Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad del parkinson
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4114325A1 (de) * 1991-05-02 1992-11-05 Sandoz Ag Octahydrobenzo(g)chinolin, seine herstellung und verwendung
US5262422A (en) * 1991-05-02 1993-11-16 Sandoz Ltd. Octahydrobenzo[g]quinoline
GB9326010D0 (en) * 1993-12-21 1994-02-23 Sandoz Ltd Improvements in or relating to organic compounds
TW357143B (en) 1995-07-07 1999-05-01 Novartis Ag Benzo[g]quinoline derivatives
TW378209B (en) * 1996-07-08 2000-01-01 Novartis Ag Benzo[g]quinoline derivatives, their preparation and the pharmaceutical composition containing them

Also Published As

Publication number Publication date
NZ530314A (en) 2005-08-26
IL159255A0 (en) 2004-06-01
HUP0400833A3 (en) 2010-03-29
RU2004102398A (ru) 2005-07-10
RU2300532C2 (ru) 2007-06-10
MY130656A (en) 2007-07-31
CN1293071C (zh) 2007-01-03
DE60233740D1 (de) 2009-10-29
US20040171628A1 (en) 2004-09-02
JP2004538278A (ja) 2004-12-24
NO20040059L (no) 2004-01-07
KR101069948B1 (ko) 2011-10-04
EP1419149A1 (en) 2004-05-19
NO327549B1 (no) 2009-08-10
PL365254A1 (en) 2004-12-27
KR20100007983A (ko) 2010-01-22
PE20030240A1 (es) 2003-04-16
EP1419149B1 (en) 2009-09-16
AU2002328856B2 (en) 2005-08-04
JP2010024243A (ja) 2010-02-04
JP5006505B2 (ja) 2012-08-22
IL159255A (en) 2010-05-17
CA2452920A1 (en) 2003-01-23
CN1525969A (zh) 2004-09-01
US7105528B2 (en) 2006-09-12
ATE443060T1 (de) 2009-10-15
HK1066211A1 (en) 2005-03-18
ES2330732T3 (es) 2009-12-15
WO2003006458A1 (en) 2003-01-23
PL208284B1 (pl) 2011-04-29
MXPA03012039A (es) 2004-03-26
CA2452920C (en) 2010-03-30
AR036131A1 (es) 2004-08-11
ECSP024377A (es) 2004-08-27
BR0210894A (pt) 2004-06-22
ZA200309642B (en) 2004-10-04
KR20040013126A (ko) 2004-02-11
HUP0400833A2 (hu) 2004-07-28

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