CN1285581C - 制备4,6－二甲氧基－2－(甲基磺酰基)－1,3－嘧啶的方法 - Google Patents

制备4,6－二甲氧基－2－(甲基磺酰基)－1,3－嘧啶的方法 Download PDF

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Publication number
CN1285581C
CN1285581C CNB018131492A CN01813149A CN1285581C CN 1285581 C CN1285581 C CN 1285581C CN B018131492 A CNB018131492 A CN B018131492A CN 01813149 A CN01813149 A CN 01813149A CN 1285581 C CN1285581 C CN 1285581C
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CN
China
Prior art keywords
pyrimidine
organic solvent
reaction
dimethoxy
reaction mixture
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Expired - Fee Related
Application number
CNB018131492A
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English (en)
Chinese (zh)
Other versions
CN1443175A (zh
Inventor
B·杰欧
B·厄维勒
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Syngenta Participations AG
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Syngenta Participations AG
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Publication date
Application filed by Syngenta Participations AG filed Critical Syngenta Participations AG
Publication of CN1443175A publication Critical patent/CN1443175A/zh
Application granted granted Critical
Publication of CN1285581C publication Critical patent/CN1285581C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB018131492A 2000-07-21 2001-07-19 制备4,6－二甲氧基－2－(甲基磺酰基)－1,3－嘧啶的方法 Expired - Fee Related CN1285581C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1439/2000 2000-07-21
CH1439/00 2000-07-21
CH14392000 2000-07-21

Publications (2)

Publication Number Publication Date
CN1443175A CN1443175A (zh) 2003-09-17
CN1285581C true CN1285581C (zh) 2006-11-22

Family

ID=4565478

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018131492A Expired - Fee Related CN1285581C (zh) 2000-07-21 2001-07-19 制备4,6－二甲氧基－2－(甲基磺酰基)－1,3－嘧啶的方法

Country Status (18)

Country Link
US (1) US6693194B2 (https=)
EP (1) EP1301491A1 (https=)
JP (1) JP3507483B1 (https=)
KR (1) KR100516535B1 (https=)
CN (1) CN1285581C (https=)
AR (1) AR033677A1 (https=)
AU (2) AU2001289701B2 (https=)
BR (1) BR0112712A (https=)
CA (1) CA2411155C (https=)
HU (1) HUP0301038A3 (https=)
IL (1) IL153662A0 (https=)
MX (1) MXPA03000431A (https=)
PL (1) PL362686A1 (https=)
RU (1) RU2276142C2 (https=)
TW (1) TWI288132B (https=)
UA (1) UA75888C2 (https=)
WO (1) WO2002008207A1 (https=)
ZA (1) ZA200300510B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1786430E (pt) * 2004-08-20 2013-06-04 Buck Inst For Age Res Pequenas moléculas que substituam ou agonizam a função p53
WO2007117399A2 (en) 2006-03-31 2007-10-18 Janssen Pharmaceutica N.V. Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
SG192446A1 (en) 2008-06-30 2013-08-30 Janssen Pharmaceutica Nv Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
CN102137672B (zh) 2008-06-30 2014-03-26 詹森药业有限公司 取代的嘧啶衍生物的制备方法
CN101747283B (zh) * 2008-12-11 2011-06-08 中国中化股份有限公司 一种制备4，6-二甲氧基-2-甲磺酰基嘧啶的方法
CN105026376B (zh) * 2013-02-18 2018-05-11 加尔达化学有限公司 用于制备双草醚钠及其中间体的方法
PT2964229T (pt) 2013-03-06 2020-03-23 Janssen Pharmaceutica Nv Moduladores de piridina benzimidazol-2-ilo do recetor h4 de histamina
CN112552244A (zh) * 2020-12-22 2021-03-26 内蒙古科硕新材料科技有限公司 一种4,6-二甲氧基-2-甲磺酰基嘧啶的生产工艺
CN115215805B (zh) * 2022-08-11 2024-06-25 上海奥萝拉医药科技有限公司 一种2-氰基嘧啶的制备工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3525977A1 (de) 1985-07-20 1987-01-29 Bayer Ag Verfahren zur herstellung von 2-cyanamino-pyrimidin-derivaten
JP2561480B2 (ja) 1987-08-06 1996-12-11 イハラケミカル工業株式会社 ４，６−ジアルコキシ−２−アルキルチオピリミジン類の製造方法
US5149357A (en) 1990-06-19 1992-09-22 Fmc Corporation Herbicidal substituted benzoylsulfonamides
KR100233068B1 (ko) * 1991-11-26 1999-12-01 하인즈 모제르 2-치환된 4,6-디알콕시피리미딘의 제조방법
TWI220428B (en) * 1999-02-05 2004-08-21 Syngenta Participations Ag Method of producing thiobarbituric acid derivatives

Also Published As

Publication number Publication date
HUP0301038A2 (hu) 2003-08-28
IL153662A0 (en) 2003-07-06
ZA200300510B (en) 2004-04-20
US20030135047A1 (en) 2003-07-17
AU8970101A (en) 2002-02-05
AR033677A1 (es) 2004-01-07
JP3507483B1 (ja) 2004-03-15
RU2276142C2 (ru) 2006-05-10
BR0112712A (pt) 2003-05-20
JP2004504387A (ja) 2004-02-12
MXPA03000431A (es) 2003-06-24
EP1301491A1 (en) 2003-04-16
CN1443175A (zh) 2003-09-17
US6693194B2 (en) 2004-02-17
HUP0301038A3 (en) 2004-06-28
KR20030047992A (ko) 2003-06-18
UA75888C2 (uk) 2006-06-15
CA2411155C (en) 2009-12-08
CA2411155A1 (en) 2002-01-31
AU2001289701B2 (en) 2004-06-24
TWI288132B (en) 2007-10-11
WO2002008207A1 (en) 2002-01-31
KR100516535B1 (ko) 2005-09-22
PL362686A1 (en) 2004-11-02

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Granted publication date: 20061122

Termination date: 20170719